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Article ; Online: Female Sexually Fluid (Non)identity Management Strategies at Work.

Pham, Quan Thuong

2022 Volume 71, Issue 1, Page(s) 232–258

Abstract: Previous research on sexual identity management at work focuses on default fixed sexual categories and related strategies such ... ...

Abstract	Previous research on sexual identity management at work focuses on default fixed sexual categories and related strategies such as
MeSH term(s)	Humans ; Female ; Sexual and Gender Minorities ; Sexual Behavior ; Gender Identity ; Social Identification ; Workplace
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	193138-6
ISSN	1540-3602 ; 0091-8369
ISSN (online)	1540-3602
ISSN	0091-8369
DOI	10.1080/00918369.2022.2111537
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Article ; Online: Virus-assisted directed evolution of biomolecules.

Jewel, Delilah / Pham, Quan / Chatterjee, Abhishek

Current opinion in chemical biology

2023 Volume 76, Page(s) 102375

Abstract: Directed evolution is a powerful technique that uses principles of natural evolution to enable the development of biomolecules with novel functions. However, the slow pace of natural evolution does not support the demand for rapidly generating new ... ...

Abstract	Directed evolution is a powerful technique that uses principles of natural evolution to enable the development of biomolecules with novel functions. However, the slow pace of natural evolution does not support the demand for rapidly generating new biomolecular functions in the laboratory. Viruses offer a unique path to design fast laboratory evolution experiments, owing to their innate ability to evolve much more rapidly than most living organisms, facilitated by a smaller genome size that tolerate a high frequency of mutations, as well as a fast rate of replication. These attributes offer a great opportunity to evolve various biomolecules by linking their activity to the replication of a suitable virus. This review highlights the recent advances in the application of virus-assisted directed evolution of designer biomolecules in both prokaryotic and eukaryotic cells.
MeSH term(s)	Viruses/genetics ; Mutation ; Directed Molecular Evolution/methods
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	1439176-4
ISSN	1879-0402 ; 1367-5931
ISSN (online)	1879-0402
ISSN	1367-5931
DOI	10.1016/j.cbpa.2023.102375
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Zs.A 4986: Show issues

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Article ; Online: Chemical Tagging of Bioactive Amides by Cooperative Catalysis: Applications in the Syntheses of Drug Conjugates.

Zhao, Cunyuan / Wang, Yuankai / Pham, Quan / Dai, Changhang / Chatterjee, Abhishek / Wasa, Masayuki

Journal of the American Chemical Society

2023 Volume 145, Issue 26, Page(s) 14233–14250

Abstract: We disclose a practical catalytic method for arming bioactive amide-based natural products and other small-molecule drugs with various functional handles for the synthesis of drug conjugates. We demonstrate that a set of readily available Sc-based Lewis ... ...

Abstract	We disclose a practical catalytic method for arming bioactive amide-based natural products and other small-molecule drugs with various functional handles for the synthesis of drug conjugates. We demonstrate that a set of readily available Sc-based Lewis acids and N-based Brønsted bases can function cooperatively to deprotonate amide N-H bonds in polyfunctional drug molecules. An aza-Michael reaction between the resulting amidate and α,β-unsaturated compounds produces an array of drug analogues that are equipped with an alkyne, azide, maleimide, tetrazine, or diazirine moiety under redox and pH-neutral conditions. The utility of this chemical tagging strategy is showcased through the production of drug conjugates by the click reaction between the alkyne-tagged drug derivatives and an azide-containing green fluorescent protein, nanobody, or antibody.
MeSH term(s)	Amides ; Azides/chemistry ; Oxidation-Reduction ; Catalysis ; Alkynes/chemistry ; Click Chemistry/methods
Chemical Substances	Amides ; Azides ; Alkynes
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c00169
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Article ; Online: Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant

Tran, Khai Quang / Nguyen, Thuy Thi Dieu / Pham, Van Hung / Pham, Quan Minh / Tran, Hung Do

Advances in respiratory medicine

2023 Volume 91, Issue 2, Page(s) 135–145

Abstract: In recent years, the pathogenic role and antibiotic resistance of methicillin- ... ...

Abstract	In recent years, the pathogenic role and antibiotic resistance of methicillin-resistant
MeSH term(s)	Child ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Vancomycin/pharmacology ; Staphylococcus aureus ; Linezolid ; Staphylococcal Infections/drug therapy ; Cross-Sectional Studies ; Southeast Asian People ; Community-Acquired Infections/drug therapy ; Drug Resistance, Microbial ; Pneumonia
Chemical Substances	Vancomycin (6Q205EH1VU) ; Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.3390/arm91020012
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Article ; Online: Receptivity to misinformation is associated with a preference for complementary alternative medicine for atopic dermatitis.

Pham, Quan / Hrin, Matthew L / Ghamrawi, Rima I / Fleischer, Alan B / Taylor, Sarah L / Feldman, Steven R

International journal of dermatology

2024

Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.17143
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Article ; Online: Investigating the microbial pathogens of sexually transmitted infections among heterosexual Vietnamese men with symptomatic urethritis.

