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  1. Article ; Online: PURL: Let low-risk moms eat during labor?

    Phelps, Karen / Deavers, Justin / Seehusen, Dean A / Stevermer, James J

    The Journal of family practice

    2018  Volume 67, Issue 6, Page(s) 379–380

    Abstract: Allowing low-risk pregnant women to eat less restrictive diets during labor may not only make them happier, but may shorten labor, too. ...

    Abstract Allowing low-risk pregnant women to eat less restrictive diets during labor may not only make them happier, but may shorten labor, too.
    MeSH term(s) Eating ; Female ; Humans ; Labor, Obstetric ; Pregnancy
    Language English
    Publishing date 2018-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 197883-4
    ISSN 1533-7294 ; 0094-3509
    ISSN (online) 1533-7294
    ISSN 0094-3509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The spiritual assessment.

    Saguil, Aaron / Phelps, Karen

    American family physician

    2012  Volume 86, Issue 6, Page(s) 546–550

    Abstract: More than 80 percent of Americans perceive religion as important. Issues of belief can affect the health care encounter, and patients may wish to discuss spirituality with their physician. Many physicians report barriers to broaching the subject of ... ...

    Abstract More than 80 percent of Americans perceive religion as important. Issues of belief can affect the health care encounter, and patients may wish to discuss spirituality with their physician. Many physicians report barriers to broaching the subject of spirituality, including lack of time and experience, difficulty identifying patients who want to discuss spirituality, and the belief that addressing spiritual concerns is not a physician's responsibility. Spiritual assessment tools such as the FICA, the HOPE questions, and the Open Invite provide efficient means of eliciting patients' thoughts on this topic. The spiritual assessment allows physicians to support patients by stressing empathetic listening, documenting spiritual preferences for future visits, incorporating the precepts of patients' faith traditions into treatment plans, and encouraging patients to use the resources of their spiritual traditions and communities for overall wellness. Conducting the spiritual assessment also may help strengthen the physician-patient relationship and offer physicians opportunities for personal renewal, resiliency, and growth.
    MeSH term(s) Attitude of Health Personnel ; Evidence-Based Medicine ; Humans ; Physician's Role ; Physician-Patient Relations ; Religion ; Religion and Medicine ; Spirituality
    Language English
    Publishing date 2012-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Closing gaps in the human genome with fosmid resources generated from multiple individuals.

    Bovee, Donald / Zhou, Yang / Haugen, Eric / Wu, Zaining / Hayden, Hillary S / Gillett, Will / Tuzun, Eray / Cooper, Gregory M / Sampas, Nick / Phelps, Karen / Levy, Ruth / Morrison, V Anne / Sprague, James / Jewett, Donald / Buckley, Danielle / Subramaniam, Sandhya / Chang, Jean / Smith, Douglas R / Olson, Maynard V /
    Eichler, Evan E / Kaul, Rajinder

    Nature genetics

    2008  Volume 40, Issue 1, Page(s) 96–101

    Abstract: The human genome sequence has been finished to very high standards; however, more than 340 gaps remained when the finished genome was published by the International Human Genome Sequencing Consortium in 2004. Using fosmid resources generated from ... ...

    Abstract The human genome sequence has been finished to very high standards; however, more than 340 gaps remained when the finished genome was published by the International Human Genome Sequencing Consortium in 2004. Using fosmid resources generated from multiple individuals, we targeted gaps in the euchromatic part of the human genome. Here we report 2,488,842 bp of previously unknown euchromatic sequence, 363,114 bp of which close 26 of 250 euchromatic gaps, or 10%, including two remaining euchromatic gaps on chromosome 19. Eight (30.7%) of the closed gaps were found to be polymorphic. These sequences allow complete annotation of several human genes as well as the assignment of mRNAs. The gap sequences are 2.3-fold enriched in segmentally duplicated sequences compared to the whole genome. Our analysis confirms that not all gaps within 'finished' genomes are recalcitrant to subcloning and suggests that the paired-end-sequenced fosmid libraries could prove to be a rich resource for completion of the human euchromatic genome.
    MeSH term(s) Base Sequence ; Chromosomes, Human, Pair 19 ; Cloning, Molecular ; Euchromatin ; Gene Library ; Genetic Vectors ; Genome, Human ; Human Genome Project ; Humans ; Molecular Sequence Data ; Polymorphism, Genetic
    Chemical Substances Euchromatin
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.2007.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mapping and sequencing of structural variation from eight human genomes.

