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Book ; Online: Advances in Transoral Approaches for Laryngeal Cancer

Piazza, Cesare / Peretti, Giorgio / Vander Poorten, Vincent

2019

Keywords	Medicine ; Oncology ; Laryngeal cancer ; Salvage Surgery ; Transoral laser microsurgery ; Squamous cell carcinoma ; transoral robotic surgery ; Supraglottic partial laryngectomy ; Organ preservation surgery ; Laryngeal imaging ; Oncologic outcomes ; prognosis
Size	1 electronic resource (111 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021229868
ISBN	9782889457779 ; 288945777X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Exploring Muscle Synergies for Performance Enhancement and Learning in Myoelectric Control Maps.

Tse, K C / Capsi-Morales, P / Castaneda, T Spiegeler / Piazza, C

IEEE ... International Conference on Rehabilitation Robotics : [proceedings

2023 Volume 2023, Page(s) 1–6

Abstract: This work proposes two myoelectric control maps based on a DoF-wise synergy algorithm, inspired by human motor control studies. One map, called intuitive, matches control outputs with body movement directions. The second one, named non-intuitive, takes ... ...

Abstract	This work proposes two myoelectric control maps based on a DoF-wise synergy algorithm, inspired by human motor control studies. One map, called intuitive, matches control outputs with body movement directions. The second one, named non-intuitive, takes advantage of different synergies contribution to each DoF, without specific correlation to body movement directions. The effectiveness and learning process for the two maps is evaluated through performance metrics in ten able-bodied individuals. The analysis was conducted using a 2-DoFs center-reach-out task and a survey. Results showed equivalent performance and perception for both mappings. However, learning is only visible in subjects that performed better in non-intuitive mapping, that required some familiarization to then exploit its features. Most of the myoelectric control designs use intuitive mappings. Nevertheless, non-intuitive mapping could provide more design flexibility, which can be especially interesting for patients with motor disabilities.
MeSH term(s)	Humans ; Electromyography/methods ; Muscle, Skeletal/physiology ; Movement/physiology ; Learning ; Algorithms
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-7901
ISSN (online)	1945-7901
DOI	10.1109/ICORR58425.2023.10304809
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inferring Markov Chains to Describe Convergent Tumor Evolution With CIMICE.

Rossi, Nicolo / Gigante, Nicola / Vitacolonna, Nicola / Piazza, Carla

IEEE/ACM transactions on computational biology and bioinformatics

2024 Volume 21, Issue 1, Page(s) 106–119

Abstract: The field of tumor phylogenetics focuses on studying the differences within cancer cell populations. Many efforts are done within the scientific community to build cancer progression models trying to understand the heterogeneity of such diseases. These ... ...

Abstract	The field of tumor phylogenetics focuses on studying the differences within cancer cell populations. Many efforts are done within the scientific community to build cancer progression models trying to understand the heterogeneity of such diseases. These models are highly dependent on the kind of data used for their construction, therefore, as the experimental technologies evolve, it is of major importance to exploit their peculiarities. In this work we describe a cancer progression model based on Single Cell DNA Sequencing data. When constructing the model, we focus on tailoring the formalism on the specificity of the data. We operate by defining a minimal set of assumptions needed to reconstruct a flexible DAG structured model, capable of identifying progression beyond the limitation of the infinite site assumption. Our proposal is conservative in the sense that we aim to neither discard nor infer knowledge which is not represented in the data. We provide simulations and analytical results to show the features of our model, test it on real data, show how it can be integrated with other approaches to cope with input noise. Moreover, our framework can be exploited to produce simulated data that follows our theoretical assumptions. Finally, we provide an open source R implementation of our approach, called CIMICE, that is publicly available on BioConductor.
MeSH term(s)	Humans ; Markov Chains ; Neoplasms/genetics ; Neoplasms/pathology ; Phylogeny ; Sequence Analysis, DNA
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2023.3337258
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Article ; Online: Compartmental surgery for T4b oral squamous cell carcinoma involving the masticatory space.