Nguyen, Bac Hoai / Pham, Quan Minh / Hoang, Long / Sansone, Andrea / Jannini, Emmanuele A / Tran, Chau Minh

The aging male : the official journal of the International Society for the Study of the Aging Male

2022 Volume 25, Issue 1, Page(s) 125–133

Abstract: Objective: To explore the microbial etiology of urethritis in Vietnamese men and the association with patients' characteristics, especially their sexual behaviors.: Methods: This study was conducted on 349 men who presented with symptomatic ... ...

Abstract	Objective: To explore the microbial etiology of urethritis in Vietnamese men and the association with patients' characteristics, especially their sexual behaviors. Methods: This study was conducted on 349 men who presented with symptomatic urethritis and evidence of STIs (determined by multiplex PCR tests) at the Department of Andrology and Sexual Medicine-Hanoi Medical University Hospital. All information regarding medical history, sexual activities, and symptoms of urethritis was documented. Results: C. trachomatis Conclusions: Our findings suggested the important role of other microorganisms, especially
MeSH term(s)	Chlamydia trachomatis ; Coinfection/complications ; Coinfection/epidemiology ; Female ; Gonorrhea/complications ; Heterosexuality ; Humans ; Male ; Mycoplasma Infections/complications ; Mycoplasma Infections/diagnosis ; Mycoplasma Infections/epidemiology ; Mycoplasma genitalium ; Prevalence ; Sex Workers ; Sexually Transmitted Diseases/complications ; Sexually Transmitted Diseases/epidemiology ; Urethritis/diagnosis ; Urethritis/epidemiology ; Urethritis/etiology ; Vietnam/epidemiology
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2108146-3
ISSN	1473-0790 ; 1368-5538
ISSN (online)	1473-0790
ISSN	1368-5538
DOI	10.1080/13685538.2022.2063272
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Zs.A 5776: Show issues

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Article ; Online: Acceptability of prenatal diagnosis and prenatal treatment of haemophilia using cell and gene therapies within US haemophilia community.

Pham, Quan D M / Thomson, Sharon M / Schaible, Burk N / Mills, Kevin D / Atala, Anthony / Porada, Christopher D / Almeida-Porada, Graça

Haemophilia : the official journal of the World Federation of Hemophilia

2023 Volume 29, Issue 4, Page(s) 1024–1031

Abstract: Background: The overall burden of disease in persons with haemophilia continues to be high despite the latest advancements in therapeutics. Clinical trials testing prenatal treatments for several genetic disorders are underway or are recruiting subjects, ...

Abstract	Background: The overall burden of disease in persons with haemophilia continues to be high despite the latest advancements in therapeutics. Clinical trials testing prenatal treatments for several genetic disorders are underway or are recruiting subjects, attesting to the much-needed change in paradigm of how patients with monogenic disorders can be treated. Here we investigate the overall attitude towards prenatal diagnosis, preferences on types of prenatal therapies for haemophilia, the level of 'acceptable' risk tolerated, and which social and moral pressures or disease personal experiences may predict willingness of individuals to consider foetal therapy in a future pregnancy. Results: A multidisciplinary team designed the survey, and the study was carried out using REDCap, and publicized through the National Haemophilia Foundation. Subjects ≥18 years of age were eligible to participate in the study. We assessed participants' attitudes towards prenatal therapy and their level of 'acceptable' risk towards the procedure and therapy. The survey was completed by 67 adults, the majority females. Respondents were willing to undergo prenatal diagnosis, and their main concerns related to the well-being of the pregnant woman and the foetus regarding lasting therapeutic efficacy, side effects of the therapy, and procedural risks, but they were likely to accept a wide range of prenatal therapeutic options, particularly if the foetal therapy proved to be long-lasting and safe. Conclusions: These data demonstrate the willingness of persons with haemophilia, and the haemophilia community, to explore new treatment options beyond the currently offered approaches.
MeSH term(s)	Pregnancy ; Adult ; Female ; Humans ; Hemophilia A/diagnosis ; Hemophilia A/therapy ; Hemophilia A/genetics ; Prenatal Diagnosis ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1229713-6
ISSN	1365-2516 ; 1351-8216 ; 1355-0691
ISSN (online)	1365-2516
ISSN	1351-8216 ; 1355-0691
DOI	10.1111/hae.14805
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Zs.A 4249: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Photoredox-Catalyzed Labeling of Hydroxyindoles with Chemoselectivity (PhotoCLIC) for Site-Specific Protein Bioconjugation.

Singha Roy, Soumya Jyoti / Loynd, Conor / Jewel, Delilah / Canarelli, Sarah E / Ficaretta, Elise D / Pham, Quan A / Weerapana, Eranthie / Chatterjee, Abhishek

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 27, Page(s) e202300961

Abstract: We have developed a novel visible-light-catalyzed bioconjugation reaction, PhotoCLIC, that enables chemoselective attachment of diverse aromatic amine reagents onto a site-specifically installed 5-hydroxytryptophan residue (5HTP) on full-length proteins ... ...

