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  1. Article ; Online: Efficacy and aesthetic outcomes for quilting sutures in the prevention of seroma after mastectomy

    Arthur Foulon / Albine Mancaux / Pierrick Theret / Philippe Naepels / Johanna Mychaluk / Philippe Merviel / Pascal Abboud / Raffaele Fauvet

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 7

    Abstract: Abstract Worldwide, mastectomy for breast cancer is one of the most frequently performed surgical procedures. As one of the main complications of mastectomy, seroma is associated with pain, infections and a prolonged hospital stay. We performed a ... ...

    Abstract Abstract Worldwide, mastectomy for breast cancer is one of the most frequently performed surgical procedures. As one of the main complications of mastectomy, seroma is associated with pain, infections and a prolonged hospital stay. We performed a prospective multicenter randomized trial to assess the efficacy and esthetic outcomes associated with quilting the skin flap. Eighty-seven patients were included. The proportion of patients with seroma on postoperative day 15 was significantly lower in the quilting group (12 out of 39 (30.8%)) than in a control group with conventional wound closure (21 out of 40 (52.5%); P = 0.05). The mean breast seroma volume was significantly lower in the quilting group (130.2 mL) than in the control group (236.8 mL; P = 0.02). There were no differences in the esthetic outcomes. The pain level on day 1 was similar in the quilting and control groups (mean visual analog scale score: 2.5 vs. 2.1, respectively; P = 0.3). Quilting the skin flap was associated with a lower prevalence of seroma and a lower seroma volume, and did not worsen the esthetic outcomes or pain levels. This technique is technically straightforward and should be offered to all patients scheduled for mastectomy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: An exceptional case of degenerative endometriosis of the uterine torus

    Philippe Merviel / Christie Rebahi / Pandora James / Isabelle Kergastel / Fanny Bourhis‐Guizien / Virginie Conan‐Charlet / Fanny Derquin / Anne‐Claire Hardy‐Bessard / Pierre‐François Dupré / Karine Morcel

    Clinical Case Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract There are less than ten cases of deep endometriosis degeneration in the literature. The duration of endometriosis, the ovarian stimulation, the perimenopause and the obesity exposes the woman to an increased risk of endometriosis degeneration. ...

    Abstract Abstract There are less than ten cases of deep endometriosis degeneration in the literature. The duration of endometriosis, the ovarian stimulation, the perimenopause and the obesity exposes the woman to an increased risk of endometriosis degeneration.
    Keywords deep endometriosis ; high‐grade clear cell carcinoma ; MRI—risk factors ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Laparoscopy‐assisted immediate vaginal reconstruction with a vertical pedicled deep inferior epigastric perforator flap for primary melanoma of the vagina

    Pierre‐François Dupré / Delphine Legoupil / Camille Vigouroux / Virginie Conan‐Charlet / Isabelle Kergastel / Philippe Merviel / Nathalie Kerfant

    Clinical Case Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract The vagina is a rare site for primary melanoma. Here, we report on a case of laparoscopy‐assisted immediate vaginal reconstruction with vertical pedicled deep inferior epigastric perforator flap. ...

    Abstract Abstract The vagina is a rare site for primary melanoma. Here, we report on a case of laparoscopy‐assisted immediate vaginal reconstruction with vertical pedicled deep inferior epigastric perforator flap.
    Keywords DIEP ; melanoma ; treatment ; vagina ; vaginal reconstruction ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Xanthogranulomatous endometritis

    Philippe Merviel / Pandora James / Marianne Carlier / Isabelle Thomas‐Kergastel / Marine Guilloique / Virginie Conan‐Charlet / Clara Bastard / Pascale Marcorelles / Yannick Jobic / Pierre‐François Dupré

    Clinical Case Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)

    A case report and literature review

    2021  

    Abstract: Abstract Xanthogranulomatous endometritis is a rare benign pathology mimicking endometrial carcinoma. ...