Mattavelli, Davide / Montenegro, Claudia / Piazza, Cesare

Current opinion in otolaryngology & head and neck surgery

2024 Volume 32, Issue 2, Page(s) 55–61

Abstract: Purpose of review: This review aims to describe the oncological outcomes of T4b oral squamous cell carcinomas (OSCC) with masticatory space involvement as well as the surgical approaches that are able to achieve compartmental 'en bloc' resection of ... ...

Abstract	Purpose of review: This review aims to describe the oncological outcomes of T4b oral squamous cell carcinomas (OSCC) with masticatory space involvement as well as the surgical approaches that are able to achieve compartmental 'en bloc' resection of these lesions. Recent findings: The masticatory space is subdivided into infra-notch and supra-notch spaces according to the axial plane passing through the mandibular notch between the coronoid process and the condyle neck. Compartmental resection for T4b OSCC with masticatory space invasion can be successfully achieved via purely external approaches or combining external and transnasal endoscopic routes. Infra-notch T4b OSCC showed survival outcomes comparable to T4a OSCC, thus prompting treatment with curative intent. Summary: Compartmental resection of the masticatory space is technically feasible with comprehensive control of tumour margins. Use of a transnasal endoscopic anterior route within a multiportal approach may provide better control of margins at the level of the pterygo-maxillary fissure. Equivalent survival outcomes between T4a and infra-notch T4b OSCC are reported. Thus, a downstaging of the latter to T4a is advisable and compartmental surgery of such advanced lesions could be considered as a first-line treatment option in selected patients.
MeSH term(s)	Humans ; Mouth Neoplasms/surgery ; Mouth Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/surgery ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000958
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Article ; Online: Head and neck nonmelanoma skin cancers: surgical management and debated issues.

Rampinelli, Vittorio / Pinacoli, Aurora / Piazza, Cesare

Current opinion in otolaryngology & head and neck surgery

2024 Volume 32, Issue 2, Page(s) 62–70

Abstract: Purpose of review: This review critically assesses the current literature and guidelines, aiming to clarify some of the most important factors that impact surgical strategies of head and neck nonmelanoma skin cancers (NMSCs), focusing on squamous, basal, ...

Abstract	Purpose of review: This review critically assesses the current literature and guidelines, aiming to clarify some of the most important factors that impact surgical strategies of head and neck nonmelanoma skin cancers (NMSCs), focusing on squamous, basal, and Merkel cell carcinomas. Recent findings: Recent developments underscore the complexity of treatment for NMSC, particularly in the head and neck region. There is a lack of high-level evidence for the management of these tumors, especially in advanced stages. The need to tailor the extent of surgical margins and parotid/neck management to different histotypes, considering the varying risk factors for recurrence, is beginning to emerge in the literature. Moreover, the role of immunotherapy and targeted therapies for locally advanced disease, alongside traditional treatment options, is progressively growing. Summary: NMSCs represent a heterogeneous group of malignancies with varying treatment complexities and prognoses. Management of NMSC is evolving towards an increasingly personalized strategy within a multidisciplinary therapeutic framework.
MeSH term(s)	Humans ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/surgery ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology ; Prognosis ; Head and Neck Neoplasms/surgery ; Immunotherapy
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000960
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Article ; Online: Editorial: Oral Oncology: From Precise Surgery to Precision Medicine and Surgery.

Saidak, Zuzana / Piazza, Cesare

Frontiers in oral health

2022 Volume 3, Page(s) 913172

Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Editorial
ISSN	2673-4842
ISSN (online)	2673-4842
DOI	10.3389/froh.2022.913172
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Article ; Online: WGA-LP: a pipeline for whole genome assembly of contaminated reads.

