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  1. Book ; Online ; E-Book: Handbook of HER2-targeted agents in breast cancer

    Alvarez, Ricardo / Cortes, Javier / Falzon, Mary / Gianni, Luca / Harbeck, Nadia / Piccart, Martine

    2016  

    Author's details Ricardo H. Alvarez, Javier Cortés, Mary Falzon, Michael Gandy, Luca Gianni, Nadia Harbeck, Martine Piccart
    Keywords Breast Neoplasms / drug therapy ; Breast Neoplasms / genetics ; Genes, erbB-2 ; Gene Targeting ; Breast cancer ; Cancer ; HER2 ; HER2-positive ; Oncology ; Pertuzumab ; Trastuzumab
    Subject code 610
    Language English
    Size 1 Online-Ressource (110 Seiten), Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Note Lizenzpflichtig
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019455877
    ISBN 978-3-319-28216-9 ; 9783319282145 ; 3-319-28216-6 ; 331928214X
    DOI 10.1007/978-3-319-28216-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Molecular Imaging in Breast Cancer: Martine Piccart and Géraldine Gebhart Talk with David Mankoff About 2 Generations of Research.

    Gebhart, Géraldine / Piccart, Martine / Mankoff, David

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  

    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.124.267461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  3. Book: Triple negative breast cancer in focus

    Piccart-Gebhart, Martine J.

    from biology to novel therapeutics

    (Annals of oncology ; 23, Suppl. 6)

    2012  

    Title variant Triple-negative breast cancer in focus
    Author's details guest ed.: M. Piccart
    Series title Annals of oncology ; 23, Suppl. 6
    Collection
    Language English
    Size 65 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017437797
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2862 -23,Suppl.6- not available for loan Zeitschriften-Lesesaal

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  4. Book: Breast cancer: progress and promise / 1 / guest ed. Martine J. Piccart-Gebhart ...

    Piccart-Gebhart, Martine J.

    (The oncologist ; 15, Suppl. 5)

    2010  

    Series title The oncologist ; 15, Suppl. 5
    Breast cancer ; progress and promise
    Collection Breast cancer ; progress and promise
    Language English
    Size 65 S. : Ill., graph. Darst.
    Publisher AlphaMed Press
    Publishing place Durham, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT016674036
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4845 -15,Suppl.5- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: Systemic therapy for early-stage breast cancer: learning from the past to build the future.

    Agostinetto, Elisa / Gligorov, Joseph / Piccart, Martine

    Nature reviews. Clinical oncology

    2022  Volume 19, Issue 12, Page(s) 763–774

    Abstract: The treatment of breast cancer has improved dramatically over the past century, from a strictly surgical approach to a coordinated one, including local and systemic therapies. Systemic therapies for early-stage disease were initially tested against ... ...

    Abstract The treatment of breast cancer has improved dramatically over the past century, from a strictly surgical approach to a coordinated one, including local and systemic therapies. Systemic therapies for early-stage disease were initially tested against observation or placebo only in adjuvant trials. Subsequent clinical trials focusing on treatment 'fine-tuning' had a marked increase in cohort size, duration and costs, leading to a growing interest in the neoadjuvant setting in the past decade. Neoadjuvant trial designs have the advantages of enabling the direct evaluation of treatment effects on tumour diameter and offer unique translational research opportunities through the comparative analysis of tumour biology before, during and after treatment. Current technologies enabling the identification of better predictive biomarkers are shaping the new era of (neo)adjuvant trials. An urgent need exists to reinforce collaboration between the pharmaceutical industry and academia to share data and thus establish large databases of biomarker data coupled with patient outcomes that are easily accessible to the scientific community. In this Review, we summarize the evolution of (neo)adjuvant trials from the pre-genomic to the post-genomic era and provide critical insights into how neoadjuvant studies are currently designed, discussing the need for better end points and treatment strategies that are more personalized, including in the post-neoadjuvant setting.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Neoadjuvant Therapy ; Chemotherapy, Adjuvant
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-022-00687-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6029: Show issues Location:
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    Zs.MG 103: Show issues

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  7. Article: International research to address the challenges of metastatic breast cancer: the AURORA Program (BIG 14-01).

    Caballero, Carmela / Irrthum, Alexandre / Goulioti, Theodora / Cameron, David / Norton, Larry / Piccart, Martine

    NPJ breast cancer

    2023  Volume 9, Issue 1, Page(s) 42

    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 2374-4677
    ISSN 2374-4677
    DOI 10.1038/s41523-023-00548-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Breast Cancer Management and Molecular Medicine: Towards Tailored Approaches

    Piccart, Martine J. / Cardoso, Fatima / Hung, Chie-Mien / Solin, Lawrence J. / Wood, William C.

    2006  

    Author's details edited by Martine J. PiccartWilliam C. Wood, Chie-Mien Hung, Lawrence J. Solin et al
    Keywords Gynecology ; Oncology ; Radiotherapy ; Surgery
    Language English
    Publisher Springer-Verlag GmbH
    Publishing place Berlin Heidelberg
    Document type Book ; Online
    HBZ-ID TT050387627
    ISBN 978-3-540-28265-5 ; 978-3-540-28266-2 ; 3-540-28265-3 ; 3-540-28266-1
    DOI 10.1007/978-3-540-28266-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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    Inter-library loan at ZB MED

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  9. Book: Breast cancer: progress and promise

    Piccart-Gebhart, Martine J. / Hudis, Clifford A.

    (The oncologist : European edition ; 16, Suppl. 1)

    2011  

    Author's details guest ed. Martine J. Piccart-Gebhart and Clifford A. Hudis
    Series title The oncologist : European edition ; 16, Suppl. 1
    The oncologist
    The oncologist ; European edition
    Collection The oncologist
    The oncologist ; European edition
    Language English
    Size 90 S. : Ill., graph. Darst.
    Publisher AlphaMed Press
    Publishing place Durham, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT017050994
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4845 -16,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  10. Article ; Online: Why your preferred targeted drugs may become unaffordable.

    Piccart, Martine J

    Cancer research

    2013  Volume 73, Issue 19, Page(s) 5849–5851

    Abstract: Trastuzumab, a monoclonal antibody directed at the HER2 receptor, is one of the most impressive targeted drugs developed in the last two decades. Indeed, when given in conjunction with chemotherapy, it improves the survival of women with HER2 positive ... ...

    Abstract Trastuzumab, a monoclonal antibody directed at the HER2 receptor, is one of the most impressive targeted drugs developed in the last two decades. Indeed, when given in conjunction with chemotherapy, it improves the survival of women with HER2 positive breast cancer, both in advanced and in early disease. Its optimal duration, however, is poorly defined in both settings with a significant economic impact in the adjuvant setting where the drug is arbitrarily given for 1 year. This article reviews current attempts at shortening this treatment duration, emphasizing the likelihood of inconclusive results and, therefore, the need to investigate this important variable as part of the initial pivotal trials and with the support of public health systems. Failure to do so has major consequences on treatment affordability. Ongoing adjuvant trials of dual HER2 blockade, using trastuzumab in combination with a second anti-HER2 agent, and trials of the antibody-drug conjugate T-DM1 (trastuzumab-emtansine) have to all be designed with 12 months of targeted therapy.
    MeSH term(s) Antibodies, Monoclonal, Humanized/economics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/economics ; Breast Neoplasms/metabolism ; Drug Delivery Systems ; Female ; Humans ; Molecular Targeted Therapy/economics ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/immunology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2013-10-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-13-1486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.135/5: Show issues Location:
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