LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article ; Online: Personally Collected Health Data for Precision Medicine and Longitudinal Research

Pierluigi D'Antrassi / Marco Prenassi / Lorenzo Rossi / Roberta Ferrucci / Sergio Barbieri / Alberto Priori / Sara Marceglia

Frontiers in Medicine, Vol

2019 Volume 6

Abstract: Health data autonomously collected by users are presently considered as largely beneficial for wellness, prevention, disease management, as well as clinical research, especially when longitudinal, chronic, home-based monitoring is needed. However, data ... ...

Abstract	Health data autonomously collected by users are presently considered as largely beneficial for wellness, prevention, disease management, as well as clinical research, especially when longitudinal, chronic, home-based monitoring is needed. However, data quality and reliability are the main barriers to overcome, in order to exploit such potential. To this end, we designed, implemented, and tested a system to integrate patient-generated personally collected health data into the clinical research data workflow, using a standards-based architecture that ensures the fulfillment of the major requirements for digital data in clinical studies. The system was tested in a clinical investigation for the optimization of deep brain stimulation (DBS) therapy in patients with Parkinson's disease that required both the collection of patient-generated data and of clinical and neurophysiological data. The validation showed that the implemented system was able to provide a reliable solution for including the patient as direct digital data source, ensuring reliability, integrity, security, attributability, and auditability of data. These results suggest that personally collected health data can be used as a reliable data source in longitudinal clinical research, thus improving holistic patient's personal assessment and monitoring.
Keywords	personal health records ; personal health systems ; personal health monitoring ; telehealth ; longitudinal studies ; Medicine (General) ; R5-920
Subject code	027
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Fiber Bragg Grating sensors for deformation monitoring of GEM foils in HEP detectors

Benussi, L. / Bianco, S. / Caponero, M. / Muhammad, S. / Passamonti, L. / Piccolo, D. / Pierluigi, D. / Raffone, G. / Russo, A. / Saviano, G.

2015

Abstract: Fiber Bragg Grating (FBG) sensors have been so far mainly used in high energy physics (HEP) as high precision positioning and re-positioning sensors and as low cost, easy to mount, radiation hard and low space- consuming temperature and humidity devices. ...

Abstract	Fiber Bragg Grating (FBG) sensors have been so far mainly used in high energy physics (HEP) as high precision positioning and re-positioning sensors and as low cost, easy to mount, radiation hard and low space- consuming temperature and humidity devices. FBGs are also commonly used for very precise strain measurements. In this work we present a novel use of FBGs as flatness and mechanical tensioning sensors applied to the wide Gas Electron Multiplier (GEM) foils of the GE1/1 chambers of the Compact Muon Solenoid (CMS) experiment at Large Hadron Collider (LHC) of CERN. A network of FBG sensors has been used to determine the optimal mechanical tension applied and to characterize the mechanical stress applied to the foils. The preliminary results of the test performed on a full size GE1/1 final prototype and possible future developments will be discussed. Comment: Four pages, seven figures. Presented by Michele Caponero at IWASI 2015, Gallipoli (Italy)
Keywords	Physics - Instrumentation and Detectors
Subject code	621
Publishing date	2015-12-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Autologous Unpurged Bone Marrow Transplantation for Acute Non Lymphoblastic Leukemia in First Remission.

Carella, A M / Nati, S / Carlier, P / Pierluigi, D / Giordano, D / Congiu, A / Santini, G / Scarpati, D / Barra, S / Corvo, R / Vitale, V / Raffo, M R / Cerri, R / Risso, M / Spriano, M / Vimercati, R / Pungolino, E / Bacigalupo, A / Damasio, E

Leukemia & lymphoma

2016 Volume 5, Issue 1, Page(s) 43–47

Abstract: Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed ... ...

