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Article ; Online: Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort study.

Reyes, Luis F / Bastidas, Alirio / Narváez, Paula O / Parra-Tanoux, Daniela / Fuentes, Yuli V / Serrano-Mayorga, Cristian C / Ortíz, Valentina / Caceres, Eder L / Ospina-Tascon, Gustavo / Díaz, Ana M / Jibaja, Manuel / Vera, Magdalena / Silva, Edwin / Gorordo-Delsol, Luis Antonio / Maraschin, Francesca / Varón-Vega, Fabio / Buitrago, Ricardo / Poveda, Marcela / Saucedo, Lina M /

Estenssoro, Elisa / Ortíz, Guillermo / Nin, Nicolás / Calderón, Luis E / Montaño, Gina S / Chaar, Aldair J / García, Fernanda / Ramírez, Vanessa / Picoita, Fabricio / Peláez, Cristian / Unigarro, Luis / Friedman, Gilberto / Cucunubo, Laura / Bruhn, Alejandro / Hernández, Glenn / Martin-Loeches, Ignacio

PloS one

2022 Volume 17, Issue 3, Page(s) e0265529

Abstract: Purpose: The COVID-19 pandemic has spread worldwide, and almost 396 million people have been infected around the globe. Latin American countries have been deeply affected, and there is a lack of data in this regard. This study aims to identify the ... ...

Abstract	Purpose: The COVID-19 pandemic has spread worldwide, and almost 396 million people have been infected around the globe. Latin American countries have been deeply affected, and there is a lack of data in this regard. This study aims to identify the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19. Furthermore, to describe the functional status of patients at hospital discharge after the acute episode of COVID-19. Material and methods: This was a prospective, multicenter, multinational observational cohort study of subjects admitted to 22 hospitals within Latin America. Data were collected prospectively. Descriptive statistics were used to characterize patients, and multivariate regression was carried out to identify factors associated with severe COVID-19. Results: A total of 3008 patients were included in the study. A total of 64.3% of patients had severe COVID-19 and were admitted to the ICU. Patients admitted to the ICU had a higher mean (SD) 4C score (10 [3] vs. 7 [3)], p<0.001). The risk factors independently associated with progression to ICU admission were age, shortness of breath, and obesity. In-hospital mortality was 24.1%, whereas the ICU mortality rate was 35.1%. Most patients had equal self-care ability at discharge 43.8%; however, ICU patients had worse self-care ability at hospital discharge (25.7% [497/1934] vs. 3.7% [40/1074], p<0.001). Conclusions: This study confirms that patients with SARS CoV-2 in the Latin American population had a lower mortality rate than previously reported. Systemic complications are frequent in patients admitted to the ICU due to COVID-19, as previously described in high-income countries.
MeSH term(s)	COVID-19/epidemiology ; Cohort Studies ; Hospital Mortality ; Hospitals ; Humans ; Intensive Care Units ; Latin America/epidemiology ; Pandemics ; Prospective Studies
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0265529
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?

PloS one

2019 Volume 14, Issue 12, Page(s) e0225181

Abstract: Background: The spontaneous breathing trial (SBT) assesses the risk of weaning failure by evaluating some physiological responses to the massive venous return increase imposed by discontinuing positive pressure ventilation. This trial can be very ... ...

