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Article ; Online: Transcranial direct current stimulation of the right temporoparietal junction facilitates hippocampal spatial learning in Alzheimer's disease and mild cognitive impairment.

Philippen, S / Hanert, A / Schönfeld, R / Granert, O / Yilmaz, R / Jensen-Kondering, U / Splittgerber, M / Moliadze, V / Siniatchkin, M / Berg, D / Bartsch, T

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2023 Volume 157, Page(s) 48–60

Abstract: Objective: Spatial memory deficits are an early symptom in Alzheimer's disease (AD), reflecting the neurodegenerative processes in the neuronal navigation network such as in hippocampal and parietal cortical areas. As no effective treatment options are ... ...

Abstract	Objective: Spatial memory deficits are an early symptom in Alzheimer's disease (AD), reflecting the neurodegenerative processes in the neuronal navigation network such as in hippocampal and parietal cortical areas. As no effective treatment options are available, neuromodulatory interventions are increasingly evaluated. Against this backdrop, we investigated the neuromodulatory effect of anodal transcranial direct current stimulation (tDCS) on hippocampal place learning in patients with AD or mild cognitive impairment (MCI). Methods: In this randomized, double-blind, sham-controlled study with a cross-over design anodal tDCS of the right temporoparietal junction (2 mA for 20 min) was applied to 20 patients diagnosed with AD or MCI and in 22 healthy controls while they performed a virtual navigation paradigm testing hippocampal place learning. Results: We show an improved recall performance of hippocampal place learning after anodal tDCS in the patient group compared to sham stimulation but not in the control group. Conclusions: These results suggest that tDCS can facilitate spatial memory consolidation via stimulating the parietal-hippocampal navigation network in AD and MCI patients. Significance: Our findings suggest that tDCS of the temporoparietal junction may restore spatial navigation and memory deficits in patients with AD and MCI.
MeSH term(s)	Humans ; Alzheimer Disease/therapy ; Cognitive Dysfunction/therapy ; Hippocampus ; Memory Disorders ; Spatial Learning ; Transcranial Direct Current Stimulation/methods ; Double-Blind Method
Language	English
Publishing date	2023-11-15
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2023.11.003
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Article ; Online: Deep brain stimulation of the subthalamic nucleus restores spatial reversal learning in patients with Parkinson's disease.

Schneider, Isabel / Schönfeld, Robby / Hanert, Annika / Philippen, Sarah / Tödt, Inken / Granert, Oliver / Mehdorn, Maximilian / Becktepe, Jos / Deuschl, Günther / Berg, Daniela / Paschen, Steffen / Bartsch, Thorsten

Brain communications

2024 Volume 6, Issue 2, Page(s) fcae068

Abstract: Spatial learning and navigation are supported by distinct memory systems in the human brain such as the hippocampus-based navigational system and the striatum-cortex-based system involved in motor sequence, habit and reversal learning. Here, we studied ... ...

Abstract	Spatial learning and navigation are supported by distinct memory systems in the human brain such as the hippocampus-based navigational system and the striatum-cortex-based system involved in motor sequence, habit and reversal learning. Here, we studied the role of subthalamic circuits in hippocampus-associated spatial memory and striatal-associated spatial reversal learning formation in patients with Parkinson's disease, who underwent a deep brain stimulation of the subthalamic nucleus. Deep brain stimulation patients (Parkinson's disease-subthalamic nucleus:
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcae068
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Article: Attitudes and viewpoints toward prevention trials in Alzheimer's disease

Pauli, Philipp / Goetz, Katja / Rogge, Annette / Bartsch, Thorsten / Philippen, Sarah / Berg, Daniela / Hertrampf, Katrin

GeroPsych

2023 , Page(s) 1–7

Abstract: Alzheimer's disease (AD) prevention studies use biomarkers to determine risk in asymptomatic study participants. This involves multifaceted implications. Determinants regarding participation in these trials are therefore of particular relevance. We used ... ...

Title translation	Einstellungen und Standpunkte zu Präventionsstudien bei der Alzheimer-Krankheit (DeepL)
Abstract	Alzheimer's disease (AD) prevention studies use biomarkers to determine risk in asymptomatic study participants. This involves multifaceted implications. Determinants regarding participation in these trials are therefore of particular relevance. We used semistructured individual interviews to interview uninvolved persons (n = 10), relatives of Alzheimer's patients (n = 10), and patients with mild cognitive impairment (n = 5) and analyzed the interviews using qualitative content analysis according to Mayring. We discovered various factors to be positive motivations for participation; the most significant inhibiting factor was concern about negative psychological effects. These motivations and concerns should be specifically addressed in the study design of AD prevention trials. The fears and concerns expressed highlight the importance of a good methodological and ethical framework to increase participant acceptance.
Keywords	Alzheimer's Disease ; Alzheimersche Krankheit ; Clinical Trials ; Content Analysis ; Gesundheitseinstellungen ; Health Attitudes ; Inhaltsanalyse ; Interviews ; Klinische Prüfung ; Motivation ; Participation ; Partizipation ; Prevention ; Prävention ; Risikowahrnehmung ; Risk Perception
Language	English
Document type	Article
ZDB-ID	2536939-8
ISSN	1662-971X ; 1662-9647
ISSN (online)	1662-971X
ISSN	1662-9647
DOI	10.1024/1662-9647/a000311
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Article ; Online: Reduced overnight memory consolidation and associated alterations in sleep spindles and slow oscillations in early Alzheimer's disease.