    Abstract Abstract Xanthogranulomatous endometritis is a rare benign pathology mimicking endometrial carcinoma.
    Keywords endometritis ; histopathology ; magnetic resonance imaging ; pyometra ; xanthogranulomatous ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Nonpuerperal uterine inversion due to adenomyosis

    Philippe Merviel / Sandrine Guilbert / Coline Abou Hassan / Isabelle Thomas‐Kergastel / Virginie Conan‐Charlet / Pascale Marcorelles / Pierre‐François Dupré

    Clinical Case Reports, Vol 7, Iss 12, Pp 2420-

    A case report and a literature review

    2019  Volume 2424

    Abstract: Abstract Nonpuerperal uterine inversion is a very rare event. We reported on the first ever case of nonpuerperal uterine inversion due to adenomyosis. Magnetic resonance imaging is recommended in cases with an unusual vaginal mass, so that this possible ... ...

    Abstract Abstract Nonpuerperal uterine inversion is a very rare event. We reported on the first ever case of nonpuerperal uterine inversion due to adenomyosis. Magnetic resonance imaging is recommended in cases with an unusual vaginal mass, so that this possible uterine etiology can be taken into consideration.
    Keywords adenomyosis ; inversion ; MRI ; uterus ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Mitochondria: Participation to infertility as source of energy and cause of senescence

    Benkhalifa, Moncef / Henri Copin / Hikmat Chahine / Noureddine Louanjli / Philippe Merviel / Pierre Miron / Yannick J. Ferreira

    international journal of biochemistry & cell biology. 2014 Oct., v. 55

    2014  

    Abstract: Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling, reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis and sex steroid hormones biosynthesis. Improvement of sperm parameters such ...

    Abstract Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling, reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis and sex steroid hormones biosynthesis. Improvement of sperm parameters such as motility, capacitation, acrosome reaction, and oocyte interaction, involve regulation of ROS levels by the mitochondria. In human, the relation between the quantitative level of mitochondrial DNA (mtDNA), oocyte cytoplasm maturation and fertilization potential, is not clear. It has been hypothesized that oocytes without sufficient wild type mtDNA and therefore able to generate ATP, would not normally be ovulated. This is reflected in the low numbers of mtDNA observed in degenerate oocytes obtained through super ovulation protocols during assisted reproductive technology programs. Different theories place mitochondria in a central role of oxidative damage to cells and tissues related to infertility declining and aging. Mitochondria-dependent apoptosis seems to be responsible for the pre and post-natal decline in germ cells, embryo development, implantation failure, and miscarriages.
    Keywords abortion (animals) ; acrosome reaction ; adenosine triphosphate ; apoptosis ; assisted reproductive technologies ; biosynthesis ; calcium signaling ; cell cycle checkpoints ; embryogenesis ; energy ; humans ; mitochondria ; mitochondrial DNA ; oocytes ; ovulation ; oxidative stress ; reactive oxygen species ; sex hormones ; spermatozoa ; steroid hormones ; tissues
    Language English
    Dates of publication 2014-10
    Size p. 60-64.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2014.08.011
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Physiopathology of human embryonic implantation

    Pauline Demailly / MÊlanie Brzakowski / VÊronique Boulard / Rosalie Cabry / Emmanuelle Lourdel / Philippe Merviel / Françoise Brasseur / Henri Copin / Aviva Devaux

    Folia Histochemica et Cytobiologica, Vol 47, Iss 5, Pp 25-

    clinical incidences.

    2010  Volume 34

    Abstract: Embryo implantation consists of a series of events promoting the invasion of the endometrium and then the uterine arterial system by the extra-embryonic trophoblast. In order for this semi-heterologous implantation to succeed, the endometrium has to ... ...

