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  1. Article: Direct injection/h.p.l.c. methods for the analysis of drugs in biological samples.

    Doyle, E / Huber, R / Picot, V S

    Xenobiotica; the fate of foreign compounds in biological systems

    1992  Volume 22, Issue 7, Page(s) 765–774

    Abstract: 1. Direct injection h.p.l.c. methods for zaprinast, and pantoprazole and its sulphone metabolite were developed. 2. Optimal recovery of pantoprazole and its sulphone metabolite was effected by the absence of transfer losses and the effective adjustment ... ...

    Abstract 1. Direct injection h.p.l.c. methods for zaprinast, and pantoprazole and its sulphone metabolite were developed. 2. Optimal recovery of pantoprazole and its sulphone metabolite was effected by the absence of transfer losses and the effective adjustment of sample pH on-line. 3. Acetonitrile reduced the recovery of pantoprazole and its sulphone metabolite at acetonitrile concentrations greater than 5% in serum. 4. Direct injection h.p.l.c. methods minimize sample handling losses, reduce human contact with biological samples and are sufficiently accurate and reproducible to be used to support pharmacodynamic and toxicokinetic studies.
    MeSH term(s) 2-Pyridinylmethylsulfinylbenzimidazoles ; Animals ; Benzimidazoles/analysis ; Benzimidazoles/blood ; Benzimidazoles/metabolism ; Benzimidazoles/urine ; Chromatography, High Pressure Liquid/methods ; Hydrogen-Ion Concentration ; Omeprazole/analogs & derivatives ; Pantoprazole ; Pharmaceutical Preparations/analysis ; Proton Pump Inhibitors ; Purinones/analysis ; Purinones/blood ; Purinones/urine ; Rats ; Sulfones/analysis ; Sulfones/blood ; Sulfones/urine ; Sulfoxides/analysis ; Sulfoxides/blood ; Sulfoxides/urine ; Time Factors
    Chemical Substances 2-Pyridinylmethylsulfinylbenzimidazoles ; Benzimidazoles ; Pharmaceutical Preparations ; Proton Pump Inhibitors ; Purinones ; Sulfones ; Sulfoxides ; SK&F 95601 (103949-62-8) ; Pantoprazole (D8TST4O562) ; zaprinast (GXT25D5DS0) ; Omeprazole (KG60484QX9)
    Language English
    Publishing date 1992-07
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 120287-x
    ISSN 1366-5928 ; 0049-8254
    ISSN (online) 1366-5928
    ISSN 0049-8254
    DOI 10.3109/00498259209053139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Analysis of zaprinast in rat and human plasma by automated solid-phase extraction and reversed-phase high-performance liquid chromatography.

    Picot, V S / Doyle, E / Pearce, J C

    Journal of chromatography

    1990  Volume 527, Issue 2, Page(s) 454–460

    MeSH term(s) 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors ; Animals ; Chromatography, High Pressure Liquid/methods ; Humans ; Purinones/blood ; Quality Control ; Rats
    Chemical Substances Purinones ; 3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17) ; zaprinast (GXT25D5DS0)
    Language English
    Publishing date 1990-05-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/s0378-4347(00)82131-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Determination of temelastine and a hydroxymethyl-pyridyl metabolite in biological fluid by high-performance liquid chromatography.

    Doyle, E / Mitchell, A M / Picot, V S / Rogers, S J

    Journal of pharmaceutical sciences

    1990  Volume 79, Issue 6, Page(s) 524–526

    Abstract: A high-performance liquid chromatographic method for the analysis of temelastine (1) and 2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-5-[6-hydroxymethy lpyrid-3- ylmethyl]-pyrimidin-4(1H)-one (1-A) in biological fluid is presented. The method combines ... ...

    Abstract A high-performance liquid chromatographic method for the analysis of temelastine (1) and 2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-5-[6-hydroxymethy lpyrid-3- ylmethyl]-pyrimidin-4(1H)-one (1-A) in biological fluid is presented. The method combines the previously reported extraction procedure and new chromatography conditions capable of resolving 1, 1-A, and structurally similar compounds formed by the oxidation of 1. The modified method has been used to measure concentrations of 1 and 1-A in biological fluids taken from the rat and dog, and to look for the presence of 1-A in humans following administration of 1.
    MeSH term(s) Animals ; Chromatography, High Pressure Liquid ; Dogs ; Female ; Humans ; Pyrimidinones/analysis ; Pyrimidinones/blood ; Pyrimidinones/urine ; Rats ; Rats, Inbred Strains ; Species Specificity ; Spectrophotometry, Ultraviolet
    Chemical Substances Pyrimidinones ; 2-(4-(5-bromo-3-methylpyrid-2-yl)butylamino)-5-(6-hydroxymethylpyrid-3-ylmethyl)pyrimidin-4(1H)-one (86181-45-5) ; temelastine (BF6IGI53XH)
    Language English
    Publishing date 1990-06
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1002/jps.2600790614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Analysis of drugs from biological fluids using disposable solid phase columns.

    Doyle, E / Pearce, J C / Picot, V S / Lee, R M

    Journal of chromatography

    1987  Volume 411, Page(s) 325–333

    Abstract: The traditional liquid-liquid extraction method for the removal of drug from biological matrix is being superseded by solid phase extraction. This involves the selection of an appropriate sorbent (normal-phase, reversed-phase, ion-exchange etc.), but ... ...

