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Article ; Online: Advances in the study of GPCRs by

Picard, Louis-Philippe / Prosser, Robert Scott

2021 Volume 69, Page(s) 169–176

Abstract: Crystallography and cryo-electron microscopy have advanced atomic resolution perspectives of inactive and active states of G protein-coupled receptors (GPCRs), alone and in complex with G proteins or arrestin. ...

Abstract	Crystallography and cryo-electron microscopy have advanced atomic resolution perspectives of inactive and active states of G protein-coupled receptors (GPCRs), alone and in complex with G proteins or arrestin.
MeSH term(s)	Cryoelectron Microscopy ; Magnetic Resonance Spectroscopy ; Protein Conformation ; Receptors, G-Protein-Coupled ; Signal Transduction
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-06-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1068353-7
ISSN	1879-033X ; 0959-440X
ISSN (online)	1879-033X
ISSN	0959-440X
DOI	10.1016/j.sbi.2021.05.001
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Article: An Intensive Ambulatory Care Program for Adolescents With Eating Disorders Combining In-Person and Web-Based Care: Protocol for a Single-Site Naturalistic Trial.

Novack, Kaylee / Dufour, Rachel / Picard, Louis / Booij, Linda / Chadi, Nicholas

JMIR research protocols

2022 Volume 11, Issue 11, Page(s) e37420

Abstract: Background: The incidence of eating disorders (EDs) among adolescents has significantly increased since the beginning of the COVID-19 pandemic. Hybrid care, which combines web-based and in-person modalities, is a promising approach for adolescents with ... ...

Abstract	Background: The incidence of eating disorders (EDs) among adolescents has significantly increased since the beginning of the COVID-19 pandemic. Hybrid care, which combines web-based and in-person modalities, is a promising approach for adolescents with EDs but remains understudied in this population. Objective: We aimed to implement a novel hybrid (web-based and in-person) intensive ambulatory care program for youth and evaluate its feasibility, acceptability, and preliminary effectiveness. Methods: We will use a naturalistic pretest-posttest design to evaluate our proposed pilot Intensive Ambulatory Care Program (IACP). This novel type of day hospital care follows evidence-based principles and uses a family-centered, educational, and motivational approach. It will be tailored to the psychological needs of each participant and will be delivered in a hybrid format. A total of 100 participants meeting the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) criteria for EDs, aged 12-18 years, will be recruited over the 2-year trial period. We will examine recruitment, retention, and adhesion-to-protocol rates; participant and family satisfaction; and preliminary effectiveness using quantitative self-report questionnaires. Results: Rolling recruitment will take place from winter 2022 to fall 2023, during which time we expect to recruit approximately 80% (100/120) of eligible participants, retain at least 75% (75/100) of enrolled participants and have at least 70% (70/100) of enrolled participants complete at least one therapeutic session per week and all pre- and postintervention questionnaires. Data collection will occur concurrently. We base our recruitment and retention estimates on previous literature and consider that the highly flexible design of the IACP and the fact that no extra work will be required of individuals in the program to participate in the study, will lead to high levels of feasibility. We anticipate that participants and their families will be satisfied with both the program and hybrid delivery format. We expect that participation in the IACP will be associated with a medium effect size reduction in ED psychopathology from baseline to end of treatment. The data analysis and manuscript writing are expected to be completed by the summer of 2024. Conclusions: Given the high clinical burden associated with EDs, this study has the potential to fill an important research gap by testing the implementation of a novel hybrid mode of intervention. If feasible, acceptable, and effective, the IACP could lead to important improvements in health care services for adolescents with EDs. International registered report identifier (irrid): PRR1-10.2196/37420.
Language	English
Publishing date	2022-11-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/37420
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The use of technology in the treatment of youth with eating disorders: A scoping review.

Dufour, Rachel / Novack, Kaylee / Picard, Louis / Chadi, Nicholas / Booij, Linda

Journal of eating disorders

2022 Volume 10, Issue 1, Page(s) 182

Abstract: Background: Adolescence and young adulthood is a high-risk period for the development of eating disorders. In recent years, there has been an increase in use of technology-based interventions (TBIs) for the treatment of eating disorders. The objective ... ...

