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Article ; Online: Protective efficacy of four heat-shock proteins as recombinant vaccines against photobacteriosis in Asian seabass (Lates calcarifer).

Pham, Trung Hieu / Cheng, Ta-Chih / Wang, Pei-Chi / Chen, Shih-Chu

2021 Volume 111, Page(s) 179–188

Abstract: Photobacterium damselae subsp. piscicida (Phdp) is the causative agent of photobacteriosis in marine fish and is responsible for huge losses to marine aquaculture worldwide. Efforts have been made to develop a vaccine against this disease. Heat-shock ... ...

Abstract	Photobacterium damselae subsp. piscicida (Phdp) is the causative agent of photobacteriosis in marine fish and is responsible for huge losses to marine aquaculture worldwide. Efforts have been made to develop a vaccine against this disease. Heat-shock proteins (HSPs) are a family of proteins that are ubiquitous in cellular life. Bacteria produce elevated levels of HSPs as a survival strategy when exposed to stressful environments in a host during infection. This group of proteins are also important antigens that can induce both humoral and cellular immune responses. In this study, four HSPs of Phdp, HSP90, HSP33, HSP70, and DnaJ, were selected for cloning and recombinant expression. Western blotting with rabbit anti-Phdp helped identify rHSP70 and rHSP33 as immunogenic proteins. Asian seabass (Lates calcarifer) immunised with rHSP90, rHSP33, rHSP70, and rDnaJ showed 48.28%, 62.07%, 51.72%, and 31.03% relative percent survival, respectively, after being challenged with Phdp strain AOD105021. High expression levels of immune-related genes and high antibody titres were observed in the rHSP33 group, and the sera of this group also exhibited a high level of bactericidal activity against Phdp. Collectively, our results suggest that HSP33 is a potential candidate for vaccine development against Phdp infection.
MeSH term(s)	Animals ; Bacterial Vaccines/immunology ; Bass ; Fish Diseases/immunology ; Fish Diseases/microbiology ; Fish Diseases/prevention & control ; Fish Proteins/immunology ; Gram-Negative Bacterial Infections/immunology ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/prevention & control ; Gram-Negative Bacterial Infections/veterinary ; Heat-Shock Proteins/immunology ; Photobacterium/physiology ; Vaccines, Synthetic/immunology
Chemical Substances	Bacterial Vaccines ; Fish Proteins ; Heat-Shock Proteins ; Vaccines, Synthetic
Language	English
Publishing date	2021-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2021.02.002
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Article ; Online: Post-COVID condition: a survey of patients recovered from COVID-19 in Central Vietnam.

Tran, Toan Khanh / Nguyen Truong, Son / Tran Thanh, Loan / Le Hoang Gia, Ngoc / Pham Trung, Hieu / Tran Dinh, Binh

Journal of infection in developing countries

2023 Volume 17, Issue 9, Page(s) 1213–1220

Abstract: Introduction: Evidence on post-COVID-19 conditions is emerging. This study aims to assess post-COVID conditions and related factors in COVID-19 patients in Central Vietnam.: Methodology: A descriptive cross-sectional study was performed on people who ...

Abstract	Introduction: Evidence on post-COVID-19 conditions is emerging. This study aims to assess post-COVID conditions and related factors in COVID-19 patients in Central Vietnam. Methodology: A descriptive cross-sectional study was performed on people who have recovered from COVID-19 at least 2 weeks prior to the online survey. Participants were interviewed face-to-face after 6 and 9 months from the first survey. Results: 53 patients (21.2%) were confirmed to have persistent symptoms, of which, 100% and 94.3% reported prolonged fatigue and full-body weakness respectively. Loss of appetite was reported by 90.6%, while persistent cough, insomnia, and trouble sleeping were reported by 86.3% of patients. Headaches and dyspnea were reported by 69.5% and 56.8% respectively, while other symptoms had lower rates. The prevalence of post-COVID condition showed a statistically significant relationship with the time of infection, duration of illness, treatment place, use of herbal medicine, adherence to the 5K message from Vietnam's Ministry of Health, and daily saltwater mouthwash (p < 0.05). However, the use of medicine and supplements was not related to the post-COVID condition (p > 0.05). After 6 months, 125 participants were interviewed face-to-face, and only 15 people (12.0%) reported having post-COVID symptoms, mainly prolonged fatigue (33.3%) and persistent cough (26.7%). After 9 months, these 15 patients no longer had symptoms related to the post- COVID-19 condition. Conclusions: The post-COVID condition can persist for several weeks or months, but will mostly be in remission after 6 months, and completely resolve after 9 months from the onset of the infection.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Cough/epidemiology ; Cross-Sectional Studies ; Vietnam/epidemiology ; Post-Acute COVID-19 Syndrome ; Fatigue/epidemiology
Language	English
Publishing date	2023-09-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.18029
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Article ; Online: An Integrated in silico and in vivo study of nucleic acid vaccine against Nocardia seriolae infection in orange-spotted grouper Epinephelus coioides.

