Artikel: Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects.
2001 Band 24, Heft 3, Seite(n) 489–494
Abstract: Objective: To evaluate the effects of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels.: Research design and methods: A total of 10 obese nondiabetic male patients were studied before and after a 14-day treatment with 2,550 mg/day ... ...
| Abstract | Objective: To evaluate the effects of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels. Research design and methods: A total of 10 obese nondiabetic male patients were studied before and after a 14-day treatment with 2,550 mg/day metformin and were compared with 10 untreated obese control subjects. On days 0 and 15, leptin and GLP-1(7-36)amide/(7-37) levels were assessed before and after an oral glucose load during a euglycemic hyperinsulinemic clamp to avoid the interference of variations of insulinemia and glycemia on GLP-1 and leptin secretion. The effects of metformin on GLP-1(7-36)amide degradation in human plasma and in a buffer solution containing dipeptidyl peptidase IV (DPP-IV) were also studied. Results: Leptin levels were not affected by the oral glucose load, and they were not modified after metformin treatment. Metformin induced a significant (P < 0.05) increase of GLP-1(7-36)amide/(7-37) at 30 and 60 min after the oral glucose load (63.8 +/- 29.0 vs. 50.3 +/- 15.6 pmol/l and 75.8 +/- 35.4 vs. 46.9 +/- 20.0 pmol/l, respectively), without affecting baseline GLP-1 levels. No variations of GLP-1 levels were observed in the control group. In pooled human plasma, metformin (0.1-0.5 microg/ml) significantly inhibited degradation of GLP-1(7-36)amide after a 30-min incubation at 37 degrees C; similar results were obtained in a buffer solution containing DPP-IV. Conclusions: Metformin significantly increases GLP-1 levels after an oral glucose load in obese nondiabetic subjects; this effect could be due to an inhibition of GLP-1 degradation. |
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| Mesh-Begriff(e) | Adolescent ; Adult ; Blood Glucose/metabolism ; Glucagon ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptides ; Glucose Clamp Technique ; Humans ; Hypoglycemic Agents/therapeutic use ; Leptin/blood ; Male ; Metformin/therapeutic use ; Middle Aged ; Obesity/blood ; Obesity/drug therapy ; Peptide Fragments/blood ; Peptides/blood |
| Chemische Substanzen | Blood Glucose ; Hypoglycemic Agents ; Leptin ; Peptide Fragments ; Peptides ; glucagon-like peptide 1 (7-36)amide (119637-73-9) ; Glucagon-Like Peptides (62340-29-8) ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon (9007-92-5) ; Metformin (9100L32L2N) ; glucagon-like peptide 1 (7-37) (PI470C66NT) |
| Sprache | Englisch |
| Erscheinungsdatum | 2001-03-09 |
| Erscheinungsland | United States |
| Dokumenttyp | Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 441231-x |
| ISSN | 1935-5548 ; 0149-5992 |
| ISSN (online) | 1935-5548 |
| ISSN | 0149-5992 |
| DOI | 10.2337/diacare.24.3.489 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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