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  1. Article ; Online: Molecular Research on Plasmodium Infection and Immunity.

    Coutelier, Jean-Paul / Pied, Sylviane

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: The WHO's global strategy for malaria targets a reduction of at least 90% of both incidence and mortality rates for 2030 [ ... ]. ...

    Abstract The WHO's global strategy for malaria targets a reduction of at least 90% of both incidence and mortality rates for 2030 [...].
    MeSH term(s) Humans ; Malaria/epidemiology
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The IL-33/ST2 Pathway in Cerebral Malaria.

    Glineur, Corine / Leleu, Inès / Pied, Sylviane

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Interleukin-33 (IL-33) is an immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. IL-33 is abundant within the brain and spinal cord tissues where it acts as a key cytokine to coordinate the exchange ... ...

    Abstract Interleukin-33 (IL-33) is an immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. IL-33 is abundant within the brain and spinal cord tissues where it acts as a key cytokine to coordinate the exchange between the immune and central nervous system (CNS). In this review, we report the recent advances to our knowledge regarding the role of IL-33 and of its receptor ST2 in cerebral malaria, and in particular, we highlight the pivotal role that IL-33/ST2 signaling pathway could play in brain and cerebrospinal barriers permeability. IL-33 serum levels are significantly higher in children with severe
    MeSH term(s) Child ; Humans ; Malaria, Cerebral ; Interleukin-33/metabolism ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Endothelial Cells/metabolism ; Malaria, Falciparum/parasitology ; Cytokines ; Plasmodium falciparum/metabolism
    Chemical Substances Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; Cytokines
    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113457
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  3. Article: Autophagy Pathways in the Genesis of

    Leleu, Inès / Alloo, Jeremy / Cazenave, Pierre-André / Roland, Jacques / Pied, Sylviane

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 3

    Abstract: Malaria, caused ... ...

    Abstract Malaria, caused by
    Language English
    Publishing date 2022-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12030415
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  4. Article ; Online: Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana.

    Saidi, Nasreddine / Blaizot, Romain / Prévot, Ghislaine / Aoun, Karim / Demar, Magalie / Cazenave, Pierre André / Bouratbine, Aida / Pied, Sylviane

    Frontiers in immunology

    2023  Volume 14, Page(s) 1134020

    Abstract: Cutaneous leishmaniasis (CL) caused by infection with the ... ...

    Abstract Cutaneous leishmaniasis (CL) caused by infection with the parasite
    MeSH term(s) Humans ; French Guiana/epidemiology ; Leishmaniasis, Cutaneous ; Leishmania ; Africa, Northern ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1134020
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  5. Article ; Online: Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral malaria.

    Hellani, Fatima / Leleu, Inès / Saidi, Nasreddine / Martin, Nathalie / Lecoeur, Cécile / Werkmeister, Elisabeth / Koffi, David / Trottein, François / Yapo-Etté, Hélène / Das, Bidyut / Abbadie, Corinne / Pied, Sylviane

    Brain, behavior, and immunity

    2023  Volume 117, Page(s) 20–35

    Abstract: Background: Cerebral malaria (CM) is a fatal neuroinflammatory syndrome caused (in humans) by the protozoa Plasmodium (P.) falciparum. Glial cell activation is one of the mechanisms that contributes to neuroinflammation in CM.: Result: By studying a ... ...

    Abstract Background: Cerebral malaria (CM) is a fatal neuroinflammatory syndrome caused (in humans) by the protozoa Plasmodium (P.) falciparum. Glial cell activation is one of the mechanisms that contributes to neuroinflammation in CM.
    Result: By studying a mouse model of CM (caused by P. berghei ANKA), we describe that the induction of autophagy promoted p21-dependent senescence in astrocytes and that CXCL-10 was part of the senescence-associated secretory phenotype. Furthermore, p21 expression was observed in post-mortem brain and peripheral blood samples from patients with CM. Lastly, we found that the depletion of senescent astrocytes with senolytic drugs abrogated inflammation and protected mice from CM.
    Conclusion: Our data provide evidence for a novel mechanism through which astrocytes could be involved in the neuropathophysiology of CM. p21 gene expression in blood cell and an elevated plasma CXCL-10 concentration could be valuable biomarkers of CM in humans. In the end, we believe senolytic drugs shall open up new avenues to develop newer treatment options.
    MeSH term(s) Humans ; Animals ; Mice ; Malaria, Cerebral ; Neuroinflammatory Diseases ; Astrocytes ; Senotherapeutics ; Autophagy
    Chemical Substances Senotherapeutics
    Language English
    Publishing date 2023-12-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.12.030
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    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  6. Article ; Online: A noncanonical autophagy is involved in the transfer of