    Kidd, Jeffrey M / Cooper, Gregory M / Donahue, William F / Hayden, Hillary S / Sampas, Nick / Graves, Tina / Hansen, Nancy / Teague, Brian / Alkan, Can / Antonacci, Francesca / Haugen, Eric / Zerr, Troy / Yamada, N Alice / Tsang, Peter / Newman, Tera L / Tüzün, Eray / Cheng, Ze / Ebling, Heather M / Tusneem, Nadeem /
    David, Robert / Gillett, Will / Phelps, Karen A / Weaver, Molly / Saranga, David / Brand, Adrianne / Tao, Wei / Gustafson, Erik / McKernan, Kevin / Chen, Lin / Malig, Maika / Smith, Joshua D / Korn, Joshua M / McCarroll, Steven A / Altshuler, David A / Peiffer, Daniel A / Dorschner, Michael / Stamatoyannopoulos, John / Schwartz, David / Nickerson, Deborah A / Mullikin, James C / Wilson, Richard K / Bruhn, Laurakay / Olson, Maynard V / Kaul, Rajinder / Smith, Douglas R / Eichler, Evan E

    Nature

    2008  Volume 453, Issue 7191, Page(s) 56–64

    Abstract: Genetic variation among individual humans occurs on many different scales, ranging from gross alterations in the human karyotype to single nucleotide changes. Here we explore variation on an intermediate scale--particularly insertions, deletions and ... ...

    Abstract Genetic variation among individual humans occurs on many different scales, ranging from gross alterations in the human karyotype to single nucleotide changes. Here we explore variation on an intermediate scale--particularly insertions, deletions and inversions affecting from a few thousand to a few million base pairs. We employed a clone-based method to interrogate this intermediate structural variation in eight individuals of diverse geographic ancestry. Our analysis provides a comprehensive overview of the normal pattern of structural variation present in these genomes, refining the location of 1,695 structural variants. We find that 50% were seen in more than one individual and that nearly half lay outside regions of the genome previously described as structurally variant. We discover 525 new insertion sequences that are not present in the human reference genome and show that many of these are variable in copy number between individuals. Complete sequencing of 261 structural variants reveals considerable locus complexity and provides insights into the different mutational processes that have shaped the human genome. These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects.
    MeSH term(s) Chromosome Inversion/genetics ; Euchromatin/genetics ; Gene Deletion ; Genetic Variation/genetics ; Genome, Human/genetics ; Geography ; Haplotypes ; Humans ; Mutagenesis, Insertional/genetics ; Physical Chromosome Mapping ; Polymorphism, Single Nucleotide/genetics ; Racial Groups/genetics ; Reproducibility of Results ; Sequence Analysis, DNA
    Chemical Substances Euchromatin
    Language English
    Publishing date 2008-05-02
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature06862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The DNA sequence, annotation and analysis of human chromosome 3.

    Muzny, Donna M / Scherer, Steven E / Kaul, Rajinder / Wang, Jing / Yu, Jun / Sudbrak, Ralf / Buhay, Christian J / Chen, Rui / Cree, Andrew / Ding, Yan / Dugan-Rocha, Shannon / Gill, Rachel / Gunaratne, Preethi / Harris, R Alan / Hawes, Alicia C / Hernandez, Judith / Hodgson, Anne V / Hume, Jennifer / Jackson, Andrew /
    Khan, Ziad Mohid / Kovar-Smith, Christie / Lewis, Lora R / Lozado, Ryan J / Metzker, Michael L / Milosavljevic, Aleksandar / Miner, George R / Morgan, Margaret B / Nazareth, Lynne V / Scott, Graham / Sodergren, Erica / Song, Xing-Zhi / Steffen, David / Wei, Sharon / Wheeler, David A / Wright, Mathew W / Worley, Kim C / Yuan, Ye / Zhang, Zhengdong / Adams, Charles Q / Ansari-Lari, M Ali / Ayele, Mulu / Brown, Mary J / Chen, Guan / Chen, Zhijian / Clendenning, James / Clerc-Blankenburg, Kerstin P / Chen, Runsheng / Chen, Zhu / Davis, Clay / Delgado, Oliver / Dinh, Huyen H / Dong, Wei / Draper, Heather / Ernst, Stephen / Fu, Gang / Gonzalez-Garay, Manuel L / Garcia, Dawn K / Gillett, Will / Gu, Jun / Hao, Bailin / Haugen, Eric / Havlak, Paul / He, Xin / Hennig, Steffen / Hu, Songnian / Huang, Wei / Jackson, Laronda R / Jacob, Leni S / Kelly, Susan H / Kube, Michael / Levy, Ruth / Li, Zhangwan / Liu, Bin / Liu, Jing / Liu, Wen / Lu, Jing / Maheshwari, Manjula / Nguyen, Bao-Viet / Okwuonu, Geoffrey O / Palmeiri, Anthony / Pasternak, Shiran / Perez, Lesette M / Phelps, Karen A / Plopper, Farah J H / Qiang, Boqin / Raymond, Christopher / Rodriguez, Ruben / Saenphimmachak, Channakhone / Santibanez, Jireh / Shen, Hua / Shen, Yan / Subramanian, Sandhya / Tabor, Paul E / Verduzco, Daniel / Waldron, Lenee / Wang, Jian / Wang, Jun / Wang, Qiaoyan / Williams, Gabrielle A / Wong, Gane K-S / Yao, Zhijian / Zhang, JingKun / Zhang, Xiuqing / Zhao, Guoping / Zhou, Jianling / Zhou, Yang / Nelson, David / Lehrach, Hans / Reinhardt, Richard / Naylor, Susan L / Yang, Huanming / Olson, Maynard / Weinstock, George / Gibbs, Richard A

    Nature

    2006  Volume 440, Issue 7088, Page(s) 1194–1198

    Abstract: After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human ...