Rossi, N / Colautti, A / Iacumin, L / Piazza, C

Bioinformatics (Oxford, England)

2021 Volume 38, Issue 3, Page(s) 846–848

Abstract: Summary: Whole genome assembly (WGA) of bacterial genomes with short reads is a quite common task as DNA sequencing has become cheaper with the advances of its technology. The process of assembling a genome has no absolute golden standard and it ... ...

Abstract	Summary: Whole genome assembly (WGA) of bacterial genomes with short reads is a quite common task as DNA sequencing has become cheaper with the advances of its technology. The process of assembling a genome has no absolute golden standard and it requires to perform a sequence of steps each of which can involve combinations of many different tools. However, the quality of the final assembly is always strongly related to the quality of the input data. With this in mind we built WGA-LP, a package that connects state-of-the-art programs for microbial analysis and novel scripts to check and improve the quality of both samples and resulting assemblies. WGA-LP, with its conservative decontamination approach, has shown to be capable of creating high quality assemblies even in the case of contaminated reads. Availability and implementation: WGA-LP is available on GitHub (https://github.com/redsnic/WGA-LP) and Docker Hub (https://hub.docker.com/r/redsnic/wgalp). The web app for node visualization is hosted by shinyapps.io (https://redsnic.shinyapps.io/ContigCoverageVisualizer/). Supplementary information: Supplementary data are available at Bioinformatics online.
MeSH term(s)	Software ; High-Throughput Nucleotide Sequencing/methods ; Sequence Analysis, DNA/methods ; Genome, Bacterial
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btab719
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Article ; Online: Measuring financial toxicity in head and neck cancer: a systematic review.

Raggini, Elisa / Mattavelli, Davide / Zigliani, Gabriele / Bossi, Paolo / Piazza, Cesare

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2024 Volume 44, Issue 1, Page(s) 1–12

Abstract: Objective: The current study systematically reviews the literature about financial toxicity (FT) in head and neck cancer patients. Three databases were reviewed: PubMed, Scopus and Web of Science.: Methods: Full text English papers published from ... ...

Abstract	Objective: The current study systematically reviews the literature about financial toxicity (FT) in head and neck cancer patients. Three databases were reviewed: PubMed, Scopus and Web of Science. Methods: Full text English papers published from 2000 to 2022 reporting on quantitative results about FT in head and neck cancer survivors collected through structured questionnaires or interviews were included. Results: Twenty-seven articles were included. Most of the articles were published after 2015 and from United States. There was a slight prevalence of papers dealing with oropharyngeal cancer, squamous-cell carcinoma and locally advanced head and neck cancer. Measures of FT were obtained through validated questionnaires like COST, FIT and FDQ. Collected data were mostly referrable to financial spending, financial resources, psychosocial aspect, support seeking, coping care and coping lifestyle subdomain. FT scores by COST were found to be worse in the COVID era. Financial counseling and adequate information about the costs of treatment were two effective strategies to mitigate FT. Conclusions: FT is a relatively new challenge in head and neck cancer treatment, whose expenses are higher than therapies for other cancers. A universal method to assess FT and a unified guideline for the administration of questionnaires are needed to mitigate FT and to improve patient outcomes.
MeSH term(s)	Humans ; Financial Stress ; Head and Neck Neoplasms/economics ; Oropharyngeal Neoplasms/economics ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2024-02-14
Publishing country	Italy
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2762
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Article ; Online: Cervical exenteration and its variants for locally advanced thyroid cancer: when, why, and how?

Piazza, Cesare / Lancini, Davide / Paderno, Alberto

Current opinion in otolaryngology & head and neck surgery

2023 Volume 31, Issue 2, Page(s) 65–72

Abstract: Purpose of review: To describe the modern surgical approach for management of advanced thyroid cancers infiltrating the cervicovisceral axis with special attention to well differentiated tumors not amenable to organ-sparing techniques. In particular, ... ...

