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  1. Article: Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity.

    Castruita, Patricia Alejandra / Piña-Escudero, Stefanie Danielle / Rentería, Miguel E / Yokoyama, Jennifer S

    Current genetic medicine reports

    2022  Volume 10, Issue 3, Page(s) 25–34

    Abstract: Purpose of review: "Healthy aging" is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness. This literature review presents an overview of recent studies that explore how biological, social, and ... ...

    Abstract Purpose of review: "Healthy aging" is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness. This literature review presents an overview of recent studies that explore how biological, social, and environmental factors contribute to healthy aging.
    Recent findings: A number of genome-wide association studies have been conducted recently for traits related to healthy aging, such as frailty index, healthspan, muscle strength, and parental longevity, leading to the discovery of dozens of genetic variants associated with these traits. In parallel, associations between healthy aging measures and multiple non-biological environmental elements have been identified as key moderators of the aging process, indirectly influencing day-to-day homeostatic processes.
    Summary: Individual variations in lifespan and healthspan are influenced by genetic factors, with a heritability of ~ 25% in developed countries. Non-genetic risk variance is explained in part by social, cultural, and lifestyle conditions. Altogether, these factors contribute to a multifaceted state of wellness over time, shaping individual risk to frailty and resilience during the aging process. Notably, "Blue Zone" populations, which are characterized by an abundance in healthy lifestyles across generations, share some commonalities regarding determinants of health.
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2167-4876
    ISSN 2167-4876
    DOI 10.1007/s40142-022-00205-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contextualizing mistreatment in cognitive impairment in Latin America.

    Piña-Escudero, Stefanie Danielle / Weinstein, Cindy A / Ritchie, Christine

    Journal of elder abuse & neglect

    2019  Volume 31, Issue 3, Page(s) 255–261

    Abstract: Mistreatment is an important social outcome of the growing cognitive impairment epidemic, particularly in developing countries. This study aimed to bring to light what is known about mistreatment in cognitively impaired individuals in Latin American ... ...

    Abstract Mistreatment is an important social outcome of the growing cognitive impairment epidemic, particularly in developing countries. This study aimed to bring to light what is known about mistreatment in cognitively impaired individuals in Latin American Countries. We identified a gap in the literature on this topic that opens the door for future research.
    MeSH term(s) Aged ; Cognitive Dysfunction/ethnology ; Dementia/ethnology ; Elder Abuse/ethnology ; Humans ; Latin America/ethnology
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018101-5
    ISSN 1540-4129 ; 0894-6566
    ISSN (online) 1540-4129
    ISSN 0894-6566
    DOI 10.1080/08946566.2019.1584070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Caregiving for Patients With Frontotemporal Dementia in Latin America.

    Piña-Escudero, Stefanie Danielle / Aguirre, Gloria Annette / Javandel, Shireen / Longoria-Ibarrola, Erika Mariana

    Frontiers in neurology

    2021  Volume 12, Page(s) 665694

    Abstract: Latin America is a vast heterogeneous territory where chronic diseases such as mild cognitive impairment or dementia are becoming higher. Frontotemporal dementia (FTD) prevalence in this region is estimated to be around 12-18 cases per thousand persons. ... ...

    Abstract Latin America is a vast heterogeneous territory where chronic diseases such as mild cognitive impairment or dementia are becoming higher. Frontotemporal dementia (FTD) prevalence in this region is estimated to be around 12-18 cases per thousand persons. However, this prevalence is underestimated given the lack of awareness of FTD even among healthcare professionals. Family members are responsible for the care of patients with FTD at home. These caregivers deliver care despite being ill-equipped and living in the context of austerity policies and social inequities. They often face unsurmountable financial and social burdens that are specific to the region. The most important step to support caregivers in Latin America is to increase awareness of the disease at all levels. Healthcare diplomacy is fundamental to create joint efforts that push policies forward to protect caregivers of FTD patients.
    Language English
    Publishing date 2021-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.665694
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  4. Article ; Online: Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration.

    Pina-Escudero, Stefanie Danielle / Okada de Oliveira, Maira / Snyder, Alisson / Miller, Bruce L

    Neurocase

    2021  Volume 27, Issue 2, Page(s) 209–211

    Abstract: Awake bruxism is an understudied feature of behavioral variant of frontotemporal dementia (bvFTD). We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his ... ...

    Abstract Awake bruxism is an understudied feature of behavioral variant of frontotemporal dementia (bvFTD). We present the case of aman who presented with psychiatric, behavioral, cognitive changes, and teeth clenching that resulted in significant changes in his teeth alignment including an underbite. He received multiple treatments with partial response. He then started using acannabidiol (CBD) capsule, and the grinding was almost completely relieved after this intervention. There is still no standardized pharmacology treatment for bruxism in patients with bvFTD. As aconsequence, acase-by-case approach is suggested. CBD can be helpful as an adjunct therapeutic agent for awake bruxism.Not StartedCompletedRejected.
    MeSH term(s) Atrophy ; Bruxism/complications ; Bruxism/drug therapy ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Frontotemporal Dementia ; Humans ; Male
    Chemical Substances Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2021-05-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1302651-3
    ISSN 1465-3656 ; 1355-4794
    ISSN (online) 1465-3656
    ISSN 1355-4794
    DOI 10.1080/13554794.2021.1917620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Neurodegenerative Disease and the Experience of Homelessness.