    Abstract Embryo implantation consists of a series of events promoting the invasion of the endometrium and then the uterine arterial system by the extra-embryonic trophoblast. In order for this semi-heterologous implantation to succeed, the endometrium has to first undergo a number of structural and biochemical changes (decidualization). The decidua's various constituents subsequently play a role in the embryonic implantation. The third step is the transformation of the uterine vascular system and the growth of the placenta, which will provide the foetoplacental unit with nutrients. Several physiopathological aspects will be discussed: 1) the implantation window, regulated by maternal and embryonic hormonal secretions and thus influenced by any defects in the latter: dysharmonic luteal phase, 21-hydroxylase block, abnormal integrin expression, 2) the successive trophoblast invasions of uterine vessels which, when defective, lead to early embryo loss or late-onset vascular pathologies, as preeclampsia, 3) the pregnancy's immunological equilibrium, with a spontaneously tolerated semi-allogeneic implant, 4) the impact of pro-coagulant factors (thrombophilia) on the pregnancy's progression, 5) the environment of the uterus, ranging from hydrosalpinx to uterine contractions. In summary, the least anatomical or physiological perturbation can interfere with human embryonic implantation - a very particular phenomenon and a true biological paradox.
    Keywords Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Polish Histochemical and Cytochemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The genomic architecture of NLRP7 is Alu rich and predisposes to disease-associated large deletions.

    Reddy, Ramesh / Nguyen, Ngoc M P / Sarrabay, Guillaume / Rezaei, Maryam / Rivas, Mayra C G / Kavasoglu, Aysenur / Berkil, Hakan / Elshafey, Alaa / Nunez, Kristin P / Dreyfus, Hélène / Philippe, Merviel / Hadipour, Zahra / Durmaz, Asude / Eaton, Erin E / Schubert, Brittany / Ulker, Volkan / Hadipour, Fatemeh / Ahmadpour, Fatemeh / Touitou, Isabelle /
    Fardaei, Majid / Slim, Rima

    European journal of human genetics : EJHG

    2016  Volume 24, Issue 10, Page(s) 1445–1452

    Abstract: NLRP7 is a major gene responsible for recurrent hydatidiform moles. Here, we report 11 novel NLRP7 protein truncating variants, of which five deletions of more than 1-kb. We analyzed the transcriptional consequences of four variants. We demonstrate that ... ...

    Abstract NLRP7 is a major gene responsible for recurrent hydatidiform moles. Here, we report 11 novel NLRP7 protein truncating variants, of which five deletions of more than 1-kb. We analyzed the transcriptional consequences of four variants. We demonstrate that one large homozygous deletion removes NLRP7 transcription start site and results in the complete absence of its transcripts in a patient in good health besides her reproductive problem. This observation strengthens existing data on the requirement of NLRP7 only for female reproduction. We show that two other variants affecting the splice acceptor of exon 6 lead to its in-frame skipping while another variant affecting the splice donor site of exon 9 leads to an in-frame insertion of 54 amino acids. Our characterization of the deletion breakpoints demonstrated that most of the breakpoints occurred within Alu repeats and the deletions were most likely mediated by microhomology events. Our data define a hotspot of Alu instability and deletions in intron 5 with six different breakpoints and rearrangements. Analysis of NLRP7 genomic sequences for repetitive elements demonstrated that Alu repeats represent 48% of its intronic sequences and these repeats seem to have been inserted into the common NLRP2/7 primate ancestor before its duplication into two genes.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adult ; Alu Elements/genetics ; Chromosome Breakpoints ; Evolution, Molecular ; Exons ; Female ; Gene Deletion ; Humans ; Hydatidiform Mole/diagnosis ; Hydatidiform Mole/genetics ; Mutagenesis, Insertional ; Pregnancy
    Chemical Substances Adaptor Proteins, Signal Transducing ; NLRP7 protein, human
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/ejhg.2016.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The genomic architecture of NLRP7 is Alu rich and predisposes to disease-associated large deletions.

