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  1. Book ; Thesis: Reelin modifiziert über die Rho-GTPase Cdc42 das Aktinzytoskelett kortikaler Nervenzellen

    Pichler, Marina

    2013  

    Author's details vorgelegt von Martina Pichler
    Language German
    Size 97 Bl., Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2013
    HBZ-ID HT018803430
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 MB 1208 order for loan Magazin

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  2. Book ; Online: Social Ecology State of the Art and Future Prospects

    Pichler, Melanie / Zimmermann, Martin / Kramm, Johanna / Schaffartzik, Anke

    2017  

    Abstract: The book 'Social Ecology. State of the Art and Future Prospects' is published by ISOE - Institute for Social-Ecological Research, Frankfurt am Main and the Vienna Institute of Social Ecology (SEC). Both institutes have made defining contributions to the ... ...

    Abstract The book 'Social Ecology. State of the Art and Future Prospects' is published by ISOE - Institute for Social-Ecological Research, Frankfurt am Main and the Vienna Institute of Social Ecology (SEC). Both institutes have made defining contributions to the field of social ecology. How the complex relations between society and nature can be theoretically captured, empirically investigated and sustainably shaped is a focal question for both institutes. This book provides an overview of the current state of social-ecological research. It contains 11 contributions from 29 scientists, edited by Johanna Kramm and Martin Zimmermann (ISOE) and Melanie Pichler and Anke Schaffartzik (SEC). Topics range from the conceptional and theoretical foundations of social ecology to empirical case studies and research frontiers. The peer-reviewed essays highlight the role of social ecology as a critical, transdisciplinary science, discussing the current challenges for social-ecological transformations. Key concepts for sustainability research like ecosystem services, societal metabolism, risk, or extractive economies are applied and advanced
    Keywords Environmental sciences
    Size 1 electronic resource (VII, 192 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020096788
    ISBN 9783038425465 ; 9783038425472 ; 303842546X ; 3038425478
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Diagnostik in der Katathym Imaginativen Psychotherapie

    Pichler, Mathilde

    (In: Höfner, Claudia; Hochgerner, Markus (Ed.), Psychotherapeutische Diagnostik. Kompendium für alle in Österreich anerkannten Therapieverfahren (S. 201-213). Berlin, Heidelberg: Springer)

    2022  

    Abstract: In der Katathym Imaginativen Psychotherapie basiert der diagnostische Prozess auf einem psychodynamischen Verständnis der Symptomatik. Die Diagnosekriterien richten sich nach entwicklungspsychologisch relevanten Positionen, die die Erfassung der ... ...

    Title translation Diagnostics in guided imagery therapy
    Series title In: Höfner, Claudia; Hochgerner, Markus (Ed.), Psychotherapeutische Diagnostik. Kompendium für alle in Österreich anerkannten Therapieverfahren (S. 201-213). Berlin, Heidelberg: Springer
    Abstract In der Katathym Imaginativen Psychotherapie basiert der diagnostische Prozess auf einem psychodynamischen Verständnis der Symptomatik. Die Diagnosekriterien richten sich nach entwicklungspsychologisch relevanten Positionen, die die Erfassung der Grundkonflikte nach Rudolf (2008) und die entsprechende strukturelle Zuordnung nach Ermann (2016) beinhalten. Eine besondere Bedeutung kommt der Diagnostik der Symbolisierungs- und Mentalisierungsfähigkeit zu, da diese auf die therapeutische Arbeit mit den Imaginationen einen grundlegenden Einfluss hat und die Art der Behandlungstechnik maßgeblich entscheidet. Der Einsatz von (Initial)-Imaginationen erweitert die diagnostischen Möglichkeiten erheblich. (c) Springer-Verlag GmbH Deutschland
    Keywords Diagnosis ; Diagnostik ; Geleitete Fantasievorstellung ; Guided Imagery ; Psychodiagnosis ; Psychodiagnostik ; Psychodynamics ; Psychodynamik ; Psychotherapeutic Processes ; Psychotherapeutische Prozesse
    Language German
    Document type Article
    DOI 10.1007/978-3-662-61450-1_16
    Database PSYNDEX

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  4. Article ; Online: Cost-effectiveness analysis of the use of immunotherapy in metastatic solid tumours in Austria by applying the ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS) version 1.1.