    Leleu, Inès / Genete, Delphine / Desnoulez, Sophie Salomé / Saidi, Nasreddine / Brodin, Priscille / Lafont, Frank / Tomavo, Stanislas / Pied, Sylviane

    Autophagy

    2021  Volume 18, Issue 7, Page(s) 1583–1598

    Abstract: Cerebral malaria is a neuroinflammatory disease induced ... ...

    Abstract Cerebral malaria is a neuroinflammatory disease induced by
    MeSH term(s) Animals ; Astrocytes/metabolism ; Autophagy ; Malaria, Cerebral/parasitology ; Malaria, Cerebral/pathology ; Mice ; Mice, Inbred C57BL ; Plasmodium ; Plasmodium berghei
    Language English
    Publishing date 2021-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2021.1993704
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    Zs.A 6741: Show issues Location:
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  7. Article ; Online: Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation.

    Keswani, Tarun / Roland, Jacques / Herbert, Fabien / Delcroix-Genete, Delphine / Bauderlique-Le Roy, Hélène / Gaayeb, Lobna / Cazenave, Pierre-André / Pied, Sylviane

    Genes and immunity

    2019  Volume 21, Issue 1, Page(s) 45–62

    Abstract: Genetic mapping and genome-wide studies provide evidence for the association of several genetic polymorphisms with malaria, a complex pathological disease with multiple severity degrees. We have previously described Berr1and Berr2 as candidate genes ... ...

    Abstract Genetic mapping and genome-wide studies provide evidence for the association of several genetic polymorphisms with malaria, a complex pathological disease with multiple severity degrees. We have previously described Berr1and Berr2 as candidate genes identified in the WLA/Pas inbreed mouse strain predisposing to resistance to cerebral malaria (CM) induced by P. berghei ANKA. We report in this study the phenotypic and functional characteristics of a congenic strain we have derived for Berr2
    MeSH term(s) Alleles ; Animals ; Brain/immunology ; Brain/metabolism ; Brain/pathology ; Chromosome Mapping ; Disease Models, Animal ; Disease Resistance/genetics ; Disease Resistance/immunology ; Female ; Genotype ; Malaria, Cerebral/genetics ; Malaria, Cerebral/metabolism ; Malaria, Cerebral/parasitology ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; Microglia/physiology ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism
    Chemical Substances CLM-1 protein, mouse ; Receptors, Immunologic
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-019-0085-9
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    Zs.A 5592: Show issues Location:
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  8. Article ; Online: Uptake of parasite-derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria.

    Shrivastava, Sandeep K / Dalko, Esther / Delcroix-Genete, Delphine / Herbert, Fabien / Cazenave, Pierre-André / Pied, Sylviane

    Glia

    2017  Volume 65, Issue 1, Page(s) 75–92

    Abstract: Astrocytes and microglia are activated during cerebral malaria (CM) and contribute to the production and release of several mediators during neuroinflammatory processes. Whether these changes are the consequence of a direct crosstalk between glial cells ... ...

    Abstract Astrocytes and microglia are activated during cerebral malaria (CM) and contribute to the production and release of several mediators during neuroinflammatory processes. Whether these changes are the consequence of a direct crosstalk between glial cells and the malarial parasite and how these cells participate in the pathogenesis of CM is not yet clear. We therefore examined the interaction of astrocytes and microglia with Plasmodium berghei ANKA-infected red blood cells using primary cell cultures derived from newborn C57BL/6 mice. We observed a dynamic transfer of vesicles from the parasite to astrocytes within minutes of contact, and the phagocytosis of infected red blood cells by microglia. Differential gene expression studies using the Affymetrix GeneChip
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.23075
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    Zs.A 2345: Show issues Location:
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  9. Article ; Online: Vivax infection alters peripheral B-cell profile and induces persistent serum IgM.