Nguyen, Phuong T D / Giovanni, Andre / Maekawa, Shun / Pham, Trung Hieu / Wang, Pei-Chi / Chen, Shih-Chu

Fish & shellfish immunology

2023 Volume 143, Page(s) 109202

Abstract: Nocardiosis in aquatic animals caused by Nocardia seriolae is a frequently occurring serious infection that has recently spread to many countries. In this study, DNA vaccines containing potential bacterial antigens predicted using the reverse vaccinology ...

Abstract	Nocardiosis in aquatic animals caused by Nocardia seriolae is a frequently occurring serious infection that has recently spread to many countries. In this study, DNA vaccines containing potential bacterial antigens predicted using the reverse vaccinology approach were developed and evaluated in orange-spotted groupers. In silico analysis indicated that proteins including cholesterol oxidase, ld-transpeptidase, and glycosyl hydroxylase have high immunogenicity and are potential vaccine candidates. In vitro assays revealed the mature and biological configurations of these proteins. Importantly, when compared to a control PBS injection, N. seriolae DNA-based vaccines showed significantly higher expression of IL1β, IL17, and IFNγ at 1 or 2 days, in line with higher serum antibody production and expression of other cellular immune-related genes, such as MHCI, CD4, and CD8, at 7 days post-immunization. Remarkably, enhanced immune responses and strong protective efficacy against a highly virulent strain of N. seriolae were recorded in DNA vaccine-cholesterol oxidase (pcD::Cho) injected fish, with a relative survival rate of 73.3%. Our results demonstrate that the reverse vaccinology approach is a valid strategy for screening vaccine candidates and pcD::Cho is a promising candidate that can boost both innate and adaptive immune responses and confer considerable protection against N. seriolae infection.
MeSH term(s)	Animals ; Bass ; Nucleic Acid-Based Vaccines ; Cholesterol Oxidase ; Nocardia Infections/prevention & control ; Nocardia Infections/veterinary ; Vaccines, DNA ; Fish Diseases
Chemical Substances	Nucleic Acid-Based Vaccines ; Cholesterol Oxidase (EC 1.1.3.6) ; Vaccines, DNA
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2023.109202
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Article: Protective efficacy of four heat-shock proteins as recombinant vaccines against photobacteriosis in Asian seabass (Lates calcarifer)

Pham, Trung Hieu / Cheng, Ta-Chih / Wang, Pei-Chi / Chen, Shih-Chu

Fish & shellfish immunology. 2021 Apr., v. 111

2021

Abstract	Photobacterium damselae subsp. piscicida (Phdp) is the causative agent of photobacteriosis in marine fish and is responsible for huge losses to marine aquaculture worldwide. Efforts have been made to develop a vaccine against this disease. Heat-shock proteins (HSPs) are a family of proteins that are ubiquitous in cellular life. Bacteria produce elevated levels of HSPs as a survival strategy when exposed to stressful environments in a host during infection. This group of proteins are also important antigens that can induce both humoral and cellular immune responses. In this study, four HSPs of Phdp, HSP90, HSP33, HSP70, and DnaJ, were selected for cloning and recombinant expression. Western blotting with rabbit anti-Phdp helped identify rHSP70 and rHSP33 as immunogenic proteins. Asian seabass (Lates calcarifer) immunised with rHSP90, rHSP33, rHSP70, and rDnaJ showed 48.28%, 62.07%, 51.72%, and 31.03% relative percent survival, respectively, after being challenged with Phdp strain AOD105021. High expression levels of immune-related genes and high antibody titres were observed in the rHSP33 group, and the sera of this group also exhibited a high level of bactericidal activity against Phdp. Collectively, our results suggest that HSP33 is a potential candidate for vaccine development against Phdp infection.
Keywords	Lates calcarifer ; antibacterial properties ; antibodies ; etiological agents ; mariculture ; marine fish ; rabbits ; shellfish ; vaccine development
Language	English
Dates of publication	2021-04
Size	p. 179-188.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2021.02.002
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Article: The moonlighting protein fructose 1,6-bisphosphate aldolase as a potential vaccine candidate against Photobacterium damselae subsp. piscicida in Asian sea bass (Lates calcarifer)