    Pichler, M / Steyrer, J

    ESMO open

    2021  Volume 6, Issue 4, Page(s) 100198

    Abstract: Background: Immune checkpoint inhibitors (ICIs) treatment is a breakthrough in managing metastatic solid tumours, but its use is associated with a high financial burden for public health care systems. Validated tools such as the European Society for ... ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) treatment is a breakthrough in managing metastatic solid tumours, but its use is associated with a high financial burden for public health care systems. Validated tools such as the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS) are frameworks that might help to better assess the clinical benefit of these novel innovative cancer drugs.
    Methods: Here, we systematically analysed the number of European Medicines Agency-approved ICIs labels with an ESMO-MCBS grade <4 and the impact of the ICIs on incremental costs, gain of life years (LYs), quality-adjusted life years (QALYs) and the incremental cost-effectiveness ratio in the Austrian population.
    Results: Of 23 ICIs treatment settings, we identified three clinical scenarios in metastatic solid cancers with an ESMO-MCBS grade <4 with no otherwise approved alternatives. In triple-negative breast cancer (TNBC), the addition of first-line atezolizumab increased QALYs by 0.33 compared with nab-paclitaxel only, with an incremental cost per QALY of €143 853. In small-cell lung cancer (SCLC), the addition of first-line atezolizumab increased the QALY by 0.09, with an incremental cost per QALY of €373 256, and the addition of first-line durvalumab increased the QALYs by 0.11, with an incremental cost per QALY of €589 527.
    Conclusions: Overall, most of the approved ICIs carry significant clinical benefit (≥4). Although TNBC and SCLC are challenging treatment scenarios, currently approved ICIs with an ESMO-MCBS grade <4 substantially increase the cost of medical treatment, and under a willingness-to-pay threshold of €100 000, they do not have a cost-effective comparative benefit.
    MeSH term(s) Austria ; Cost-Benefit Analysis ; Humans ; Immunotherapy ; Medical Oncology ; Neoplasms/drug therapy
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Journal Article
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1016/j.esmoop.2021.100198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhancing oncogenic signaling to kill cancer cells.

    Noeparast, Maxim / Timofeev, Oleg / Pichler, Martin

    Trends in pharmacological sciences

    2024  

    Abstract: Cancer-targeted therapies that inhibit oncogenic signaling often lead to resistance and recurrence. In a recent study, Dias et al. propose activating oncogenic pathways and inducing replication stress, resulting in cell death and tumor-suppressive ... ...

    Abstract Cancer-targeted therapies that inhibit oncogenic signaling often lead to resistance and recurrence. In a recent study, Dias et al. propose activating oncogenic pathways and inducing replication stress, resulting in cell death and tumor-suppressive mechanisms in colorectal cancer (CRC). This approach could spark a new wave of target discovery, and drug development and repurposing against cancer.
    Language English
    Publishing date 2024-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2024.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework.

    Timofeev, Oleg / Giron, Philippe / Lawo, Steffen / Pichler, Martin / Noeparast, Maxim

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 70

    Abstract: At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp). Inhibitors targeting various effectors within the ERKp have been developed and explored for over two decades. Conversely, a substantial body of evidence suggests that ...

    Abstract At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp). Inhibitors targeting various effectors within the ERKp have been developed and explored for over two decades. Conversely, a substantial body of evidence suggests that both normal human cells and, notably to a greater extent, cancer cells exhibit susceptibility to hyperactivation of ERKp. However, this vulnerability of cancer cells remains relatively unexplored. In this review, we reexamine the evidence on the selective lethality of highly elevated ERKp activity in human cancer cells of varying backgrounds. We synthesize the insights proposed for harnessing this vulnerability of ERK-associated cancers for therapeutical approaches and contextualize these insights within established pharmacological cancer-targeting models. Moreover, we compile the intriguing preclinical findings of ERK pathway agonism in diverse cancer models. Lastly, we present a conceptual framework for target discovery regarding ERKp agonism, emphasizing the utilization of mutual exclusivity among oncogenes to develop novel targeted therapies for precision oncology.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00554-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Von Checkpoint- über Tyrosinkinase- bis zu HIF-Inhibitoren. Gegenwart und Zukunft der Therapie des Nierenzellkarzinoms

    Pichler, M. / Terzic, J.

    Urologik

    2021  Volume 28, Issue 2, Page(s) 19

    Language German
    Document type Article
    ZDB-ID 2065143-0
    ISSN 1561-526X
    Database Current Contents Medicine

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    Zs.A 5597: Show issues Location:
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  8. Article ; Online: Genome streamlining and clonal erosion in nutrient-limited environments: a test using genome-size variable populations.

    Stelzer, Claus-Peter / Pichler, Maria / Stadler, Peter

    Evolution; international journal of organic evolution

    2023  Volume 77, Issue 11, Page(s) 2378–2391

    Abstract: Some selection-based theories propose that genome streamlining, favoring smaller genome sizes, is advantageous in nutritionally limited environments, particularly under P-limitation. To test this prediction, we conducted several experimental evolution ... ...

    Abstract Some selection-based theories propose that genome streamlining, favoring smaller genome sizes, is advantageous in nutritionally limited environments, particularly under P-limitation. To test this prediction, we conducted several experimental evolution trials on clonal populations of a facultatively asexual rotifer that exhibits intraspecific variation in genome size. Most trials showed a rapid decline in clonal diversity, which was accelerated in populations that were initially nonadapted. Populations consisting of three rotifer clones often became monoclonal within a few weeks, while populations starting with 120 clones eroded to 10 multilocus genotypes, of which only five were abundant in higher numbers. While P-limitation affected population growth during the experiments, it did not affect the outcome of clonal competition or the speed at which clonal diversity was lost. Common garden transplant experiments revealed that the evolved populations were better adapted to the experimental conditions than the ancestral controls. However, contrary to expectations, the evolved populations did not show an overrepresentation of small genomes. Intermediate genomes were also frequently abundant, although very large genomes were rare. Our findings suggest that fitness is more influenced by genotypic differences among clones than by differences in GS, and indicate that such differences might hinder genome streamlining during early adaptation to a new environment.
    MeSH term(s) Genetic Variation ; Genome Size ; Genotype
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036375-8
    ISSN 1558-5646 ; 0014-3820
    ISSN (online) 1558-5646
    ISSN 0014-3820
    DOI 10.1093/evolut/qpad144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Can predictive models be used for causal inference?

    Pichler, Maximilian / Hartig, Florian

    2023  

    Abstract: Supervised machine learning (ML) and deep learning (DL) algorithms excel at predictive tasks, but it is commonly assumed that they often do so by exploiting non-causal correlations, which may limit both interpretability and generalizability. Here, we ... ...

    Abstract Supervised machine learning (ML) and deep learning (DL) algorithms excel at predictive tasks, but it is commonly assumed that they often do so by exploiting non-causal correlations, which may limit both interpretability and generalizability. Here, we show that this trade-off between explanation and prediction is not as deep and fundamental as expected. Whereas ML and DL algorithms will indeed tend to use non-causal features for prediction when fed indiscriminately with all data, it is possible to constrain the learning process of any ML and DL algorithm by selecting features according to Pearl's backdoor adjustment criterion. In such a situation, some algorithms, in particular deep neural networks, can provide near unbiased effect estimates under feature collinearity. Remaining biases are explained by the specific algorithmic structures as well as hyperparameter choice. Consequently, optimal hyperparameter settings are different when tuned for prediction or inference, confirming the general expectation of a trade-off between prediction and explanation. However, the effect of this trade-off is small compared to the effect of a causally constrained feature selection. Thus, once the causal relationship between the features is accounted for, the difference between prediction and explanation may be much smaller than commonly assumed. We also show that such causally constrained models generalize better to new data with altered collinearity structures, suggesting generalization failure may often be due to a lack of causal learning. Our results not only provide a perspective for using ML for inference of (causal) effects but also help to improve the generalizability of fitted ML and DL models to new data.

    Comment: 47 pages, 4 figures
    Keywords Statistics - Machine Learning ; Computer Science - Machine Learning ; Statistics - Methodology
    Subject code 006
    Publishing date 2023-06-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Mechanisch unterstützte CPR: Die Anwendung in der Praxis

    Trimmel, H. / Pimiskern, M. / Beywinkler, C. / Binder, S. / Pichler, M.

    Rettungsdienst

    2023  Volume 46, Issue 2, Page(s) 27

    Language German
    Document type Article
    ZDB-ID 632510-5
    ISSN 0178-2525
    Database Current Contents Medicine

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