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Article ; Online: Should RAAS blockade therapy be continued in patients with advanced renal disease?

Pham, Kim / Beyer, Carli

2023 Volume 72, Issue 3, Page(s) 144–145

Abstract: Probably. Renin-angiotensin-aldosterone system (RAAS) blockade therapy should be continued in most patients with advanced renal disease and comorbid conditions; however, individualized treatment is warranted as data on the benefits and harms in all-cause ...

Abstract	Probably. Renin-angiotensin-aldosterone system (RAAS) blockade therapy should be continued in most patients with advanced renal disease and comorbid conditions; however, individualized treatment is warranted as data on the benefits and harms in all-cause mortality, cardiovascular mortality, and risk for renal replacement therapy are inconclusive (strength of recommendation [SOR]: B, based on observational studies, systematic reviews, and meta-analyses of randomized controlled trials [RCTs]). Certain patient populations, such as patients with diabetes or those with cardiovascular risk or history, may benefit most from continued RAAS blockade therapy (SOR: A, based on systematic reviews and meta-analyses of RCTs).
MeSH term(s)	Humans ; Renin-Angiotensin System ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists/therapeutic use ; Diabetes Mellitus
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	197883-4
ISSN	1533-7294 ; 0094-3509
ISSN (online)	1533-7294
ISSN	0094-3509
DOI	10.12788/jfp.0577
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Article: The Impact of a Dedicated Multidisciplinary Team Approach for Prosthetic Joint Infections of the Lower Limb.

Sires, James D / Pham, Kim / Wilson, Christopher J

Indian journal of orthopaedics

2023 Volume 57, Issue 5, Page(s) 696–702

Abstract: Introduction: Prosthetic joint infections (PJI) of the hip and knee have significant morbidity and mortality, and present with varying local, host and microbiological factors. Given the broad presentation and complexity of PJI's, we developed a ... ...

Abstract	Introduction: Prosthetic joint infections (PJI) of the hip and knee have significant morbidity and mortality, and present with varying local, host and microbiological factors. Given the broad presentation and complexity of PJI's, we developed a dedicated multidisciplinary team (MDT) to manage this complex patient cohort, and report on our early outcomes. Methods: This was a retrospective observational study of all patients diagnosed with a prosthetic joint infection of the hip or knee ( Results: 85.2% of individuals in the pre-MDT, and 85.7% of individuals in the post-MDT group were considered cured at a minimum 2 years post-operatively according to the Delphi-based definition. The total number of admissions to hospital (2.44 vs. 1.84) and total number of antibiotics used (3.37 vs. 2.75) decreased in the post-MDT group; however, differences were not considered statistically significant. Discussion: Implementation of a dedicated MDT in the management of individuals with PJI's of the lower limb at our hospital has allowed early and effective collaboration between healthcare personnel, with early promising results. Given the broad nature of PJI, future studies are ongoing to determine modifiable risk factors to reduce the incidence and improve outcomes of individuals with PJI's where systems can then be implemented into already established MDTs to achieve the best clinical outcome for our patients. Supplementary information: The online version contains supplementary material available at 10.1007/s43465-023-00842-5.
Language	English
Publishing date	2023-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-00842-5
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Article ; Online: The impact of air pollution on neurocognitive development: Adverse effects and health disparities.

Pham, Kim-Chi T / Chiew, Kimberly S

Developmental psychobiology

2023 Volume 65, Issue 8, Page(s) e22440

Abstract: Air pollution is recognized as a major public health concern. The number of deaths related to ambient air pollution has increased in recent years and is projected to continue rising. Additionally, both short- and long-term air pollution exposure has been ...

Abstract	Air pollution is recognized as a major public health concern. The number of deaths related to ambient air pollution has increased in recent years and is projected to continue rising. Additionally, both short- and long-term air pollution exposure has been linked with deleterious effects on neurocognitive function and development. While air pollution poses as a threat to everyone, people of color and individuals of lower socioeconomic status are often exposed to elevated levels of air pollution as a function of systemic racism and classism. Further, given additional disparities in access to healthcare and other compounding stressors, adverse effects of air pollution on neurocognitive health are exacerbated among individuals who hold marginalized identities-making effects both less likely to be detected and treated. This review examines evidence of the effects of air pollution on neurocognitive development across the lifespan and incorporates an environmental justice perspective to highlight disparities in air pollution exposure across race and socioeconomic status. Last, upon the reviewed evidence, limitations of past research and recommendations for policy are discussed.
MeSH term(s)	Humans ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Air Pollution/adverse effects ; Social Class
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	4107-5
ISSN	1098-2302 ; 0012-1630
ISSN (online)	1098-2302
ISSN	0012-1630
DOI	10.1002/dev.22440
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Book ; Online: Laser-driven ultrafast impedance spectroscopy for measuring complex ion hopping processes

Pham, Kim H. / Cushing, Scott K.