    Reddy, Ramesh / Nguyen, Ngoc M P / Sarrabay, Guillaume / Rezaei, Maryam / Rivas, Mayra C G / Kavasoglu, Aysenur / Berkil, Hakan / Elshafey, Alaa / Abdalla, Ebtesam / Nunez, Kristin P / Dreyfus, Hélène / Philippe, Merviel / Hadipour, Zahra / Durmaz, Asude / Eaton, Erin E / Schubert, Brittany / Ulker, Volkan / Hadipour, Fatemeh / Touitou, Isabelle /
    Fardaei, Majid / Slim, Rima

    European journal of human genetics : EJHG

    2016  Volume 24, Issue 10, Page(s) 1516

    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/ejhg.2016.96
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Women and health professionals’ perspectives on a conditional cash transfer programme to improve pregnancy follow-up

    Celine Chauleur / Jacob Hannigsberg / Philippe Merviel / Marc Bardou / Franck Perrotin / Thomas Schmitz / Olivier Picone / Jeanne Sibiude / Karine Chemin / Dominique Dallay / Frédéric Coatleven / Loïc Sentilhes / Céline Brochot / Astrid Eckman-Lacroix / Elise Thellier / Frédérique Falchier / Philippe Deruelle / Muriel Doret / Xavier Carcopino-Tusoli /
    Nicolas Meunier-Beillard / Hervé Fernandez / Vincent Villefranque / Caroline Diguisto / Damien Subtil / Clémence Houssin / Philippe Gillard / Laurent Mandelbrot / Aurelie Godard-Marceau / Nathalie Lesavre / Claude Virtos / Elodie Debras / Aude Bourtembourg / Claire Toubin / Danièle Addes / Véronique Uguen / Cleo Tourbot / Caroline Lelievre / Christophe Tremouilhac / Anne-Hélène Saliou / Aurelie Derrieu / Stephanie Auget / Anne Legourrierec / Anne Leroux / Julie Fort-Jacquier / Marion Serclerat / Nathalie Laurenceau / Audrey Renouleau / Eliane Catteau / Julie Blanc / Candice Ronin / Laurence Piechon / Séverine Puppo / Fanny Greco / Sandrine Pettazzoni / Muriel Athlani / Amina Desvignes / Annie Petiteau / Amina El Yaakoubi / Valérie Bechadergue / Valérie Vaugirard / Marie-Emmanuelle Neveu / Caroline Geyl / Marie-Victoire Senat / Claire Colmant / Marie Houllier / Myriam Virlouet / Marion Mir / Yasmina Bejaoui / Hélène Le Cornu / Lauriane Nikel / Elodie Gustave / Amandine Stadler / Ahmad Mehdi / Tiphaine Barjat / Suzanne Lima / Thomas Corsini / Anne Genod / Charlotte Vermesch / Cécile Fanget / Marianne Perrot / Manuela Munoz / Sylvie Pitaval / Fanny Magand / Françoise Baldi / Stephanie Bret / Anne-Lise Verdier / Christelle Denis / Carine Arlicot / Jérôme Potin / Stéphanie Chretien / Julie Paternotte / Nathalie Trignol / Élisabeth Blin / Camille Mathieu / Anne Dubreuil / Anne Viallon Pelletier / Catherine Guerin / Chloé Arthuis / Christophe Vayssieres / Olivier Parant / Marion Groussolles / Maria Denis / M Mathieu Morin / Marie-Thérèse Bavoux / Juliette Pelloux / Anne-Claire Jambon / Madeleine Santraine / Veronique Lebuffe / Pascale Broux / Thierry Dzukou / Magloire Gnansounou / Didier Hubert / Claire Djazet / Ludivine Destoop / Marine Derue / Pierrick Theret / Dominique Delzenne / Stéphanie Daussin / Alice Fraissinet / Mélanie Vannerum / Cyril Faraguet / Laurence Landais / Mariana Radu / Anne Rouget / Sena Al Sudani / Bernard Guillon / Estelle Wucher / Véronique Selva / Sandrine Reviron / Francis Schwetterlé / Cécile Chassande / Véronique Grandin / Eliane Krtoliza / Patrick Becher / Marie Sarrau / Claire Lecoq / Elsa Lutringer / Denis Roux / Noémie Berge / Clémentine Barbier / Anne Heron / Audrey Farina-Bracquart / Marie-Paule Curtet / Evelyne Lefebure / Marie-Hélène Le Douarin / Hassan Al Rayes / Émilie Magne / Nathalie Destampes / Émilie Ricard / Pascale Ghezzi / Catherine Guillen / Fanny Alazard / Marie-Thé Campanaro / Florence Mojard / Magalie David-Reynard / Patricia Fuma / Remy De Montgolfier / Capucine Neel / Guillaume Legendre / Isabelle Andre / Sylvie Nordstrom / Brigitte Guionnet / Catherine Crenn Hebert / Chloé Dussaux / Karine Achaintre / Anne Wagner / Martine Werveake / Eloïse De Gouville / George Theresin / Marie Pierre Couetoux / Lydia Caillaud / Marie-Pierre Fernandez / Sabrina Bottet / M Alain Almodovar / Elisa Etienne / Véronique Guiteras / Angélique Torres / N. Roche / Myriam Nassef / Christine Abel-Faure / Marie Louvet / Carole Ettori / Guillaume Ducarme / Valérie Bonnenfant-Mezeray / Laurence Szezot-Renaudeau / Marie-Pierre Berte / Elodie Netier-Herault / Stéphanie Manson-Gallone / Franck Mauviel / Nathalie Agostini / Marine Mazeaud / Jean-Claude Dausset / Isabelle De Murcia / Emilie Alliot / Anne-Marie Bes / Magali Biferi Magali / Hélène Heckenroth / Sophie Morange / Gersende Chiuot / Audrey Gnisci / Annie Allegre / Laetitia Lecq / Eva Balenbois / Claire Tourette / Aude Figarella / Dio Andriamanjay / Pauline Vignoles / Catherine Cazelles / Véronique Lejeune Saada / Benafsheh Kashani / Isabelle Chevalier / Muriel Terrieres / Audrey Cointement / Valérie Benhaïm / Najat Lindoune / Anne-Sophie Maisonneuve / M Frédéric Daubercy / Guilia Mencattini / Vanessa Combaud / Isabelle Moya / Xavier-Côme Donato / Raoul Desbriere / Marie Lafon / Véronique Baudet

