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Article ; Online: How should we define cure after parathyroidectomy for normocalcemic primary hyperparathyroidism? A retrospective cohort study.

Cano-Valderrama, Oscar / Ochagavía, Santiago / Sanabria, Concepción / Familiar, Cristina / Díaz, Jesús / Picazo, Sara / Sáez-Carlin, Patricia / Torres, Antonio J

Updates in surgery

2021 Volume 73, Issue 6, Page(s) 2293–2299

Abstract: Cure after surgery for normocalcemic primary hyperparathyroidism (NHPT) is defined as parathyroid hormone (PTH) normalization. However, an increase of PTH is frequently observed in cured patients with hypercalcemic primary hyperparathyroidism (HHPT). ... ...

Abstract	Cure after surgery for normocalcemic primary hyperparathyroidism (NHPT) is defined as parathyroid hormone (PTH) normalization. However, an increase of PTH is frequently observed in cured patients with hypercalcemic primary hyperparathyroidism (HHPT). Therefore, this criterion must be redefined. A single-center retrospective study was performed including all patients who underwent surgery for Primary Hyperparathyroidism from 2013 to 2019. Cure rates of different types of hyperparathyroidism were analyzed. PTH reduction was studied as a possible criterion to define cure in patients with NHPT. One-hundred and eighty-six patients were included: 173 with HHPT and 13 with NHPT. After a mean follow-up of 33.4 months, 174 (93.6%) patients were considered cured. Cure was more frequent in the group of patients with HHPT (97.1% vs. 46.2%, p < 0.001). In the multivariate analysis, surgical failure was associated with NHPT and multiglandular disease. Forty-nine (30.1%) cured patients with HHPT had an increased PTH during the follow-up. When decline of PTH levels was studied in patients with HHPT to define cure, the area under curve was 0.92. A cut-off value of 40% in PTH reduction achieved a sensitivity and specificity of 83.4% and 80.0%. If cure was defined as a 40% reduction of PTH, cure rate in the group of patients with NHPT would increase to 69.2%. Patients with NHPT had a lower cure rate than patients with HHPT. A significant number of cured patients with HHPT had an increased PTH during follow-up. A 40% reduction in PTH levels is proposed as an alternative definition for cure in patients with NHPT.
MeSH term(s)	Calcium ; Humans ; Hyperparathyroidism, Primary/surgery ; Parathyroid Hormone ; Parathyroidectomy ; Retrospective Studies
Chemical Substances	Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-06-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-021-01108-1
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Article ; Online: Gastrointestinal Perforation After Treatment With Tocilizumab : An Unexpected Consequence of COVID-19 Pandemic.

Rojo, Mikel / Cano-Valderrama, Oscar / Picazo, Sara / Saez, Carlos / Gómez, Lorena / Sánchez, Cristina / Sanz-Ortega, Gonzalo / Torres, Antonio J

The American surgeon

2020 Volume 86, Issue 6, Page(s) 565–566

MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Betacoronavirus ; Colonic Diseases/chemically induced ; Colonic Diseases/diagnostic imaging ; Colonic Diseases/surgery ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Drug Therapy, Combination ; Fatal Outcome ; Female ; Hematoma/chemically induced ; Hematoma/diagnostic imaging ; Hematoma/surgery ; Humans ; Intestinal Perforation/chemically induced ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/surgery ; Methylprednisolone/therapeutic use ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Tomography, X-Ray Computed
Chemical Substances	Anti-Inflammatory Agents ; Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011) ; Methylprednisolone (X4W7ZR7023)
Keywords	covid19
Language	English
Publishing date	2020-07-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820926481
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Article ; Online: Inorganic and Total Arsenic Contents in Rice and Rice-Based Foods Consumed by a Potential Risk Subpopulation: Sportspeople.

Cano-Lamadrid, M / Munera-Picazo, S / Burgos-Hernández, A / Burló, F / Carbonell-Barrachina, Ángel A

Journal of food science

2016 Volume 81, Issue 4, Page(s) T1031–7

Abstract: One of the main routes of exposure to inorganic arsenic (i-As) in humans is food, especially rice and rice-based products. There are certain groups of consumers that could be highly exposed to i-As. Maximum levels of i-As have been issued for infants and ...