Hanert, Annika / Schönfeld, Robby / Weber, Frederik D / Nowak, Alexander / Döhring, Juliane / Philippen, Sarah / Granert, Oliver / Burgalossi, Andrea / Born, Jan / Berg, Daniela / Göder, Robert / Häussermann, Peter / Bartsch, Thorsten

Neurobiology of disease

2023 Volume 190, Page(s) 106378

Abstract: Spatial navigation critically underlies hippocampal-entorhinal circuit function that is early affected in Alzheimer's disease (AD). There is growing evidence that AD pathophysiology dynamically interacts with the sleep/wake cycle impairing hippocampal ... ...

Abstract	Spatial navigation critically underlies hippocampal-entorhinal circuit function that is early affected in Alzheimer's disease (AD). There is growing evidence that AD pathophysiology dynamically interacts with the sleep/wake cycle impairing hippocampal memory. To elucidate sleep-dependent consolidation in a cohort of symptomatic AD patients (n = 12, 71.25 ± 2.16 years), we tested hippocampal place learning by means of a virtual reality task and verbal memory by a word-pair association task before and after a night of sleep. Our results show an impaired overnight memory retention in AD compared with controls in the verbal task, together with a significant reduction of sleep spindle activity (i.e., lower amplitude of fast sleep spindles, p = 0.016) and increased duration of the slow oscillation (SO; p = 0.019). Higher spindle density, faster down-to-upstate transitions within SOs, and the time delay between SOs and nested spindles predicted better memory performance in healthy controls but not in AD patients. Our results show that mnemonic processing and memory consolidation in AD is slightly impaired as reflected by dysfunctional oscillatory dynamics and spindle-SO coupling during NonREM sleep. In this translational study based on experimental paradigms in animals and extending previous work in healthy aging and preclinical disease stages, our results in symptomatic AD further deepen the understanding of the memory decline within a bidirectional relationship of sleep and AD pathology.
MeSH term(s)	Humans ; Memory Consolidation/physiology ; Alzheimer Disease ; Polysomnography ; Sleep/physiology ; Memory/physiology ; Memory Disorders/etiology
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2023.106378
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Article ; Online: Disease- and stage-specific alterations of the oral and fecal microbiota in Alzheimer's disease.

Troci, Alba / Philippen, Sarah / Rausch, Philipp / Rave, Julius / Weyland, Gina / Niemann, Katharina / Jessen, Katharina / Schmill, Lars-Patrick / Aludin, Schekeb / Franke, Andre / Berg, Daniela / Bang, Corinna / Bartsch, Thorsten

PNAS nexus

2023 Volume 3, Issue 1, Page(s) pgad427

Abstract: Microbial communities in the intestinal tract are suggested to impact the ethiopathogenesis of Alzheimer's disease (AD). The human microbiome might modulate neuroinflammatory processes and contribute to neurodegeneration in AD. However, the microbial ... ...

Abstract	Microbial communities in the intestinal tract are suggested to impact the ethiopathogenesis of Alzheimer's disease (AD). The human microbiome might modulate neuroinflammatory processes and contribute to neurodegeneration in AD. However, the microbial compositions in patients with AD at different stages of the disease are still not fully characterized. We used 16S rRNA analyses to investigate the oral and fecal microbiota in patients with AD and mild cognitive impairment (MCI;
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgad427
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Article ; Online: Characterizing mixed location hemorrhages/microbleeds with CSF markers.

Jensen-Kondering, Ulf / Margraf, Nils G / Weiler, Caroline / Maetzler, Walter / Dargvainiene, Justina / Falk, Kim / Philippen, Sarah / Bartsch, Thorsten / Flüh, Charlotte / Röcken, Christoph / Möller, Bettina / Royl, Georg / Neumann, Alexander / Brüggemann, Norbert / Roeben, Benjamin / Schulte, Claudia / Bender, Benjamin / Berg, Daniela / Kuhlenbäumer, Gregor

International journal of stroke : official journal of the International Stroke Society

2023 Volume 18, Issue 6, Page(s) 728–735

Abstract: Objective: Cerebral amyloid angiopathy (CAA) is a common cause of lobar and subarachnoid hemorrhages in the elderly. A diagnosis of CAA requires multiple lobar hemorrhagic lesions (intracerebral hemorrhage and/or cerebral microbleeds) and/or cortical ... ...