2023

Abstract: Superionic conductors, or solid-state ion-conductors that surpass 0.01 S/cm in conductivity, can enable more energy dense batteries, robust artificial ion pumps, and optimized fuel cells. However, tailoring superionic conductors require precise knowledge ...

Abstract	Superionic conductors, or solid-state ion-conductors that surpass 0.01 S/cm in conductivity, can enable more energy dense batteries, robust artificial ion pumps, and optimized fuel cells. However, tailoring superionic conductors require precise knowledge of ion migration mechanisms that are still not well understood, due to limitations set by available spectroscopic tools. Most spectroscopic techniques do not probe ion hopping on its inherent picosecond timescale, nor the many-body correlations between the migrating ions, lattice vibrational modes, and charge screening clouds--all of which are posited to greatly enhance ionic conduction. Here, we develop an ultrafast technique that measures the time-resolved change in impedance upon light excitation which triggers selective ion-coupled correlations. We apply our proposed technique to study a solid-state Li+ conductor Li0.5La0.5TiO3 (LLTO). We compare the relative change in impedance of LLTO before and after a UV to THz frequency excitation to map the corresponding ion-many-body-interaction correlations. We also develop a cost-effective, non-time-resolved laser-driven impedance method that is more accessible for lab-scale adoption. From both our techniques, we determine that electronic screening and phonon-mode interactions dominate the ion migration pathway of LLTO. Although we only present one case study, our technique can also probe O2-, H+, or other ion and charge carrier transport phenomena where ultrafast correlations control transport. Furthermore, the temporal relaxation of the measured impedance can distinguish ion transport effects caused by many-body correlations, optical heating, correlation, and memory behavior.
Keywords	Physics - Instrumentation and Detectors ; Physics - Applied Physics
Subject code	612
Publishing date	2023-10-13
Publishing country	us
Document type	Book ; Online
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Article ; Online: When Institutions Harm Those Who Depend on Them: A Scoping Review of Institutional Betrayal.

Christl, Maria-Ernestina / Pham, Kim-Chi Tran / Rosenthal, Adi / DePrince, Anne P

Trauma, violence & abuse

2024 , Page(s) 15248380241226627

Abstract: The term institutional betrayal (Smith and Freyd, 2014) builds on the conceptual framework of betrayal trauma theory (see Freyd, 1996) to describe the ways that institutions (e.g., universities, workplaces) fail to take appropriate steps to prevent and/ ... ...

Abstract	The term institutional betrayal (Smith and Freyd, 2014) builds on the conceptual framework of betrayal trauma theory (see Freyd, 1996) to describe the ways that institutions (e.g., universities, workplaces) fail to take appropriate steps to prevent and/or respond appropriately to interpersonal trauma. A nascent literature has begun to describe individual costs associated with institutional betrayal throughout the United States (U.S.), with implications for public policy and institutional practice. A scoping review was conducted to quantify existing study characteristics and key findings to guide research and practice going forward. Multiple academic databases were searched for keywords (i.e., "institutional betrayal" and "organizational betrayal"). Thirty-seven articles met inclusion criteria (i.e., peer-reviewed empirical studies of institutional betrayal) and were included in analyses. Results identified research approaches, populations and settings, and predictor and outcome variables frequently studied in relation to institutional betrayal. This scoping review describes a strong foundation of published studies and provides recommendations for future research, including longitudinal research with diverse individuals across diverse institutional settings. The growing evidence for action has broad implications for research-informed policy and institutional practice.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2070884-1
ISSN	1552-8324 ; 1524-8380
ISSN (online)	1552-8324
ISSN	1524-8380
DOI	10.1177/15248380241226627
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Article ; Online: Remote collection of electrophysiological data with brain wearables: opportunities and challenges.

Sugden, Richard James / Pham-Kim-Nghiem-Phu, Viet-Linh Luke / Campbell, Ingrid / Leon, Alberto / Diamandis, Phedias

Bioelectronic medicine

2023 Volume 9, Issue 1, Page(s) 12

Abstract: Collection of electroencephalographic (EEG) data provides an opportunity to non-invasively study human brain plasticity, learning and the evolution of various neuropsychiatric disorders. Traditionally, due to sophisticated hardware, EEG studies have been ...

Abstract	Collection of electroencephalographic (EEG) data provides an opportunity to non-invasively study human brain plasticity, learning and the evolution of various neuropsychiatric disorders. Traditionally, due to sophisticated hardware, EEG studies have been largely limited to research centers which restrict both testing contexts and repeated longitudinal measures. The emergence of low-cost "wearable" EEG devices now provides the prospect of frequent and remote monitoring of the human brain for a variety of physiological and pathological brain states. In this manuscript, we survey evidence that EEG wearables provide high-quality data and review various software used for remote data collection. We then discuss the growing body of evidence supporting the feasibility of remote and longitudinal EEG data collection using wearables including a discussion of potential biomedical applications of these protocols. Lastly, we discuss some additional challenges needed for EEG wearable research to gain further widespread adoption.
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2929561-0
ISSN	2332-8886 ; 2332-8886
ISSN (online)	2332-8886
ISSN	2332-8886
DOI	10.1186/s42234-023-00114-5
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Article ; Online: Are SERMs safe and effective for the treatment of hypogonadism in men?