Abstract	One of the main routes of exposure to inorganic arsenic (i-As) in humans is food, especially rice and rice-based products. There are certain groups of consumers that could be highly exposed to i-As. Maximum levels of i-As have been issued for infants and young children by the European Union, but perhaps other groups are also at risk. Sportspeople could be one of those groups, due to their specific nutritional requirements, especially its high consumption of cereals, such as rice. Because of the well-known relationship between rice and i-As, the intake of i-As by sportspeople deserved especial attention and was estimated in Spain. This study demonstrated that rice-based products reached a maximum i-As content of 178 μg/kg, with a mean for all studied products of 56 μg/kg; the maximum contents were found in rice cakes (149 μg/kg) and brown rice (111 μg/kg). The estimated daily intake of i-As were 0.16 and 0.18 μg/kg bw (body weight)/d, in sportsmen and sportswomen, respectively. These values were below the BMDL01 , 0.3 to 8.0 μg/kg bw/d; thus, it can be concluded that the sportspeople group is not at a significant risk regarding the intake of i-As. However, further studies are needed to evaluate their whole diet and not only rice-based products. Finally, it is important to claim that companies producing rice products include as much information as possible about the rice used in their products, including rice percentage and geographical origin.
MeSH term(s)	Arsenic/analysis ; Athletes ; Child ; Child, Preschool ; Diet ; Edible Grain/chemistry ; Environmental Exposure/analysis ; European Union ; Feeding Behavior ; Female ; Food Contamination/analysis ; Humans ; Infant ; Male ; Oryza/chemistry ; Risk ; Spain
Chemical Substances	Arsenic (N712M78A8G)
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.13269
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Article: Arsenic speciation in rice-based food for adults with celiac disease

Munera-Picazo, S. / Burlo, F. / Carbonell-Barrachina, A. A.

Food additives & contaminants : Part A, Chemistry, analysis, control, exposure & risk assessment

2014 Volume 31, Issue 8, Page(s) 1358

Language	English
Document type	Article
ZDB-ID	2431696-9
ISSN	0265-203X ; 1944-0049
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Phytoremediation assessment of Gomphrena globosa and Zinnia elegans grown in arsenic-contaminated hydroponic conditions as a safe and feasible alternative to be applied in arsenic-contaminated soils of the Bengal Delta.

Signes-Pastor, A J / Munera-Picazo, S / Burló, F / Cano-Lamadrid, M / Carbonell-Barrachina, A A

Environmental monitoring and assessment

2015 Volume 187, Issue 6, Page(s) 387

Abstract: Several agricultural fields show high contents of arsenic because of irrigation with arsenic-contaminated groundwater. Vegetables accumulate arsenic in their edible parts when grown in contaminated soils. Polluted vegetables are one of the main sources ... ...

Abstract	Several agricultural fields show high contents of arsenic because of irrigation with arsenic-contaminated groundwater. Vegetables accumulate arsenic in their edible parts when grown in contaminated soils. Polluted vegetables are one of the main sources of arsenic in the food chain, especially for people living in rural arsenic endemic villages of India and Bangladesh. The aim of this study was to assess the feasibility of floriculture in the crop rotation system of arsenic endemic areas of the Bengal Delta. The effects of different arsenic concentrations (0, 0.5, 1.0, and 2.0 mg As L(-1)) and types of flowering plant (Gomphrena globosa and Zinnia elegans) on plant growth and arsenic accumulation were studied under hydroponic conditions. Total arsenic was quantified using atomic absorption spectrometer with hydride generation (HG-AAS). Arsenic was mainly accumulated in the roots (72 %), followed by leaves (12 %), stems (10 %), and flowers (<1 %). The flowering plants studied did not show as high phytoremediation capacities as other wild species, such as ferns. However, they behaved as arsenic tolerant plants and grew and bloomed well, without showing any phytotoxic signs. This study proves that floriculture could be included within the crop rotation system in arsenic-contaminated agricultural soils, in order to improve food safety and also food security by increasing farmer's revenue.
MeSH term(s)	Agriculture ; Arsenic/analysis ; Arsenic/metabolism ; Bangladesh ; Biodegradation, Environmental ; Environmental Monitoring ; Ferns/physiology ; Hydroponics ; India ; Plant Leaves/chemistry ; Plant Roots/chemistry ; Soil/chemistry ; Soil Pollutants/analysis ; Soil Pollutants/metabolism ; Spectrophotometry, Atomic ; Vegetables
Chemical Substances	Soil ; Soil Pollutants ; Arsenic (N712M78A8G)
Language	English
Publishing date	2015-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-015-4618-z
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Article ; Online: Arsenic in your food