Abstract	Background: The spontaneous breathing trial (SBT) assesses the risk of weaning failure by evaluating some physiological responses to the massive venous return increase imposed by discontinuing positive pressure ventilation. This trial can be very demanding for some critically ill patients, inducing excessive physical and cardiovascular stress, including muscle fatigue, heart ischemia and eventually cardiac dysfunction. Extubation failure with emergency reintubation is a serious adverse consequence of a failed weaning process. Some data suggest that as many as 50% of patients that fail weaning do so because of cardiac dysfunction. Unfortunately, monitoring cardiovascular function at the time of the SBT is complex. The aim of our study was to explore if central venous pressure (CVP) changes were related to weaning failure after starting an SBT. We hypothesized that an early rise on CVP could signal a cardiac failure when handling a massive increase on venous return following a discontinuation of positive pressure ventilation. This CVP rise could identify a subset of patients at high risk for extubation failure. Methods: Two-hundred and four mechanically ventilated patients in whom an SBT was decided were subjected to a monitoring protocol that included blinded assessment of CVP at baseline, and at 2 minutes after starting the trial (CVP-test). Weaning failure was defined as reintubation within 48-hours following extubation. Comparisons between two parametric or non-parametric variables were performed with student T test or Mann Whitney U test, respectively. A logistic multivariate regression was performed to determine the predictive value on extubation failure of usual clinical variables and CVP at 2-min after starting the SBT. Results: One-hundred and sixty-five patients were extubated after the SBT, 11 of whom were reintubated within 48h. Absolute CVP values at 2-minutes, and the change from baseline (dCVP) were significantly higher in patients with extubation failure as compared to those successfully weaned. dCVP was an early predictor for reintubation (OR: 1.70 [1.31,2.19], p<0.001). Conclusions: An early rise in CVP after starting an SBT was associated with an increased risk of extubation failure. This might represent a warning signal not captured by usual SBT monitoring and could have relevant clinical implications.
MeSH term(s)	Adult ; Aged ; Airway Extubation/methods ; Central Venous Pressure/physiology ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Risk Assessment ; Ventilator Weaning/methods
Language	English
Publishing date	2019-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0225181
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.

Hernández, Glenn / Ospina-Tascón, Gustavo A / Damiani, Lucas Petri / Estenssoro, Elisa / Dubin, Arnaldo / Hurtado, Javier / Friedman, Gilberto / Castro, Ricardo / Alegría, Leyla / Teboul, Jean-Louis / Cecconi, Maurizio / Ferri, Giorgio / Jibaja, Manuel / Pairumani, Ronald / Fernández, Paula / Barahona, Diego / Granda-Luna, Vladimir / Cavalcanti, Alexandre Biasi / Bakker, Jan /

Ospina-Tascón, Gustavo / Petri Damiani, Lucas / Rodriguez, Nicolás / Holger, Patricia / Soto, Natalia / Pozo, Mario / Cook, Deborah / Vincent, Jean-Louis / Rhodes, Andrew / Kavanagh, Bryan P / Dellinger, Phil / Rietdijk, Wim / Carpio, David / Pavéz, Nicolás / Henriquez, Elizabeth / Bravo, Sebastian / Valenzuela, Emilio Daniel / Vera, Magdalena / Dreyse, Jorge / Oviedo, Vanessa / Cid, Maria Alicia / Larroulet, Macarena / Petruska, Edward / Sarabia, Claudio / Gallardo, David / Sanchez, Juan Eduardo / González, Hugo / Arancibia, José Miguel / Muñoz, Alex / Ramirez, Germán / Aravena, Florencia / Aquevedo, Andrés / Zambrano, Fabián / Bozinovic, Milan / Valle, Felipe / Ramirez, Manuel / Rossel, Victor / Muñoz, Pilar / Ceballos, Carolina / Esveile, Christian / Carmona, Cristian / Candia, Eva / Mendoza, Daniela / Sanchez, Aída / Ponce, Daniela / Lastra, Jaime / Nahuelpán, Bárbara / Fasce, Fabrizio / Luengo, Cecilia / Medel, Nicolas / Cortés, Cesar / Campassi, Luz / Rubatto, Paolo / Horna, Nahime / Furche, Mariano / Pendino, Juan Carlos / Bettini, Lisandro / Lovesio, Carlos / González, María Cecilia / Rodruguez, Jésica / Canales, Héctor / Caminos, Francisco / Galletti, Cayetano / Minoldo, Estefanía / Aramburu, Maria Jose / Olmos, Daniela / Nin, Nicolás / Tenzi, Jordán / Quiroga, Carlos / Lacuesta, Pablo / Gaudín, Agustín / Pais, Richard / Silvestre, Ana / Olivera, Germán / Rieppi, Gloria / Berrutti, Dolores / Ochoa, Marcelo / Cobos, Paul / Vintimilla, Fernando / Ramirez, Vanessa / Tobar, Milton / García, Fernanda / Picoita, Fabricio / Remache, Nelson / Granda, Vladimir / Paredes, Fernando / Barzallo, Eduardo / Garcés, Paul / Guerrero, Fausto / Salazar, Santiago / Torres, German / Tana, Cristian / Calahorrano, José / Solis, Freddy / Torres, Pedro / Herrera, Luís / Ornes, Antonio / Peréz, Verónica / Delgado, Glenda / López, Alexei / Espinosa, Eliana / Moreira, José / Salcedo, Blanca / Villacres, Ivonne / Suing, Jhonny / Lopez, Marco / Gomez, Luis / Toctaquiza, Guillermo / Cadena Zapata, Mario / Orazabal, Milton Alonso / Pardo Espejo, Ruben / Jimenez, Jorge / Calderón, Alexander / Paredes, Gustavo / Barberán, José Luis / Moya, Tatiana / Atehortua, Horacio / Sabogal, Rodolfo / Ortiz, Guillermo / Lara, Antonio / Sanchez, Fabio / Hernán Portilla, Alvaro / Dávila, Humberto / Mora, Jorge Antonio / Calderón, Luis Eduardo / Alvarez, Ingrid / Escobar, Elena / Bejarano, Alejandro / Bustamante, Luis Alfonso / Aldana, José Luis

