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Article ; Online: Defining osteoblast and adipocyte lineages in the bone marrow.

Pierce, J L / Begun, D L / Westendorf, J J / McGee-Lawrence, M E

2018 Volume 118, Page(s) 2–7

Abstract: Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and ... ...

Abstract	Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and hematopoietic progenitors and their derivative terminal cell types. Amongst these progenitors, bone marrow mesenchymal stem/stromal cells (BMSCs) may differentiate into osteogenic, adipogenic, myogenic, and chondrogenic lineages to support musculoskeletal development as well as tissue homeostasis, regeneration and repair during adulthood. With age, the commitment of BMSCs to osteogenesis slows, bone formation decreases, fracture risk rises, and marrow adiposity increases. An unresolved question is whether osteogenesis and adipogenesis are co-regulated in the bone marrow. Osteogenesis and adipogenesis are controlled by specific signaling mechanisms, circulating cytokines, and transcription factors such as Runx2 and Pparγ, respectively. One hypothesis is that adipogenesis is the default pathway if osteogenic stimuli are absent. However, recent work revealed that Runx2 and Osx1-expressing preosteoblasts form lipid droplets under pathological and aging conditions. Histone deacetylase 3 (Hdac3) and other epigenetic regulators suppress lipid storage in preosteoblasts and/or control marrow adiposity. Establishing a better understanding of fat storage in bone marrow cells, as well as the osteoblast-adipocyte relationship within the bone marrow niche is necessary to understand the mechanisms underlying disease- and aging-related marrow fat storage and may lead to the development of new therapeutic targets for "fatty bone" and osteoporosis.
MeSH term(s)	Adipocytes/cytology ; Adipogenesis ; Aging/physiology ; Animals ; Bone Marrow Cells/cytology ; Cell Lineage ; Humans ; Osteoblasts/cytology
Language	English
Publishing date	2018-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2018.05.019
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Identification of testicular cancer driver genes by a cross-species comparative oncology approach.

Sanchez, A / Xu, L / Pierce, J L / Lafin, J T / Abe, D / Bagrodia, A / Frazier, A L / Amatruda, J F

Andrology

2019 Volume 7, Issue 4, Page(s) 545–554

Abstract: Background: Germ cell tumors arise in the testis, ovary, or extragonadal locations and have a wide range of histopathological and clinical presentations. The relative lack of animal models of germ cell tumors has impeded functional assessment of ... ...

Abstract	Background: Germ cell tumors arise in the testis, ovary, or extragonadal locations and have a wide range of histopathological and clinical presentations. The relative lack of animal models of germ cell tumors has impeded functional assessment of candidate driver genes. Previously, we described the development of testicular germ cell tumors in zebrafish carrying a mutation in bmpr1bb, a BMP family receptor, and demonstrated that human germ cell tumors have defects in BMP signaling. Objective: To further credential the zebrafish model for studies of human germ cell tumor, and to elucidate conserved genetic programs underlying the development of germ cell tumor. Materials and methods: We used genetic techniques to ablate the germ cell lineage in developing fish and tested tumors for loss-of-heterozygosity of the wild-type allele of bmpr1bb. We performed comparative gene expression profiling of zebrafish and human germ cell tumors and carried out functional studies of selected genes. Results: Ablation of germ cells completely prevents testis tumor formation in the fish, definitively establishing the germ cell origin of the tumors. Germ cell tumors in bmpr1bb heterozygous mutants retain the wild-type allele, indicating haploinsufficiency of bmpr1bb as the mechanism of tumor formation. Comparison of RNA-Seq and microarray data from human and zebrafish germ cell tumors revealed a unique overlapping signature shared by the zebrafish tumors with human seminomas, yolk sac tumors, and embryonal carcinomas. The most highly conserved gene set in this cross-species analysis included potential driver genes such as JUP, which we show to be essential for germ cell tumor cell growth. Conclusion: Our findings highlight the value of cross-species comparative oncology for the identification of candidate human cancer genes.
MeSH term(s)	Animals ; Bone Morphogenetic Protein Receptors/genetics ; Cell Line, Tumor ; Genes, Neoplasm ; Genomics ; Humans ; Neoplasms, Germ Cell and Embryonal/genetics ; Testicular Neoplasms/genetics ; Zebrafish
Chemical Substances	Bone Morphogenetic Protein Receptors (EC 2.7.11.30)
Language	English
Publishing date	2019-05-13
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.12644
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Article ; Online: Effect of inorganic or organic selenium supplementation on reproductive performance and tissue trace mineral concentrations in gravid first-parity gilts, fetuses, and nursing piglets.