Abstract	Background: Adolescence and young adulthood is a high-risk period for the development of eating disorders. In recent years, there has been an increase in use of technology-based interventions (TBIs) for the treatment of eating disorders. The objective of this study was to determine the types of technology used for eating disorder treatment in youth and their effectiveness. Methods: A scoping review was conducted according to PRISMA-ScR guidelines. Four databases were searched. Eligible articles included: (1) a TBI (2) participants with a mean age between 10- and 25-years and meeting DSM-IV or DSM-5 criteria for any eating disorder and (3) qualitative or quantitative designs. Quantitative and qualitative studies were assessed for quality. Results: The search identified 1621 articles. After screening of titles and abstracts, 130 articles were read in full and assessed for eligibility by two raters. Forty-nine (29 quantitative and 20 qualitative, observational, or mixed methods studies) met inclusion criteria. Quality ratings indicated that 78% of quantitative studies had a low risk of bias and 22% had a moderate risk. Technologies reviewed in our study included videoconference therapy, mobile applications, and online self-help. We considered interventions used both within sessions with clinicians as well as those used in between sessions by patients alone. Fifteen of 18 (83%) quantitative studies found that TBIs reduce eating disorder symptomatology, with nine of those reporting medium-to-large effect sizes. Qualitative data was of high quality and suggested that virtual interventions are acceptable in this population. Conclusions: Although identified studies are of high quality, they are limited in number. More research is needed, particularly regarding videoconferencing and mobile applications. Nonetheless, TBIs show promise for the treatment of eating disorders in youth. Trial registration: Not applicable.
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-022-00697-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings: Sustainable development and human security in Africa

Picard, Louis A

governance as the missing link

(Public administration and public policy ; 197)

2015

Institution	Africa Sustainable Development Conference
Event/congress	Africa Sustainable Development Conference (2011.03, PittsburghPa.)
Author's details	ed. by Louis A. Picard
Series title	Public administration and public policy ; 197
Keywords	Human security ; Sustainable development ; Entwicklungshilfe ; Nachhaltigkeit ; Governance-Ansatz ; Entwicklung ; Menschenrechte ; Afrika ; Africa
Language	English
Size	XXII, 335 S., graph. Darst.
Publisher	CRC Press
Publishing place	Boca Raton, Fla. u.a.
Document type	Book ; Conference proceedings
Note	Based on the proceedings of a two-day conference entitled "Achieving Sustainable Development in Africa" held at the University of Pittsburgh in March 2011. ; Enth. 17 Beitr. ; Includes bibliographical references and index
ISBN	9781482255416 ; 1482255413
Database	ECONomics Information System

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Book ; Conference proceedings: Sustainable development and human security in Africa

Picard, Louis A

governance as the missing link

(Public administration and public policy ; 197)

2015

Institution	Africa Sustainable Development Conference
Event/congress	Africa Sustainable Development Conference (2011.03, PittsburghPa.)
Author's details	ed. by Louis A. Picard
Series title	Public administration and public policy ; 197
Keywords	Human security ; Sustainable development ; Entwicklungshilfe ; Nachhaltigkeit ; Governance-Ansatz ; Entwicklung ; Menschenrechte ; Afrika ; Africa
Language	English
Size	XXII, 335 S., graph. Darst.
Publisher	CRC Press
Publishing place	Boca Raton, Fla. u.a.
Document type	Book ; Conference proceedings
Note	Based on the proceedings of a two-day conference entitled "Achieving Sustainable Development in Africa" held at the University of Pittsburgh in March 2011. ; Enth. 17 Beitr. ; Includes bibliographical references and index
ISBN	9781482255416 ; 1482255413
Database	Former special subject collection: coastal and deep sea fishing

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Article: Canadian pediatric eating disorder programs and virtual care during the COVID-19 pandemic: a mixed-methods approach to understanding clinicians' perspectives.

Novack, Kaylee / Dufour, Rachel / Picard, Louis / Taddeo, Danielle / Nadeau, Pierre-Olivier / Katzman, Debra K / Booij, Linda / Chadi, Nicholas

Annals of general psychiatry

2023 Volume 22, Issue 1, Page(s) 16

Abstract: Background: As a result of the public health measures put in place during the COVID-19 pandemic in Canada, many health services, including those for the treatment of eating disorders, were provided at a distance. This study aims to describe the ... ...

