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Article: Case Report: First attempt by off-label use of tenecteplase to treat acute extensive portal venous system thrombosis.

Li, Qianqian / Piao, Ying / Zhang, Yongguo / Qi, Xingshun

2024 Volume 11, Page(s) 1342529

Abstract: Acute extensive portal venous system thrombosis (PVST) can cause lethal complications. Herein, we have for the first time reported the use of anticoagulation combined with systemic thrombolysis by tenecteplase in a male patient with a diagnosis of acute ... ...

Abstract	Acute extensive portal venous system thrombosis (PVST) can cause lethal complications. Herein, we have for the first time reported the use of anticoagulation combined with systemic thrombolysis by tenecteplase in a male patient with a diagnosis of acute extensive PVST but without liver cirrhosis. After thrombolytic therapy, abdominal pain obviously alleviated. However, urinary bleeding developed, which was reversible by stopping thrombolytic drugs. Finally, this case developed cavernous transformation of the portal vein without portal venous recanalization. In future, the efficacy and safety of tenecteplase should be explored in acute extensive PVST cases.
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1342529
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Article: Global research and emerging trends in autophagy in lung cancer: a bibliometric and visualized study from 2013 to 2022.

Liu, Bo-Na / Chen, Juan / Piao, Ying

Frontiers in pharmacology

2024 Volume 15, Page(s) 1352422

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1352422
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Article ; Online: Rapid motor progression of Parkinson's disease associates with clinical and genetic variants.

Cao, Ling-Xiao / Jiang, Yong / Piao, Ying-Shan / Huang, Yue

Frontiers in bioscience (Landmark edition)

2022 Volume 26, Issue 12, Page(s) 1503–1512

Abstract: Introduction: Parkinson's disease (PD) is caused by the interplay of genetic and environmental factors during brain aging. About 90 single nucleotide polymorphisms (SNPs) have been recently discovered associations with PD, but whether they associate ... ...

Abstract	Introduction: Parkinson's disease (PD) is caused by the interplay of genetic and environmental factors during brain aging. About 90 single nucleotide polymorphisms (SNPs) have been recently discovered associations with PD, but whether they associate with the clinical features of PD have not been fully addressed yet. Methods: Clinical data of 365 patients with PD who enrolled in Parkinson's Progression Markers Initiative (PPMI) study were obtained. Patients with rapid motor progression were determined through clinical assessments over five years follow-up. In addition, genetic information of 44 targeted SNPs was extracted from the genetic database of NeuroX for the same cohort. Logistic regression was used to analyze the genetic associations with rapid motor progression of PD. Results: Among 365 patients with PD, there are more male (66%) than female (34%). Seven SNPs (rs6808178, rs115185635, rs12497850, rs34311866, rs3793947, rs11060180, rs9568188) were associated with faster motor progression (p < 0.05), and only rs6808178 passed multiple comparison correction (p < 0.0011). In addition, the extended 44 SNPs with autonomic dysfunction reach a fair prediction of AUC at 0.821. Conclusion: Genetics and autonomic function factors contribute to the motor progression at the clinical initiation of PD.
MeSH term(s)	Biomarkers ; Brain ; Cognition ; Cohort Studies ; Disease Progression ; Female ; Humans ; Male ; Parkinson Disease/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-01-07
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.52586/5044
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Article ; Online: Efficacy of breast conservative surgery versus modified radical mastectomy for triple-negative breast cancer: A systematic review and meta-analysis.

Wu, Hong-Xing / Lin, Zi-Wen / Song, Tian-Ye / Piao, Ying-Shi

Asian journal of surgery

2022 Volume 45, Issue 7, Page(s) 1491–1493

MeSH term(s)	Breast Neoplasms/surgery ; Female ; Humans ; Lymphatic Metastasis ; Mastectomy ; Mastectomy, Modified Radical ; Mastectomy, Segmental ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Triple Negative Breast Neoplasms/surgery
Language	English
Publishing date	2022-03-21
Publishing country	China
Document type	Letter ; Meta-Analysis ; Systematic Review
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.03.007
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Article ; Online: Active Breathing Coordinator reduces radiation dose to the stomach in patients with left breast cancer.

Piao, Ying / Chen, Hongtao / Yuan, Fengshun / Fan, Juan / Wu, Shihai / Li, Xianming / Yang, Dong

Acta oncologica (Stockholm, Sweden)

2023 Volume 62, Issue 12, Page(s) 1873–1879

Abstract: Background/purpose: Gastric dose parameters comparison for deep inspiration breath-hold (DIBH) or free breathing (FB) mode during radiotherapy (RT) for left-sided breast cancer patients (LSBCPs) has not been investigated before. This study aimed to ... ...