Ma, Y L / Lindemann, M D / Pierce, J L / Unrine, J M / Cromwell, G L

Journal of animal science

2014 Volume 92, Issue 12, Page(s) 5540–5550

Abstract: The objective of this experiment was to evaluate 2 supplemental forms of Se on reproductive performance and tissue trace mineral concentration in fetus and first-parity gilts during pregnancy and their progeny. Crossbred gilts (n=100) were selected at ... ...

Abstract	The objective of this experiment was to evaluate 2 supplemental forms of Se on reproductive performance and tissue trace mineral concentration in fetus and first-parity gilts during pregnancy and their progeny. Crossbred gilts (n=100) were selected at 183±2.7 d and 137±10 kg BW and fed a common diet. After 1 mo, 8 gilts were sacrificed to establish baseline liver Se concentration and the remaining 92 gilts allotted to receive Se (0.3 mg/kg diet) as inorganic Se (Na2SeO3) or a Se supplement that contains organoselenium compounds (Sel-Plex; Alltech Inc., Nicholasville, KY). At 267±5.7 d (171±11 kg), gilts were estrus-synchronized and bred. Gilts were then slaughtered at defined time points throughout gestation (d 0, 43, 58, 73, 91, 101, or 108 of gestation; n=6 to 12 gilts/time point). A week before the expected farrowing day, 10 pregnant gilts (5 from each treatment) were moved to farrowing crates and monitored. Two pigs from each litter were randomly selected and euthanized at d 0 (within 2 h after birth; nursing deprived), 7, 14, and 21 from each litter. During the gestation phase, maternal liver, and fetal body and liver were collected for determination of trace mineral concentration by inductively coupled plasma mass spectrometry. Total number of fetus, crown-rump length, and corpora lutea of gilts were recorded as well. During the lactation phase, pigs (without liver and gastrointestinal tract) and associated liver were analyzed for Se concentration. The results demonstrated that the source of Se generally did not affect the maternal reproductive traits and fetal characteristics. Also, the source of Se supplemented to the maternal diet did not, in general, affect Cu, Fe, Mn, or Zn concentrations in the tissues evaluated other than the observation of a greater maternal liver Mn content (P<0.01) in gilts fed Sel-Plex and a greater amount of Fe accumulated in the entire litter (P<0.01) in gilts fed Sel-Plex. However, with regard to Se concentrations, Se in fetal body, fetal liver, and maternal liver were greater (P<0.01) when Sel-Plex was fed. Postnatal pigs from gilts fed Sel-Plex had greater (P<0.05) Se retention in body and liver with similar growth performance during the 21-d period. The results demonstrate Se form differences wherein Sel-Plex is associated with greater Se accumulation in both maternal and fetal tissues.
MeSH term(s)	Animals ; Animals, Suckling/metabolism ; Crown-Rump Length ; Dietary Supplements ; Female ; Fetus/metabolism ; Least-Squares Analysis ; Linear Models ; Liver/chemistry ; Mass Spectrometry/veterinary ; Parity ; Pregnancy ; Reproduction/drug effects ; Selenium/administration & dosage ; Selenium/pharmacology ; Sus scrofa/metabolism ; Sus scrofa/physiology ; Swine ; Trace Elements/metabolism
Chemical Substances	Trace Elements ; Selenium (H6241UJ22B)
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/jas.2014-7590
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Article: Should Medicare providers be Peace Corps volunteers?

Pierce, J L

Texas dental journal

1992 Volume 109, Issue 11, Page(s) 27, 33

MeSH term(s)	Economics, Dental ; Health Policy ; Humans ; Medicaid ; United States
Language	English
Publishing date	1992-11
Publishing country	United States
Document type	Letter
ZDB-ID	412554-x
ISSN	0040-4284
ISSN	0040-4284
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Article: Anticipating Stream Ecosystem Responses to Climate Change: Toward Predictions that Incorporate Effects Via Land–Water Linkages

Davis, J. M / Baxter, C. V / Rosi-Marshall, E. J / Pierce, J. L / Crosby, B. T

Ecosystems. 2013 Aug., v. 16, no. 5

2013

Abstract: Climate change (CC) is projected to increase the frequency and severity of natural disturbances (wildfires, insect outbreaks, and debris flows) and shift distributions of terrestrial ecosystems on a global basis. Although such terrestrial changes may ... ...