    Abstract After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion.
    MeSH term(s) Animals ; Base Sequence ; Chromosome Breakage/genetics ; Chromosome Inversion/genetics ; Chromosomes, Human, Pair 3/genetics ; Contig Mapping ; CpG Islands/genetics ; DNA, Complementary/genetics ; Evolution, Molecular ; Expressed Sequence Tags ; Human Genome Project ; Humans ; Macaca mulatta/genetics ; Molecular Sequence Data ; Pan troglodytes/genetics ; Sequence Analysis, DNA ; Synteny/genetics
    Chemical Substances DNA, Complementary
    Language English
    Publishing date 2006-04-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature04728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The DNA sequence of human chromosome 7.

    Hillier, Ladeana W / Fulton, Robert S / Fulton, Lucinda A / Graves, Tina A / Pepin, Kymberlie H / Wagner-McPherson, Caryn / Layman, Dan / Maas, Jason / Jaeger, Sara / Walker, Rebecca / Wylie, Kristine / Sekhon, Mandeep / Becker, Michael C / O'Laughlin, Michelle D / Schaller, Mark E / Fewell, Ginger A / Delehaunty, Kimberly D / Miner, Tracie L / Nash, William E /
    Cordes, Matt / Du, Hui / Sun, Hui / Edwards, Jennifer / Bradshaw-Cordum, Holland / Ali, Johar / Andrews, Stephanie / Isak, Amber / Vanbrunt, Andrew / Nguyen, Christine / Du, Feiyu / Lamar, Betty / Courtney, Laura / Kalicki, Joelle / Ozersky, Philip / Bielicki, Lauren / Scott, Kelsi / Holmes, Andrea / Harkins, Richard / Harris, Anthony / Strong, Cynthia Madsen / Hou, Shunfang / Tomlinson, Chad / Dauphin-Kohlberg, Sara / Kozlowicz-Reilly, Amy / Leonard, Shawn / Rohlfing, Theresa / Rock, Susan M / Tin-Wollam, Aye-Mon / Abbott, Amanda / Minx, Patrick / Maupin, Rachel / Strowmatt, Catrina / Latreille, Phil / Miller, Nancy / Johnson, Doug / Murray, Jennifer / Woessner, Jeffrey P / Wendl, Michael C / Yang, Shiaw-Pyng / Schultz, Brian R / Wallis, John W / Spieth, John / Bieri, Tamberlyn A / Nelson, Joanne O / Berkowicz, Nicolas / Wohldmann, Patricia E / Cook, Lisa L / Hickenbotham, Matthew T / Eldred, James / Williams, Donald / Bedell, Joseph A / Mardis, Elaine R / Clifton, Sandra W / Chissoe, Stephanie L / Marra, Marco A / Raymond, Christopher / Haugen, Eric / Gillett, Will / Zhou, Yang / James, Rose / Phelps, Karen / Iadanoto, Shawn / Bubb, Kerry / Simms, Elizabeth / Levy, Ruth / Clendenning, James / Kaul, Rajinder / Kent, W James / Furey, Terrence S / Baertsch, Robert A / Brent, Michael R / Keibler, Evan / Flicek, Paul / Bork, Peer / Suyama, Mikita / Bailey, Jeffrey A / Portnoy, Matthew E / Torrents, David / Chinwalla, Asif T / Gish, Warren R / Eddy, Sean R / McPherson, John D / Olson, Maynard V / Eichler, Evan E / Green, Eric D / Waterston, Robert H / Wilson, Richard K

    Nature

    2003  Volume 424, Issue 6945, Page(s) 157–164

    Abstract: Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present ... ...

    Abstract Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first metacentric chromosome completed so far. The sequence has excellent concordance with previously established physical and genetic maps, and it exhibits an unusual amount of segmentally duplicated sequence (8.2%), with marked differences between the two arms. Our initial analyses have identified 1,150 protein-coding genes, 605 of which have been confirmed by complementary DNA sequences, and an additional 941 pseudogenes. Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame.
    MeSH term(s) Animals ; Base Sequence ; Chromosomes, Human, Pair 7 ; Gene Duplication ; Humans ; Mice ; Molecular Sequence Data ; Physical Chromosome Mapping ; Proteins/genetics ; Pseudogenes ; RNA, Untranslated ; Sequence Analysis, DNA ; Species Specificity ; Williams Syndrome/genetics
    Chemical Substances Proteins ; RNA, Untranslated
    Language English
    Publishing date 2003-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature01782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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