    Abstract The traditional liquid-liquid extraction method for the removal of drug from biological matrix is being superseded by solid phase extraction. This involves the selection of an appropriate sorbent (normal-phase, reversed-phase, ion-exchange etc.), but once this has been achieved the method is quick and simple to operate. Most sample handling losses are avoided so recovery of drug is high and it is easily automated. Disposable columns have several advantages. Samples of 0.05-2.0 ml can be analysed routinely. Several wash stages can be included in a method to provide a specific extraction prior to a quick analysis by high-performance liquid chromatography (HPLC), radioimmunoassay, UV etc. A potential problem is that retention of the drug may involve more than one mechanism. Elution of drug may therefore require a stronger eluting solvent than analytical HPLC systems using the same stationary phase.
    MeSH term(s) Antihypertensive Agents/analysis ; Antihypertensive Agents/blood ; Antihypertensive Agents/urine ; Bile/analysis ; Chromatography, High Pressure Liquid ; Histamine H2 Antagonists/analysis ; Histamine H2 Antagonists/blood ; Histamine H2 Antagonists/urine ; Humans ; Pharmaceutical Preparations/analysis ; Pharmaceutical Preparations/blood ; Pharmaceutical Preparations/urine ; Pyridazines/analysis ; Pyridazines/blood ; Pyridazines/urine ; Pyrimidinones/analysis ; Pyrimidinones/blood ; Pyrimidinones/urine
    Chemical Substances Antihypertensive Agents ; Histamine H2 Antagonists ; Pharmaceutical Preparations ; Pyridazines ; Pyrimidinones ; SK&F 95018 ; temelastine (BF6IGI53XH) ; donetidine (E9730RXS4H)
    Language English
    Publishing date 1987-12-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/s0021-9673(00)93983-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Two systems for the automated analysis of drugs in biological fluids using high-performance liquid chromatography.

    Doyle, E / McDowall, R D / Murkitt, G S / Picot, V S / Rogers, S J

    Journal of chromatography

    1990  Volume 527, Issue 1, Page(s) 67–77

    Abstract: This paper describes two fully automated assays. One for zaprinast, a cGMP specific phosphodiesterase inhibitor, which uses the Gilson-Advanced Automated Sample Processor combination, and the other for an H+/K+ ATPase inhibitor and its sulphone ... ...

    Abstract This paper describes two fully automated assays. One for zaprinast, a cGMP specific phosphodiesterase inhibitor, which uses the Gilson-Advanced Automated Sample Processor combination, and the other for an H+/K+ ATPase inhibitor and its sulphone metabolite, which uses direct injection. Both assays were developed to support pharmacokinetic studies at therapeutic doses in small animals as well as in man. Plasma or serum (20-200 microliters) is placed directly into an autosampler and all subsequent manipulations are performed mechanically.
    MeSH term(s) 2-Pyridinylmethylsulfinylbenzimidazoles ; 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors ; Adenosine Triphosphatases/antagonists & inhibitors ; Animals ; Benzimidazoles/blood ; Chromatography, High Pressure Liquid ; H(+)-K(+)-Exchanging ATPase ; Humans ; Omeprazole/analogs & derivatives ; Pantoprazole ; Purinones/blood ; Pyridines/blood ; Sulfoxides/blood
    Chemical Substances 2-Pyridinylmethylsulfinylbenzimidazoles ; Benzimidazoles ; Purinones ; Pyridines ; Sulfoxides ; 5-difluoromethoxy-2-((3,4 dimethoxy-2-pyridyl)methylsulfonyl)-1H-benzimidazole (127780-16-9) ; Pantoprazole (D8TST4O562) ; 3',5'-Cyclic-GMP Phosphodiesterases (EC 3.1.4.35) ; Adenosine Triphosphatases (EC 3.6.1.-) ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10) ; zaprinast (GXT25D5DS0) ; Omeprazole (KG60484QX9)
    Language English
    Publishing date 1990-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/s0378-4347(00)82084-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sample preparation for the HPLC analysis of drugs in biological fluids.

    McDowall, R D / Doyle, E / Murkitt, G S / Picot, V S

    Journal of pharmaceutical and biomedical analysis

    1989  Volume 7, Issue 9, Page(s) 1087–1096

    Abstract: Sample preparation for the analysis of drugs in biological fluids consists of a number of unit operations that are used for (i) release of the drug from a conjugate or biological matrix; (ii) removal of endogenous compounds that could interfere with the ... ...

    Abstract Sample preparation for the analysis of drugs in biological fluids consists of a number of unit operations that are used for (i) release of the drug from a conjugate or biological matrix; (ii) removal of endogenous compounds that could interfere with the assay; and (iii) techniques for liquid handling. The trends in sample preparation that have occurred over the past 10 years in the authors' laboratory are discussed. In general, there has been a move from the traditional liquid-liquid extraction to methods using bonded-silica which permit rapid throughput and efficient extraction. Automation of sample preparation has seen further gains in productivity; however, the present generation of equipment lack the control and communication systems that are essential for the development of the automated integrated laboratory of the future.
    MeSH term(s) Automation ; Body Fluids/chemistry ; Chromatography, High Pressure Liquid/methods ; Humans ; Pharmaceutical Preparations/analysis ; Specimen Handling
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 1989
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/0731-7085(89)80047-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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