Abstract	Climate change (CC) is projected to increase the frequency and severity of natural disturbances (wildfires, insect outbreaks, and debris flows) and shift distributions of terrestrial ecosystems on a global basis. Although such terrestrial changes may affect stream ecosystems, they have not been incorporated into predictions of stream responses to CC. Here, we introduce a conceptual framework to evaluate to what extent responses of streams to CC will be driven by not only changes in thermal and hydrologic regimes, but also alterations of terrestrial processes. We focused on forested watersheds of western North America because this region is projected to experience CC-induced alteration of terrestrial processes. This provided a backdrop for investigating interactive effects of climate and terrestrial responses on streams. Because stream responses to terrestrial processes have been well-studied in contexts largely independent of CC research, we synthesized this knowledge to demonstrate how CC-induced alterations of terrestrial ecosystems may affect streams. Our synthesis indicated that altered terrestrial processes will change terrestrial–aquatic linkages and autotrophic production, potentially yielding greater sensitivity of streams to CC than would be expected based on shifts in temperature and precipitation regime alone. Despite uncertainties that currently constrain predictions regarding stream responses to these additional pathways of change, this synthesis highlighted broader effects of CC that require additional research. Based on widespread evidence that CC is linked to changing terrestrial processes, we conclude that accurate predictions of CC effects on streams may be coupled to the accuracy of predictions for long-term changes in terrestrial ecosystems.
Keywords	climate ; climate change ; ecosystems ; forested watersheds ; hydrology ; insects ; streams ; temperature ; wildfires ; North America
Language	English
Dates of publication	2013-08
Size	p. 909-922.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1428921-0
ISSN	1435-0629 ; 1432-9840
ISSN (online)	1435-0629
ISSN	1432-9840
DOI	10.1007/s10021-013-9653-4
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Article ; Audio / Video: Meta-analysis of Laying Hen Trials Using Diets With or Without Allzyme SSF Enzyme Complex

Hooge, D.M / Pierce, J.L / McBride, K.W / Rigolin, P.J

International journal of poultry science. 2010, v. 9, no. 9

2010

Abstract: A statistical meta-analysis was conducted using results from 16 laying hen trials (1995-2008; plus some undated reports) from several countries to demonstrate effects of a dietary enzyme complex (+SSF; Allzyme SSF, Alltech, Inc., Nicholasville, Kentucky ... ...

Abstract	A statistical meta-analysis was conducted using results from 16 laying hen trials (1995-2008; plus some undated reports) from several countries to demonstrate effects of a dietary enzyme complex (+SSF; Allzyme SSF, Alltech, Inc., Nicholasville, Kentucky USA) versus no supplement (nCON, negative control) on 6 performance parameters. The paired t-test (Statistix 8, Analytical Software, Tallahassee, Florida USA) was used in the statistical analysis. A total of 26 comparisons from 16 trials were possible for hen-day egg production, egg weight and daily egg mass production and 24 comparisons from 14 trials were possible for daily feed intake, feed/dozen eggs and kg feed/kg eggs. Overall averages for the parameters were calculated and levels of significance (p-values) were given. The inclusion rates for the enzyme product in the diets was listed. Hen-day egg production was numerically (p = 0.136) improved by 1.09% actual (+1.29% relative) for +SSF compared to nCON diets. Egg weight was significantly (p = 0.006) greater for eggs from hens fed +SSF rather than nCON diets (+0.89 g or +1.49%). Daily egg mass produced was significantly greater (p = 0.014) for +SSF than for nCON fed hens (+1.74 g/hen/day or +3.47%). Feed intake was numerically (p = 0.281) lowered by 0.50 g/hen daily (-0.44%) by using +SSF diets compared to nCON diets. Feed/dozen eggs was significantly (p = 0.028) reduced by 0.027 kg/dozen (1.65%) and kg feed/kg eggs was significantly (p = 0.004) reduced by 0.069 (3.04%) for +SSF diets compared to nCON diets. Enzyme supplementation (Allzyme SSF) at 150 g/tonne of feed is recommended to improve the egg weight, daily egg mass and feed conversion ratios of laying hens.
Keywords	laying hens ; enzymes ; diet ; meta-analysis ; feeds ; dietary supplements ; egg production ; egg weight ; egg masses ; feed intake ; feed conversion
Language	English
Size	p. 824-827.
Document type	Article ; Audio / Video
ZDB-ID	2180471-0
ISSN	1682-8356
ISSN	1682-8356
Database	NAL-Catalogue (AGRICOLA)

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Article ; Audio / Video: Meta-analysis of Broiler Chicken Trials Using Diets With or Without Allzyme SSF Enzyme Complex

Hooge, D.M / Pierce, J.L / McBride, K.W / Rigolin, P.J

International journal of poultry science. 2010, v. 9, no. 9

2010

Abstract: A meta-analysis of body weight and feed conversion ratio results from broiler chicken pen trials plus a few commercial trials (2001-2009) from several countries was conducted to demonstrate effects of a dietary enzyme complex (Allzyme® SSF, Alltech, Inc., ...

