Article ; Online: Inborn errors of immunity underlying defective T-cell memory.
Current opinion in allergy and clinical immunology
2023 Volume 23, Issue 6, Page(s) 491–499
Abstract: Purpose of review: T-cell memory is a complex process not well understood involving specific steps, pathways and different T-cell subpopulations. Inborn errors of immunity (IEIs) represent unique models to decipher some of these requirements in humans. ... ...
| Abstract | Purpose of review: T-cell memory is a complex process not well understood involving specific steps, pathways and different T-cell subpopulations. Inborn errors of immunity (IEIs) represent unique models to decipher some of these requirements in humans. More than 500 different IEIs have been reported to date, and recently a subgroup of monogenic disorders characterized by memory T-cell defects has emerged, providing novel insights into the pathways of T-cell memory generation and maintenance, although this new knowledge is mostly restricted to peripheral blood T-cell memory populations. Recent findings: This review draws up an inventory of the main and recent IEIs associated with T-cell memory defects and their mice models, with a particular focus on the nuclear factor kappa B (NF-κB) signalling pathway, including the scaffold protein capping protein regulator and myosin 1 linker 2 (CARMIL2) and the T-cell co-stimulatory molecules CD28 and OX-40. Besides NF-κB, IKZF1 (IKAROS), a key transcription factor of haematopoiesis and STAT3-dependent interleukin-6 signals involving the transcription factor ZNF341 also appear to be important for the generation of T cell memory. Somatic reversion mosaicism in memory T cells is documented for several gene defects supporting the critical role of these factors in the development of memory T cells with a potential clinical benefit. Summary: Systematic examination of T-cell memory subsets could be helpful in the diagnosis of IEIs. |
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| MeSH term(s) | Humans ; Mice ; Animals ; NF-kappa B/metabolism ; Memory T Cells ; Signal Transduction ; T-Lymphocyte Subsets ; Gene Expression Regulation |
| Chemical Substances | NF-kappa B |
| Language | English |
| Publishing date | 2023-10-05 |
| Publishing country | United States |
| Document type | Review ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2088710-3 |
| ISSN | 1473-6322 ; 1528-4050 |
| ISSN (online) | 1473-6322 |
| ISSN | 1528-4050 |
| DOI | 10.1097/ACI.0000000000000946 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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