Abstract	Background/purpose: Gastric dose parameters comparison for deep inspiration breath-hold (DIBH) or free breathing (FB) mode during radiotherapy (RT) for left-sided breast cancer patients (LSBCPs) has not been investigated before. This study aimed to analyze the impact of Active Breath Coordinator (ABC)-DIBH technique on the dose received by the stomach during RT for LSBCPs and to provide organ-specific dosimetric parameters. Materials and methods: The study included 73 LSBCPs. The dosimetric parameters of the stomach were compared between FB and DIBH mode. The correlation between the stomach volume and dosimetric parameters was analyzed. Results: Compared to FB mode, statistically significant reductions were observed in gastric dose parameters in ABC-DIBH mode, including Dmax (46.60 vs 17.25, Conclusions: The implementation of ABC-DIBH in LSBCPs radiotherapy resulted in lower irradiation of the stomach. Larger stomach volume was associated with statistically significantly higher dose irradiation in FB mode. To reduce radiotherapy related side effects in FB mode, patients should be fast for at least 2 hours before the CT simulation and treatment.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/radiotherapy ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Dosage ; Breath Holding ; Unilateral Breast Neoplasms/radiotherapy ; Stomach ; Radiation Dosage ; Heart/radiation effects ; Organs at Risk/radiation effects
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2023.2275288
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Article ; Online: Ginsenoside Rg3 overcomes tamoxifen resistance through inhibiting glycolysis in breast cancer cells.

Zhao, Wenhui / Ma, Jianli / Zhang, Qingyuan / Zhang, Han / Ma, Wenjie / Li, Shuo / Piao, Ying / Zhao, Shu / Dai, Shaochun / Tang, Dabei

Cell biology international

2024 Volume 48, Issue 4, Page(s) 496–509

Abstract: Tamoxifen (TAM) resistance poses a significant clinical challenge in human breast cancer and exhibits high heterogeneity among different patients. Rg3, an original ginsenoside known to inhibit tumor growth, has shown potential for enhancing TAM ... ...

Abstract	Tamoxifen (TAM) resistance poses a significant clinical challenge in human breast cancer and exhibits high heterogeneity among different patients. Rg3, an original ginsenoside known to inhibit tumor growth, has shown potential for enhancing TAM sensitivity in breast cancer cells. However, the specific role and underlying mechanisms of Rg3 in this context remain unclear. Aerobic glycolysis, a metabolic process, has been implicated in chemotherapeutic resistance. In this study, we demonstrate that elevated glycolysis plays a central role in TAM resistance and can be effectively targeted and overcome by Rg3. Mechanistically, we observed upregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a key mediator of glycolysis, in TAM-resistant MCF-7/TamR and T-47D/TamR cells. Crucially, PFKFB3 is indispensable for the synergistic effect of TAM and Rg3 combination therapy, which suppresses cell proliferation and glycolysis in MCF-7/TamR and T-47D/TamR cells, both in vitro and in vivo. Moreover, overexpression of PFKFB3 in MCF-7 cells mimicked the TAM resistance phenotype. Importantly, combination treatment significantly reduced TAM-resistant MCF-7 cell proliferation in an in vivo model. In conclusion, this study highlights the contribution of Rg3 in enhancing the therapeutic efficacy of TAM in breast cancer, and suggests that targeting TAM-resistant PFKFB3 overexpression may represent a promising strategy to improve the response to combination therapy in breast cancer.
MeSH term(s)	Humans ; Female ; Tamoxifen/pharmacology ; Breast Neoplasms/pathology ; Ginsenosides/pharmacology ; Ginsenosides/therapeutic use ; Antineoplastic Agents, Hormonal/pharmacology ; Antineoplastic Agents, Hormonal/therapeutic use ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; MCF-7 Cells ; Glycolysis ; Gene Expression Regulation, Neoplastic
Chemical Substances	Tamoxifen (094ZI81Y45) ; ginsenoside Rg3 (227D367Y57) ; Ginsenosides ; Antineoplastic Agents, Hormonal
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.12123
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Article: The effect of respiratory capacity for dose sparing in left-sided breast cancer irradiation with active breathing coordinator technique.

Chen, Hongtao / Piao, Ying / Yang, Dong / Kuang, Peipei / Li, Zihuang / Liao, Guixiang / Zhong, Heli

Frontiers in oncology

2022 Volume 12, Page(s) 989220

Abstract: Background and aim: A subsequent cardiac toxicity is deemed to be dose-dependent for left-sided breast cancer irradiation. This study aims to demonstrate the effect of respiratory capacity for dose sparing when the deep inspiration breath hold with ... ...