Pham, Trung Hieu / Rao, Shreesha / Cheng, Ta-Chih / Wang, Pei-Chi / Chen, Shih-Chu

Developmental and comparative immunology. 2021 Nov., v. 124

2021

Abstract: Vaccination is the most effective, safe, and environmentally friendly method to prevent the outbreak of Photobacterium damselae subsp. piscicida (Phdp), a dangerous pathogen in aquaculture worldwide. Here, recombinant proteins of catalase, superoxide ... ...

Abstract	Vaccination is the most effective, safe, and environmentally friendly method to prevent the outbreak of Photobacterium damselae subsp. piscicida (Phdp), a dangerous pathogen in aquaculture worldwide. Here, recombinant proteins of catalase, superoxide dismutase, isocitrate dehydrogenase, fructose 1,6-bisphosphate aldolase (Fba), and a mixture of all four proteins were investigated for their immunoprotective effects against photobacteriosis in Asian sea bass (Lates calcarifer). After immunization, experimental fish showed an increase in specific antibody levels and lysozyme activities, especially the Fba group. After a lethal challenge with Phdp strain AOD105021, the Fba group achieved the highest relative percentage of survival rate (70.21%) and a significantly lower bacterial load in the spleens than other groups 3 days after infection. The results suggest that Fba is a good candidate for subunit vaccine development against photobacteriosis in fish.
Keywords	Lates calcarifer ; antibodies ; aquaculture ; catalase ; fish ; fructose-bisphosphate aldolase ; isocitrate dehydrogenase ; lysozyme ; microbial load ; pathogens ; subunit vaccines ; superoxide dismutase ; survival rate ; sustainable technology ; vaccination ; vaccine development
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2021.104187
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Article ; Online: Genotypic diversity, and molecular and pathogenic characterization of Photobacterium damselae subsp. piscicida isolated from different fish species in Taiwan.

Pham, Trung Hieu / Cheng, Ta-Chih / Wang, Pei-Chi / Chen, Shih-Chu

Journal of fish diseases

2020 Volume 43, Issue 7, Page(s) 757–774

Abstract: Photobacteriosis, caused by Photobacterium damselae subsp. piscicida (Phdp), is a serious disease in marine fish species worldwide. To date, the epidemiological characterization of this pathogen in Taiwan remains limited. In this study, we collected 39 ... ...

Abstract	Photobacteriosis, caused by Photobacterium damselae subsp. piscicida (Phdp), is a serious disease in marine fish species worldwide. To date, the epidemiological characterization of this pathogen in Taiwan remains limited. In this study, we collected 39 Phdp isolates obtained from different farmed fish for phenotypic and genotypic analysis. Phenotype bioassays using API-20E and API-20NE systems showed that the Phdp is a homogeneous group. However, genotyping using the pulsed-field gel electrophoresis (PFGE) technique revealed genetic variability among Phdp isolates when 13 and 11 different PFGE band patterns were obtained with SmaI and NotI as restriction enzymes, respectively. Phylogenetic analysis using 16S rDNA and the Fur gene clustered Taiwanese isolates and other species of P. damselae in the same clade. In contrast, the ToxR phylogenetic tree, a powerful discriminatory marker, separated the two subspecies. Furthermore, the virulence-associated genes, AIP56, P55, PDP_0080, Sod and Irp1, were detected from all isolates. Virulence testing with nine representative isolates in cobia (Rachycentron canadum) and Asian sea bass (Lates calcarifer) showed that some were highly pathogenic with 80%-100% mortality rates. This study provides epidemiological data of Phdp infections in farmed fish in Taiwan, which is necessary to develop comprehensive prevention and control strategies for the disease.
MeSH term(s)	Animals ; Fish Diseases/microbiology ; Fishes ; Genetic Variation ; Genotype ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/veterinary ; Phenotype ; Photobacterium/genetics ; Photobacterium/pathogenicity ; Photobacterium/physiology ; Phylogeny ; Taiwan ; Virulence/genetics
Language	English
Publishing date	2020-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	432109-1
ISSN	1365-2761 ; 0140-7775
ISSN (online)	1365-2761
ISSN	0140-7775
DOI	10.1111/jfd.13173
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Article: Novel technique for scapulothoracic arthroscopy: A case report of the application of intraoperative 3D imaging.

