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Article ; Online: Patient management problem.

Pierce, Aimee

Continuum (Minneapolis, Minn.)

2013 Volume 19, Issue 2 Dementia, Page(s) 519–537

MeSH term(s)	Alzheimer Disease/diagnosis ; Alzheimer Disease/therapy ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/therapy ; Disease Management ; Disease Progression ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2013-05-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1538-6899
ISSN (online)	1538-6899
DOI	10.1212/01.CON.0000429166.97320.81
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Article ; Online: Dementia in the oldest old: Beyond Alzheimer disease.

Pierce, Aimee L / Kawas, Claudia H

PLoS medicine

2017 Volume 14, Issue 3, Page(s) e1002263

Abstract: In a Perspective, Aimee Pierce and Claudia Kawas discuss risk factors and pathologies of dementia in the oldest-old. ...

Abstract	In a Perspective, Aimee Pierce and Claudia Kawas discuss risk factors and pathologies of dementia in the oldest-old.
MeSH term(s)	Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/etiology ; Dementia/epidemiology ; Dementia/etiology ; Humans ; Risk Factors
Language	English
Publishing date	2017-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185925-5
ISSN	1549-1676 ; 1549-1277
ISSN (online)	1549-1676
ISSN	1549-1277
DOI	10.1371/journal.pmed.1002263
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Article: Patient Portal Use Among Diabetic Patients With Different Races and Ethnicities.

Wang, Hao / Kirby, Ryan / Pierce, Aimee / Barbaro, Michael / Ho, Amy F / Blalock, Jake / Schrader, Chet D

Journal of clinical medicine research

2022 Volume 14, Issue 10, Page(s) 400–408

Abstract: Background: Patient portal (PP) use varies among different patient populations, specifically among those with diabetes mellitus (DM). In addition, it is still uncertain whether PP use could be linked to improved clinical outcomes. Therefore, the aim of ... ...

Abstract	Background: Patient portal (PP) use varies among different patient populations, specifically among those with diabetes mellitus (DM). In addition, it is still uncertain whether PP use could be linked to improved clinical outcomes. Therefore, the aim of this paper was to determine PP use status for patients, recognize factors promoting PP use, and further identify the association between PP use and clinical outcome among diabetic patients of different races and ethnicities. Methods: This was a single-center cross-section study. Patients were divided into non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic/Latino groups. PP use was compared among these three groups. Multivariate logistic regressions were used to determine factors associated with PP use, serum glycemic control, and emergency department (ED) hospitalizations. Results: A total of 77,977 patients were analyzed. The rate of PP use among patients of NHW (24%) was higher than those of NHB (19%) and Hispanic/Latinos (18%, P < 0.0001). The adjusted odds ratio (AOR) of insurance coverage associated with PP use was 2.12 (2.02 - 2.23, P < 0.0001), and having a primary care physician (PCP) associated with PP use was 3.89 (3.71 - 4.07, P < 0.0001). In terms of clinical outcomes, the AOR of PP use associated with serum glycemic control was 0.98 (0.90 - 1.05, P = 0.547) and ED hospitalization was 0.79 (0.73 - 0.86, P < 0.0001). Conclusion: PP use disparity occurred among NHB and Hispanic/Latino patients in the ED. Having insurance coverage and PCPs seem to correlate with PP use. PP use did not seem to associate with serum glycemic control among DM patients present in the ED but could possibly reduce patient hospitalizations.
Language	English
Publishing date	2022-10-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr4822
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Article: Current Role for Biomarkers in Clinical Diagnosis of Alzheimer Disease and Frontotemporal Dementia.

Sheikh-Bahaei, Nasim / Sajjadi, Seyed Ahmad / Pierce, Aimee L

Current treatment options in neurology

2017 Volume 19, Issue 12, Page(s) 46

Abstract: Purpose of review Alzheimer's disease (AD) and frontotemporal dementia can often be diagnosed accurately with careful clinical history, cognitive testing, neurological examination, and structural brain MRI. However, there are certain circumstances ... ...

Abstract	Purpose of review Alzheimer's disease (AD) and frontotemporal dementia can often be diagnosed accurately with careful clinical history, cognitive testing, neurological examination, and structural brain MRI. However, there are certain circumstances wherein detection of specific biomarkers of neurodegeneration or underlying AD pathology will impact the clinical diagnosis or treatment plan. We will review the currently available biomarkers for AD and frontotemporal dementia (FTD) and discuss their clinical importance. Recent findings With the advent of
Language	English
Publishing date	2017-11-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057342-X
ISSN	1534-3138 ; 1092-8480
ISSN (online)	1534-3138
ISSN	1092-8480
DOI	10.1007/s11940-017-0484-z
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Article ; Online: Late-Onset Alzheimer Disease.