Abstract	A meta-analysis of body weight and feed conversion ratio results from broiler chicken pen trials plus a few commercial trials (2001-2009) from several countries was conducted to demonstrate effects of a dietary enzyme complex (Allzyme® SSF, Alltech, Inc., Nicholasville, Kentucky USA) versus no supplement (negative control) on live performance. In the statistical meta-analysis, 28 references provided results for 51 comparisons (paired t-test) from which overall averages for body weight and feed conversion ratio were calculated. The final age (days) in each trial or in the experimental feeding period was noted and an estimate of final age was calculated using the ending age in each trial. Broiler chicken final body weight with the dietary enzyme complex product was found to be 0.057 kg or 3.73% greater than unsupplemented chicken body weight whereas feed conversion ratio was lowered by 0.043 or 2.64% with the enzyme product. These changes in live performance exceed those of Fisher and Wilson (1974) and those predicted by linear regression analysis using data from Jackson et al. (1982) and Waldroup (1996) for 75 extra kcal ME/kg of diet. Therefore, the 75 kcal ME/kg uplift used in the manufacturer's ingredient matrix appears to be conservative for the enzyme complex product based on results in the cited publications. Base on results presented herein, this enzyme complex product is recommended for use in broiler chicken feeds either by addition on top to take advantage of expected benefits or by reformulating the diets with 75 kcal less ME/kg (along with -0.1% calcium, -0.1% available phosphorus and -1% essential amino acids used in formulation). The usual rate of inclusion is 0.02% or 200 g/tonne.
Keywords	broiler chickens ; enzymes ; diet ; meta-analysis ; body weight ; feed conversion ; dietary supplements ; feeds
Language	English
Size	p. 819-823.
Document type	Article ; Audio / Video
ZDB-ID	2180471-0
ISSN	1682-8356
ISSN	1682-8356
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Article: Effects of citric acid, alpha-galactosidase and protease inclusion on in vitro nutrient release from soybean meal and trypsin inhibitor content in raw whole soybeans

Ao, T / Cantor, A.H / Pescatore, A.J / Pierce, J.L / Dawson, K.A

Animal feed science and technology. 2010 Nov. 25, v. 162, no. 1-2

2010

Abstract: An experiment was conducted to evaluate the effects of citric acid (CA) and commercial preparations of α-galactosidase (α-GAL) and protease on in vitro nutrient release from soybean meal (SBM) and trypsin inhibitor (TI) content in raw defatted whole ... ...

Abstract	An experiment was conducted to evaluate the effects of citric acid (CA) and commercial preparations of α-galactosidase (α-GAL) and protease on in vitro nutrient release from soybean meal (SBM) and trypsin inhibitor (TI) content in raw defatted whole soybeans. An in vitro model was used to simulate the chicken's digestive process in the crop, the stomach (proventriculus and gizzard) and the small intestine. Soybean meal and ground whole soybeans were used as substrates. Graded levels of either α-GAL (0-13,792units/kg) or protease (0-888units/kg) and 0 or 20g CA per kg were added to the substrates in a factorial arrangement. Reducing sugars (RS) and α-amino N were measured at the end of the crop phase, the stomach phase, and the whole phase (crop through small intestine). Trypsin inhibitor content was measured at the end of the stomach phase. Increasing α-GAL levels linearly (P<0.01) increased the release of RS in both the crop and the whole phases. Addition of CA with α-GAL further increased enzyme activity, resulting in a significant interaction (P<0.01). Linear increases (P<0.05) in α-amino N occurred with increasing doses of protease at the crop, the stomach and the whole phases. Inclusion of CA in the incubation mixture also increased (P<0.05) α-amino N at all three phases. An interactive effect (P<0.01) between protease and CA was observed only in the crop phase. Neither protease nor CA had an effect on TI activity in raw soybeans. The results suggest that α-GAL and protease may be useful in hydrolyzing the carbohydrates and proteins, respectively, in SBM and the effects of these two enzymes may be enhanced by acidifying the diet.
Keywords	soybean meal ; trypsin inhibitors ; antinutritional factors ; citric acid ; alpha-galactosidase ; proteinases ; in vitro digestibility ; in vitro digestion ; nutrient availability ; in vitro studies ; chickens ; crop (digestive system) ; gizzard ; proventriculus ; small intestine ; soybeans ; dosage ; reducing sugars ; amino nitrogen ; enzymatic hydrolysis ; dietary carbohydrate ; dietary protein ; digestive enzymes ; pH
Language	English
Dates of publication	2010-1125
Size	p. 58-65.
Publishing place	[New York, NY]: Elsevier Science
Document type	Article
ZDB-ID	196563-3
ISSN	0377-8401
ISSN	0377-8401
DOI	10.1016/j.anifeedsci.2010.08.014
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Article: Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat.