    Piña-Escudero, Stefanie Danielle / López, Lucía / Sriram, Sandeepa / Longoria Ibarrola, Erika Mariana / Miller, Bruce / Lanata, Serggio

    Frontiers in neurology

    2021  Volume 11, Page(s) 562218

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.562218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Subjective cognitive decline and elder mistreatment in Mexican community-dwelling older adults.

    Piña-Escudero, Stefanie Danielle / Chodos, Anna / Weinstein, Cindy A / Allen, Isabel Elaine / Ávila-Funes, José Alberto / Ritchie, Christine

    Archives of gerontology and geriatrics

    2020  Volume 92, Page(s) 104242

    Abstract: Background and objectives: Elder mistreatment in individuals with subjective cognitive decline is an understudied public health problem that violates human rights.: Design and methods: Cross-sectional study of 386 Mexican community-dwelling older ... ...

    Abstract Background and objectives: Elder mistreatment in individuals with subjective cognitive decline is an understudied public health problem that violates human rights.
    Design and methods: Cross-sectional study of 386 Mexican community-dwelling older adults. Individuals with episodic memory, executive function, language, visuospatial skills or attention cognitive complaints without low cognitive performance scores in the Mini-Mental State Examination and the Isaacs Set Test that were considered positive for subjective cognitive decline (SCD). Elder mistreatment (EM) was considered positive if any of the questions on the Geriatric Mistreatment Scale were answered affirmatively. Logistic regression models were created to test the association between SCD and EM.
    Results: After adjustments made by age, sex, education and depressive symptoms a positive association was found between SCD and EM (OR = 2.226; 95%CI = 1.296 to 3.822

    p = 0.004). This association was observed in all subtypes of cognitive complaints except excecutive function: episodic memory (OR = 2.219

    95%CI = 1.321 to 3.728

    p = 0.003), language (OR = 2.500

    95% CI = 1.422 to 4.396

    p = 0.001), visuospatial (OR = 2.158

    95%CI = 1.162 to 4.007

    p = 0.015), attention (OR = 2.197

    95%CI = 1.206 to 4.001

    p = 0.010) and executive (OR = 1 2.062

    95%CI = 0.981 to 4.333

    p = 0.056). Discussion and Implications: This study brings to light the relation between SCD and EM in a population where it has been understudied. Exploring mistreatment in older adults who experience subjective cognitive decline might help preserve their safety and create future prevention and intervention strategies.
    MeSH term(s) Aged ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cross-Sectional Studies ; Elder Abuse ; Humans ; Independent Living ; Mexico/epidemiology ; Risk Factors
    Language English
    Publishing date 2020-09-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2020.104242
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  7. Article ; Online: Dementia caregiving across Latin America and the Caribbean and brain health diplomacy.

    Ibáñez, Agustin / Pina-Escudero, Stefanie Danielle / Possin, Katherine L / Quiroz, Yakeel T / Peres, Fernando Aguzzoli / Slachevsky, Andrea / Sosa, Ana Luisa / Brucki, Sonia M D / Miller, Bruce L

    The Lancet. Healthy longevity

    2021  Volume 2, Issue 4, Page(s) e222–e231

    Abstract: The prevalence of dementia in Latin America and the Caribbean is growing rapidly, increasing the burden placed on caregivers. Exacerbated by fragile health-care systems, unstable economies, and extensive inequalities, caregiver burden in this region is ... ...

    Abstract The prevalence of dementia in Latin America and the Caribbean is growing rapidly, increasing the burden placed on caregivers. Exacerbated by fragile health-care systems, unstable economies, and extensive inequalities, caregiver burden in this region is among the highest in the world. We reviewed the major challenges to caregiving in Latin America and the Caribbean, and we propose regional and coordinated actions to drive future change. Current challenges include the scarcity of formal long-term care, socioeconomic and social determinants of health disparities, gender-biased burdens, growing dementia prevalence, and the effect of the current COVID-19 pandemic on families affected by dementia. Firstly, we propose local and regional short-term strategic recommendations, including systematic identification of specific caregiver needs, testing of evidence-based local interventions, contextual adaptation of strategies to different settings and cultures, countering gender bias, strengthening community support, provision of basic technology, and better use of available information and communications technology. Additionally, we propose brain health diplomacy (ie, global actions aimed to overcome the systemic challenges to brain health by bridging disciplines and sectors) and convergence science as frameworks for long-term coordinated responses, integrating tools, knowledge, and strategies to expand access to digital technology and develop collaborative models of care. Addressing the vast inequalities in dementia caregiving across Latin America and the Caribbean requires innovative, evidence-based solutions coordinated with the strengthening of public policies.
    MeSH term(s) Brain ; COVID-19 ; Caribbean Region ; Dementia ; Diplomacy ; Female ; Humans ; Latin America ; Male ; Pandemics ; Sexism
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/s2666-7568(21)00031-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The impacts of social determinants of health and cardiometabolic factors on cognitive and functional aging in Colombian underserved populations.