Abstract	Background and aim: A subsequent cardiac toxicity is deemed to be dose-dependent for left-sided breast cancer irradiation. This study aims to demonstrate the effect of respiratory capacity for dose sparing when the deep inspiration breath hold with Active Breathing Coordinator technique (ABC-DIBH) is used in left-sided breast cancer irradiation. Methods: 74 left-sided breast cancer patients, who received whole breast or post-mastectomy chest wall radiotherapy with ABC-DIBH between 2020 and 2021 in our center, were retrospectively reviewed in this study. CT scans of free breath (FB) and ABC-DIBH were done for each patient, and two treatment plans with a prescription dose of 5000 cGy/25 Fr were designed separately. The dose to heart, left anterior descending artery (LAD) and lungs was compared between FB and ABC-DIBH. The correlation between individual parameters (dose to organs at risk (OARs) and minimum heart distance (MHD)) was analyzed, and the effect of respiratory capacity for dose sparing was assessed. Results: The plans with ABC-DIBH achieved lower Dmean for heart (34.80%, P < 0.01) and LAD (29.33%, P < 0.01) than those with FB. Regression analysis revealed that both Dmean and D2 of heart were negatively correlated with MHD in the plans with FB and ABC-DIBH, which decreased with the increase in MHD by 37.8 cGy and 309.9 cGy per 1mm, respectively. Besides, a lower Dmean of heart was related to a larger volume of ipsilateral lung in plans with FB. With the increase in volume of ipsilateral lung, the linear correlation was getting weaker and weaker until the volume of ipsilateral lung reached 1700 cc. Meanwhile, a negative linear correlation between Dmean of LAD and MHD in plans with FB and ABC-DIBH was observed, whose slope was 162.5 and 135.9 cGy/mm, respectively. Furthermore, when the respiratory capacity of ABC-DIBH reached 1L, and the relative ratio (ABC-DIBH/FB) reached 3.6, patients could obtain the benefit of dose sparing. The larger difference in respiratory capacity had no significant effect in the larger difference of MHD, Dmean of heart and Dmean of LAD between FB and ABC-DIBH. Conclusion: This study demonstrates the sufficiently good effect of ABC-DIBH when utilizing for cardiac sparing. It also reveals the correlations among individual parameters and the effect of respiratory capacity for dose sparing. This helps take optimal advantage of the ABC-DIBH technique and predict clinical benefits.
Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.989220
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Article ; Online: Gastric side effects and the stomach dosimetric analysis in left-sided breast cancer radiotherapy in free-breathing and deep inspiration breath-hold technique.

Yang, Dong / Piao, Ying / Yuan, Fengshun / Chen, Hongtao / Zhang, Ding / Li, Xianming

Radiation oncology (London, England)

2022 Volume 17, Issue 1, Page(s) 2

Abstract: Background: Adjuvant radiotherapy following surgery reduces the local recurrence and improves the prognosis. However, a considerable part of patients developed digestive reaction in daily treatment. In order to explore the correlation between breast ... ...

Abstract	Background: Adjuvant radiotherapy following surgery reduces the local recurrence and improves the prognosis. However, a considerable part of patients developed digestive reaction in daily treatment. In order to explore the correlation between breast radiotherapy and gastric toxicity, we investigated the clinic symptoms and stomach dose during DIBH or FB mode while left-sided breast cancer patients (LSBCP) receiving radiotherapy. Methods: In the study, 124 LSBCP received adjuvant radiotherapy after surgery at our department were analyzed clinical characteristics and enquired about gastrointestinal side effects after treatment. Moreover, dosimetric parameters were assessed. Results: There was no statistically significant difference between the two groups in age, T staging, N staging, hormone receptors, human epidermal receptor-2 (HER2), surgical methods, fractionated regimen, and chemotherapy conditions. However, larger stomach volumes and higher fractionated dose (Dmax/F) were associated with a statistically significantly greater risk for acute radiotherapy toxicity. In addition, the use of the DIBH gating technique (FB/DIBH) reduced the incidence of digestive reactions. Conclusion: In order to cut down gastric side effects after breast radiotherapy, large meals should be avoided before treatment. DIBH treatment should be implemented in centers where conditions are satisfied to reduce radiotherapy side effects. Furthermore, dose limitation in stomach should be considered when the radiotherapy plan was formulated, especially for the patients treated with hypofractionated radiotherapy.
MeSH term(s)	Adult ; Aged ; Breath Holding ; Correlation of Data ; Female ; Humans ; Middle Aged ; Radiation Injuries/etiology ; Radiometry ; Radiotherapy Dosage ; Radiotherapy, Adjuvant/adverse effects ; Radiotherapy, Adjuvant/methods ; Respiration ; Stomach/radiation effects ; Unilateral Breast Neoplasms/radiotherapy
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2224965-5
ISSN	1748-717X ; 1748-717X
ISSN (online)	1748-717X
ISSN	1748-717X
DOI	10.1186/s13014-021-01963-7
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Article ; Online: Association Between Neutrophil-to-Lymphocyte Ratio with Inflammatory Activity and Fibrosis in Non-alcoholic Fatty Liver Disease.