Munera-Picazo S / Cano-Lamadrid M / Castaño-Iglesias MC / Burló F / Carbonell-Barrachina ÁA

Nutrition and Dietary Supplements, Vol 2015, Iss default, Pp 1-

potential health hazards from arsenic found in rice

2015 Volume 10

Abstract: Sandra Munera-Picazo,1 Marina Cano-Lamadrid,1 María Concepción Castaño-Iglesias,2 Francisco Burló,1 Ángel A Carbonell-Barrachina11Food Quality and Safety Group, Department of Agro-Food Technology, Universidad Miguel Hernández, Orihuela, 2Servicio de ... ...

Abstract	Sandra Munera-Picazo,1 Marina Cano-Lamadrid,1 María Concepción Castaño-Iglesias,2 Francisco Burló,1 Ángel A Carbonell-Barrachina11Food Quality and Safety Group, Department of Agro-Food Technology, Universidad Miguel Hernández, Orihuela, 2Servicio de Pediatría, Hospital Universitario San Juan de Alicante, Alicante, SpainAbstract: Rice is a staple food for over half of the world population, but there is some concern about the occurrence of arsenic (As) in this cereal and the possible overexposure to this metalloid. Recently, the Codex Alimentarius Commission established a maximum limit of 200 µg kg–1 for inorganic arsenic (iAs) in rice. Because the maximum content of As in water has been reduced to 10 µg L–1, intoxication through rice and rice-based products can be considered an important source of As poisoning. The chronic effects of this iAs exposure can be lung and bladder cancer, skin lesions, or other noncarcinogenic diseases. There is clear evidence of high levels of iAs in rice and rice-based products. Different solutions for the reduction of As intake are proposed at different levels: 1) during the plant-growing process through agronomic practices, 2) pretreatment of rice before its use in the food industry, 3) optimization of the conditions of unit operations during processing, and 4) by cooking.Keywords: arsenic speciation, food safety, dietary exposure, Oryza sativa
Keywords	Public aspects of medicine ; RA1-1270 ; Medicine ; R
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Arsenic speciation in rice-based food for adults with celiac disease.

Munera-Picazo, Sandra / Burló, Francisco / Carbonell-Barrachina, Ángel Antonio

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

2014 Volume 31, Issue 8, Page(s) 1358–1366

Abstract: Celiac disease (CD) may affect up to 1% of the Western population. It is a disease whose diagnosis has been made mainly in childhood, but now the profile has changed, with one out of five newly diagnosed individuals being over 65 years old. The only ... ...

Abstract	Celiac disease (CD) may affect up to 1% of the Western population. It is a disease whose diagnosis has been made mainly in childhood, but now the profile has changed, with one out of five newly diagnosed individuals being over 65 years old. The only treatment for this population is a gluten-free diet. Therefore, the objective of this study was to analyse the occurrence of arsenic (As) in gluten-free products, basically those rice-based, intended for celiac adult consumers. The current study demonstrated that these rice-based products contained important contents of total arsenic (t-As) (up to 120 μg kg(-1)) and inorganic arsenic (i-As) (up to 85.8 μg kg(-1)). It was estimated that the contents of t-As and i-As in rice used as the main ingredient of these foods were as high as 235 and 198 μg kg(-1), respectively. The estimated daily intake of i-As was 0.46 and 0.45 μg kg(-1) bw in women and men of 58 and 75 kg of body weight (bw), respectively. These values indicate that a health risk to these consumers cannot be excluded. Finally, legislation is needed to delimit the safety intake by health agencies and to improve the labelling of these special rice-based foods for celiac adult consumers. The label should include information about percentage, geographical origin and cultivar of the rice used; besides and if companies want to clearly prove the safety of their products, the exact content of i-As should also be included.
MeSH term(s)	Adult ; Arsenic/analysis ; Arsenic/classification ; Celiac Disease/diet therapy ; Female ; Humans ; Limit of Detection ; Male ; Oryza/chemistry
Chemical Substances	Arsenic (N712M78A8G)
Language	English
Publishing date	2014
Publishing country	England
Document type	Journal Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2014.933491
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Article ; Online: Gastrointestinal Perforation After Treatment With Tocilizumab ; An Unexpected Consequence of COVID-19 Pandemic

Rojo, Mikel / Cano-Valderrama, Oscar / Picazo, Sara / Saez, Carlos / Gómez, Lorena / Sánchez, Cristina / Sanz-Ortega, Gonzalo / Torres, Antonio J.

