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  1. Article ; Online: Massive Ischemic Strokes in a Young Patient With Severe Coronavirus Disease 2019 Pneumonia.

    Achebe, Ikechukwu / Nagubadi, Swamy / Pierre-Louis, Serge J C

    Journal of investigative medicine high impact case reports

    2021  Volume 9, Page(s) 23247096211028389

    Abstract: Stroke is an identified sequela of severe coronavirus disease 2019 (COVID-19) infection. While the pathophysiology remains poorly understood, endothelial dysfunction and intravascular thrombosis secondary to sepsis-induced hypercoagulability likely ... ...

    Abstract Stroke is an identified sequela of severe coronavirus disease 2019 (COVID-19) infection. While the pathophysiology remains poorly understood, endothelial dysfunction and intravascular thrombosis secondary to sepsis-induced hypercoagulability likely increase the risk of stroke. This report describes the rare case of an otherwise healthy 42-year-old male who developed large bilateral ischemic infarcts during admission for severe hypoxemic respiratory failure secondary to COVID pneumonia. This report adds to scarce literature describing massive cerebrovascular injury in COVID patients and emphasizes the importance of increased clinical suspicion for stroke in patients who exhibit acute change in mental status or motor function, as well as rapid clinical deterioration.
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096211028389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of von Willebrand factor D4 domain mutations in patients of Afro-Caribbean descent: In vitro characterization.

    Dubois, Marie-Daniéla / Peyron, Ivan / Pierre-Louis, Olivier-Nicolas / Pierre-Louis, Serge / Rabout, Johalène / Boisseau, Pierre / de Jong, Annika / Susen, Sophie / Goudemand, Jenny / Neviere, Rémi / Fuseau, Pascal / Christophe, Olivier D / Lenting, Peter J / Denis, Cécile V / Casari, Caterina

    Research and practice in thrombosis and haemostasis

    2022  Volume 6, Issue 4, Page(s) e12737

    Abstract: Background: Von Willebrand disease was diagnosed in two Afro-Caribbean patients and sequencing of the VWF gene (: Objectives: Our goal was to characterize how the D4 variants p.(Pro2145Thrfs*5) and p.(Cys2216Phefs*9) influenced VWF biosynthesis/ ... ...

    Abstract Background: Von Willebrand disease was diagnosed in two Afro-Caribbean patients and sequencing of the VWF gene (
    Objectives: Our goal was to characterize how the D4 variants p.(Pro2145Thrfs*5) and p.(Cys2216Phefs*9) influenced VWF biosynthesis/secretion and functions using in vitro assays.
    Methods: Recombinant VWF (rVWF), mutant or wild-type, was produced via transient transfection of the human embryonic kidney cell line 293T. The use of different tags for the wild-type and the mutant allele allowed us to distinguish between the two forms when measuring VWF antigen in medium and cell lysates. Binding of rVWF to its ligands, collagen, factor VIII, ADAMTS13, and platelet receptors was also investigated.
    Results: Homozygous expression of the p.(Cys2216Phefs*9)-rVWF mutation resulted in an almost complete intracellular retention of the protein. Heterozygous expression led to secretion of almost exclusively wild-type-rVWF, logically capable of normal interaction with the different ligands. In contrast, the p.(Pro2145Thrfs*5)-rVWF exhibited reduced binding to type III collagen and αIIbβ3 integrin compared to wild-type-rVWF.
    Conclusions: We report two mutations of the D4 domains that induced combined qualitative and quantitative defects.
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient.

    Dubois, Marie Daniela / Pierre-Louis, Serge / Rabout, Johalène / Denis, Cécile V / Christophe, Olivier / Susen, Sophie / Goudemand, Jenny / Boisseau, Pierre / Neviere, Rémi / Pierre-Louis, Olivier

    TH open : companion journal to thrombosis and haemostasis

    2020  Volume 4, Issue 4, Page(s) e318–e321

    Language English
    Publishing date 2020-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0040-1718703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient

    Dubois, Marie Daniela / Pierre-Louis, Serge / Rabout, Johalène / Denis, Cécile V. / Christophe, Olivier / Susen, Sophie / Goudemand, Jenny / Boisseau, Pierre / Neviere, Rémi / Pierre-Louis, Olivier

    TH Open

    2020  Volume 04, Issue 04, Page(s) e318–e321

    Language English
    Publishing date 2020-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0040-1718703
    Database Thieme publisher's database

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  5. Article ; Online: Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium.

    Pierre-Louis, Serge J C / Brannegan, Richard T / Evans, Arthur T

    Clinical neurology and neurosurgery

    2009  Volume 111, Issue 5, Page(s) 437–441

    Abstract: Objectives: To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium.: Methods: Prospective ... ...

