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  1. Article ; Online: Creating misinformation: how a headline in

    Winters, Maike / Oppenheim, Ben / Pick, Jonas / Nordenstedt, Helena

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m2384

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communication ; Coronavirus Infections/mortality ; Hospital Mortality ; Humans ; Mortality ; Pandemics ; Periodicals as Topic ; Pneumonia, Viral/mortality ; SARS-CoV-2 ; Social Media
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  2. Book ; Online ; Thesis: Die Bedeutung von CTLA-4 für IL-17-bildende CD8+ T-Zellen

    Pick, Jonas Verfasser] / Simeoni, Luca [Gutachter] / [Kalinke, Ulrich [Gutachter]

    2020  

    Author's details Jonas Pick ; Gutachter: Luca Simeoni, Ulrich Kalinke
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Otto-von-Guericke-Universität
    Publishing place Magdeburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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  4. Book ; Online: Creating misinformation

    Winters, Maike / Oppenheim, Ben / Pick, Jonas / Nordenstedt, Helena

    how a headline in The BMJ about covid-19 spread virally

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-06-18 02:36:12.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Creating misinformation

    Winters, Maike / Oppenheim, Ben / Pick, Jonas / Nordenstedt, Helena

    BMJ

    how a headline in The BMJ about covid-19 spread virally

    2020  , Page(s) m2384

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2384
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article: The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs.

    Arra, Aditya / Lingel, Holger / Kuropka, Benno / Pick, Jonas / Schnoeder, Tina / Fischer, Thomas / Freund, Christian / Pierau, Mandy / Brunner-Weinzierl, Monika C

    Oncoimmunology

    2017  Volume 6, Issue 2, Page(s) e1273300

    Abstract: As the blockade of inhibitory surface-molecules such as CTLA-4 on T cells has led to recent advances in antitumor immune therapy, there is great interest in identifying novel mechanisms of action of ... ...

    Abstract As the blockade of inhibitory surface-molecules such as CTLA-4 on T cells has led to recent advances in antitumor immune therapy, there is great interest in identifying novel mechanisms of action of CD8
    Language English
    Publishing date 2017-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2016.1273300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CTLA-4 (CD152) enhances the Tc17 differentiation program.

    Pick, Jonas / Arra, Aditya / Lingel, Holger / Hegel, J Kolja / Huber, Magdalena / Nishanth, Gopala / Jorch, Gerhard / Fischer, Klaus-Dieter / Schlüter, Dirk / Tedford, Kerry / Brunner-Weinzierl, Monika C

    European journal of immunology

    2014  Volume 44, Issue 7, Page(s) 2139–2152

    Abstract: Although CD8(+) T cells that produce IL-17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8(+) T cells. Here, we show that CTLA-4 enhances the frequency of IL-17 in CD8( ...

    Abstract Although CD8(+) T cells that produce IL-17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8(+) T cells. Here, we show that CTLA-4 enhances the frequency of IL-17 in CD8(+) T cells, indicating that CTLA-4 (CD152) specifically promotes Tc17 differentiation. Simultaneous stimulation of CTLA-4(+/+) and CTLA-4(-/-) T cells in cocultures and agonistic CTLA-4 stimulation unambiguously revealed a cell-intrinsic mechanism for IL-17 control by CTLA-4. The quality of CTLA-4-induced Tc17 cells was tested in vivo, utilizing infection with the facultative intracellular bacterium Listeria monocytogenes (LM). Unlike CTLA-4(+/+) Tc17 cells, CTLA-4(-/-) were nearly as efficient as Tc1 CTLA-4(+/+) cells in LM clearance. Additionally, adoptively transferred CTLA-4(-/-) Tc17 cells expressed granzyme B after rechallenge, and produced Tc1 cytokines such as IFN-γ and TNF-α, which strongly correlate with bacterial clearance. CTLA-4(+/+) Tc17 cells demonstrated a high-quality Tc17 differentiation program ex vivo, which was also evident in isolated IL-17-secreting Tc17 cells, with CTLA-4-mediated enhanced upregulation of Tc17-related molecules such as IL-17A, RORγt, and IRF-4. Our results show that CTLA-4 promotes Tc17 differentiation that results in robust Tc17 responses. Its inactivation might therefore represent a central therapeutic target to enhance clearance of infection.
    MeSH term(s) Animals ; Apoptosis ; CD8-Positive T-Lymphocytes/cytology ; CTLA-4 Antigen/physiology ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cytokines/biosynthesis ; Cytotoxicity, Immunologic ; Granzymes/biosynthesis ; Interleukin-17/biosynthesis ; Mice ; Mice, Inbred C57BL
    Chemical Substances CTLA-4 Antigen ; Ctla4 protein, mouse ; Cytokines ; Interleukin-17 ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2014-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201343497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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