Abstract	Objective: Cerebral amyloid angiopathy (CAA) is a common cause of lobar and subarachnoid hemorrhages in the elderly. A diagnosis of CAA requires multiple lobar hemorrhagic lesions (intracerebral hemorrhage and/or cerebral microbleeds) and/or cortical superficial siderosis (cSS). In contrast, hemorrhagic lesions located in the deep structures are the hallmark of hypertensive arteriopathy (HTN-A). They are an exclusion criterion for CAA, and when present with lobar hemorrhagic lesions considered a separate entity: mixed location hemorrhages/microbleeds (MLHs). We compared clinical, radiological, and cerebrospinal fluid (CSF) marker data in patients with CAA, MLH, and Alzheimer's disease (AD), and healthy controls (HCs) and used it to position MLH in the disease spectrum. Patients and methods: Retrospective cohort study of consecutive patients with CAA (n = 31), MLH (n = 31), AD (n = 28), and HC (n = 30). Analysis of clinical, radiological, CSF biomarker (Aß42, Aß40, t-tau, and p-tau), and histopathological data in patients each group. Results: cSS was significantly more common in CAA than MLH (45% vs 13%, p = 0.011), and cSS in MLH was associated with intracerebral hemorrhage (ICH) (p = 0.037). Aß42 levels and the Aß42/Aß40 ratio, diagnostic groups followed the order HC > MLH > CAA > AD and the opposite order for Conclusion: Our data suggest that MLH and CAA are mutually not exclusive diagnoses, and are part of a spectrum with variable contributions of both CAA and HTN-A.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; Magnetic Resonance Imaging ; Stroke/complications ; Cerebral Hemorrhage/complications ; Subarachnoid Hemorrhage/complications ; Cerebral Amyloid Angiopathy/complications ; Siderosis ; Alzheimer Disease/complications
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2303728-3
ISSN	1747-4949 ; 1747-4930
ISSN (online)	1747-4949
ISSN	1747-4930
DOI	10.1177/17474930231152124
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Article: Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy: New Data and Quantitative Meta-Analysis.

Margraf, Nils G / Jensen-Kondering, Ulf / Weiler, Caroline / Leypoldt, Frank / Maetzler, Walter / Philippen, Sarah / Bartsch, Thorsten / Flüh, Charlotte / Röcken, Christoph / Möller, Bettina / Royl, Georg / Neumann, Alexander / Brüggemann, Norbert / Roeben, Benjamin / Schulte, Claudia / Bender, Benjamin / Berg, Daniela / Kuhlenbäumer, Gregor

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 783996

Abstract: Background: To evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers in patients with probable cerebral amyloid angiopathy (CAA) according to the modified Boston criteria in a retrospective multicentric cohort.: Methods: Beta- ... ...

Abstract	Background: To evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers in patients with probable cerebral amyloid angiopathy (CAA) according to the modified Boston criteria in a retrospective multicentric cohort. Methods: Beta-amyloid 1-40 (Aβ40), beta-amyloid 1-42 (Aβ42), total tau (t-tau), and phosphorylated tau 181 (p-tau Results: In our data Aβ42/40 (AUC 0.88) discriminated best between CAA and controls while Aβ40 did not perform well (AUC 0.63). Differentiating between CAA and AD, p-tau Conclusion: The analyzed parameters differentiate between controls and CAA with clinically useful accuracy (AUC > ∼0.85) but not between CAA and AD. Since there is a neuropathological, clinical and diagnostic continuum between CAA and AD, other diagnostic markers, e.g., novel CSF biomarkers or other parameters might be more successful.
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.783996
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Article ; Online: Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube.

Abbasi, R / Ackermann, M / Adams, J / Agarwalla, S K / Aguilar, J A / Ahlers, M / Alameddine, J M / Amin, N M / Andeen, K / Anton, G / Argüelles, C / Ashida, Y / Athanasiadou, S / Axani, S N / Bai, X / Balagopal, V A / Baricevic, M / Barwick, S W / Basu, V /