    Abstract Objectives: To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium.
    Methods: Prospective evaluation of consecutive adult outpatients at an urban public hospital who were followed for 6 months after switching drug formulations. Seizure frequency was estimated from patient self-reports. Medication side-effects were monitored with a structured interview (tremor, fatigue, GI upset, hair loss), physician exam (nystagmus, tremor), a drawing test (tremor) and a specific 25-item questionnaire assessing the impact of tremor on activities of daily living.
    Results: Forty-seven patients were included in the study but six patients were either lost to follow-up or had insufficient data. Seizure frequency and side-effect profile did not change significantly after switching drug formulations. However, patients had significant subjective improvement in their tremor with the extended-release formulation as assessed by the 25-item questionnaire (p=0.009 at 3 months and p=0.04 at 6 months); other measures of tremor severity showed no change during the 6-month follow-up period. Most patients (71%) preferred the extended-release formulation.
    Conclusion: Patients with epilepsy can be switched overnight from standard to extended-release divalproex sodium, without significant change in seizure frequency and drug side-effect profile. Most patients prefer the extended-release formulation, in part due to subjective decrease in tremor during daily activities.
    MeSH term(s) Activities of Daily Living ; Adult ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Body Weight/drug effects ; Cohort Studies ; Data Interpretation, Statistical ; Delayed-Action Preparations ; Epilepsy/drug therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Patient Satisfaction ; Prospective Studies ; Seizures/drug therapy ; Seizures/etiology ; Tremor/prevention & control ; Valproic Acid/administration & dosage ; Valproic Acid/adverse effects ; Valproic Acid/therapeutic use ; Young Adult
    Chemical Substances Anticonvulsants ; Delayed-Action Preparations ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2009-06
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2008.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hepatitis C virus (HCV) genotypes in the Caribbean island of Martinique: evidence for a large radiation of HCV-2 and for a recent introduction from Europe of HCV-4.

    Martial, Jenny / Morice, Yoann / Abel, Sylvie / Cabié, André / Rat, Christelle / Lombard, Frédéric / Edouard, André / Pierre-Louis, Serge / Garsaud, Philippe / Béra, Odile / Chout, Roger / Gordien, Emmanuel / Deny, Paul / Césaire, Raymond

    Journal of clinical microbiology

    2003  Volume 42, Issue 2, Page(s) 784–791

    Abstract: Molecular epidemiological studies of hepatitis C virus (HCV) in the Caribbean may help to specify the origin and spread of HCV infection. Indeed, the Caribbean population is intermixed from European and African origins and geographically close to the ... ...

    Abstract Molecular epidemiological studies of hepatitis C virus (HCV) in the Caribbean may help to specify the origin and spread of HCV infection. Indeed, the Caribbean population is intermixed from European and African origins and geographically close to the American continent. We characterized HCV genotypes in the Caribbean island of Martinique. HCV genotypes were analyzed by sequencing or reverse hybridization in the 5' noncoding region (5'NC) in 250 HCV-monoinfected and 85 HCV-human immunodeficiency virus (HIV)-coinfected patients. In addition, sequencing in the nonstructural 5B (NS5B) gene was required to determine the subtype or to perform phylogenetic analysis in selected samples. Genotypes 1 to 6 were found, respectively, in 84.4, 6.8, 5.2, 2.8, 0.4, and 0.4% of 250 HCV-monoinfected patients and in 71.7, 7.1, 15.3, 5.9, 0, and 0% of 85 HCV-HIV-coinfected patients. HCV-1b was found in 66.4% of the HCV-monoinfected patients and was associated with blood transfusion, whereas HCV-1a was detected in 41.2% of the HCV-HIV-coinfected patients and was associated with intravenous drug use (IVDU). The HCV-3 strains belonged to subtype 3a and were linked to IVDU. Phylogenetic analyses were focused on HCV-2 and HCV-4, which are common in Africa. Two opposite patterns were evidenced. NS5B sequences from 19 HCV-2 isolates were affiliated with many different subtypes described either in Europe or in West Africa, suggesting an ancient radiation. In contrast, seven of the nine HCV-4 NS5B sequences ranged within HCV-4a and HCV-4d clusters spreading in continental France by the IVDU route. Epidemiological data demonstrate the recent introduction of HCV-4a and -4d subtypes into the Caribbean.
    MeSH term(s) Adult ; Age Distribution ; Aged ; Europe ; Female ; Genotype ; Hepacivirus/classification ; Hepacivirus/genetics ; Hepatitis C/classification ; Hepatitis C/epidemiology ; Humans ; Male ; Martinique/epidemiology ; Middle Aged ; Phylogeny ; RNA, Viral/genetics ; RNA, Viral/isolation & purification
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2003-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.42.2.784-791.2004
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