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  1. Book ; Thesis: Die Rolle von Interleukin-10 im murinen Schlaganfall

    Piepke, Marius / Mittrücker, Hans-Willi / Gelderblom, Mathias

    2022  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Marius Piepke ; Prüfungsausschuss, der/die Vorsitzende: Prof. Dr. Hans Willi Mittrücker, Prüfungsausschuss, zweite/r Gutachter/in: PD Dr. Mathias Gelderblom
    Language German ; English
    Size 37 Blätter, Illustrationen, Diagramme
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2023
    Note Text in deutsch, Zeitschriftenartikel in englisch ; Dissertation angenommen von der Medizinischen Fakultät der Universität Hamburg ; Enthält 1 Zeitschriftenartikel
    HBZ-ID HT030346327
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1236 order for loan Magazin

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  2. Article ; Online: Clinical Judgment vs Triage Scales for Detecting Large Vessel Occlusions in Suspected Acute Stroke.

    Schlemm, Eckhard / Piepke, Marius / Kessner, Simon S / Meyer, Lukas / Cheng, Bastian / Gerloff, Christian / Thomalla, Götz

    JAMA network open

    2023  Volume 6, Issue 9, Page(s) e2332894

    MeSH term(s) Humans ; Judgment ; Triage ; Stroke/diagnosis
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.32894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interleukin-1 Mediates Ischemic Brain Injury via Induction of IL-17A in γδ T Cells and CXCL1 in Astrocytes.

    Schädlich, Ines Sophie / Vienhues, Jonas Heinrich / Jander, Alina / Piepke, Marius / Magnus, Tim / Lambertsen, Kate Lykke / Clausen, Bettina Hjelm / Gelderblom, Mathias

    Neuromolecular medicine

    2022  Volume 24, Issue 4, Page(s) 437–451

    Abstract: As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-stroke inflammation, whereas its neutralization is protective. To further investigate the underlying cell-type-specific IL-1 effects, we subjected IL-1 (α/β) ... ...

    Abstract As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-stroke inflammation, whereas its neutralization is protective. To further investigate the underlying cell-type-specific IL-1 effects, we subjected IL-1 (α/β) knockout (Il1
    MeSH term(s) Mice ; Animals ; Interleukin-17/genetics ; Chemokine CXCL1/genetics ; Chemokine CXCL1/metabolism ; Interleukin-1/metabolism ; Astrocytes/metabolism ; Mice, Inbred C57BL ; Stroke/metabolism ; T-Lymphocytes ; Brain Injuries ; Disease Models, Animal
    Chemical Substances Interleukin-17 ; Chemokine CXCL1 ; Interleukin-1
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077809-0
    ISSN 1559-1174 ; 1535-1084
    ISSN (online) 1559-1174
    ISSN 1535-1084
    DOI 10.1007/s12017-022-08709-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5818: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke.

    Gelderblom, Mathias / Koch, Simon / Strecker, Jan-Kolja / Jørgensen, Carina / Garcia-Bonilla, Lidia / Ludewig, Peter / Schädlich, Ines Sophie / Piepke, Marius / Degenhardt, Karoline / Bernreuther, Christian / Pinnschmidt, Hans / Arumugam, Thiruma V / Thomalla, Götz / Faber, Cornelius / Sedlacik, Jan / Gerloff, Christian / Minnerup, Jens / Clausen, Bettina H / Anrather, Josef /
    Magnus, Tim

    Brain communications

    2023  Volume 5, Issue 2, Page(s) fcad090

    Abstract: Multiple consensus statements have called for preclinical randomized controlled trials to improve translation in stroke research. We investigated the efficacy of an interleukin-17A neutralizing antibody in a multi-centre preclinical randomized controlled ...

    Abstract Multiple consensus statements have called for preclinical randomized controlled trials to improve translation in stroke research. We investigated the efficacy of an interleukin-17A neutralizing antibody in a multi-centre preclinical randomized controlled trial using a murine ischaemia reperfusion stroke model. Twelve-week-old male C57BL/6 mice were subjected to 45 min of transient middle cerebral artery occlusion in four centres. Mice were randomly assigned (1:1) to receive either an anti-interleukin-17A (500 µg) or isotype antibody (500 µg) intravenously 1 h after reperfusion. The primary endpoint was infarct volume measured by magnetic resonance imaging three days after transient middle cerebral artery occlusion. Secondary analysis included mortality, neurological score, neutrophil infiltration and the impact of the gut microbiome on treatment effects. Out of 136 mice, 109 mice were included in the analysis of the primary endpoint. Mixed model analysis revealed that interleukin-17A neutralization significantly reduced infarct sizes (anti-interleukin-17A: 61.77 ± 31.04 mm
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcad090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response.

    Piepke, Marius / Clausen, Bettina H / Ludewig, Peter / Vienhues, Jonas H / Bedke, Tanja / Javidi, Ehsan / Rissiek, Björn / Jank, Larissa / Brockmann, Leonie / Sandrock, Inga / Degenhardt, Karoline / Jander, Alina / Roth, Vanessa / Schädlich, Ines S / Prinz, Immo / Flavell, Richard A / Kobayashi, Yasushi / Renné, Thomas / Gerloff, Christian /
    Huber, Samuel / Magnus, Tim / Gelderblom, Mathias

    Journal of neuroinflammation

    2021  Volume 18, Issue 1, Page(s) 265

    Abstract: Background: Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of T cell-subtype specific transgenic mouse models it now ... ...