    Santamaria-Garcia, Hernando / Moguilner, Sebastian / Rodriguez-Villagra, Odir Antonio / Botero-Rodriguez, Felipe / Pina-Escudero, Stefanie Danielle / O'Donovan, Gary / Albala, Cecilia / Matallana, Diana / Schulte, Michael / Slachevsky, Andrea / Yokoyama, Jennifer S / Possin, Katherine / Ndhlovu, Lishomwa C / Al-Rousan, Tala / Corley, Michael J / Kosik, Kenneth S / Muniz-Terrera, Graciela / Miranda, J Jaime / Ibanez, Agustin

    GeroScience

    2023  Volume 45, Issue 4, Page(s) 2405–2423

    Abstract: Global initiatives call for further understanding of the impact of inequity on aging across underserved populations. Previous research in low- and middle-income countries (LMICs) presents limitations in assessing combined sources of inequity and outcomes ...

    Abstract Global initiatives call for further understanding of the impact of inequity on aging across underserved populations. Previous research in low- and middle-income countries (LMICs) presents limitations in assessing combined sources of inequity and outcomes (i.e., cognition and functionality). In this study, we assessed how social determinants of health (SDH), cardiometabolic factors (CMFs), and other medical/social factors predict cognition and functionality in an aging Colombian population. We ran a cross-sectional study that combined theory- (structural equation models) and data-driven (machine learning) approaches in a population-based study (N = 23,694; M = 69.8 years) to assess the best predictors of cognition and functionality. We found that a combination of SDH and CMF accurately predicted cognition and functionality, although SDH was the stronger predictor. Cognition was predicted with the highest accuracy by SDH, followed by demographics, CMF, and other factors. A combination of SDH, age, CMF, and additional physical/psychological factors were the best predictors of functional status. Results highlight the role of inequity in predicting brain health and advancing solutions to reduce the cognitive and functional decline in LMICs.
    MeSH term(s) Humans ; Social Factors ; Social Determinants of Health ; Cross-Sectional Studies ; Colombia/epidemiology ; Vulnerable Populations ; Aging ; Cognition ; Cardiovascular Diseases
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-023-00755-z
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  9. Article: Factors Associated with Surrogate Self-Efficacy in Decision-Making for Patients with End-Stage Renal Disease.

    Piña-Escudero, Stefanie Danielle / García-Avilés, Roberto De Jesús / Fajardo-Juárez, Armando Iván / López, César Urtiz / Moral-Trejo, Ana Karene Del / Ramírez-Ambriz, Pedro Manuel / Tovar-Serrano, Alejandro / Antonio, García-Lara Juan Miguel

    Indian journal of palliative care

    2019  Volume 25, Issue 1, Page(s) 3–8

    Abstract: Aim: The aim of the study is to assess which factors are associated with self-efficacy for making these decisions in surrogates of end-stage kidney disease patients.: Materials and methods: Cross-sectional study conducted in the hemodialysis clinic ... ...

    Abstract Aim: The aim of the study is to assess which factors are associated with self-efficacy for making these decisions in surrogates of end-stage kidney disease patients.
    Materials and methods: Cross-sectional study conducted in the hemodialysis clinic of a private hospital in Mexico City. A total of 124 surrogates of patients in hemodialysis were included in the study. Self-efficacy for decision-making was assessed with the Family Decision-Making Self-Efficacy Scale. As factors related to decision-making self-efficacy, sociodemographic data, health information, and professional help received for dealing with end-of-life issues were assessed in both patients and surrogates. Functional status and advanced directives of the patient as well as prior experience in decision-making of the surrogates were also included. Logistic regression models were used to establish the associations.
    Results: The mean age of participants was 49.4 years (standard deviation: 14). Factors associated to decision-making self-efficacy were awareness of the surrogate about the terminal disease of the patient (
    Conclusions: This study provides information of which factors are associated with self-effectiveness in surrogates of terminally ill renal patients so that strategies based on these considerations might be implemented in the future.
    Language English
    Publishing date 2019-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 0973-1075
    ISSN 0973-1075
    DOI 10.4103/IJPC.IJPC_147_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Depressive symptoms increase the risk of mortality in older Mexican community-dwelling adults.

    Piña-Escudero, Stefanie Danielle / Navarrete-Reyes, Ana Patricia / Avila-Funes, José Alberto

    Journal of the American Geriatrics Society

    2011  Volume 59, Issue 11, Page(s) 2171–2172

    MeSH term(s) Aged ; Aged, 80 and over ; Depression/complications ; Depression/diagnosis ; Depression/mortality ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/mortality ; Male ; Mexico/epidemiology ; Prognosis ; Risk Factors ; Severity of Illness Index ; Survival Rate/trends
    Language English
    Publishing date 2011-11
    Publishing country United States
    Document type Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/j.1532-5415.2011.03641.x
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