Bay, R / Beatty, J J / Becker Tjus, J / Beise, J / Bellenghi, C / Benning, C / BenZvi, S / Berley, D / Bernardini, E / Besson, D Z / Blaufuss, E / Blot, S / Bontempo, F / Book, J Y / Boscolo Meneguolo, C / Böser, S / Botner, O / Böttcher, J / Bourbeau, E / Braun, J / Brinson, B / Brostean-Kaiser, J / Burley, R T / Busse, R S / Butterfield, D / Campana, M A / Carloni, K / Carnie-Bronca, E G / Chattopadhyay, S / Chau, N / Chen, C / Chen, Z / Chirkin, D / Choi, S / Clark, B A / Classen, L / Coleman, A / Collin, G H / Connolly, A / Conrad, J M / Coppin, P / Correa, P / Cowen, D F / Dave, P / De Clercq, C / DeLaunay, J J / Delgado, D / Deng, S / Deoskar, K / Desai, A / Desiati, P / de Vries, K D / de Wasseige, G / DeYoung, T / Diaz, A / Díaz-Vélez, J C / Dittmer, M / Domi, A / Dujmovic, H / DuVernois, M A / Ehrhardt, T / Eller, P / Ellinger, E / El Mentawi, S / Elsässer, D / Engel, R / Erpenbeck, H / Evans, J / Evenson, P A / Fan, K L / Fang, K / Farrag, K / Fazely, A R / Feigl, N / Fiedlschuster, S / Fienberg, A T / Finley, C / Fischer, L / Fox, D / Franckowiak, A / Fritz, A / Fürst, P / Gallagher, J / Ganster, E / Garcia, A / Gerhardt, L / Ghadimi, A / Glaser, C / Glauch, T / Glüsenkamp, T / Goehlke, N / Gonzalez, J G / Goswami, S / Grant, D / Gray, S J / Gries, O / Griffin, S / Griswold, S / Groth, K M / Günther, C / Gutjahr, P / Haack, C / Hallgren, A / Halliday, R / Halve, L / Halzen, F / Hamdaoui, H / Ha Minh, M / Hanson, K / Hardin, J / Harnisch, A A / Hatch, P / Haungs, A / Helbing, K / Hellrung, J / Henningsen, F / Heuermann, L / Heyer, N / Hickford, S / Hidvegi, A / Hill, C / Hill, G C / Hoffman, K D / Hori, S / Hoshina, K / Hou, W / Huber, T / Hultqvist, K / Hünnefeld, M / Hussain, R / Hymon, K / In, S / Ishihara, A / Jacquart, M / Janik, O / Jansson, M / Japaridze, G S / Jeong, M / Jin, M / Jones, B J P / Kang, D / Kang, W / Kang, X / Kappes, A / Kappesser, D / Kardum, L / Karg, T / Karl, M / Karle, A / Katz, U / Kauer, M / Kelley, J L / Khatee Zathul, A / Kheirandish, A / Kiryluk, J / Klein, S R / Kochocki, A / Koirala, R / Kolanoski, H / Kontrimas, T / Köpke, L / Kopper, C / Koskinen, D J / Koundal, P / Kovacevich, M / Kowalski, M / Kozynets, T / Krishnamoorthi, J / Kruiswijk, K / Krupczak, E / Kumar, A / Kun, E / Kurahashi, N / Lad, N / Lagunas Gualda, C / Lamoureux, M / Larson, M J / Latseva, S / Lauber, F / Lazar, J P / Lee, J W / Leonard DeHolton, K / Leszczyńska, A / Lincetto, M / Liu, Q R / Liubarska, M / Lohfink, E / Love, C / Lozano Mariscal, C J / Lucarelli, F / Luszczak, W / Lyu, Y / Madsen, J / Mahn, K B M / Makino, Y / Manao, E / Mancina, S / Marie Sainte, W / Mariş, I C / Marka, S / Marka, Z / Marsee, M / Martinez-Soler, I / Maruyama, R / Mayhew, F / McElroy, T / McNally, F / Mead, J V / Meagher, K / Mechbal, S / Medina, A / Meier, M / Merckx, Y / Merten, L / Micallef, J / Mitchell, J / Montaruli, T / Moore, R W / Morii, Y / Morse, R / Moulai, M / Mukherjee, T / Naab, R / Nagai, R / Nakos, M / Naumann, U / Necker, J / Negi, A / Neumann, M / Niederhausen, H / Nisa, M U / Noell, A / Novikov, A / Nowicki, S C / Obertacke Pollmann, A / O'Dell, V / Oehler, M / Oeyen, B / Olivas, A / Orsoe, R / Osborn, J / O'Sullivan, E / Pandya, H / Pankova, D V / Park, N / Parker, G K / Paudel, E N / Paul, L / Pérez de Los Heros, C / Peterson, J / Philippen, S / Pizzuto, A / Plum, M / Pontén, A / Popovych, Y / Prado Rodriguez, M / Pries, B / Procter-Murphy, R / Przybylski, G T / Raab, C / Rack-Helleis, J / Rawlins, K / Rechav, Z / Rehman, A / Reichherzer, P / Renzi, G / Resconi, E / Reusch, S / Rhode, W / Riedel, B / Rifaie, A / Roberts, E J / Robertson, S / Rodan, S / Roellinghoff, G / Rongen, M / Rott, C / Ruhe, T / Ruohan, L / Ryckbosch, D / Safa, I / Saffer, J / Salazar-Gallegos, D / Sampathkumar, P / Sanchez Herrera, S E / Sandrock, A / Santander, M / Sarkar, S / Savelberg, J / Savina, P / Schaufel, M / Schieler, H / Schindler, S / Schlickmann, L / Schlüter, B / Schlüter, F / Schmeisser, N / Schmidt, T / Schneider, J / Schröder, F G / Schumacher, L / Schwefer, G / Sclafani, S / Seckel, D / Seikh, M / Seunarine, S / Shah, R / Sharma, A / Shefali, S / Shimizu, N / Silva, M / Skrzypek, B / Smithers, B / Snihur, R / Soedingrekso, J / Søgaard, A / Soldin, D / Soldin, P / Sommani, G / Spannfellner, C / Spiczak, G M / Stamatikos, M / Stanev, T / Stezelberger, T / Stürwald, T / Stuttard, T / Sullivan, G W / Taboada, I / Ter-Antonyan, S / Thiesmeyer, M / Thompson, W G / Thwaites, J / Tilav, S / Tollefson, K / Tönnis, C / Toscano, S / Tosi, D / Trettin, A / Tung, C F / Turcotte, R / Twagirayezu, J P / Ty, B / Unland Elorrieta, M A / Upadhyay, A K / Upshaw, K / Valtonen-Mattila, N / Vandenbroucke, J / van Eijndhoven, N / Vannerom, D / van Santen, J / Vara, J / Veitch-Michaelis, J / Venugopal, M / Vereecken, M / Verpoest, S / Veske, D / Vijai, A / Walck, C / Weaver, C / Weigel, P / Weindl, A / Weldert, J / Wen, A Y / Wendt, C / Werthebach, J / Weyrauch, M / Whitehorn, N / Wiebusch, C H / Willey, N / Williams, D R / Witthaus, L / Wolf, A / Wolf, M / Wrede, G / Xu, X W / Yanez, J P / Yildizci, E / Yoshida, S / Young, R / Yu, F / Yu, S / Zhang, Z / Zhelnin, P / Zilberman, P / Zimmerman, M

