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  1. AU="Pichardo-González, Priamo A"
  2. AU="Cannegieter, Suzanne"
  3. AU="Trocino, Giuseppe"
  4. AU="Emiliano, Thais Moura"
  5. AU=Sinelli Mariateresa
  6. AU="De-guo LÜ"
  7. AU="Benoit-Pilven, Clara"
  8. AU="Lanza, Stefania"
  9. AU="Chilingarian, A"
  10. AU="Baldovini, Nicolas"
  11. AU="López Rodríguez, David"
  12. AU="Alexander König"
  13. AU="Jakobsen, Henrik L"
  14. AU="Yong-Zhao Dai"
  15. AU="Tara L. Pukala"
  16. AU="Addo‐Danso, Shalom D."
  17. AU=Ficheux Q.
  18. AU="Tomoyo Sawada"
  19. AU="Mohammad Kawsar Sharif Siam"
  20. AU=Kushnareva Yulia
  21. AU="Canova, Christopher T"
  22. AU="Hasnaoui, Naoual"
  23. AU="Maradana, Jhansi"
  24. AU="Raggini, Elisa"
  25. AU="Baxter, A."
  26. AU="Jackson, Shirnae"
  27. AU="Schenzle, Lisa"
  28. AU="Veronica Phillips"
  29. AU="Braun, Jörg"
  30. AU="Cassandra E. Holbert"
  31. AU="Trevisan Alexandra"

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  1. Artikel ; Online: Imaging the Bacterial Cell Wall Using

    Lee, Sang Hee / Kim, Jung Min / López-Álvarez, Marina / Wang, Chao / Sorlin, Alexandre M / Bobba, Kondapa Naidu / Pichardo-González, Priamo A / Blecha, Joseph / Seo, Youngho / Flavell, Robert R / Engel, Joanne / Ohliger, Michael A / Wilson, David M

    ACS sensors

    2023  Band 8, Heft 12, Seite(n) 4554–4565

    Abstract: Imaging infections in patients is challenging using conventional methods, motivating the development of positron emission tomography (PET) radiotracers targeting bacteria-specific metabolic pathways. Numerous techniques have focused on the bacterial cell ...

    Abstract Imaging infections in patients is challenging using conventional methods, motivating the development of positron emission tomography (PET) radiotracers targeting bacteria-specific metabolic pathways. Numerous techniques have focused on the bacterial cell wall, although peptidoglycan-targeted PET tracers have been generally limited to the short-lived carbon-11 radioisotope (
    Mesh-Begriff(e) Humans ; Muramic Acids ; Peptidoglycan ; Positron-Emission Tomography/methods ; Fluorine Radioisotopes ; Bacteria ; Cell Wall
    Chemische Substanzen Fluorine-18 (GZ5I74KB8G) ; N-acetylmuramic acid (246FXU111L) ; Muramic Acids ; Peptidoglycan ; Fluorine Radioisotopes
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c01477
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.

    Parker, Matthew F L / López-Álvarez, Marina / Alanizi, Aryn A / Luu, Justin M / Polvoy, Ilona / Sorlin, Alexandre M / Qin, Hecong / Lee, Sanghee / Rabbitt, Sarah J / Pichardo-González, Priamo A / Ordonez, Alvaro A / Blecha, Joseph / Rosenberg, Oren S / Flavell, Robert R / Engel, Joanne / Jain, Sanjay K / Ohliger, Michael A / Wilson, David M

    The Journal of infectious diseases

    2023  Band 228, Heft Suppl 4, Seite(n) S281–S290

    Abstract: Background: Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel ... ...

    Abstract Background: Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel metabolism-targeted positron emission tomography (PET) radiotracers for detecting living Staphylococcus aureus and other bacteria in vivo, but their head-to-head performance in a well-validated VDO animal model has not been reported.
    Methods: We compared the performance of several PET radiotracers in a rat model of VDO. [11C]PABA and [18F]FDS were assessed for their ability to distinguish S aureus, the most common non-tuberculous pathogen VDO, from Escherichia coli.
    Results: In the rat S aureus VDO model, [11C]PABA could detect as few as 103 bacteria and exhibited the highest signal-to-background ratio, with a 20-fold increased signal in VDO compared to uninfected tissues. In a proof-of-concept experiment, detection of bacterial infection and discrimination between S aureus and E coli was possible using a combination of [11C]PABA and [18F]FDS.
    Conclusions: Our work reveals that several bacteria-targeted PET radiotracers had sufficient signal to background in a rat model of S aureus VDO to be potentially clinically useful. [11C]PABA was the most promising tracer investigated and warrants further investigation in human VDO.
    Mesh-Begriff(e) Humans ; Rats ; Animals ; Discitis/diagnostic imaging ; 4-Aminobenzoic Acid ; Escherichia coli ; Positron-Emission Tomography/methods ; Staphylococcal Infections/diagnostic imaging ; Osteomyelitis/microbiology ; Bacteria ; Staphylococcus aureus ; Radiopharmaceuticals
    Chemische Substanzen Carbon-11 ; 4-Aminobenzoic Acid (TL2TJE8QTX) ; Radiopharmaceuticals
    Sprache Englisch
    Erscheinungsdatum 2023-10-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad159
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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