The American Surgeon

2020 Volume 86, Issue 6, Page(s) 565–566

Keywords	General Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820926481
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Total and inorganic arsenic in Iranian rice.

Cano-Lamadrid, Marina / Munera-Picazo, Sandra / Burló, Francisco / Hojjati, Mohammad / Carbonell-Barrachina, Ángel A

Journal of food science

2015 Volume 80, Issue 5, Page(s) T1129–35

Abstract: It is well known that arsenic (As) exposure, particularly to inorganic species (i-As), has adverse effects on humans. Nowadays, the European Union (EU) has still not regulated the maximum residue limit of As in commercial samples of rice and rice-based ... ...

Abstract	It is well known that arsenic (As) exposure, particularly to inorganic species (i-As), has adverse effects on humans. Nowadays, the European Union (EU) has still not regulated the maximum residue limit of As in commercial samples of rice and rice-based products, although it is actively working on the topic. The European Food Safety Authority (EFSA) is collecting data on total arsenic (t-As) and i-As from different rice-producing regions not only from EU countries but also from other parts of the world to finally set up this maximum threshold. As Iran is a rice-producing country, the aim of this work was to evaluate the contents of t-As and i-As in 15 samples of Iranian white, nonorganic, and aromatic rice collected from the most important rice-producing regions of the country. The means of t-As and i-As were 120 and 82 μg/kg, respectively. The experimental i-As mean in Iranian rice was below the Chinese standard for the i-As in rice, 150 μg/kg, and the Food and Agriculture Organization of the United Nations (FAO) limit, 200 μg/kg. Therefore, Iranian rice seems to have reasonable low i-As content and it is safe to be marketed in any market, including China and the EU.
MeSH term(s)	Agriculture ; Arsenic/analysis ; China ; Data Collection ; European Union ; Food Contamination/analysis ; Food Safety ; Humans ; Iran ; Oryza/chemistry
Chemical Substances	Arsenic (N712M78A8G)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.12849
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Article: Arsenic speciation in rice-based food for adults with celiac disease

Munera-Picazo, Sandra / Burló, Francisco / Carbonell-Barrachina, Ángel Antonio

Food additives & contaminants. 2014 Aug. 3, v. 31, no. 8

2014

Abstract	Celiac disease (CD) may affect up to 1% of the Western population. It is a disease whose diagnosis has been made mainly in childhood, but now the profile has changed, with one out of five newly diagnosed individuals being over 65 years old. The only treatment for this population is a gluten-free diet. Therefore, the objective of this study was to analyse the occurrence of arsenic (As) in gluten-free products, basically those rice-based, intended for celiac adult consumers. The current study demonstrated that these rice-based products contained important contents of total arsenic (t-As) (up to 120 μg kg ⁻¹) and inorganic arsenic (i-As) (up to 85.8 μg kg ⁻¹). It was estimated that the contents of t-As and i-As in rice used as the main ingredient of these foods were as high as 235 and 198 μg kg ⁻¹, respectively. The estimated daily intake of i-As was 0.46 and 0.45 μg kg ⁻¹ bw in women and men of 58 and 75 kg of body weight (bw), respectively. These values indicate that a health risk to these consumers cannot be excluded. Finally, legislation is needed to delimit the safety intake by health agencies and to improve the labelling of these special rice-based foods for celiac adult consumers. The label should include information about percentage, geographical origin and cultivar of the rice used; besides and if companies want to clearly prove the safety of their products, the exact content of i-As should also be included.
Keywords	adults ; arsenic ; average daily intake ; body weight ; business enterprises ; celiac disease ; childhood ; cultivars ; gluten-free diet ; gluten-free foods ; ingredients ; laws and regulations ; men ; provenance ; rice ; risk ; women
Language	English
Dates of publication	2014-0803
Size	p. 1358-1366.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2014.933491
Database	NAL-Catalogue (AGRICOLA)

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