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  1. Article ; Online: Searching for a Vulnerable Cardiovascular Endotype in Obstructive Sleep Apnea: Is the Humble Pulse Wave a Useful Biomarker?

    Phillips, Craig L / Marshall, Nathaniel S

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 12, Page(s) 1553–1555

    MeSH term(s) Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/physiopathology ; Risk Factors ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology ; Heart Disease Risk Factors ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202304-0739ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Obstructive sleep apnoea in obesity: A review.

    Tai, Jian E / Phillips, Craig L / Yee, Brendon J / Grunstein, Ronald R

    Clinical obesity

    2024  , Page(s) e12651

    Abstract: Obstructive sleep apnea is a common comorbidity that occurs in individuals with obesity. It classically manifests with excessive daytime sleepiness, resulting in reduced quality of life, workplace productivity, and an increased risk of motor vehicle ... ...

    Abstract Obstructive sleep apnea is a common comorbidity that occurs in individuals with obesity. It classically manifests with excessive daytime sleepiness, resulting in reduced quality of life, workplace productivity, and an increased risk of motor vehicle accidents. Weight gain plays an important role in its pathogenesis through worsening upper airway collapsibility, and current treatment options are targeted towards mechanically overcoming upper airway obstruction and weight loss. Continuous positive airway pressure therapy remains the most widely prescribed treatment for obstructive sleep apnea but poor tolerance is a common barrier to effective treatment. Sustainable weight loss is an important treatment option but can be difficult to achieve without bariatric surgery. The recent advances in incretin-based pharmacotherapies represent a promising avenue not only in achieving long-term weight loss but also in treating obstructive sleep apnoea and alleviating the burden of its symptoms and comorbidities.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2625816-X
    ISSN 1758-8111 ; 1758-8103
    ISSN (online) 1758-8111
    ISSN 1758-8103
    DOI 10.1111/cob.12651
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  3. Article ; Online: Predicting Weight-Loss Effects on Obstructive Sleep Apnea and Cardiometabolic Health: In Search of the Craniofacial "Holy Grail".

    Phillips, Craig L / Cayanan, Elizabeth A / Yee, Brendon J

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 6, Page(s) 614–616

    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Humans ; Polysomnography ; Sleep Apnea, Obstructive/therapy ; Weight Loss
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202112-2750ED
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  4. Article ; Online: Treating moderate-severe obstructive sleep apnoea for cardiovascular health: Is what stake the stakeholder holds important?

    Phillips, Craig L / Grunstein, Ronald R

    Respirology (Carlton, Vic.)

    2019  Volume 24, Issue 4, Page(s) 302–303

    MeSH term(s) Cardiovascular Diseases ; Consensus ; Humans ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2019-01-10
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13467
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  5. Article ; Online: Giving weight to incretin-based pharmacotherapy for obesity-related sleep apnea: a revolution or a pipe dream?

    Grunstein, Ronald R / Wadden, Thomas A / Chapman, Julia L / Malhotra, Atul / Phillips, Craig L

    Sleep

    2023  Volume 46, Issue 10

    Abstract: Obesity is a chronic disease affecting over 670 million adults globally, with multiple complications including obstructive sleep apnea (OSA). Substantial weight loss in patients with obesity-related OSA can reduce or even eliminate OSA as well as reduce ... ...

    Abstract Obesity is a chronic disease affecting over 670 million adults globally, with multiple complications including obstructive sleep apnea (OSA). Substantial weight loss in patients with obesity-related OSA can reduce or even eliminate OSA as well as reduce sleepiness and improve cardio-metabolic health. Evidence suggests that these improvements exceed those that occur with device-based OSA therapies like continuous positive airway pressure which continue to be the first-line of therapy. Resistance to weight management as a first-line strategy to combat OSA could arise from the complexities in delivering and maintaining adequate weight management, particularly in sleep clinic settings. Recently, incretin-based pharmacotherapies including glucagon-like peptide 1 (GLP-1) receptor agonists alone or combined with glucose-dependent insulinotropic polypeptide (GIP) receptor agonists have been developed to target glycemic control in type 2 diabetes. These medications also slow gastric emptying and reduce energy intake. In randomized, placebo-controlled trials of these medications in diabetic and non-diabetic populations with obesity, participants on active medication lost up to 20% of their body weight, with corresponding improvements in blood pressure, lipid levels, physical functioning, and fat mass loss. Their adverse effects are predominantly gastrointestinal-related, mild, and transient. There are trials currently underway within individuals with obesity-related OSA, with a focus on reduction in weight, OSA severity, and cardio-metabolic outcomes. These medications have the potential to substantially disrupt the management of OSA. Pending coming data, we will need to consider pharmacological weight loss as a first-line therapy and how that influences training and management guidelines.
    MeSH term(s) Adult ; Humans ; Incretins/therapeutic use ; Incretins/physiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Obesity/complications ; Obesity/drug therapy ; Weight Loss ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/drug therapy
    Chemical Substances Incretins
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is obstructive sleep apnoea an innocent bystander in the pathophysiology of arterial stiffening?