    Patgaonkar, Mandar / Herbert, Fabien / Powale, Krushali / Gandhe, Prajakta / Gogtay, Nithya / Thatte, Urmila / Pied, Sylviane / Sharma, Shobhona / Pathak, Sulabha

    Parasite immunology

    2018  Volume 40, Issue 10, Page(s) e12580

    Abstract: B cell-mediated humoral responses are essential for controlling malarial infection. Studies have addressed the effects of Plasmodium falciparum infection on peripheral B-cell subsets but not much is known for P. vivax infection. Furthermore, majority of ... ...

    Abstract B cell-mediated humoral responses are essential for controlling malarial infection. Studies have addressed the effects of Plasmodium falciparum infection on peripheral B-cell subsets but not much is known for P. vivax infection. Furthermore, majority of the studies investigate changes during acute infection, but not after parasite clearance. In this prospective study, we analysed peripheral B-cell profiles and antibody responses during acute P. vivax infection and upon recovery (30 days post-treatment) in a low-transmission area in India. Dengue patients were included as febrile-condition controls. Both dengue and malaria patients showed a transient increase in atypical memory B cells during acute infection. However, transient B cell-activating factor (BAFF)-independent increase in the percentage of total and activated immature B cells was observed in malaria patients. Naïve B cells from malaria patients also showed increased TLR4 expression. Total IgM levels remained unchanged during acute infection but increased significantly at recovery. Serum antibody profiling showed a parasite-specific IgM response that persisted at recovery. A persistent IgM autoantibody response was also observed in malaria but not dengue patients. Our data suggest that in hypoendemic regions acute P. vivax infection skews peripheral B-cell subsets and results in a persistent parasite-specific and autoreactive IgM response.
    MeSH term(s) Adult ; Antibodies, Protozoan/blood ; Antibodies, Protozoan/immunology ; Antibody Formation ; B-Cell Activating Factor/metabolism ; B-Lymphocyte Subsets/immunology ; Female ; Humans ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; India ; Malaria, Vivax/immunology ; Malaria, Vivax/parasitology ; Male ; Middle Aged ; Plasmodium vivax/immunology ; Prospective Studies ; Toll-Like Receptor 4/biosynthesis
    Chemical Substances Antibodies, Protozoan ; B-Cell Activating Factor ; Immunoglobulin M ; TLR4 protein, human ; TNFSF13B protein, human ; Toll-Like Receptor 4
    Language English
    Publishing date 2018-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.12580
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    Zs.A 1509: Show issues Location:
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  10. Article ; Online: Plasmodium yoelii

    Keswani, Tarun / Delcroix-Genete, Delphine / Herbert, Fabien / Leleu, Ines / Lambert, Claire / Draheim, Marion / Salome-Desnoulez, Sophie / Saliou, Jean Michel / Cazenave, Pierre-André / Silvie, Olivier / Roland, Jacques / Pied, Sylviane

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 205, Issue 11, Page(s) 3071–3082

    Abstract: Malaria is associated with complicated immunopathogenesis. In this study, we provide evidence for an unexpected role of TLR3 in promoting the establishment ... ...

    Abstract Malaria is associated with complicated immunopathogenesis. In this study, we provide evidence for an unexpected role of TLR3 in promoting the establishment of
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Immunity, Innate/immunology ; Immunoglobulin G/immunology ; Inflammation/immunology ; Inflammation/parasitology ; Interferon Type I/immunology ; Interferon-gamma/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/parasitology ; Malaria/immunology ; Malaria/parasitology ; Mammals/immunology ; Mammals/parasitology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-kappa B/immunology ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/parasitology ; Parasitemia/immunology ; Plasmodium yoelii/immunology ; Signal Transduction/immunology ; Toll-Like Receptor 3/immunology ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances Immunoglobulin G ; Interferon Type I ; NF-kappa B ; TLR3 protein, mouse ; Toll-Like Receptor 3 ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1901317
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