Pierce, Aimee L / Bullain, Szofia S / Kawas, Claudia H

Neurologic clinics

2017 Volume 35, Issue 2, Page(s) 283–293

Abstract: The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease ( ... ...

Abstract	The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.
MeSH term(s)	Age of Onset ; Aging ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Dementia/pathology ; Dementia/physiopathology ; Humans
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1013148-6
ISSN	1557-9875 ; 0733-8619
ISSN (online)	1557-9875
ISSN	0733-8619
DOI	10.1016/j.ncl.2017.01.006
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Article ; Online: Attitudes toward Potential Participant Registries.

Grill, Joshua D / Holbrook, Andrew / Pierce, Aimee / Hoang, Dan / Gillen, Daniel L

Journal of Alzheimer's disease : JAD

2017 Volume 56, Issue 3, Page(s) 939–946

Abstract: Difficult participant recruitment is a consistent barrier to successful medical research. Potential participant registries represent an increasingly common intervention to overcome this barrier. A variety of models for registries exist, but few data are ... ...

Abstract	Difficult participant recruitment is a consistent barrier to successful medical research. Potential participant registries represent an increasingly common intervention to overcome this barrier. A variety of models for registries exist, but few data are available to instruct their design and implementation. To provide such data, we surveyed 110 cognitively normal research participants enrolled in a longitudinal study of aging and dementia. Seventy-four (67%) individuals participated in the study. Most (78%, CI: 0.67, 0.87) participants were likely to enroll in a registry. Willingness to participate was reduced for registries that required enrollment through the Internet using a password (26%, CI: 0.16, 0.36) or through email (38%, CI: 0.27, 0.49). Respondents acknowledged their expectations that researchers share information about their health and risk for disease and their concerns that their data could be shared with for-profit companies. We found no difference in respondent preferences for registries that shared contact information with researchers, compared to honest broker models that take extra precautions to protect registrant confidentiality (28% versus 30%; p = 0.46). Compared to those preferring a shared information model, respondents who preferred the honest broker model or who lacked model preference voiced increased concerns about sharing registrant data, especially with for-profit organizations. These results suggest that the design of potential participant registries may impact the population enrolled, and hence the population that will eventually be enrolled in clinical studies. Investigators operating registries may need to offer particular assurances about data security to maximize registry enrollment but also must carefully manage participant expectations.
MeSH term(s)	Aged ; Aging ; Attitude ; Biomedical Research ; Confidentiality ; Dementia/epidemiology ; Female ; Follow-Up Studies ; Humans ; Internet ; Longitudinal Studies ; Male ; Registries ; Surveys and Questionnaires
Language	English
Publishing date	2017-01-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-160873
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Article ; Online: Participant Satisfaction With Learning Alzheimer Disease Clinical Trial Results.

Pierce, Aimee L / Cox, Chelsea G / Nguyen, Huong T / Hoang, Dan / Witbracht, Megan / Gillen, Daniel L / Grill, Joshua D

Alzheimer disease and associated disorders

2018 Volume 32, Issue 4, Page(s) 366–368

MeSH term(s)	Aged ; Alzheimer Disease/drug therapy ; Antibodies, Monoclonal, Humanized/administration & dosage ; Clinical Trials as Topic ; Female ; Humans ; Interviews as Topic ; Patient Satisfaction ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; solanezumab (5D6PWO0333)
Language	English
Publishing date	2018-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1002700-2
ISSN	1546-4156 ; 0893-0341
ISSN (online)	1546-4156
ISSN	0893-0341
DOI	10.1097/WAD.0000000000000258
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Article ; Online: Retention of Alzheimer Disease Research Participants.

Grill, Joshua D / Kwon, Jimmy / Teylan, Merilee A / Pierce, Aimee / Vidoni, Eric D / Burns, Jeffrey M / Lindauer, Allison / Quinn, Joseph / Kaye, Jeff / Gillen, Daniel L / Nan, Bin

Alzheimer disease and associated disorders

2019 Volume 33, Issue 4, Page(s) 299–306

Abstract: Introduction: Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research.: Methods: We surveyed representative investigators from NIH- ... ...

