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  1. AU="Phillip Hawkins"
  2. AU="Wang, Taihuan"
  3. AU="Hodsman, Anthony B"
  4. AU="Zheng, Bai-Feng"
  5. AU="Lawless, Nathan"
  6. AU="Lim, Ji Young"
  7. AU="Sehdev, Simran"
  8. AU="Del Amor, Francisco M"
  9. AU="Chen, Hanbo"
  10. AU=Song Shiyu
  11. AU="Shen, Chien-Wen"
  12. AU="Philip D King"
  13. AU="Yan, Zhongyu"
  14. AU="Cicalini, Carolina" AU="Cicalini, Carolina"
  15. AU="Magdalena Lange"
  16. AU="Riley, Julie"
  17. AU="Benherrif, Oussama"
  18. AU="Grau, A."
  19. AU=Tao Qiushan
  20. AU="Qin, Guole"
  21. AU="Reis, Jennifer"
  22. AU=Rothstein Eric S
  23. AU="Bruszel, Bella"
  24. AU="Edwin R. Chilvers"
  25. AU="Marco Heredia-R"
  26. AU="Barbora Chladkova"
  27. AU=Chen Yi-Ning
  28. AU="Dirce Maria Lobo Marchioni"
  29. AU="Martínez Fernández, Lidia"
  30. AU="Graham J. T"
  31. AU="Płońska-Gościniak, Edyta"
  32. AU="Shackira, A M"
  33. AU="Fukui, Mototaka"
  34. AU="Jones, Clare A"
  35. AU="Chen, Yonghua"
  36. AU=Das Nilay Kanti
  37. AU="Christine Brittsan"
  38. AU="Skinner, Henry"
  39. AU=Wang Wan-Ying
  40. AU="Ingrid Natalia Muñoz Quijano"
  41. AU="Xu, Jianrong"
  42. AU="Klutts, Abigail"
  43. AU="Corumlu, Ufuk"
  44. AU="Frank Dickmann"
  45. AU="Paz-Priel, Ido"
  46. AU=Budhraja Anshul

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  1. Artikel ; Online: More paths to PI3Kγ.

    Len Stephens / Phillip Hawkins

    PLoS Biology, Vol 11, Iss 6, p e

    2013  Band 1001594

    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

    Hashem Koohy / Daniel J. Bolland / Louise S. Matheson / Stefan Schoenfelder / Claudia Stellato / Andrew Dimond / Csilla Várnai / Peter Chovanec / Tamara Chessa / Jeremy Denizot / Raquel Manzano Garcia / Steven W. Wingett / Paula Freire-Pritchett / Takashi Nagano / Phillip Hawkins / Len Stephens / Sarah Elderkin / Mikhail Spivakov / Peter Fraser /
    Anne E. Corcoran / Patrick D. Varga-Weisz

    Genome Biology, Vol 19, Iss 1, Pp 1-

    2018  Band 24

    Abstract: Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin ... ...

    Abstract Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin features genome-wide, including histone modifications and chromosome conformation, in bone marrow pro-B and pre-B cells from young and aged mice. Results Our analysis reveals that the expression levels of most genes are generally preserved in B cell precursors isolated from aged compared with young mice. Nonetheless, age-specific expression changes are observed at numerous genes, including microRNA encoding genes. Importantly, these changes are underpinned by multi-layered alterations in chromatin structure, including chromatin accessibility, histone modifications, long-range promoter interactions, and nuclear compartmentalization. Previous work has shown that differentiation is linked to changes in promoter-regulatory element interactions. We find that aging in B cell precursors is accompanied by rewiring of such interactions. We identify transcriptional downregulation of components of the insulin-like growth factor signaling pathway, in particular downregulation of Irs1 and upregulation of Let-7 microRNA expression, as a signature of the aged phenotype. These changes in expression are associated with specific alterations in H3K27me3 occupancy, suggesting that Polycomb-mediated repression plays a role in precursor B cell aging. Conclusions Changes in chromatin and 3D genome organization play an important role in shaping the altered gene expression profile of aged precursor B cells. Components of the insulin-like growth factor signaling pathways are key targets of epigenetic regulation in aging in bone marrow B cell precursors.
    Schlagwörter Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2018-09-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Angulo, Ivan / Alain Fischer / Alison Condliffe / Andrew J. Cant / Anita Chandra / Anna Kielkowska / Anne Durandy / Capucine Picard / Changxin Wu / Christine Fiddler / Deborah Smyth / Deirdre Cilliers / Dinakantha Kumararatne / Edward Banham-Hall / Edwin R. Chilvers / Fabien Garçon / Gašper Markelj / Gabriela Barcenas-Morales / George Farmer /
    Helen Baxendale / Isabelle Pellier / James A. Morris / James Curtis / Jatinder Juss / Jeffrey C. Barrett / Jonathan Clark / Katherine Blake-Palmer / Klaus Okkenhaug / Len Stephens / Mailis Maes / Marianne Debré / Mario Abinun / Menna Clatworthy / Nada Jabado / Olga Perisic / Oscar Vadas / Phillip Hawkins / Rainer Doffinger / Roger L. Williams / Sergey Nejentsev / Sven Kracker / Tanya Coulter / Timothy R. Leahy / Vincent Plagnol

    Science. 2013 Nov. 15, v. 342, no. 6160

    2013  

    Abstract: Answers from Exomes Exome sequencing, which targets only the protein-coding regions of the genome, has the potential to identify the underlying genetic causes of rare inherited diseases. Angulo et al. (p. 866, published online 17 October; see Perspective ...

    Abstract Answers from Exomes Exome sequencing, which targets only the protein-coding regions of the genome, has the potential to identify the underlying genetic causes of rare inherited diseases. Angulo et al. (p. 866, published online 17 October; see Perspective by Conley and Fruman) performed exome sequencing of individuals from seven unrelated families with severe, recurrent respiratory infections. The patients carried the same mutation in the gene coding for the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ). The mutation caused aberrant activation of this kinase, which plays a key role in immune cell signaling. Drugs inhibiting PI3Kδ are already in clinical trials for other disorders.
    Schlagwörter clinical trials ; drugs ; genes ; inheritance (genetics) ; mutation ; patients ; phosphatidylinositol 3-kinase ; protein subunits ; respiratory tract diseases ; sequence analysis
    Sprache Englisch
    Erscheinungsverlauf 2013-1115
    Umfang p. 866-871.
    Erscheinungsort American Association for the Advancement of Science
    Dokumenttyp Artikel
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1243292
    Datenquelle NAL Katalog (AGRICOLA)

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