Abstract	We have developed a novel visible-light-catalyzed bioconjugation reaction, PhotoCLIC, that enables chemoselective attachment of diverse aromatic amine reagents onto a site-specifically installed 5-hydroxytryptophan residue (5HTP) on full-length proteins of varied complexity. The reaction uses catalytic amounts of methylene blue and blue/red light-emitting diodes (455/650 nm) for rapid site-specific protein bioconjugation. Characterization of the PhotoCLIC product reveals a unique structure formed likely through a singlet oxygen-dependent modification of 5HTP. PhotoCLIC has a wide substrate scope and its compatibility with strain-promoted azide-alkyne click reaction, enables site-specific dual-labeling of a target protein.
MeSH term(s)	Proteins/chemistry ; Azides/chemistry ; 5-Hydroxytryptophan/chemistry ; Alkynes/chemistry ; Catalysis
Chemical Substances	Proteins ; Azides ; 5-Hydroxytryptophan (C1LJO185Q9) ; Alkynes
Language	English
Publishing date	2023-05-23
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202300961
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Article ; Online: Precise Manipulation of the Site and Stoichiometry of Capsid Modification Enables Optimization of Functional Adeno-Associated Virus Conjugates.

Erickson, Sarah B / Pham, Quan / Cao, Xiaofu / Glicksman, Jake / Kelemen, Rachel E / Shahraeini, Seyed S / Bodkin, Sebastian / Kiyam, Zainab / Chatterjee, Abhishek

Bioconjugate chemistry

2023 Volume 35, Issue 1, Page(s) 64–71

Abstract: The ability to engineer adeno-associated virus (AAV) vectors for targeted transduction of specific cell types is critically important to fully harness their potential for human gene therapy. A promising approach to achieve this objective involves ... ...

Abstract	The ability to engineer adeno-associated virus (AAV) vectors for targeted transduction of specific cell types is critically important to fully harness their potential for human gene therapy. A promising approach to achieve this objective involves chemically attaching retargeting ligands onto the virus capsid. Site-specific incorporation of a bioorthogonal noncanonical amino acid (ncAA) into the AAV capsid proteins provides a particularly attractive strategy to introduce such modifications with exquisite precision. In this study, we show that using ncAA mutagenesis, it is possible to systematically alter the attachment site of a retargeting ligand (cyclic-RGD) on the AAV capsid to create diverse conjugate architectures and that the site of attachment heavily impacts the retargeting efficiency. We further demonstrate that the performance of these AAV conjugates is highly sensitive to the stoichiometry of capsid labeling (labels per capsid), with an intermediate labeling density providing optimal activity for cRGD-mediated retargeting. Finally, we developed a technology to more precisely control the number of attachment sites per AAV capsid by selectively incorporating an ncAA into the minor capsid proteins with high fidelity and efficiency, such that AAV conjugates with varying stoichiometry can be synthesized. Together, this platform provides unparalleled control over the site and stoichiometry of capsid modification, which will enable the development of next-generation AAV vectors tailored with desirable attributes.
MeSH term(s)	Humans ; Capsid Proteins/genetics ; Capsid Proteins/chemistry ; Capsid/chemistry ; Dependovirus/genetics ; Dependovirus/metabolism ; Genetic Vectors ; Transduction, Genetic
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2023-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.3c00411
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Article ; Online: Enhanced Directed Evolution in Mammalian Cells Yields a Hyperefficient Pyrrolysyl tRNA for Noncanonical Amino Acid Mutagenesis.

Jewel, Delilah / Kelemen, Rachel E / Huang, Rachel L / Zhu, Zeyu / Sundaresh, Bharathi / Malley, Kaitlin / Pham, Quan / Loynd, Conor / Huang, Zeyi / van Opijnen, Tim / Chatterjee, Abhishek

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 9, Page(s) e202316428

Abstract: Heterologous tRNAs used for noncanonical amino acid (ncAA) mutagenesis in mammalian cells typically show poor activity. We recently introduced a virus-assisted directed evolution strategy (VADER) that can enrich improved tRNA mutants from naïve libraries ...

Abstract	Heterologous tRNAs used for noncanonical amino acid (ncAA) mutagenesis in mammalian cells typically show poor activity. We recently introduced a virus-assisted directed evolution strategy (VADER) that can enrich improved tRNA mutants from naïve libraries in mammalian cells. However, VADER was limited to processing only a few thousand mutants; the inability to screen a larger sequence space precluded the identification of highly active variants with distal synergistic mutations. Here, we report VADER2.0, which can process significantly larger mutant libraries. It also employs a novel library design, which maintains base-pairing between distant residues in the stem regions, allowing us to pack a higher density of functional mutants within a fixed sequence space. VADER2.0 enabled simultaneous engineering of the entire acceptor stem of M. mazei pyrrolysyl tRNA (tRNA
MeSH term(s)	Amino Acids/chemistry ; Amino Acyl-tRNA Synthetases/genetics ; Escherichia coli/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Mutagenesis
Chemical Substances	Amino Acids ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; RNA, Transfer (9014-25-9)
Language	English
Publishing date	2024-01-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202316428
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