Abstract	Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT. The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants.
Language	English
Publishing date	2016-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428199109068103
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2997: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Book ; Online: Preliminary results of Resistive Plate Chambers operated with eco-friendly gas mixtures for application in the CMS experiment

Abbrescia, M. / Van Auwegem, P. / Benussi, L. / Bianco, S. / Cauwenbergh, S. / Ferrini, M. / Muhammad, S. / Passamonti, L. / Pierluigi, D. / Piccolo, D. / Primavera, F. / Russo, A. / Saviano, G. / Tytgat, M.

2016

Abstract: The operations of Resistive Plate Chambers in LHC experiments require Fluorine based (F-based) gases for optimal performance. Recent European regulations demand the use of environmentally unfriendly F-based gases to be limited or banned. In view of the ... ...

Abstract	The operations of Resistive Plate Chambers in LHC experiments require Fluorine based (F-based) gases for optimal performance. Recent European regulations demand the use of environmentally unfriendly F-based gases to be limited or banned. In view of the CMS experiment upgrade, several tests are ongoing to measure the performance of the detector with these new ecological gas mixtures, in terms of efficiency, streamer probability, induced charge and time resolution. Prototype chambers with readout pads and with the standard CMS electronic setup are under test. In this paper preliminary results on performance of RPCs operated with a potential eco-friendly gas candidate 1,3,3,3-Tetrafluoropropene, commercially known as HFO-1234ze, with CO2 and CF3I based gas mixtures are presented and discussed for the possible application in the CMS experiment. Comment: 7 pages, 7 figures. arXiv admin note: text overlap with arXiv:1505.01648
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2016-05-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Eco-friendly gas mixtures for Resistive Plate Chambers based on Tetrafluoropropene and Helium

Abbrescia, M. / Benussi, L. / Bianco, S. / Ferrini, M. / Muhammad, S. / Passamonti, L. / Pierluigi, D. / Piccolo, D. / Primavera, F. / Russo, A. / Saviano, G.

2016

Abstract: Due to the recent restrictions deriving from the application of the Kyoto protocol, the main components of the gas mixtures presently used in the Resistive Plate Chambers systems of the LHC experiments will be most probably phased out of production in ... ...

Abstract	Due to the recent restrictions deriving from the application of the Kyoto protocol, the main components of the gas mixtures presently used in the Resistive Plate Chambers systems of the LHC experiments will be most probably phased out of production in the coming years. Identifying possible replacements with the adequate characteristics requires an intense R&D, which was recently started, also in collaborations across the various experiments. Possible candidates have been proposed and are thoroughly investigated. Some tests on one of the most promising candidate - HFO-1234ze, an allotropic form of tetrafluoropropane- have already been reported. Here an innovative approach, based on the use of Helium, to solve the problems related to the too elevate operating voltage of HFO-1234ze based gas mixtures, is discussed and the relative first results are shown. Comment: 9 pages, 6 figures, 1 table
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2016-05-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Utilità del dosaggio del precursore del peptide natriuretico cerebrale come predittore di cardioversione efficace nei pazienti con tachicardie e tachiaritmie sopraventricolari, osservati e trattati in Pronto Soccorso.

Magioncalda, Antonio / Sartini, Marina / Costaguta, Chiara / Castellaneta, Marco / Schenone, Emanuela / Tognoni, Elisabetta / Pierluigi, Daniela / Cremonesi, Paolo

Recenti progressi in medicina

2008 Volume 99, Issue 3, Page(s) 141–145

Abstract: Many patients arrive at the emergency room (ER) with recent-onset atrial fibrillation or other forms of supraventricular tachyarrhythmia (SV Ta) or tachycardia. The restoration of sinus rhythm (SR) is always desirable and, in addition, can enable many ... ...