Joseph, Tina / Gibbs, Lawrence M / Pham, Kim

The Journal of family practice

2022 Volume 71, Issue 1, Page(s) E18–E21

Abstract: YES. For both normal-weight and obese men with low testosterone levels and hypogonadal symptoms, selective estrogen receptor modulators (SERMs), such as clomiphene citrate (CC) and enclomiphene citrate (EC), appear to be effective and safe for improving ... ...

Abstract	YES. For both normal-weight and obese men with low testosterone levels and hypogonadal symptoms, selective estrogen receptor modulators (SERMs), such as clomiphene citrate (CC) and enclomiphene citrate (EC), appear to be effective and safe for improving serum testosterone levels (strength of recommendation [SOR]: C, disease-oriented outcomes from randomized controlled trials [RCTs] and cohort studies). Studies also show that symptom improvement is comparable to that with exogenous testosterone replacement and similar to eugonadal men (SOR: B, patient-oriented outcomes from retrospective cohort studies).
MeSH term(s)	Clomiphene/therapeutic use ; Enclomiphene ; Humans ; Hypogonadism/drug therapy ; Male ; Selective Estrogen Receptor Modulators ; Testosterone/therapeutic use
Chemical Substances	Selective Estrogen Receptor Modulators ; Clomiphene (1HRS458QU2) ; Testosterone (3XMK78S47O) ; Enclomiphene (R6D2UI4FLS)
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	197883-4
ISSN	1533-7294 ; 0094-3509
ISSN (online)	1533-7294
ISSN	0094-3509
DOI	10.12788/jfp.0342
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Zs.A 1274: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 444: Show issues

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Article ; Online: Multimodal method for the scattering by an array of plates connected to an elastic half-space.

Maurel, Agnès / Pham, Kim

The Journal of the Acoustical Society of America

2020 Volume 146, Issue 6, Page(s) 4402

Abstract: An accurate and numerically inexpensive method is presented to calculate the reflection of in-plane waves at the free surface of an elastic substrate supporting a periodic array of plates. The method is based on the expansions of the elastic fields on ... ...

Abstract	An accurate and numerically inexpensive method is presented to calculate the reflection of in-plane waves at the free surface of an elastic substrate supporting a periodic array of plates. The method is based on the expansions of the elastic fields on the pseudo-periodic modes in the substrate and on the Lamb modes in the plates. These expansions involve unknown amplitudes which are determined by simple matrix inversion when accounting for the boundary conditions at the surface of the substrate and at the free edges of the plates. Exemplifying results are reported in a wide range of frequency covering two resonances of the plates which are analyzed: a flexural resonance of slender bodies and the quasi-resonance of the so-called edge mode. The convergence of the method is inspected quantitatively; it is shown that it is good in view of the fact that the stress is singular at the corners of the plates in contact with the substrate. In particular, the scattering coefficients converge as 1/N
Language	English
Publishing date	2020-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.5139408
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Zs.B 591: Show issues

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Article: Revisiting imperfect interface laws for two-dimensional elastodynamics.

Pham, Kim / Maurel, Agnès / Marigo, Jean-Jacques

Proceedings. Mathematical, physical, and engineering sciences

2021 Volume 477, Issue 2245, Page(s) 20200519

Abstract: We study the interaction of in-plane elastic waves with imperfect interfaces composed of a periodic array of voids or cracks. An effective model is derived from high-order asymptotic analysis based on two-scale homogenization and matched asymptotic ... ...

Abstract	We study the interaction of in-plane elastic waves with imperfect interfaces composed of a periodic array of voids or cracks. An effective model is derived from high-order asymptotic analysis based on two-scale homogenization and matched asymptotic technique. In two-dimensional elasticity, we obtain jump conditions set on the in-plane displacements and normal stresses; the jumps involve in addition effective parameters provided by static, elementary problems being the equivalents of the cell problems in classical two-scale homogenization. The derivation of the model is conducted in the transient regime and its stability is guarantied by the positiveness of the effective interfacial energy. Spring models are envisioned as particular cases. It is shown that
Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	209241-4
ISSN	1471-2946 ; 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
ISSN (online)	1471-2946
ISSN	1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
DOI	10.1098/rspa.2020.0519
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Article ; Online: The Frank H. Netter MD School of Medicine at Quinnipiac University.

Konopasek, Lyuba / Coplit, Lisa D / Pham, Kim-Thu C

Academic medicine : journal of the Association of American Medical Colleges

2021 Volume 95, Issue 9S A Snapshot of Medical Student Education in the United States and Canada: Reports From 145 Schools, Page(s) S74–S78

Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000003276
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Zs.A 112: Show issues

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