Abstract	Background: As a result of the public health measures put in place during the COVID-19 pandemic in Canada, many health services, including those for the treatment of eating disorders, were provided at a distance. This study aims to describe the adaptations made in specialized pediatric eating disorder programs in Canada and the impact of these adaptations on health professionals' experience of providing care. Methods: A mixed-methods design was used to survey healthcare professionals working in specialized pediatric eating disorder programs about adaptations to treatment made during the pandemic and the impact of these adaptations on their experience of providing care. Data were collected between October 2021 and March 2022 using a cross-sectional survey comprising 25 questions and via semi-structured interviews. Quantitative data were summarized using descriptive statistics and qualitative data were interpreted using qualitative content analysis. Results: Eighteen healthcare professionals in Canada completed the online survey, of whom six also participated in the semi-structured interviews. The cross-sectional survey confirmed that, unlike in pre-pandemic times, the majority of participants provided medical care (15/18) and mental health care (17/18) at a distance during the pandemic, with most participants using telephone (17/18) and videoconferencing (17/18). Most (16/18) health professionals indicated that virtual care would continue to be used as a tool in pediatric ED treatment after the pandemic. Participants used a combination of virtual and in-person care, with most reporting weighing patients both in clinic (16/18) and virtually (15/18). Qualitative content analysis generated five themes: (1) responding to increased demand with insufficient resources; (2) adapting to changes in care due to the COVID-19 pandemic; (3) dealing with uncertainty and apprehension; (4) virtual care as an acceptable and useful clinical tool, and (5) optimal conditions and future expectations. Most interview participants (5/6) had globally positive views of virtual care. Conclusions: Providing virtual multidisciplinary treatment for children and adolescents with eating disorders seemed feasible and acceptable to professionals during the pandemic. Moving forward, focusing on health professionals' perspectives and providing appropriate training in virtual interventions is essential given their central role in successful implementation and continued use of virtual and hybrid care models.
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2090401-0
ISSN	1744-859X ; 1475-2832
ISSN	1744-859X ; 1475-2832
DOI	10.1186/s12991-023-00443-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin.

Picard, Louis-Philippe / Schonegge, Anne-Marie / Bouvier, Michel

ACS pharmacology & translational science

2019 Volume 2, Issue 3, Page(s) 148–154

Abstract: G protein-coupled receptors (GPCRs) form the largest family of membrane proteins involved in signal transduction. Because of their ability to regulate a wide range of cellular responses and their dysregulation being associated with many diseases, GPCRs ... ...

Abstract	G protein-coupled receptors (GPCRs) form the largest family of membrane proteins involved in signal transduction. Because of their ability to regulate a wide range of cellular responses and their dysregulation being associated with many diseases, GPCRs remain a key therapeutic target for several clinical indications. In recent years, it has been demonstrated that ligands for a given receptor can engage distinct pathways with different relative efficacies, a concept known as biased signaling or functional selectivity. However, the structural determinants of this phenomenon remain poorly understood. Using the β2-adrenergic receptor as a model, we identified a linker residue (L124
Language	English
Publishing date	2019-04-03
Publishing country	United States
Document type	Journal Article
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.9b00012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Foreign Aid and Foreign Policy

Picard, Louis A

Lessons for the Next Half-century

2015

Abstract: This timely work presents cutting-edge analysis of the problems of U.S. foreign assistance programs - why these problems have not been solved in the past, and how they might be solved in the future. The book focuses primarily on U.S. foreign assistance ... ...

Abstract	This timely work presents cutting-edge analysis of the problems of U.S. foreign assistance programs - why these problems have not been solved in the past, and how they might be solved in the future. The book focuses primarily on U.S. foreign assistance and foreign policy as they apply to nation building, governance, and democratization. The expert contributors examine issues currently in play, and also trace the history and evolution of many of these problems over the years. They address policy concerns as well as management and organizational factors as they affect programs and policies. ""Fo
Language	English
Size	Online-Ressource (465 p)
Publisher	Taylor and Francis
Publishing place	Hoboken
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780765620439 ; 076562043X
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids.