Title translation	The utility of assaying the N-terminal of brain natriuretic peptide precursor (NT pro-BNP) to predict the clinical outcome in patients with supraventricular tachyarrhythmias observed and treated in the emergency room.
Abstract	Many patients arrive at the emergency room (ER) with recent-onset atrial fibrillation or other forms of supraventricular tachyarrhythmia (SV Ta) or tachycardia. The restoration of sinus rhythm (SR) is always desirable and, in addition, can enable many hospitalisations to be avoided, thereby achieving considerable savings in financial and healthcare resources. Even in haemodynamically stable cases, it is clearly useful to be able to evaluate which subjects will benefit most from attempts to restore SR, even when few truly diagnostic means are on hand (such as echocardiography, which is not always promptly available in the ER setting). We evaluated the brain natriuretic peptide precursor (N terminal pro-BNP) in 105 patients arriving at the ER. We observed that SR was restored in a low percentage of patients with values > 4500, while the vast majority of those with values < 1500 was normalised even by means of antiarrhythmic drugs alone. It is therefore probable that a medium-low value of the hormone indicates only an acute response to the distension of the atrial tissue induced by the arrhythmia; by contrast, decidedly elevated values are probably also caused by ventricular dysfunction and therefore indicate a lesser likelihood of restoring SR. The routine evaluation of NT pro-BNP could be used as an alternative to echocardiography in order to rapidly select patients in whom cardioversion should be attempted in the ER or Brief Observation Unit.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/blood ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/therapy ; Electric Countershock ; Emergency Service, Hospital ; Female ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prognosis ; Prospective Studies ; Statistics, Nonparametric ; Tachycardia, Supraventricular/blood ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/drug therapy ; Tachycardia, Supraventricular/therapy ; Treatment Outcome
Chemical Substances	Anti-Arrhythmia Agents ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	Italian
Publishing date	2008-03
Publishing country	Italy
Document type	Comparative Study ; English Abstract ; Evaluation Studies ; Journal Article
ZDB-ID	138266-4
ISSN	0034-1193
ISSN	0034-1193
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: La leucemia mieloide cronica. Nuove prospettive con l'autotrapianto di midollo.

Carella, A M / Carlier, P / Nati, S / Congiu, A / Pierluigi, D / Raffo, M R

Haematologica

1991 Volume 76 Suppl 3, Page(s) 337–351

Title translation	Chronic myeloid leukemia. New prospects for marrow autotransplantation.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Blast Crisis/surgery ; Bone Marrow Purging ; Bone Marrow Transplantation ; Clone Cells/pathology ; Combined Modality Therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunologic Factors/therapeutic use ; Interferon-alpha/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/surgery ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy ; Leukemia, Myeloid, Chronic-Phase/surgery ; Neoplastic Stem Cells/pathology ; Philadelphia Chromosome ; Remission Induction ; Transplantation, Autologous
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; Immunologic Factors ; Interferon-alpha
Language	Italian
Publishing date	1991-06
Publishing country	Italy
Document type	Clinical Trial ; Journal Article ; Review
ZDB-ID	2333-4
ISSN	1592-8721 ; 0390-6078 ; 0017-6567
ISSN (online)	1592-8721
ISSN	0390-6078 ; 0017-6567
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.76: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Fludarabine in combination with cyclophosphamide or with cyclophosphamide plus mitoxantrone for relapsed or refractory low-grade non-Hodgkin's lymphoma.

Santini, G / Nati, S / Spriano, M / Gallamini, A / Pierluigi, D / Congiu, A M / Truini, M / Rubagotti, A / Chisesi, T / Vimercati, R / Rossi, E / Sertoli, M R / Mattei, D / Marino, G / Gobbi, M

Haematologica

2001 Volume 86, Issue 3, Page(s) 282–286

Abstract: Background and objectives: We report the activity of two combinations of fludarabine (FLU), one with cyclophosphamide (FLU/CY) and the second with CY plus mitoxantrone (FLU/CY/MITO). The aim of the study was to evaluate the activity and toxicity of ... ...

