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  1. Article ; Online: Phototherapy and dermatologic radiotherapy during the COVID-19 emergency: The experience from the frontline of Milan.

    Spigariolo, Cristina Beatrice / Piccinno, Roberta

    Photodermatology, photoimmunology & photomedicine

    2022  Volume 38, Issue 4, Page(s) 404–405

    MeSH term(s) COVID-19 ; Humans ; Phototherapy ; SARS-CoV-2
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Letter
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hypofractionated radiotherapy for nonmelanoma skin cancer during the COVID-19 pandemic: experience in 31 cases.

    Piccinno, Roberta / Berti, Emilio / Barei, Francesca

    Tumori

    2021  Volume 108, Issue 4, Page(s) 394–396

    Abstract: As a result of the coronavirus disease 2019 (COVID-19) pandemic, radiation therapies have been modulated to reduce the risk of infection during outpatient activities and hypofractionated regimens or radiotherapy delay for nonmelanoma skin cancer (NMSC) ... ...

    Abstract As a result of the coronavirus disease 2019 (COVID-19) pandemic, radiation therapies have been modulated to reduce the risk of infection during outpatient activities and hypofractionated regimens or radiotherapy delay for nonmelanoma skin cancer (NMSC) were suggested. Hypofractionated radiotherapy not only may confer no disadvantage in regard to outcome when compared to a more protracted schedule but might also reduce the risk of infection. We report the experience of a dermatologic radiation therapy department concerning a group of patients with a diagnosis of NMSC selected for a radiation treatment plan aimed to minimize the number of their accesses to our department.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Radiation Dose Hypofractionation ; Skin Neoplasms/radiotherapy
    Language English
    Publishing date 2021-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.1177/03008916211051426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radiation therapy of non-melanoma skin cancer of the pinna: an Italian 35-year experience.

    Spigariolo, Cristina B / Berti, Emilio / Brambilla, Roberto / Piccinno, Roberta

    Italian journal of dermatology and venereology

    2021  Volume 157, Issue 1, Page(s) 92–100

    Abstract: Background: Radiation therapy (RT) is a well-known alternative to surgery for the treatment of non-melanoma skin cancer (NMSC), especially in elderly people or in patients who cannot undergo or refuse surgical procedure. It has also a pivotal role in ... ...

    Abstract Background: Radiation therapy (RT) is a well-known alternative to surgery for the treatment of non-melanoma skin cancer (NMSC), especially in elderly people or in patients who cannot undergo or refuse surgical procedure. It has also a pivotal role in those areas, as pinna, where both function and cosmesis must be preserved. We report our experience in treating cutaneous carcinoma of the auricle with radiation therapy.
    Methods: We conducted a retrospective monocentric study on 363 NMSC of the auricle treated by conventional energy radiation therapy as a primary treatment or with adjuvant and salvage purpose. Tumors involving the external canal of the ear or regional lymph node at diagnosis were excluded.
    Results: A complete response has been obtained in 95.5% with a 2- and 5-year cure rate respectively of 84% and 76%. Fifty-two tumors developed a central or marginal relapse. Aesthetic result was good or acceptable in the majority of the cases. No cartilage necrosis has been registered.
    Conclusions: Our experience confirms safety and effectiveness of RT on selected auricle carcinoma, affording good cosmetic and functional results.
    MeSH term(s) Aged ; Ear Neoplasms/radiotherapy ; Ear, External/pathology ; Humans ; Neoplasm Recurrence, Local/radiotherapy ; Retrospective Studies ; Skin Neoplasms/radiotherapy
    Language English
    Publishing date 2021-04-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.21.06905-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of radiotherapy in the management of cutaneous squamous cell carcinoma: a retrospective study on 92 cases.

    Bortoluzzi, Paolo / Brambilla, Roberto / Berti, Emilio / Marzano, Angelo V / Piccinno, Roberta

    Italian journal of dermatology and venereology

    2022  Volume 157, Issue 4, Page(s) 363–367

    Abstract: Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer in the world after basal cell carcinoma. Treatment of choice for cSCC is surgery, but radiotherapy (RT) is a valid alternative and has been ... ...