    Phillips, Craig L / Drager, Luciano F

    Thorax

    2018  Volume 73, Issue 12, Page(s) 1099–1100

    MeSH term(s) Humans ; Polysomnography ; Sleep Apnea, Obstructive ; Vascular Stiffness
    Language English
    Publishing date 2018-09-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2018-212332
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  7. Article ; Online: Is a "gut full" of bad bugs driving metabolic disease in shift workers?

    Phillips, Craig L / Comas, Maria

    Sleep medicine reviews

    2017  Volume 34, Page(s) 1–2

    MeSH term(s) Automobile Driving ; Humans ; Metabolic Diseases ; Work Schedule Tolerance
    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1414211-9
    ISSN 1532-2955 ; 1087-0792
    ISSN (online) 1532-2955
    ISSN 1087-0792
    DOI 10.1016/j.smrv.2017.02.003
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  8. Article ; Online: EEG slowing during REM sleep in older adults with subjective cognitive impairment and mild cognitive impairment.

    Lam, Aaron Kin Fu / Carrick, James / Kao, Chien-Hui / Phillips, Craig L / Zheng, Yi Zhong / Yee, Brendon J / Kim, Jong Won / Grunstein, Ronald R / Naismith, Sharon L / D'Rozario, Angela L

    Sleep

    2024  

    Abstract: Study objectives: In older adults with Alzheimer's disease, slowing of electroencephalographic (EEG) activity during REM sleep has been observed. Few studies have examined EEG slowing during REM in those with mild cognitive impairment (MCI) and none ... ...

    Abstract Study objectives: In older adults with Alzheimer's disease, slowing of electroencephalographic (EEG) activity during REM sleep has been observed. Few studies have examined EEG slowing during REM in those with mild cognitive impairment (MCI) and none have examined its relationship with cognition in this at-risk population.
    Methods: 210 older adults (mean age = 67.0, sd = 8.2 years) underwent comprehensive neuropsychological, medical, and psychiatric assessment and overnight polysomnography. Participants were classified as subjective cognitive impairment (SCI; n=75), non-amnestic MCI (naMCI, n=85), and amnestic MCI (aMCI, n=50). REM EEG slowing was defined as (delta + theta) / (alpha + sigma + beta) power and calculated for frontal, central, parietal, and occipital regions. Analysis of variance compared REM EEG slowing between groups. Correlations between REM EEG slowing and cognition, including learning and memory, visuospatial and executive functions, were examined within each subgroup.
    Results: The aMCI group had significantly greater REM EEG slowing in the parietal and occipital regions compared to the naMCI and SCI groups (partial η2 = 0.06, p<0.05 and 0.06, p<0.05, respectively), and greater EEG slowing in the central region compared to SCI group (partial η2 = 0.03, p<0.05). Greater REM EEG slowing in parietal (r = -0.49) and occipital regions (r = -0.38 (O1/M2) and -0.33 (O2/M1) were associated with poorer visuospatial performance in naMCI.
    Conclusion: REM EEG slowing may differentiate older adults with memory impairment from those without. Longitudinal studies are now warranted to examine the prognostic utility of REM EEG slowing for cognitive and dementia trajectories.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsae051
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  9. Article ; Online: Linking awake ventilatory chemosensitivity with opioid-induced respiratory depression during sleep-an important, but not a new, concept.

    Wang, David / Phillips, Craig L / Yee, Brendon J / Grunstein, Ronald R

    Journal of applied physiology (Bethesda, Md. : 1985)

    2020  Volume 129, Issue 4, Page(s) 932

    MeSH term(s) Analgesics, Opioid/adverse effects ; Humans ; Respiratory Insufficiency ; Sleep/drug effects ; Wakefulness
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2020-10-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00679.2020
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  10. Article ; Online: Is Obstructive Sleep Apnea a Risk Factor for Depression in Coronary Artery Disease?

    Hoyos, Camilla M / Bartlett, Delwyn J / Phillips, Craig L

    Annals of the American Thoracic Society

    2018  Volume 16, Issue 1, Page(s) 49–50

    MeSH term(s) Adult ; Continuous Positive Airway Pressure ; Coronary Artery Disease ; Depression ; Humans ; Risk Factors ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2018-12-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201810-728ED
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