Physical review letters

2024 Volume 132, Issue 15, Page(s) 151001

Abstract: We report on a measurement of astrophysical tau neutrinos with 9.7 yr of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate ν_{τ} events were found with visible energies ranging from roughly ...

Abstract	We report on a measurement of astrophysical tau neutrinos with 9.7 yr of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate ν_{τ} events were found with visible energies ranging from roughly 20 TeV to 1 PeV and a median expected parent ν_{τ} energy of about 200 TeV. Considering backgrounds from astrophysical and atmospheric neutrinos, and muons from π^{±}/K^{±} decays in atmospheric air showers, we obtain a total estimated background of about 0.5 events, dominated by non-ν_{τ} astrophysical neutrinos. Thus, we rule out the absence of astrophysical ν_{τ} at the 5σ level. The measured astrophysical ν_{τ} flux is consistent with expectations based on previously published IceCube astrophysical neutrino flux measurements and neutrino oscillations.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.151001
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Article ; Online: Observation of high-energy neutrinos from the Galactic plane.

Abbasi, R / Ackermann, M / Adams, J / Aguilar, J A / Ahlers, M / Ahrens, M / Alameddine, J M / Alves, A A / Amin, N M / Andeen, K / Anderson, T / Anton, G / Argüelles, C / Ashida, Y / Athanasiadou, S / Axani, S / Bai, X / Balagopal V, A / Barwick, S W /