Vo, Sy Quyen Nang / Vu, Tu Nam / Pham, Trung Hieu / Nguyen, Huu Manh / Tran, Trung Dung

International journal of surgery case reports

2021 Volume 89, Page(s) 106562

Abstract: Introduction: Snapping shoulder syndrome could be effectively treated with scapulothoracic arthroscopy. The excision of the scapular superomedial corner is assumed to help lower the recurrence rate. However, the amount of resection is still ... ...

Abstract	Introduction: Snapping shoulder syndrome could be effectively treated with scapulothoracic arthroscopy. The excision of the scapular superomedial corner is assumed to help lower the recurrence rate. However, the amount of resection is still controversial. Furthermore, we lack a technique to measure if the resected amount was adequate based only on arthroscopy evaluation. Case study presentation: We describe a 47-year-old man who suffered from severe snapping shoulder syndrome as a consequence of a deformity of the left superomedial scapular corner. The patient had endoscopic bursectomy and superomedial corner resection. Intraoperative three-dimensional CT scans (3D-CT) were used to evaluate the amount of resection. The patient recovered without incident and resumed his usual activities within 30 days following surgery. At the six-month follow-up, there were no recurrent symptoms. Conclusion: Intraoperative 3D imaging significantly enhances the safety and efficacy of scapulothoracic arthroscopy. This is a novel technique that, to our knowledge, has not been reported previously in the literature.
Language	English
Publishing date	2021-11-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2021.106562
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Article ; Online: The moonlighting protein fructose 1,6-bisphosphate aldolase as a potential vaccine candidate against Photobacterium damselae subsp. piscicida in Asian sea bass (Lates calcarifer).

Pham, Trung Hieu / Rao, Shreesha / Cheng, Ta-Chih / Wang, Pei-Chi / Chen, Shih-Chu

Developmental and comparative immunology

2021 Volume 124, Page(s) 104187

Abstract	Vaccination is the most effective, safe, and environmentally friendly method to prevent the outbreak of Photobacterium damselae subsp. piscicida (Phdp), a dangerous pathogen in aquaculture worldwide. Here, recombinant proteins of catalase, superoxide dismutase, isocitrate dehydrogenase, fructose 1,6-bisphosphate aldolase (Fba), and a mixture of all four proteins were investigated for their immunoprotective effects against photobacteriosis in Asian sea bass (Lates calcarifer). After immunization, experimental fish showed an increase in specific antibody levels and lysozyme activities, especially the Fba group. After a lethal challenge with Phdp strain AOD105021, the Fba group achieved the highest relative percentage of survival rate (70.21%) and a significantly lower bacterial load in the spleens than other groups 3 days after infection. The results suggest that Fba is a good candidate for subunit vaccine development against photobacteriosis in fish.
MeSH term(s)	Animals ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Aquaculture ; Bacterial Load/immunology ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Bacterial Proteins/isolation & purification ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Fish Diseases/microbiology ; Fish Diseases/prevention & control ; Fructose-Bisphosphate Aldolase/genetics ; Fructose-Bisphosphate Aldolase/immunology ; Fructose-Bisphosphate Aldolase/isolation & purification ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/prevention & control ; Gram-Negative Bacterial Infections/veterinary ; Muramidase/blood ; Muramidase/immunology ; Perciformes/immunology ; Perciformes/microbiology ; Photobacterium/enzymology ; Photobacterium/immunology ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/isolation & purification ; Spleen/immunology ; Spleen/microbiology ; Vaccination/veterinary ; Vaccine Efficacy ; Vaccines, Subunit/administration & dosage ; Vaccines, Subunit/immunology
Chemical Substances	Antibodies, Bacterial ; Bacterial Proteins ; Bacterial Vaccines ; Recombinant Proteins ; Vaccines, Subunit ; Muramidase (EC 3.2.1.17) ; Fructose-Bisphosphate Aldolase (EC 4.1.2.13)
Language	English
Publishing date	2021-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2021.104187
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: First report on genetic characterization, cell‐surface properties and pathogenicity of Lactococcus garvieae, emerging pathogen isolated from cage‐cultured cobia (Rachycentron canadum)

Rao, Shreesha / Pham, Trung Hieu / Poudyal, Sayuj / Cheng, Li‐Wu / Nazareth, Sandra Celenia / Wang, Pei‐Chi / Chen, Shih‐Chu

Transboundary and emerging diseases. 2022 May, v. 69, no. 3

2022

Abstract: The diseased cage‐cultured cobia (Rachycentron canadum) displayed clinical signs, haemorrhagic eyes, dorsal darkness and gross pathological lesions, enlargement of spleen and liver. Haemorrhages were found in brain, heart and liver with cumulative ... ...

