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  1. Article ; Online: Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

    David A. Spencer / Benjamin S. Goldberg / Shilpi Pandey / Tracy Ordonez / Jérémy Dufloo / Philip Barnette / William F. Sutton / Heidi Henderson / Rebecca Agnor / Lina Gao / Timothée Bruel / Olivier Schwartz / Nancy L. Haigwood / Margaret E. Ackerman / Ann J. Hessell

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: While antibodies neutralize HIV via Fab recognition of viral surface antigens, antibody Fc domains mediate effector functions, including antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC), and complement (C') activity. Here, Spencer ... ...

    Abstract While antibodies neutralize HIV via Fab recognition of viral surface antigens, antibody Fc domains mediate effector functions, including antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC), and complement (C') activity. Here, Spencer et al. modify bNAb 10E8v4 to enhance C'-mediated potency in SHIV challenged rhesus macaques to probe its function in protection, showing that in the absence of neutralization, enhancing C' activities in vitro adds no value toward reducing viremia in either blood or tissue.
    Keywords Science ; Q
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines

    Svenja Weiss / Vincenza Itri / Ruimin Pan / Xunqing Jiang / Christina C. Luo / Lynn Morris / Delphine C. Malherbe / Philip Barnette / Jeff Alexander / Xiang-Peng Kong / Nancy L. Haigwood / Ann J. Hessell / Ralf Duerr / Susan Zolla-Pazner

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Here the authors show that an HIV vaccine in non-human primates that focuses antibodies on the V1V2 region of gp120 is superior to infection or immunization with whole envelope vaccines for inducing V1V2 antibodies with anti-viral functions that ... ...

    Abstract Here the authors show that an HIV vaccine in non-human primates that focuses antibodies on the V1V2 region of gp120 is superior to infection or immunization with whole envelope vaccines for inducing V1V2 antibodies with anti-viral functions that correlate with protection.
    Keywords Science ; Q
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

    Lia Gore / Timothy J. Triche / Jason E. Farrar / Daniel Wai / Christophe Legendre / Gerald C. Gooden / Winnie S. Liang / John Carpten / David Lee / Frank Alvaro / Margaret E. Macy / Carola Arndt / Philip Barnette / Todd Cooper / Laura Martin / Aru Narendran / Jessica Pollard / Soheil Meshinchi / Jessica Boklan /
    Robert J. Arceci / Bodour Salhia

    Clinical Epigenetics, Vol 9, Iss 1, Pp 1-

    2017  Volume 13

    Abstract: Abstract Background Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we ... ...

    Abstract Abstract Background Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label study to evaluate decitabine pre-treatment before standard induction therapy in children with newly diagnosed AML to assess safety and tolerability and explore a number of biologic endpoints. Results Twenty-four patients were fully assessable for all study objectives per protocol (10 in Arm A = epigenetic priming induction, 14 in Arm B = standard induction). All patients experienced neutropenia and thrombocytopenia. The most common grade 3 and 4 non-hematologic adverse events observed were gastrointestinal toxicities and hypophosphatemia. Plasma decitabine PK were similar to previously reported adult data. Overall CR/CRi was similar for the two arms. MRD negativity at end-induction was 85% in Arm A versus 67% in Arm B patients. DNA methylation measured in peripheral blood over the course of treatment tracked with blast clearance and matched marrow aspirates at day 0 and day 21. Unlike end-induction marrow analyses, promoter methylation in blood identified an apparent reversal of response in the lone treatment failure, 1 week prior to the patient’s marrow aspirate confirming non-response. Decitabine-induced effects on end-induction (day 35–43 following initiation of treatment) marrows in Arm A were reflected by changes in DNA methylation in matched paired marrow diagnostic aspirates. Conclusions This first-in-pediatrics trial demonstrates that decitabine prior to standard combination chemotherapy is feasible and well tolerated in children with newly diagnosed AML. Pre-treatment with decitabine may represent a newer therapeutic option for pediatric AML, especially as it appears to induce important epigenetic alterations. The novel biological correlates studied in this trial offer a clinically relevant window into ...
    Keywords AML ; Epigenetics ; Pediatrics ; Pharmacokinetics ; Pharmacodynamics ; DNA methylation ; Medicine ; R ; Genetics ; QH426-470
    Subject code 610
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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