Abstract	Background and objectives: We report the activity of two combinations of fludarabine (FLU), one with cyclophosphamide (FLU/CY) and the second with CY plus mitoxantrone (FLU/CY/MITO). The aim of the study was to evaluate the activity and toxicity of these two schedules in patients with non-Hodgkin's lymphoma (NHL). Design and methods: Twenty-two patients with recurrent low grade non-Hodgkin's lymphoma (LGL) received FLU/CY (FLU 25 mg/m(2) days 1 to 3, CY 300 mg/m(2) days 1 to 3), and 31 patients received FLU/CY/MITO (FLU 25 mg/m(2) days 1 to 3, CY 300 mg/m(2) days 1 to 3, mitoxantrone 10 mg/m(2) day 1). Patients received antibiotic oral prophylaxis during all treatments and growth factors (G-CSF) when grade III granulocytopenia (WHO scale) occurred. Results: Of the 53 patients, 31 achieved complete remission (CR) (58%) and 16 partial remission (PR) (30%). Response was similar in both arms of the study. After 3 courses, 77% of patients who achieved CR showed a complete disappearance of disease. Seventy-nine per cent of patients experienced granulocytopenia. Few patients had fever, all without infection. One patient died with fever of unknown origin three months after completion of six courses of treatment. Interpretation and conclusions: Both treatments were seen to be effective in recurrent low-grade NHL. Antibiotic prophylaxis with G-CSF support seems to reduce treatment-related infection.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/toxicity ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/toxicity ; Female ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Male ; Middle Aged ; Mitoxantrone/administration & dosage ; Mitoxantrone/toxicity ; Recurrence ; Treatment Outcome ; Vidarabine/administration & dosage ; Vidarabine/analogs & derivatives
Chemical Substances	Cyclophosphamide (8N3DW7272P) ; Mitoxantrone (BZ114NVM5P) ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
Language	English
Publishing date	2001-03
Publishing country	Italy
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	2333-4
ISSN	1592-8721 ; 0390-6078 ; 0017-6567
ISSN (online)	1592-8721
ISSN	0390-6078 ; 0017-6567
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.76: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: CMS RPC Background -- Studies and Measurements

Hadjiiska, R. / Samalan, A. / Tytgat, M. / Zaganidis, N. / Alves, G. A. / Marujo, F. / De Araujo, F. Torres Da Silva / Da Costa, E. M. / Damiao, D. De Jesus / Nogima, H. / Santoro, A. / De Souza, S. Fonseca / Aleksandrov, A. / Iaydjiev, P. / Rodozov, M. / Shopova, M. / Sultanov, G. / Bonchev, M. / Dimitrov, A. /

Litov, L. / Pavlov, B. / Petkov, P. / Petrov, A. / Qian, S. J. / Bernal, C. / Cabrera, A. / Fraga, J. / Sarkar, A. / Elsayed, S. / Assran, Y. / Sawy, M. El / Mahmoud, M. A. / Mohammed, Y. / Combaret, C. / Gouzevitch, M. / Grenier, G. / Laktineh, I. / Mirabito, L. / Shchablo, K. / Bagaturia, I. / Lomidze, D. / Lomidze, I. / Bhatnagar, V. / Gupta, R. / Kumari, P. / Singh, J. / Amoozegar, V. / Boghrati, B. / Ebraimi, M. / Ghasemi, R. / Najafabadi, M. Mohammadi / Zareian, E. / Abbrescia, M. / Aly, R. / Elmetenawee, W. / De Filippis, N. / Gelmi, A. / Iaselli, G. / Leszki, S. / Loddo, F. / Margjeka, I. / Pugliese, G. / Ramos, D. / Caponero, M. / Benussi, L. / Bianco, S. / Colafranceschi, S. / Russo, A. / Passamonti, L. / Piccolo, D. / Pierluigi, D. / Saviano, G. / Buontempo, S. / Di Crescenzo, A. / Fienga, F. / De Lellis, G. / Lista, L. / Meola, S. / Paolucci, P. / Braghieri, A. / Salvini, P. / Montagna, P. / Riccardi, C. / Vitulo, P. / Francois, B. / Kim, T. J. / Park, J. / Choi, S. Y. / Hong, B. / Lee, K. S. / Goh, J. / Lee, H. / Eysermans, J. / Estrada, C. Uribe / Pedraza, I. / Castilla-Valdez, H. / Sanchez-Hernandez, A. / Herrera, C. A. Mondragon / Navarro, D. A. Perez / Sanchez, G. A. Ayala / Carrillo, S. / Vazquez, E. / Radi, A. / Ahmad, A. / Asghar, I. / Hoorani, H. / Muhammad, S. / Shah, M. A. / Crotty, I.