WenYi, Jin / Ting, Qian / PiaoPiao, Ying / JinMing, Wu

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2022 Volume 33, Issue 1, Page(s) 53–61

Abstract: Background: Inflammation plays an important role in the development and progression of non-alcoholic steatohepatitis (NASH), and NASH is a powerful driving force for the progression of fibrosis. The neutrophil-to-lymphocyte ratio (NLR) is a simple ... ...

Abstract	Background: Inflammation plays an important role in the development and progression of non-alcoholic steatohepatitis (NASH), and NASH is a powerful driving force for the progression of fibrosis. The neutrophil-to-lymphocyte ratio (NLR) is a simple emerging indicator of inflammation. We aimed to assess the potential association between NLR and histological severity of non-alcoholic fatty liver disease (NAFLD). Methods: This retrospective study consisted of 231 patients with biopsy-proven NAFLD in China from August 2017 to September 2019. The steatosis, activity, and fibrosis scoring system were used to evaluate liver biopsy tissue. Results: Of the 231 patients with NAFLD, advanced inflammatory activity was present in 43.3% and significant fibrosis in 25.5% of patients. Multivariate logistic regression analysis showed NLR to be correlated with advanced inflammatory activity (Odds ratio (OR): 0.62, 95% CI: 0.42-0.94, P = .025) and significant fibrosis (OR: 0.57, 95% CI: 0.35-0.94, P = .028). The NLR was inversely associated with the degree of steatosis, lobular inflammation and fibrosis (r = -0.16, P = .014; r = -0.15, P = .019; r = -0.13, P = .046, respectively), but had no association with the severity of ballooning. The multivariate-adjusted models had good predictability for advanced inflammatory activity (area under curves (AUC) 0.790, 95% CI: 0.730-0.850) and for significant fibrosis (AUC 0.798, 95% CI: 0.728-0.868). Conclusion: This study showed negative correlations between elevated NLR levels with advanced inflammatory activity and significant fibrosis in patients with NAFLD. Our results also suggested that NLR could be considered as a simple and noninvasive mark to identify high-risk populations in NAFLD.
MeSH term(s)	Biopsy ; Fibrosis ; Humans ; Inflammation/pathology ; Liver/pathology ; Liver Cirrhosis/complications ; Lymphocytes ; Neutrophils ; Non-alcoholic Fatty Liver Disease/complications ; Retrospective Studies
Language	English
Publishing date	2022-03-09
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2022.20715
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Article ; Online: Cell-Selective Binding Zwitterionic Polymeric Micelles Boost the Delivery Efficiency of Antibiotics.

Yu, Huahai / Piao, Ying / Zhang, Yifan / Xiang, Jiajia / Shao, Shiqun / Tang, Jianbin / Zhou, Zhuxian / Shen, Youqing

ACS nano

2023 Volume 17, Issue 22, Page(s) 22430–22443

Abstract: Effective accumulation and penetration of antibiotics in the biofilm are critical issues for bacterial infection treatment. Red blood cells (RBCs) have been widely utilized to hitchhike nanocarriers for drug delivery. It is vital and challenging to find ... ...

Abstract	Effective accumulation and penetration of antibiotics in the biofilm are critical issues for bacterial infection treatment. Red blood cells (RBCs) have been widely utilized to hitchhike nanocarriers for drug delivery. It is vital and challenging to find a nanocarrier with an appropriate affinity toward RBCs and bacteria for selective hitchhiking and release that determines the drug delivery efficiency and specificity. Herein, we report a zwitterionic polymer poly(2-(
MeSH term(s)	Micelles ; Anti-Bacterial Agents/pharmacology ; Drug Delivery Systems ; Polymers/pharmacology ; Biofilms
Chemical Substances	Micelles ; Anti-Bacterial Agents ; Polymers
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c05181
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