JAMA

2019 Volume 321, Issue 7, Page(s) 654–664

Abstract: Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic ... ...

Abstract	Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established. Objective: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality. Design, setting, and participants: Multicenter, randomized trial conducted at 28 intensive care units in 5 countries. Four-hundred twenty-four patients with septic shock were included between March 2017 and March 2018. The last date of follow-up was June 12, 2018. Interventions: Patients were randomized to a step-by-step resuscitation protocol aimed at either normalizing capillary refill time (n = 212) or normalizing or decreasing lactate levels at rates greater than 20% per 2 hours (n = 212), during an 8-hour intervention period. Main outcomes and measures: The primary outcome was all-cause mortality at 28 days. Secondary outcomes were organ dysfunction at 72 hours after randomization, as assessed by Sequential Organ Failure Assessment (SOFA) score (range, 0 [best] to 24 [worst]); death within 90 days; mechanical ventilation-, renal replacement therapy-, and vasopressor-free days within 28 days; intensive care unit and hospital length of stay. Results: Among 424 patients randomized (mean age, 63 years; 226 [53%] women), 416 (98%) completed the trial. By day 28, 74 patients (34.9%) in the peripheral perfusion group and 92 patients (43.4%) in the lactate group had died (hazard ratio, 0.75 [95% CI, 0.55 to 1.02]; P = .06; risk difference, -8.5% [95% CI, -18.2% to 1.2%]). Peripheral perfusion-targeted resuscitation was associated with less organ dysfunction at 72 hours (mean SOFA score, 5.6 [SD, 4.3] vs 6.6 [SD, 4.7]; mean difference, -1.00 [95% CI, -1.97 to -0.02]; P = .045). There were no significant differences in the other 6 secondary outcomes. No protocol-related serious adverse reactions were confirmed. Conclusions and relevance: Among patients with septic shock, a resuscitation strategy targeting normalization of capillary refill time, compared with a strategy targeting serum lactate levels, did not reduce all-cause 28-day mortality. Trial registration: ClinicalTrials.gov Identifier: NCT03078712.
MeSH term(s)	Aged ; Capillaries/physiopathology ; Cause of Death ; Female ; Fluid Therapy/methods ; Hemodynamics ; Humans ; Intensive Care Units ; Kaplan-Meier Estimate ; Lactic Acid/blood ; Male ; Middle Aged ; Organ Dysfunction Scores ; Proportional Hazards Models ; Renal Replacement Therapy ; Respiration, Artificial ; Resuscitation/methods ; Shock, Septic/blood ; Shock, Septic/mortality ; Shock, Septic/physiopathology ; Shock, Septic/therapy ; Vasoconstrictor Agents/therapeutic use
Chemical Substances	Vasoconstrictor Agents ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2019-02-27
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2019.0071
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016

Velasquez, T. / Mackey, G. / Lusk, J. / Kyle, U. G. / Fontenot, T. / Marshall, P. / Shekerdemian, L. S. / Coss-Bu, J. A. / Nishigaki, A. / Yatabe, T. / Tamura, T. / Yamashita, K. / Yokoyama, M. / Ruiz-Rodriguez, J. C. / Encina, B. / Belmonte, R. / Troncoso, I. / Tormos, P. / Riveiro, M. /