2020

Abstract: The expected radiation background in the CMS RPC system has been studied using the MC prediction with the CMS FLUKA simulation of the detector and the cavern. The MC geometry used in the analysis describes very accurately the present RPC system but still ...

Abstract	The expected radiation background in the CMS RPC system has been studied using the MC prediction with the CMS FLUKA simulation of the detector and the cavern. The MC geometry used in the analysis describes very accurately the present RPC system but still does not include the complete description of the RPC upgrade region with pseudorapidity $1.9 < \lvert \eta \rvert < 2.4$. Present results will be updated with the final geometry description, once it is available. The radiation background has been studied in terms of expected particle rates, absorbed dose and fluence. Two High Luminosity LHC (HL-LHC) scenarios have been investigated - after collecting $3000$ and $4000$ fb$^{-1}$. Estimations with safety factor of 3 have been considered, as well. Comment: 6 pages, Conference proceeding for the 2020 Resistive Plate Chambers and Related Detectors. Minor revision of the report, the results remain unchanged. Three new plots are added and some details were explained better
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2020-05-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Mobilization of cytogenetically 'normal' blood progenitors cells by intensive conventional chemotherapy for chronic myeloid and acute lymphoblastic leukemia.

Carella, A M / Pollicardo, N / Pungolino, E / Raffo, M R / Podesta, M / Ferrero, R / Pierluigi, D / Nati, S / Naibo, K / Congiu, A

Leukemia & lymphoma

1993 Volume 9, Issue 6, Page(s) 477–483

Abstract: Various lines of evidence suggest that substantial numbers of very primitive normal hematopoietic cells persist in the marrow of most patients with CML, despite the presence of an expanded Philadelphia-Chromosome (Ph) positive population, and that normal ...

Abstract	Various lines of evidence suggest that substantial numbers of very primitive normal hematopoietic cells persist in the marrow of most patients with CML, despite the presence of an expanded Philadelphia-Chromosome (Ph) positive population, and that normal clones might, in certain circumstances, have a proliferative advantage over leukemic populations. We have recently demonstrated in 5/8 CML patients with blastic phase (BP) that the blood progenitor cells/(BPC) harvested during early recovery from marrow aplasia were Ph-negative on cytogenetic analysis, suggesting that leukapheresis may provide a useful source of 'normal' progenitors for subsequent reinfusions. We report here an update on 40 patients with Ph + CML and 9 patients with ALL in first or subsequent relapses with associated cytogenetic translocations including t(8;14) t(4;8) t(4;11) and t(9;22). All these patients received intensive conventional chemotherapy and during early recovery from marrow aplasia, when the WBC reached 0.5-2.0 x 10(9)/L, BPC were collected by 4-8 leukapheresis and tested for the persistence of the marker translocations and, when possible, for the presence of the hybrid bcr/abl transcripts by polymerase chain reaction (PCR). In seven out of 10 patients with chronic phase CML, BPC were Ph-negative and in 5 PCR negative. In both accelerated phase patients, BPC were Ph-negative but PCR-positive and in eight out of 28 blastic CML patients, BPC were Ph-negative and in two cases also PCR-negative. Six out of 9 ALL patients, lost the cytogenic translocations. After complete recovery, 16 patients were subsequently given high-dose therapy followed by reinfusion of 'normal' BPC.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Agents/therapeutic use ; Base Sequence ; Bone Marrow Transplantation ; Female ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/drug effects ; Humans ; Leukapheresis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/blood ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Middle Aged ; Molecular Sequence Data ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Translocation, Genetic
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	1993-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428199309145754
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2997: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito