Article ; Online: A Novel Histone Crosstalk Pathway Important for Regulation of UV-Induced DNA Damage Repair in
2017 Volume 206, Issue 3, Page(s) 1389–1402
Abstract: Histone post-translational modifications play vital roles in a variety of nuclear processes, including DNA repair. It has been previously shown that histone H3K79 methylation is important for the cellular response to DNA damage caused by ultraviolet (UV) ...
Abstract | Histone post-translational modifications play vital roles in a variety of nuclear processes, including DNA repair. It has been previously shown that histone H3K79 methylation is important for the cellular response to DNA damage caused by ultraviolet (UV) radiation, with evidence that specific methylation states play distinct roles in UV repair. Here, we report that H3K79 methylation is reduced in response to UV exposure in |
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MeSH term(s) | DNA Breaks, Double-Stranded ; DNA Damage ; Histones/genetics ; Histones/metabolism ; Methylation ; Protein Processing, Post-Translational ; Recombinational DNA Repair ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/radiation effects ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Ultraviolet Rays |
Chemical Substances | Histones ; Saccharomyces cerevisiae Proteins |
Language | English |
Publishing date | 2017 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 2167-2 |
ISSN | 1943-2631 ; 0016-6731 |
ISSN (online) | 1943-2631 |
ISSN | 0016-6731 |
DOI | 10.1534/genetics.116.195735 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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