    Abstract Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer in the world after basal cell carcinoma. Treatment of choice for cSCC is surgery, but radiotherapy (RT) is a valid alternative and has been recommended in selected cases. The aim was to evaluate the cure rate of RT for cSCC and to compare the results in the two settings of RT as exclusive or second line treatment.
    Methods: The outcome of 92 cSCC treated with RT in the period from 2002 to 2019 in our department was retrospectively reviewed.
    Results: In 56 cases RT was first-line treatment while in 36 it was administered as second-line treatment after incomplete excision or failure of previous treatments. The five-year cure-rate was 74% (71.34% in patients treated with primary RT and 77.37% in patients treated with RT as second-line treatment), while the ten-year cure-rate was 67% (57.07% and 77.37% respectively in patients treated with primary RT or with second line RT). Log rank test showed statistical significance between the cure-rate of the two groups with better therapeutic results after second-line RT (P<0.05).
    Conclusions: Our data confirm RT as an effective therapy for cSCC when surgery excision is contraindicated or in case of tumors localized in certain regions where the cosmetic-functional outcome is better than surgery. Better therapeutic results are achieved with second-line RT.
    MeSH term(s) Carcinoma, Basal Cell/radiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Humans ; Radiation Oncology ; Retrospective Studies ; Skin Neoplasms/radiotherapy
    Language English
    Publishing date 2022-03-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.22.07286-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Risk of radiation-induced skin neoplasms after radiotherapy for cutaneous malignant tumors: a study on 5875 patients.

    Caccialanza, M / Çuka, E / Piccinno, R / Rozza, M

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2015  Volume 150, Issue 4, Page(s) 488–489

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Neoplasms, Radiation-Induced/pathology ; Retrospective Studies ; Risk ; Skin/pathology ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Skin Neoplasms/radiotherapy ; Young Adult
    Language English
    Publishing date 2015-08
    Publishing country Italy
    Document type Letter
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0026-4741 ; 0392-0488
    ISSN (online) 1827-1820
    ISSN 0026-4741 ; 0392-0488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience.

    Piccinno, Roberta / Tavecchio, Simona / Benzecry, Valentina

    The Journal of dermatological treatment

    2019  Volume 31, Issue 4, Page(s) 382–386

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Basal Cell/radiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Follow-Up Studies ; Humans ; Italy ; Lip ; Lip Neoplasms/radiotherapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Radiotherapy/adverse effects ; Remission Induction ; Retrospective Studies ; Skin Neoplasms/radiotherapy ; Treatment Outcome
    Language English
    Publishing date 2019-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2019.1605137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 53BP1-DNA repair enters a new liquid phase.

    Piccinno, Rossana / Minneker, Vera / Roukos, Vassilis

    The EMBO journal

    2019  Volume 38, Issue 16, Page(s) e102871

    Abstract: In response to DNA damage, transient repair compartments in the nucleus concentrate repair proteins and activate downstream signaling factors. In this issue of The EMBO Journal, Kilic et al show that DNA repair focal assemblies marked by accumulation of ... ...

    Abstract In response to DNA damage, transient repair compartments in the nucleus concentrate repair proteins and activate downstream signaling factors. In this issue of The EMBO Journal, Kilic et al show that DNA repair focal assemblies marked by accumulation of 53BP1 are phase separated liquid compartments. This liquid droplet-like behavior of 53BP1 compartments might help to coordinate local lesion recognition with global gene activation in response to DNA damage.
    MeSH term(s) Cell Nucleus ; DNA Damage ; DNA Repair ; Intracellular Signaling Peptides and Proteins ; Signal Transduction ; Tumor Suppressor p53-Binding Protein 1
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Tumor Suppressor p53-Binding Protein 1
    Language English
    Publishing date 2019-07-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2019102871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Artificial neural networks allow response prediction in squamous cell carcinoma of the scalp treated with radiotherapy.

    Damiani, G / Grossi, E / Berti, E / Conic, R R Z / Radhakrishna, U / Pacifico, A / Bragazzi, N L / Piccinno, R / Linder, D

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2020  Volume 34, Issue 6, Page(s) 1369–1373

    Abstract: Background: Epithelial neoplasms of the scalp account for approximately 2% of all skin cancers and for about 10-20% of the tumours affecting the head and neck area. Radiotherapy is suggested for localized cutaneous squamous cell carcinomas (cSCC) ... ...