Abstract	Introduction: Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research. Methods: We surveyed representative investigators from NIH-funded Alzheimer's Disease Research Centers (ADRC), querying their use of retention tactics across 12 strategies. We compared survey results to data from the National Alzheimer's Coordinating Center for each center. We used a generalized estimating equation with independent working covariance model and empirical standard errors to assess relationships between survey results and rates of retention, controlling for participant characteristics. Results: Twenty-five (83%) responding ADRCs employed an average 42 (SD=7) retention tactics. In a multivariable model that accounted for participant characteristics, the number of retention tactics used by a center was associated with participant retention (odds ratio=1.68, 95% confidence interval: 1.42, 1.98; P<0.001 for the middle compared with the lowest tertile survey scores; odds ratio=1.59, 95% confidence interval: 1.30, 1.94; P<0.001 for the highest compared with the lowest tertile survey scores) at the first follow-up visit. Participant characteristics such as normal cognition diagnosis, older age, higher education, and Caucasian race were also associated with higher retention. Conclusions: Retention in clinical research is more likely to be achieved by employing a variety of tactics.
MeSH term(s)	Aged ; Alzheimer Disease/psychology ; Biomedical Research ; Clinical Trials as Topic ; Female ; Humans ; Male ; Motivation ; Patient Selection ; Surveys and Questionnaires
Language	English
Publishing date	2019-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1002700-2
ISSN	1546-4156 ; 0893-0341
ISSN (online)	1546-4156
ISSN	0893-0341
DOI	10.1097/WAD.0000000000000353
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Article: Combining brain imaging with microarray: isolating molecules underlying the physiologic disorders of the brain.

Pierce, Aimee / Small, Scott A

Neurochemical research

2004 Volume 29, Issue 6, Page(s) 1145–1152

Abstract: Many diseases of the nervous system cause dysfunction by impairing neuronal physiology more than by altering brain anatomy--including age-related cognitive decline, most psychiatric disorders, and even the earliest stages of Alzheimer's disease. The ... ...

Abstract	Many diseases of the nervous system cause dysfunction by impairing neuronal physiology more than by altering brain anatomy--including age-related cognitive decline, most psychiatric disorders, and even the earliest stages of Alzheimer's disease. The absence of clear anatomical markers makes it difficult to identify targeted cells, which in turn impedes attempts to isolate the pathogenic molecules that cause physiologic disruption. Here we show how brain imaging and microarray can be used as complimentary techniques that together can characterize the cellular and molecular aspects of this class of diseases.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aging ; Brain/anatomy & histology ; Brain/growth & development ; Brain/pathology ; Brain Diseases/genetics ; Brain Diseases/physiopathology ; Humans ; Middle Aged ; Oligonucleotide Array Sequence Analysis/methods ; Transcription, Genetic
Language	English
Publishing date	2004-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1023/b:nere.0000023601.50101.7f
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Article ; Online: Constructing a Local Potential Participant Registry to Improve Alzheimer's Disease Clinical Research Recruitment.

Grill, Joshua D / Hoang, Dan / Gillen, Daniel L / Cox, Chelsea G / Gombosev, Adrijana / Klein, Kirsten / O'Leary, Steve / Witbracht, Megan / Pierce, Aimee

Journal of Alzheimer's disease : JAD

2018 Volume 63, Issue 3, Page(s) 1055–1063

Abstract: Potential participant registries are tools to address the challenge of slow recruitment to clinical research. In particular, registries may aid recruitment to secondary prevention clinical trials for Alzheimer's disease (AD), which enroll cognitively ... ...

Abstract	Potential participant registries are tools to address the challenge of slow recruitment to clinical research. In particular, registries may aid recruitment to secondary prevention clinical trials for Alzheimer's disease (AD), which enroll cognitively normal older individuals meeting specific genetic or biomarker criteria. Evidence of registry effectiveness is sparse, as is guidance on optimal designs or methods of conduct. We report our experiences of developing a novel local potential participant registry that implemented online enrollment and data collection. In the first year of operation, 957 individuals submitted email addresses to the registry, of whom 592 self-reported demographic, family history, and medical data. In addition, registrants provided information related to their interest and willingness to be contacted about studies. Local earned media and community education were the most effective methods of recruitment into the registry. Seventy-six (26%) of 298 registrants contacted about studies in the first year enrolled in those studies. One hundred twenty-nine registrants were invited to enroll in a preclinical AD trial, of whom 25 (18%) screened and 6 were randomized. These results indicate that registries can aid recruitment and provide needed guidance for investigators initiating new local registries.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/therapy ; Clinical Trials as Topic ; Female ; Humans ; Internet ; Male ; Middle Aged ; Patient Selection ; Registries ; Young Adult
Language	English
Publishing date	2018-04-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-180069
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