    BMJ Open, Vol 13, Iss

    a qualitative analysis of the NAITRE randomised controlled study

    2023  Volume 3

    Abstract: Objectives Women of low socioeconomic status have been described as having suboptimal prenatal care, which in turn has been associated with poor pregnancy outcomes. Many types of conditional cash transfer (CCT) programmes have been developed, including ... ...

    Abstract Objectives Women of low socioeconomic status have been described as having suboptimal prenatal care, which in turn has been associated with poor pregnancy outcomes. Many types of conditional cash transfer (CCT) programmes have been developed, including programmes to improve prenatal care or smoking cessation during pregnancy, and their effects demonstrated. However, ethical critiques have included paternalism and lack of informed choice. Our objective was to determine if women and healthcare professionals (HPs) shared these concerns.Design Prospective qualitative research.Setting We included economically disadvantaged women, as defined by health insurance data, who participated in the French NAITRE randomised trial assessing a CCT programme during prenatal follow-up to improve pregnancy outcomes. The HP worked in some maternities participating in this trial.Participants 26 women, 14 who received CCT and 12 who did not, mostly unemployed (20/26), and - 7 HPs.Interventions We conducted a multicentre cross-sectional qualitative study among women and HPs who participated in the NAITRE Study to assess their views on CCT. The women were interviewed after childbirth.Results Women did not perceive CCT negatively. They did not mention feeling stigmatised. They described CCT as a significant source of aid for women with limited financial resources. HP described the CCT in less positive terms, for example, expressing concern about discussing cash transfer at their first medical consultation with women. Though they emphasised ethical concerns about the basis of the trial, they recognised the importance of evaluating CCT.Conclusions In France, a high-income country where prenatal follow-up is free, HPs were concerned that the CCT programme would change their relationship with patients and wondered if it was the best use of funding. However, women who received a cash incentive said they did not feel stigmatised and indicated that these payments helped them prepare for their baby’s birth.Trial registration number NCT02402855
    Keywords Medicine ; R
    Subject code 300
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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