Basu, V / Baur, S / Bay, R / Beatty, J J / Becker, K-H / Tjus, J Becker / Beise, J / Bellenghi, C / Benda, S / BenZvi, S / Berley, D / Bernardini, E / Besson, D Z / Binder, G / Bindig, D / Blaufuss, E / Blot, S / Boddenberg, M / Bontempo, F / Book, J Y / Borowka, J / Böser, S / Botner, O / Böttcher, J / Bourbeau, E / Bradascio, F / Braun, J / Brinson, B / Bron, S / Brostean-Kaiser, J / Burley, R T / Busse, R S / Campana, M A / Carnie-Bronca, E G / Chen, C / Chen, Z / Chirkin, D / Choi, K / Clark, B A / Clark, K / Classen, L / Coleman, A / Collin, G H / Connolly, A / Conrad, J M / Coppin, P / Correa, P / Cowen, D F / Cross, R / Dappen, C / Dave, P / De Clercq, C / DeLaunay, J J / López, D Delgado / Dembinski, H / Deoskar, K / Desai, A / Desiati, P / de Vries, K D / de Wasseige, G / DeYoung, T / Diaz, A / Díaz-Vélez, J C / Dittmer, M / Dujmovic, H / Dunkman, M / DuVernois, M A / Ehrhardt, T / Eller, P / Engel, R / Erpenbeck, H / Evans, J / Evenson, P A / Fan, K L / Fazely, A R / Fedynitch, A / Feigl, N / Fiedlschuster, S / Fienberg, A T / Finley, C / Fischer, L / Fox, D / Franckowiak, A / Friedman, E / Fritz, A / Fürst, P / Gaisser, T K / Gallagher, J / Ganster, E / Garcia, A / Garrappa, S / Gerhardt, L / Ghadimi, A / Glaser, C / Glauch, T / Glüsenkamp, T / Goehlke, N / Goldschmidt, A / Gonzalez, J G / Goswami, S / Grant, D / Grégoire, T / Griswold, S / Günther, C / Gutjahr, P / Haack, C / Hallgren, A / Halliday, R / Halve, L / Halzen, F / Minh, M Ha / Hanson, K / Hardin, J / Harnisch, A A / Haungs, A / Helbing, K / Henningsen, F / Hettinger, E C / Hickford, S / Hignight, J / Hill, C / Hill, G C / Hoffman, K D / Hoshina, K / Hou, W / Huang, F / Huber, M / Huber, T / Hultqvist, K / Hünnefeld, M / Hussain, R / Hymon, K / In, S / Iovine, N / Ishihara, A / Jansson, M / Japaridze, G S / Jeong, M / Jin, M / Jones, B J P / Kang, D / Kang, W / Kang, X / Kappes, A / Kappesser, D / Kardum, L / Karg, T / Karl, M / Karle, A / Katz, U / Kauer, M / Kellermann, M / Kelley, J L / Kheirandish, A / Kin, K / Kiryluk, J / Klein, S R / Kochocki, A / Koirala, R / Kolanoski, H / Kontrimas, T / Köpke, L / Kopper, C / Kopper, S / Koskinen, D J / Koundal, P / Kovacevich, M / Kowalski, M / Kozynets, T / Krupczak, E / Kun, E / Kurahashi, N / Lad, N / Gualda, C Lagunas / Lanfranchi, J L / Larson, M J / Lauber, F / Lazar, J P / Lee, J W / Leonard, K / Leszczyńska, A / Li, Y / Lincetto, M / Liu, Q R / Liubarska, M / Lohfink, E / Mariscal, C J Lozano / Lu, L / Lucarelli, F / Ludwig, A / Luszczak, W / Lyu, Y / Ma, W Y / Madsen, J / Mahn, K B M / Makino, Y / Mancina, S / Mariş, I C / Martinez-Soler, I / Maruyama, R / McHale, S / McElroy, T / McNally, F / Mead, J V / Meagher, K / Mechbal, S / Medina, A / Meier, M / Meighen-Berger, S / Merckx, Y / Micallef, J / Mockler, D / Montaruli, T / Moore, R W / Morik, K / Morse, R / Moulai, M / Mukherjee, T / Naab, R / Nagai, R / Nahnhauer, R / Naumann, U / Necker, J / Nguyen, L V / Niederhausen, H / Nisa, M U / Nowicki, S C / Nygren, D / Pollmann, A Obertacke / Oehler, M / Oeyen, B / Olivas, A / O'Sullivan, E / Pandya, H / Pankova, D V / Park, N / Parker, G K / Paudel, E N / Paul, L / de Los Heros, C Pérez / Peters, L / Peterson, J / Philippen, S / Pieper, S / Pizzuto, A / Plum, M / Popovych, Y / Porcelli, A / Rodriguez, M Prado / Pries, B / Przybylski, G T / Raab, C / Rack-Helleis, J / Raissi, A / Rameez, M / Rawlins, K / Rea, I C / Rechav, Z / Rehman, A / Reichherzer, P / Reimann, R / Renzi, G / Resconi, E / Reusch, S / Rhode, W / Richman, M / Riedel, B / Roberts, E J / Robertson, S / Roellinghoff, G / Rongen, M / Rott, C / Ruhe, T / Ryckbosch, D / Cantu, D Rysewyk / Safa, I / Saffer, J / Salazar-Gallegos, D / Sampathkumar, P / Herrera, S E Sanchez / Sandrock, A / Santander, M / Sarkar, S / Satalecka, K / Schaufel, M / Schieler, H / Schindler, S / Schmidt, T / Schneider, A / Schneider, J / Schröder, F G / Schumacher, L / Schwefer, G / Sclafani, S / Seckel, D / Seunarine, S / Sharma, A / Shefali, S / Shimizu, N / Silva, M / Skrzypek, B / Smithers, B / Snihur, R / Soedingrekso, J / Sogaard, A / Soldin, D / Spannfellner, C / Spiczak, G M / Spiering, C / Stamatikos, M / Stanev, T / Stein, R / Stettner, J / Stezelberger, T / Stokstad, B / Stürwald, T / Stuttard, T / Sullivan, G W / Taboada, I / Ter-Antonyan, S / Thwaites, J / Tilav, S / Tischbein, F / Tollefson, K / Tönnis, C / Toscano, S / Tosi, D / Trettin, A / Tselengidou, M / Tung, C F / Turcati, A / Turcotte, R / Turley, C F / Twagirayezu, J P / Ty, B / Elorrieta, M A Unland / Valtonen-Mattila, N / Vandenbroucke, J / van Eijndhoven, N / Vannerom, D / van Santen, J / Veitch-Michaelis, J / Verpoest, S / Walck, C / Wang, W / Watson, T B / Weaver, C / Weigel, P / Weindl, A / Weiss, M J / Weldert, J / Wendt, C / Werthebach, J / Weyrauch, M / Whitehorn, N / Wiebusch, C H / Willey, N / Williams, D R / Wolf, M / Wrede, G / Wulff, J / Xu, X W / Yanez, J P / Yildizci, E / Yoshida, S / Yu, S / Yuan, T / Zhang, Z / Zhelnin, P

Science (New York, N.Y.)