    Abstract Background: Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of T cell-subtype specific transgenic mouse models it now has become possible to study the complex interplay of T cell subpopulations in ischemic stroke.
    Methods: In a murine model of experimental stroke we analyzed the effects of IL-10 on the functional outcome for up to 14 days post-ischemia and defined the source of IL-10 in ischemic brains based on immunohistochemistry, flow cytometry, and bone-marrow chimeric mice. We used neutralizing IL-17A antibodies, intrathecal IL-10 injections, and transgenic mouse models which harbor a deletion of the IL-10R on distinct T cell subpopulations to further explore the interplay between IL-10 and IL-17A pathways in the ischemic brain.
    Results: We demonstrate that IL-10 deficient mice exhibit significantly increased infarct sizes on days 3 and 7 and enlarged brain atrophy and impaired neurological outcome on day 14 following tMCAO. In ischemic brains IL-10 producing immune cells included regulatory T cells, macrophages, and microglia. Neutralization of IL-17A following stroke reversed the worse outcome in IL-10 deficient mice and intracerebral treatment with recombinant IL-10 revealed that IL-10 controlled IL-17A positive lymphocytes in ischemic brains. Importantly, IL-10 acted differentially on αβ and γδ T cells. IL-17A producing CD4
    Conclusions: Taken together, our data indicate a key function of IL-10 in restricting the detrimental IL-17A-signaling in stroke and further supports that IL-17A is a therapeutic opportunity for stroke treatment.
    MeSH term(s) Animals ; Antibodies, Neutralizing/pharmacology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Immunohistochemistry ; Infarction, Middle Cerebral Artery/prevention & control ; Injections, Spinal ; Interleukin-10/administration & dosage ; Interleukin-10/therapeutic use ; Interleukin-17/antagonists & inhibitors ; Ischemic Stroke/drug therapy ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Interleukin-10/antagonists & inhibitors ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Treatment Outcome
    Chemical Substances Antibodies, Neutralizing ; IL10 protein, mouse ; Interleukin-17 ; Receptors, Interleukin-10 ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2021-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-021-02316-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.

    Zhang, Shenpeng R / Piepke, Marius / Chu, Hannah X / Broughton, Brad Rs / Shim, Raymond / Wong, Connie Hy / Lee, Seyoung / Evans, Megan A / Vinh, Antony / Sakkal, Samy / Arumugam, Thiruma V / Magnus, Tim / Huber, Samuel / Gelderblom, Mathias / Drummond, Grant R / Sobey, Christopher G / Kim, Hyun Ah

    JCI insight

    2018  Volume 3, Issue 18

    Abstract: Stroke triggers a complex inflammatory process in which the balance between pro- and antiinflammatory mediators is critical for the development of the brain infarct. However, systemic changes may also occur in parallel with brain inflammation. Here we ... ...

    Abstract Stroke triggers a complex inflammatory process in which the balance between pro- and antiinflammatory mediators is critical for the development of the brain infarct. However, systemic changes may also occur in parallel with brain inflammation. Here we demonstrate that administration of recombinant IL-33, a recently described member of the IL-1 superfamily of cytokines, promotes Th2-type effects following focal ischemic stroke, resulting in increased plasma levels of Th2-type cytokines and fewer proinflammatory (3-nitrotyrosine+F4/80+) microglia/macrophages in the brain. These effects of IL-33 were associated with reduced infarct size, fewer activated microglia and infiltrating cytotoxic (natural killer-like) T cells, and more IL-10-expressing regulatory T cells. Despite these neuroprotective effects, mice treated with IL-33 displayed exacerbated post-stroke lung bacterial infection in association with greater functional deficits and mortality at 24 hours. Supplementary antibiotics (gentamicin and ampicillin) mitigated these systemic effects of IL-33 after stroke. Our findings highlight the complex nature of the inflammatory mechanisms differentially activated in the brain and periphery during the acute phase after ischemic stroke. The data indicate that a Th2-promoting agent can provide neuroprotection without adverse systemic effects when given in combination with antibiotics.
    MeSH term(s) Animals ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Cytokines/blood ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation ; Interleukin-10/metabolism ; Interleukin-33/metabolism ; Interleukin-33/pharmacology ; Interleukin-4/pharmacology ; Lung/drug effects ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/drug effects ; Microglia/metabolism ; Stroke/metabolism ; Th1 Cells/metabolism ; Th2 Cells/metabolism ; Treatment Outcome ; Tyrosine/analogs & derivatives
    Chemical Substances Cytokines ; IL10 protein, mouse ; Il33 protein, mouse ; Interleukin-33 ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2) ; 3-nitrotyrosine (3604-79-3) ; Tyrosine (42HK56048U)
    Language English
    Publishing date 2018-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.121560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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