Hoane, M R / Pierce, J L / Holland, M A / Anderson, G D

Neuroscience

2008 Volume 154, Issue 3, Page(s) 861–868

Abstract: Recent studies have demonstrated nicotinamide (NAM), a soluble B-group vitamin, to be an effective treatment in experimental models of traumatic brain injury (TBI). However, research on this compound has been limited to administration regimens starting ... ...

Abstract	Recent studies have demonstrated nicotinamide (NAM), a soluble B-group vitamin, to be an effective treatment in experimental models of traumatic brain injury (TBI). However, research on this compound has been limited to administration regimens starting shortly after injury. This study was conducted to establish the window of opportunity for NAM administration following controlled cortical impact (CCI) injury to the frontal cortex. Groups of rats were assigned to NAM (50 mg/kg), saline (1 ml/kg), or sham conditions and received contusion injuries or sham procedures. Injections of NAM or saline were administered at 15 min, 4 h, or 8 h post-injury, followed by five boosters at 24 h intervals. Following the last injection, blood was taken for serum NAM analysis. Animals were tested on a variety of tasks to assess somatosensory performance (bilateral tactile adhesive removal and vibrissae-forelimb placement) and cognitive performance (reference and working memory) in the Morris water maze. The results of the serum NAM analysis showed that NAM levels were significantly elevated in treated animals. Behavioral analysis on the tactile removal test showed that all NAM-treated groups facilitated recovery of function compared with saline treatment. On the vibrissae-forelimb placing test all NAM-treated groups also were significantly different from the saline-treated group. However, the acquisition of reference memory was only significantly improved in the 15-min and 4-h groups. In the working memory task both the 15-min and 4-h groups also improved working memory compared with saline treatment. The window of opportunity for NAM treatment is task-dependent and extends to 8 h for the sensorimotor tests but only extends to 4 h post-injury in the cognitive tests. These results suggest that a 50 mg/kg treatment regimen starting at the clinically relevant time point of 4 h may result in attenuated injury severity in the human TBI population.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Brain/pathology ; Brain Injuries/drug therapy ; Brain Injuries/pathology ; Brain Injuries/psychology ; Memory/drug effects ; Niacinamide/blood ; Niacinamide/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Touch/drug effects ; Vibrissae/drug effects ; Vitamins/blood ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Niacinamide (25X51I8RD4)
Language	English
Publishing date	2008-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2008.04.044
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Article: An evaluation of residential treatment for sexually aggressive youth.

Shapiro, J P / Welker, C J / Pierce, J L

Journal of child sexual abuse

2005 Volume 10, Issue 1, Page(s) 1–21

Abstract: This longitudinal study investigated the effectiveness of a one and one-half year long residential treatment program for 26 boys aged 11-15 with histories of sexually aggressive behavior. The clients were assessed with self-report and staff-report ... ...

Abstract	This longitudinal study investigated the effectiveness of a one and one-half year long residential treatment program for 26 boys aged 11-15 with histories of sexually aggressive behavior. The clients were assessed with self-report and staff-report measures at the beginning and end of treatment and at several time points in between; also, aggressive acts were tabulated during a one-year follow-up period. There was evidence of improved functioning on 10 of the 12 measures. During the follow-up, 27% of the sample committed an aggressive act, and 8% committed a sexually aggressive act. On most of the measures, improvement occurred gradually over the course of treatment, and on some measures most of the improvement occurred late in the placement.
MeSH term(s)	Adolescent ; Aggression/psychology ; Child ; Child Abuse/statistics & numerical data ; Cognition ; Follow-Up Studies ; Humans ; Juvenile Delinquency/prevention & control ; Juvenile Delinquency/statistics & numerical data ; Male ; Personality Disorders/diagnosis ; Personality Disorders/epidemiology ; Personality Inventory ; Residential Treatment ; Sex Offenses/prevention & control ; Sexual Behavior/psychology
Language	English
Publishing date	2005-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1158969-3
ISSN	1547-0679 ; 1053-8712
ISSN (online)	1547-0679
ISSN	1053-8712
DOI	10.1300/j070v10n01_01
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