2023 Volume 380, Issue 6652, Page(s) 1338–1343

Abstract: The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, ...

Abstract	The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, cosmic rays interact with matter near their sources and during propagation, which produces high-energy neutrinos. We searched for neutrino emission using machine learning techniques applied to 10 years of data from the IceCube Neutrino Observatory. By comparing diffuse emission models to a background-only hypothesis, we identified neutrino emission from the Galactic plane at the 4.5σ level of significance. The signal is consistent with diffuse emission of neutrinos from the Milky Way but could also arise from a population of unresolved point sources.
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adc9818
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Strong Constraints on Neutrino Nonstandard Interactions from TeV-Scale ν_{μ} Disappearance at IceCube.

Abbasi, R / Ackermann, M / Adams, J / Aguilar, J A / Ahlers, M / Ahrens, M / Alameddine, J M / Alispach, C / Alves, A A / Amin, N M / Andeen, K / Anderson, T / Anton, G / Argüelles, C / Ashida, Y / Axani, S / Bai, X / Balagopal, A / Barbano, A /

Barwick, S W / Bastian, B / Basu, V / Baur, S / Bay, R / Beatty, J J / Becker, K-H / Becker Tjus, J / Bellenghi, C / Benda, S / BenZvi, S / Berley, D / Bernardini, E / Besson, D Z / Binder, G / Bindig, D / Blaufuss, E / Blot, S / Boddenberg, M / Bontempo, F / Borowka, J / Böser, S / Botner, O / Böttcher, J / Bourbeau, E / Bradascio, F / Braun, J / Brinson, B / Bron, S / Brostean-Kaiser, J / Browne, S / Burgman, A / Burley, R T / Busse, R S / Campana, M A / Carnie-Bronca, E G / Chen, C / Chen, Z / Chirkin, D / Choi, K / Clark, B A / Clark, K / Classen, L / Coleman, A / Collin, G H / Conrad, J M / Coppin, P / Correa, P / Cowen, D F / Cross, R / Dappen, C / Dave, P / De Clercq, C / DeLaunay, J J / Delgado López, D / Dembinski, H / Deoskar, K / Desai, A / Desiati, P / de Vries, K D / de Wasseige, G / de With, M / DeYoung, T / Diaz, A / Díaz-Vélez, J C / Dittmer, M / Dujmovic, H / Dunkman, M / DuVernois, M A / Dvorak, E / Ehrhardt, T / Eller, P / Engel, R / Erpenbeck, H / Evans, J / Evenson, P A / Fan, K L / Fazely, A R / Fedynitch, A / Feigl, N / Fiedlschuster, S / Fienberg, A T / Filimonov, K / Finley, C / Fischer, L / Fox, D / Franckowiak, A / Friedman, E / Fritz, A / Fürst, P / Gaisser, T K / Gallagher, J / Ganster, E / Garcia, A / Garrappa, S / Gerhardt, L / Ghadimi, A / Glaser, C / Glauch, T / Glüsenkamp, T / Gonzalez, J G / Goswami, S / Grant, D / Grégoire, T / Griswold, S / Günther, C / Gutjahr, P / Haack, C / Hallgren, A / Halliday, R / Halve, L / Halzen, F / Ha Minh, M / Hanson, K / Hardin, J / Harnisch, A A / Haungs, A / Hebecker, D / Helbing, K / Henningsen, F / Hettinger, E C / Hickford, S / Hignight, J / Hill, C / Hill, G C / Hoffman, K D / Hoffmann, R / Hoshina, K / Huang, F / Huber, M / Huber, T / Hultqvist, K / Hünnefeld, M / Hussain, R / Hymon, K / In, S / Iovine, N / Ishihara, A / Jansson, M / Japaridze, G S / Jeong, M / Jin, M / Jones, B J P / Kang, D / Kang, W / Kang, X / Kappes, A / Kappesser, D / Kardum, L / Karg, T / Karl, M / Karle, A / Katz, U / Kauer, M / Kellermann, M / Kelley, J L / Kheirandish, A / Kin, K / Kintscher, T / Kiryluk, J / Klein, S R / Koirala, R / Kolanoski, H / Kontrimas, T / Köpke, L / Kopper, C / Kopper, S / Koskinen, D J / Koundal, P / Kovacevich, M / Kowalski, M / Kozynets, T / Kun, E / Kurahashi, N / Lad, N / Lagunas Gualda, C / Lanfranchi, J L / Larson, M J / Lauber, F / Lazar, J P / Lee, J W / Leonard, K / Leszczyńska, A / Li, Y / Lincetto, M / Liu, Q R / Liubarska, M / Lohfink, E / Lozano Mariscal, C J / Lu, L / Lucarelli, F / Ludwig, A / Luszczak, W / Lyu, Y / Ma, W Y / Madsen, J / Mahn, K B M / Makino, Y / Mancina, S / Mariş, I C / Martinez-Soler, I / Maruyama, R / McCarthy, S / McElroy, T / McNally, F / Mead, J V / Meagher, K / Mechbal, S / Medina, A / Meier, M / Meighen-Berger, S / Micallef, J / Mockler, D / Montaruli, T / Moore, R W / Morse, R / Moulai, M / Naab, R / Nagai, R / Naumann, U / Necker, J / Nguyễn, L V / Niederhausen, H / Nisa, M U / Nowicki, S C / Obertacke Pollmann, A / Oehler, M / Oeyen, B / Olivas, A / O'Sullivan, E / Pandya, H / Pankova, D V / Park, N / Parker, G K / Paudel, E N / Paul, L / Pérez de Los Heros, C / Peters, L / Peterson, J / Philippen, S / Pieper, S / Pittermann, M / Pizzuto, A / Plum, M / Popovych, Y / Porcelli, A / Prado Rodriguez, M / Price, P B / Pries, B / Przybylski, G T / Raab, C / Rack-Helleis, J / Raissi, A / Rameez, M / Rawlins, K / Rea, I C / Rechav, Z / Rehman, A / Reichherzer, P / Reimann, R / Renzi, G / Resconi, E / Reusch, S / Rhode, W / Richman, M / Riedel, B / Roberts, E J / Robertson, S / Roellinghoff, G / Rongen, M / Rott, C / Ruhe, T / Ryckbosch, D / Rysewyk Cantu, D / Safa, I / Saffer, J / Sanchez Herrera, S E / Sandrock, A / Santander, M / Sarkar, S / Satalecka, K / Schaufel, M / Schieler, H / Schindler, S / Schmidt, T / Schneider, A / Schneider, J / Schröder, F G / Schumacher, L / Schwefer, G / Sclafani, S / Seckel, D / Seunarine, S / Sharma, A / Shefali, S / Shimizu, N / Silva, M / Skrzypek, B / Smithers, B / Snihur, R / Soedingrekso, J / Soldin, D / Spannfellner, C / Spiczak, G M / Spiering, C / Stachurska, J / Stamatikos, M / Stanev, T / Stein, R / Stettner, J / Stezelberger, T / Stürwald, T / Stuttard, T / Sullivan, G W / Taboada, I / Ter-Antonyan, S / Thwaites, J / Tilav, S / Tischbein, F / Tollefson, K / Tönnis, C / Toscano, S / Tosi, D / Trettin, A / Tselengidou, M / Tung, C F / Turcati, A / Turcotte, R / Turley, C F / Twagirayezu, J P / Ty, B / Unland Elorrieta, M A / Valtonen-Mattila, N / Vandenbroucke, J / van Eijndhoven, N / Vannerom, D / van Santen, J / Veitch-Michaelis, J / Verpoest, S / Walck, C / Wang, W / Watson, T B / Weaver, C / Weigel, P / Weindl, A / Weiss, M J / Weldert, J / Wendt, C / Werthebach, J / Weyrauch, M / Whitehorn, N / Wiebusch, C H / Williams, D R / Wolf, M / Woschnagg, K / Wrede, G / Wulff, J / Xu, X W / Yanez, J P / Yildizci, E / Yoshida, S / Yu, S / Yuan, T / Zhang, Z / Zhelnin, P

Physical review letters

2022 Volume 129, Issue 1, Page(s) 11804

Abstract: We report a search for nonstandard neutrino interactions (NSI) using eight years of TeV-scale atmospheric muon neutrino data from the IceCube Neutrino Observatory. By reconstructing incident energies and zenith angles for atmospheric neutrino events, ... ...

Abstract	We report a search for nonstandard neutrino interactions (NSI) using eight years of TeV-scale atmospheric muon neutrino data from the IceCube Neutrino Observatory. By reconstructing incident energies and zenith angles for atmospheric neutrino events, this analysis presents unified confidence intervals for the NSI parameter ε_{μτ}. The best-fit value is consistent with no NSI at a p value of 25.2%. With a 90% confidence interval of -0.0041≤ε_{μτ}≤0.0031 along the real axis and similar strength in the complex plane, this result is the strongest constraint on any NSI parameter from any oscillation channel to date.
Language	English
Publishing date	2022-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.129.011804
Database	MEDical Literature Analysis and Retrieval System OnLINE

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