Abstract	The diseased cage‐cultured cobia (Rachycentron canadum) displayed clinical signs, haemorrhagic eyes, dorsal darkness and gross pathological lesions, enlargement of spleen and liver. Haemorrhages were found in brain, heart and liver with cumulative mortality rates ranging from 20% to 50%. Extensive congestion in the heart, liver, spleen, kidney and brain was observed histopathologically. Epicarditis and meningitis were also revealed in diseased cobia. All isolates recovered from the organs (liver, spleen, head kidney, posterior kidney, brain and muscle) of cobia were found to be gram‐positive, non‐motile, ovoid cocci, short‐chain–forming (diplococci) and α‐haemolytic. The API 32 strep system together with the polymerase chain reaction assay for species‐specific primers (pLG1 and pLG2) and the internal transcribed spacer (ITS) region (G1 and L1 primers) confirmed all four selected isolates as Lactococcus garvieae. Partial 16S rDNA nucleotide sequence (~1,100 bp) of one representative L. garvieae isolate AOD109191 (GenBank accession number, MW328528.1) shared 99.9% identities with the 16S rDNA nucleotide sequence of L. garvieae (GenBank accession numbers: MT604790.1). Transmission electron microscopy (TEM) evaluation of one representative L. garvieae isolate (AOD109191) and the results of multiplex PCR did not reveal the presence of the capsular gene cluster (CGC), thus categorizing the isolate as the KG+ phenotype. Capsule staining and TEM observations confirmed the presence of a hyaluronic acid‐like capsule, a possible virulence factor in KG+ phenotype L. garvieae isolates. The pathogenic potential of the representative isolate (AOD109191) was assessed through intraperitoneal injection challenges in cobia. The gross lesions and histopathological changes found in experimentally infected cobia were similar to those seen in naturally infected fish. This is the first report that confirms L. garvieae‐induced ‘warm water lactococcsis’ can cause outbreaks of diseases in cage‐cultured cobia.
Keywords	Lactococcus garvieae ; Rachycentron canadum ; brain ; fish ; heart ; histopathology ; internal transcribed spacers ; intraperitoneal injection ; kidneys ; liver ; meningitis ; mortality ; multigene family ; muscles ; pathogens ; phenotype ; polymerase chain reaction ; spleen ; transmission electron microscopy ; virulence
Language	English
Dates of publication	2022-05
Size	p. 1197-1211.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14083
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Article: Non-oncologic indication for elbow megaprothesis replacement: 2 cases report.

Tran Trung, Dung / Tran, Quyet / Vu Tu, Nam / Nguyen Tran Quang, Sang / Nguyen Huu, Manh / Pham Trung, Hieu

International journal of surgery case reports

2021 Volume 86, Page(s) 106356

Abstract: Introduction: Treatment of elbow bone defects is still a huge challenge in orthopaedic in order to restore the shape and function of the elbow joint. Bone defect reconstruction is very difficult due to biomechanical complexity of the elbow joint and the ...

Abstract	Introduction: Treatment of elbow bone defects is still a huge challenge in orthopaedic in order to restore the shape and function of the elbow joint. Bone defect reconstruction is very difficult due to biomechanical complexity of the elbow joint and the poor coverage tissue of this area, so mega-prothesis can be considered the most optimal solution in these cases. Case report: We present two clinical cases of megaprosthesis elbow replacement for treatment of bone defects caused by sequelae of trauma. There is one case of 3 cm bone defect at proximal ulna and one case of 3 cm bone defect at distal humerus. In the 1st case, the elbow joint is fusioned and the second case, the elbow joint is degenerated totally after 3 previous surgery. We performed total elbow replacement with a customized megaprosthesis for them. The Mayo elbow function assessment scale [1] pre-surgery was poor at 50 points. The average age is 35 years old. The mean post-operative follow-up time was 14 months. Range of elbow flexed motion was 135 degrees, both patients were maximally extension, the forearm pronation and supination were 90 and 75 degrees, respectively. The Mayo score is very good with 97,5 points. Both patients were completely satisfied with the postoperative results. Conclusion: Our results show that megaprosthesis elbow replacement is a very effective option for cases large elbow bone defects due to trauma sequelae. However, careful preoperative preparation is required for the best outcome.
Language	English
Publishing date	2021-09-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2021.106356
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