    Abstract Background: Epithelial neoplasms of the scalp account for approximately 2% of all skin cancers and for about 10-20% of the tumours affecting the head and neck area. Radiotherapy is suggested for localized cutaneous squamous cell carcinomas (cSCC) without lymph node involvement, multiple or extensive lesions, for patients refusing surgery, for patients with a poor general medical status, as adjuvant for incompletely excised lesions and/or as a palliative treatment. To date, prognostic risk factors in scalp cSCC patients are poorly characterized.
    Objective: To identify patterns of patients with higher risk of postradiotherapy recurrence.
    Methods: A retrospective observational study was performed on scalp cSCC patients with histological diagnosis who underwent conventional radiotherapy (50-120 kV) (between 1996 and 2008, follow-up from 1 to 140 months, median 14 months). Out of the 79 enrolled patients, 22 (27.8%) had previously undergone a surgery. Two months after radiotherapy, 66 (83.5%) patients achieved a complete remission, 6 (7.6%) a partial remission, whereas 2 (2.5%) proved non-responsive to the treatment and 5 cases were lost to follow-up. Demographical and clinical data were preliminarily analysed with classical descriptive statistics and with principal component analysis. All data were then re-evaluated with a machine learning-based approach using a 4th generation artificial neural networks (ANNs)-based algorithm.
    Results: Artificial neural networks analysis revealed four scalp cSCC profiles among radiotherapy responsive patients, not previously described: namely, (i) stage T2 cSCC type, aged 70-80 years; (ii) frontal cSCC type, aged <70 years; (iii) non-recurrent nodular or nodulo-ulcerated, stage T3 cSCC type, of the vertex and treated with >60 Grays (Gy); and (iv) flat, occipital, stage T1 cSCC type, treated with 50-59 Gy. The model uncovering these four predictive profiles displayed 85.7% sensitivity, 97.6% specificity and 91.7% overall accuracy.
    Conclusions: Patient profiling/phenotyping with machine learning may be a new, helpful method to stratify patients with scalp cSCCs who may benefit from a RT-treatment.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Forecasting/methods ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Neural Networks, Computer ; Phenotype ; Radiotherapy Dosage ; Retrospective Studies ; Scalp ; Skin Neoplasms/pathology ; Skin Neoplasms/radiotherapy ; Treatment Outcome
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.16210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Radiotherapy of primary cutaneous anaplastic large cell lymphoma: our experience in 30 cases.

    Piccinno, Roberta / Damiani, Giovanni / Rossi, Luisa C / Berti, Emilio

    International journal of dermatology

    2020  Volume 59, Issue 4, Page(s) 469–473

    Abstract: Background: Since the observation of new cases of primary cutaneous anaplastic large cell lymphoma (PCALCL) with a seemingly aggressive clinical presentation and a favorable response to radiation therapy (RT), a review of our series has been performed ... ...

    Abstract Background: Since the observation of new cases of primary cutaneous anaplastic large cell lymphoma (PCALCL) with a seemingly aggressive clinical presentation and a favorable response to radiation therapy (RT), a review of our series has been performed to evaluate the results of RT.
    Materials and methods: The study is a retrospective analysis of 30 patients with PCALCL treated with conventional energy RT.
    Results: About 55 fields of irradiation were performed. Complete clinical response (CCR) was obtained in 29 cases and a partial clinical response (PCR) in one. Two lesions had a marginal relapse at 7 and 37 months, respectively. In eight cases, new lesions appeared in the same body district and in six cases, in body sites at distance from the field of treatment. Total radiation dose ranged from 15 to 35 Gy (median 25 Gy). Follow-up range was 2-218 months (median 38.5 months) with a local control rate of 85% and a relapse-free rate of 49% at 5 years from RT. Three cases developed a nodal involvement.
    Conclusions: PCALCL belongs to the group of primary cutaneous CD30
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Disease-Free Survival ; Dose-Response Relationship, Radiation ; Female ; Follow-Up Studies ; Humans ; Lymphoma, Primary Cutaneous Anaplastic Large Cell/radiotherapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Radiotherapy Dosage ; Retrospective Studies ; Skin Neoplasms/radiotherapy ; Young Adult
    Language English
    Publishing date 2020-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.14754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Localized conventional radiotherapy in the treatment of Mycosis Fungoides: our experience in 100 patients.

    Piccinno, R / Caccialanza, M / Çuka, E / Recalcati, S

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2014  Volume 28, Issue 8, Page(s) 1040–1044

    Abstract: Background: Radiotherapy (RT) is one of the treatments of choice as skin-directed therapy in Mycosis Fungoides (MF), both in first stages of the disease as total skin electron beam irradiation and in tumoural stage as localized treatment with ... ...

    Abstract Background: Radiotherapy (RT) is one of the treatments of choice as skin-directed therapy in Mycosis Fungoides (MF), both in first stages of the disease as total skin electron beam irradiation and in tumoural stage as localized treatment with conventional energies or electrons.
    Objective: Through a retrospective study, to evaluate the results of localized superficial RT in a series of 100 patients affected by MF.
    Methods: All the patients, after diagnosis supported by histological and immunophenotyping investigations, have been treated with conventional RT (range 50-150 kV) and a total dose ranging from 9 to 40 Gy.
    Results: Complete remission of the irradiated lesion has been observed in 88%, partial remission in 6% and non-response in 2%. Four patients were lost to follow-up. Local relapse has been observed in 13 lesions, with a local control rate of 85% after 5 years from the end of RT. Cosmetic results have been good and acceptable in 93% of cases. The treatment has been always well tolerated. The results confirm to be dose dependent, and show that better response is found in the range of higher energies.
    Conclusion: Localized RT is an effective and safe tool in the care and palliation of MF.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Mycosis Fungoides/radiotherapy ; Radiotherapy Dosage ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.12254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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