Abstract	Purpose of review: To describe the modern surgical approach for management of advanced thyroid cancers infiltrating the cervicovisceral axis with special attention to well differentiated tumors not amenable to organ-sparing techniques. In particular, cervical exenteration, herein defined as the sum of total thyroidectomy, central compartment and lateral neck dissections, variously associated with total laryngectomy and possible partial or total pharyngoesophagectomy, represents an extreme surgical procedure that, in properly selected cases, allows for reasonable palliation of central compartment life-threatening signs/symptoms if not cure for an advanced oncologic condition. Recent findings: Cervical exenteration is not contraindicated by the presence of limited distant metastases at presentation. Even though it requires that the patient is in general good health as it can be associated with a number of complications and long in-hospital stay, when appropriately planned and performed according to the most recent reconstructive nuances, it allows good oncologic outcomes that are not inferior to those described for similarly advanced primaries of the upper aerodigestive tract. In addition, quality of life and functional results are not significantly different from those described after total laryngectomy for primary laryngeal squamous cell carcinomas. Summary: Cervical exenteration requires a tertiary, expert, multidisciplinary effort in terms of diagnosis, surgical performance, and postoperative care. A patient-centered decision process is strongly warranted taking into consideration alternative therapeutic and symptom-based palliative strategies.
MeSH term(s)	Humans ; Quality of Life ; Thyroid Neoplasms/pathology ; Thyroidectomy/methods ; Neck Dissection
Language	English
Publishing date	2023-01-28
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000873
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Article ; Online: Experimental evaluation of the impact of sEMG interfaces in enhancing embodiment of virtual myoelectric prostheses.

Castañeda, Theophil Spiegeler / Connan, Mathilde / Capsi-Morales, Patricia / Beckerle, Philipp / Castellini, Claudio / Piazza, Cristina

Journal of neuroengineering and rehabilitation

2024 Volume 21, Issue 1, Page(s) 57

Abstract: Introduction: Despite recent technological advances that have led to sophisticated bionic prostheses, attaining embodied solutions still remains a challenge. Recently, the investigation of prosthetic embodiment has become a topic of interest in the ... ...

Abstract	Introduction: Despite recent technological advances that have led to sophisticated bionic prostheses, attaining embodied solutions still remains a challenge. Recently, the investigation of prosthetic embodiment has become a topic of interest in the research community, which deals with enhancing the perception of artificial limbs as part of users' own body. Surface electromyography (sEMG) interfaces have emerged as a promising technology for enhancing upper-limb prosthetic control. However, little is known about the impact of these sEMG interfaces on users' experience regarding embodiment and their interaction with different functional levels. Methods: To investigate this aspect, a comparison is conducted among sEMG configurations with different number of sensors (4 and 16 channels) and different time delay. We used a regression algorithm to simultaneously control hand closing/opening and forearm pronation/supination in an immersive virtual reality environment. The experimental evaluation includes 24 able-bodied subjects and one prosthesis user. We assess functionality with the Target Achievement Control test, and the sense of embodiment with a metric for the users perception of self-location, together with a standard survey. Results: Among the four tested conditions, results proved a higher subjective embodiment when participants used sEMG interfaces employing an increased number of sensors. Regarding functionality, significant improvement over time is observed in the same conditions, independently of the time delay implemented. Conclusions: Our work indicates that a sufficient number of sEMG sensors improves both, functional and subjective embodiment outcomes. This prompts discussion regarding the potential relationship between these two aspects present in bionic integration. Similar embodiment outcomes are observed in the prosthesis user, showing also differences due to the time delay, and demonstrating the influence of sEMG interfaces on the sense of agency.
MeSH term(s)	Humans ; Artificial Limbs ; Electromyography/methods ; Upper Extremity ; Hand ; Algorithms
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2164377-5
ISSN	1743-0003 ; 1743-0003
ISSN (online)	1743-0003
ISSN	1743-0003
DOI	10.1186/s12984-024-01352-7
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