Overduin, Michael / Trieber, Catharine / Prosser, R Scott / Picard, Louis-Philippe / Sheff, Joey G

Membranes

2021 Volume 11, Issue 6

Abstract: Membrane proteins work within asymmetric bilayers of lipid molecules that are critical for their biological structures, dynamics and interactions. These properties are lost when detergents dislodge lipids, ligands and subunits, but are maintained in ... ...

Abstract	Membrane proteins work within asymmetric bilayers of lipid molecules that are critical for their biological structures, dynamics and interactions. These properties are lost when detergents dislodge lipids, ligands and subunits, but are maintained in native nanodiscs formed using styrene maleic acid (SMA) and diisobutylene maleic acid (DIBMA) copolymers. These amphipathic polymers allow extraction of multicomponent complexes of post-translationally modified membrane-bound proteins directly from organ homogenates or membranes from diverse types of cells and organelles. Here, we review the structures and mechanisms of transmembrane targets and their interactions with lipids including phosphoinositides (PIs), as resolved using nanodisc systems and methods including cryo-electron microscopy (cryo-EM) and X-ray diffraction (XRD). We focus on therapeutic targets including several G protein-coupled receptors (GPCRs), as well as ion channels and transporters that are driving the development of next-generation native nanodiscs. The design of new synthetic polymers and complementary biophysical tools bodes well for the future of drug discovery and structural biology of native membrane:protein assemblies (memteins).
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes11060451
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Article ; Online: Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells.

Kobayashi, Hiroyuki / Picard, Louis-Philippe / Schönegge, Anne-Marie / Bouvier, Michel

Nature protocols

2019 Volume 14, Issue 4, Page(s) 1084–1107

Abstract: Bioluminescence resonance energy transfer (BRET) is a transfer of energy between a luminescence donor and a fluorescence acceptor. Because BRET occurs when the distance between the donor and acceptor is <10 nm, and its efficiency is inversely ... ...

Abstract	Bioluminescence resonance energy transfer (BRET) is a transfer of energy between a luminescence donor and a fluorescence acceptor. Because BRET occurs when the distance between the donor and acceptor is <10 nm, and its efficiency is inversely proportional to the sixth power of distance, it has gained popularity as a proximity-based assay to monitor protein-protein interactions and conformational rearrangements in live cells. In such assays, one protein of interest is fused to a bioluminescent energy donor (luciferases from Renilla reniformis or Oplophorus gracilirostris), and the other protein is fused to a fluorescent energy acceptor (such as GFP or YFP). Because the BRET donor does not require an external light source, it does not lead to phototoxicity or autofluorescence. It therefore represents an interesting alternative to fluorescence-based imaging such as FRET. However, the low signal output of BRET energy donors has limited the spatiotemporal resolution of BRET imaging. Here, we describe how recent improvements in detection devices and BRET probes can be used to markedly improve the resolution of BRET imaging, thus widening the field of BRET imaging applications. The protocol described herein involves three main stages. First, cell preparation and transfection require 3 d, including cell culture time. Second, image acquisition takes 10-120 min per sample, after an initial 60 min for microscope setup. Finally, image analysis typically takes 1-2 h. The choices of energy donor, acceptor, luminescent substrates, cameras and microscope setup, as well as acquisition modes to be used for different applications, are also discussed.
MeSH term(s)	Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Benzeneacetamides/metabolism ; Fluorescence Resonance Energy Transfer/methods ; Gene Expression ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Imidazoles/metabolism ; Luminescent Measurements/methods ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Optical Imaging/methods ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Interaction Mapping/methods ; Pyrazines/metabolism ; Receptors, Vasopressin/genetics ; Receptors, Vasopressin/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Renilla ; Transfection ; beta-Arrestin 2/genetics ; beta-Arrestin 2/metabolism
Chemical Substances	Bacterial Proteins ; Benzeneacetamides ; Imidazoles ; Luminescent Proteins ; Membrane Proteins ; Pyrazines ; RTL8C protein, human ; Receptors, Vasopressin ; Recombinant Fusion Proteins ; beta-Arrestin 2 ; coelenteramide ; yellow fluorescent protein, Bacteria ; Green Fluorescent Proteins (147336-22-9) ; coelenterazine (3O1CB88RRD)
Language	English
Publishing date	2019-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/s41596-019-0129-7
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