Baena, J. / Sanchez, A. / BaÃ±eras, J. / CordÃ³n, J. / Duran, N. / Ruiz, A. / Caballero, J. / Nuvials, X. / Riera, J. / Serra, J. / Rutten, A. M. F. / van Ieperen, S. N. M. / Der Kinderen, E. P. H. M. / Van Logten, T. / Kovacikova, L. / Skrak, P. / Zahorec, M. / Akcan-Arikan, A. / Silva, J. C. / Goldsworthy, M. / Wood, D. / Harrison, D. / Parslow, R. / Davis, P. / Pappachan, J. / Goodwin, S. / Ramnarayan, P. / Chernyshuk, S. / Yemets, H. / Zhovnir, V. / Pulitanoâ, S. M. / De Rosa, S. / Mancino, A. / Villa, G. / Tosi, F. / Franchi, P. / Conti, G. / Patel, B. / Khine, H. / Shah, A. / Sung, D. / Singer, L. / Haghbin, S. / Inaloo, S. / Serati, Z. / Idei, M. / Nomura, T. / Yamamoto, N. / Sakai, Y. / Yoshida, T. / Matsuda, Y. / Yamaguchi, Y. / Takaki, S. / Yamaguchi, O. / Goto, T. / Longani, N. / Medar, S. / Abdel-Aal, I. R. / El Adawy, A. S. / Mohammed, H. M. E. H. / Mohamed, A. N. / Parry, S. M. / Knight, L. D. / Denehy, L. / De Morton, N. / Baldwin, C. E. / Sani, D. / Kayambu, G. / da Silva, V. Z. M. / Phongpagdi, P. / Puthucheary, Z. A. / Granger, C. L. / Rydingsward, J. E. / Horkan, C. M. / Christopher, K. B. / McWilliams, D. / Jones, C. / Reeves, E. / Atkins, G. / Snelson, C. / Aitken, L. M. / Rattray, J. / Kenardy, J. / Hull, A. M. / Ullman, A. / Le Brocque, R. / Mitchell, M. / Davis, C. / Macfarlane, B. / Azevedo, J. C. / Rocha, L. L. / De Freitas, F. F. M. / Cavalheiro, A. M. / Lucinio, N. M. / Lobato, M. S. / Ebeling, G. / Kraegpoeth, A. / Laerkner, E. / De Brito-Ashurst, I. / White, C. / Gregory, S. / Forni, L. G. / Flowers, E. / Curtis, A. / Wood, C. A. / Siu, K. / Venkatesan, K. / Muhammad, J. B. H. / Ng, L. / Seet, E. / Baptista, N. / Escoval, A. / Tomas, E. / Agrawal, R. / Mathew, R. / Varma, A. / Dima, E. / Charitidou, E. / Perivolioti, E. / Pratikaki, M. / Vrettou, C. / Giannopoulos, A. / Zakynthinos, S. / Routsi, C. / Atchade, E. / HouzÃ©, S. / Jean-Baptiste, S. / Thabut, G. / GenÃ¨ve, C. / Tanaka, S. / Lortat-Jacob, B. / Augustin, P. / Desmard, M. / Montravers, P. / de Molina, F. J. GonzÃ¡lez / Barbadillo, S. / Alejandro, R. / Ãlvarez-Lerma, F. / VallÃ©s, J. / CatalÃ¡n, R. M. / Palencia, E. / JareÃ±o, A. / Granada, R. M. / Ignacio, M. L. / Cui, N. / Liu, D. / Wang, H. / Su, L. / Qiu, H. / Li, R. / Jaffal, K. / RouzÃ©, A. / Poissy, J. / Sendid, B. / Nseir, S. / Paramythiotou, E. / Rizos, M. / Frantzeskaki, F. / Antoniadou, A. / Vourli, S. / Zerva, L. / Armaganidis, A. / Gottlieb, J. / Greer, M. / Wiesner, O. / MartÃnez, M. / AcuÃ±a, M. / Rello, J. / Welte, T. / Mignot, T. / Soussi, S. / Dudoignon, E. / Ferry, A. / Chaussard, M. / Benyamina, M. / Alanio, A. / Touratier, S. / Chaouat, M. / Lafaurie, M. / Mimoun, M. / Mebazaa, A. / Legrand, M. / Sheils, M. A. / Patel, C. / Mohankumar, L. / Akhtar, N. / Noriega, S. K. Pacheco / Aldana, N. Navarrete / LeÃ³n, J. L. Ãvila / Baquero, J. Durand / Bernal, F. FernÃ¡ndez / Ahmadnia, E. / Hadley, J. S. / Millar, M. / Hall, D. / Hewitt, H. / Yasuda, H. / Sanui, M. / Komuro, T. / Kawano, S. / Andoh, K. / Yamamoto, H. / Noda, E. / Hatakeyama, J. / Saitou, N. / Okamoto, H. / Kobayashi, A. / Takei, T. / Matsukubo, S. / Rotzel, H. B. / LÃ¡zaro, A. Serrano / Prada, D. AguillÃ³n / Gimillo, M. Rodriguez / Barinas, O. Diaz / Cortes, M. L. Blasco / Franco, J. Ferreres / Roca, J. M. Segura / CarratalÃ¡, A. / GonÃ§alves, B. / Turon, R. / Mendes, A. / Miranda, F. / Mata, P. J. / Cavalcanti, D. / Melo, N. / Lacerda, P. / Kurtz, P. / Righy, C. / Rosario, L. E. de la Cruz / Lesmes, S. P. GÃ³mez / Romero, J. C. GarcÃa / Herrera, A. N. GarcÃa / Pertuz, E. D. DÃaz / SÃ¡nchez, M. J. GÃ³mez / Sanz, E. Regidor / Hualde, J. Barado / HernÃ¡ndez, A. Ansotegui / Irazabal, J. M. GuerguÃ© / Spatenkova, V. / Bradac, O. / Suchomel, P. / Urli, T. / Lazzeri, E. Heusch / Aspide, R. / Zanello, M. / Perez-Borrero, L. / Garcia-Alvarez, J. M. / Arias-Verdu, M. D. / Aguilar-Alonso, E. / Rivera-Fernandez, R. / Mora-OrdoÃ±ez, J. / De La Fuente-Martos, C. / Castillo-Lorente, E. / Guerrero-Lopez, F. / Rosario, L. E. De la Cruz / RamÃrez, J. RoldÃ¡n / LeÃ³n, J. P. Tirapu / Navarro-GuillamÃ³n, L. / Cordovilla-Guardia, S. / Iglesias-Santiago, A. / Guerrero-LÃ³pez, F. / FernÃ¡ndez-MondÃ©jar, E. / Vidal, A. / Perez, M. / Juez, A. / Arias, N. / Colino, L. / Perez, J. L. / PÃ©rez, H. / Calpe, P. / Alcala, M. A. / Robaglia, D. / Perez, C. / Lan, S. K. / Cunha, M. M. / Moreira, T. / Santos, F. / Lafuente, E. / Fernandes, M. J. / Silva, J. G. / EcheverrÃa, J. G. Armando / Podlepich, V. / Sokolova, E. / Alexandrova, E. / Lapteva, K. / Shuinotsuka, C. / Rabello, L. / Vianna, G. / Reis, A. / Cairus, C. / Salluh, J. / Bozza, F. / Torres, J. C. Barrios / Araujo, N. J. FernÃ¡ndez / GarcÃa-Olivares, P. / Keough, E. / Dalorzo, M. / Tang, L. K. / De Sousa, I. / DÃaz, M. / Marcos-Zambrano, L. J. / Guerrero, J. E. / Gomez, S. E. Zamora / Lopez, G. D. Hernandez / Cuellar, A. I. Vazquez / Nieto, O. R. Perez / Gonzalez, J. A. Castanon / Bhasin, D. / Rai, S. / Singh, H. / Gupta, O. / Bhattal, M. K. / Sampley, S. / Sekhri, K. / Nandha, R. / Aliaga, F. A. / Olivares, F. / Appiani, F. / Farias, P. / Alberto, F. / HernÃ¡ndez, A. / Pons, S. / Sonneville, R. / Bouadma, L. / Neuville, M. / Mariotte, E. / Radjou, A. / Lebut, J. / Chemam, S. / Voiriot, G. / Dilly, M. P. / Mourvillier, B. / Dorent, R. / Nataf, P. / Wolff, M. / Timsit, J. F. / Ediboglu, O. / Ataman, S. / Ozkarakas, H. / Kirakli, C. / Vakalos, A. / Avramidis, V. / Obukhova, O. / Kurmukov, I. A. / Kashiya, S. / Golovnya, E. / Baikova, V. N. / Ageeva, T. / Haritydi, T. / Kulaga, E. V. / Rios-Toro, J. J. / Lopez-Caler, C. / Rodriguez-Fernandez, S. / Sanchez-OrÃ©zzoli, M. Gomez / Martin-Gallardo, F. / Nikhilesh, J. / Joshi, V. / Villarreal, E. / Ruiz, J. / Gordon, M. / Quinza, A. / Gimenez, J. / PiÃ±ol, M. / Castellanos, A. / Ramirez, P. / Jeon, Y. D. / Jeong, W. Y. / Kim, M. H. / Jeong, I. Y. / Ahn, M. Y. / Ahn, J. Y. / Han, S. H. / Choi, J. Y. / Song, Y. G. / Kim, J. M. / Ku, N. S. / Shah, H. / Kellner, F. / Rezai, F. / Mistry, N. / Yodice, P. / Ovnanian, V. / Fless, K. / Handler, E. / Alejos, R. MartÃnez / Romeu, J. D. MartÃ / AntÃ³n, D. GonzÃ¡lez / Quinart, A. / MartÃ, A. Torres / Llaurado-Serra, M. / Lobo-Civico, A. / Ventura-Rosado, A. / PiÃ±ol-Tena, A. / Pi-Guerrero, M. / PaÃ±os-Espinosa, C. / Peralvo-Bernat, M. / Marine-Vidal, J. / Gonzalez-Engroba, R. / Montesinos-Cerro, N. / Treso-Geira, M. / Valeiras-Valero, A. / Martinez-Reyes, L. / Sandiumenge, A. / Jimenez-Herrera, M. F. / Helyar, S. / Riozzi, P. / Noon, A. / Hallows, G. / Cotton, H. / Keep, J. / Hopkins, P. A. / Taggu, A. / Renuka, S. / Sampath, S. / Rood, P. J. T. / Frenzel, T. / Verhage, R. / Bonn, M. / Pickkers, P. / van der Hoeven, J. G. / van den Boogaard, M. / Corradi, F. / Melnyk, L. / Moggia, F. / Pienovi, R. / Adriano, G. / Brusasco, C. / Mariotti, L. / Lattuada, M. / Bloomer, M. J. / Coombs, M. / Ranse, K. / Endacott, R. / Maertens, B. / Blot, K. / Blot, S. / Amerongen, M. 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F. / Ramirez, V. / Tobar, M. / Picoita, F. / PelÃ¡ez, C. / Carpio, D. / AlegrÃa, L. / Hidalgo, C. / Godoy, K. / Bakker, J. / HernÃ¡ndez, G. / Sadamoto, Y. / Katabami, K. / Wada, T. / Ono, Y. / Maekawa, K. / Hayakawa, M. / Sawamura, A. / Gando, S. / Marin-Mateos, H. / Perez-Vela, J. L. / Garcia-Gigorro, R. / Peiretti, M. A. Corres / Lopez-Gude, M. J. / Chacon-Alves, S. / Renes-CarreÃ±o, E. / Montejo-GonzÃ¡lez, J. C. / Parlevliet, K. L. / Touw, H. R. W. / Beerepoot, M. / Boer, C. / Elbers, P. W. G. / Tuinman, P. R. / Abdelmonem, S. A. / Helmy, T. A. / El Sayed, I. / Ghazal, S. / Akhlagh, S. H. / Masjedi, M. / Hozhabri, K. / Kamali, E. / ZÃ½kovÃ¡, I. / PaldusovÃ¡, B. / SedlÃ¡k, P. / Morman, D. / Youn, A. M. / Ohta, Y. / Sakuma, M. / Bates, D. / Morimoto, T. / Su, P. L. / Chang, W. Y. / Lin, W. C. / Chen, C. 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Intensive Care Med Exp

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1186/s40635-016-0100-7
Database	COVID19

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Article ; Online: Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort study.

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Article ; Online: Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?

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Article ; Online: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.

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Article ; Online: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016

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