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  1. Article ; Online: Outbreak of silicosis in workers producing silica-based artificial kerbstones

    Steven Ronsmans / Pieter Goeminne / Vicky Nowé / Eline Vandebroek / Stephan Keirsbilck / Birgit Weynand / Peter HM. Hoet / Jeroen AJ. Vanoirbeek / Wim A. Wuyts / Jonas Yserbyt / Benoit Nemery

    Safety and Health at Work, Vol 13, Iss , Pp S255- (2022)

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: What is important for people with nontuberculous mycobacterial disease? An EMBARC-ELF patient survey

    Michal Shteinberg / Jeanette Boyd / Stefano Aliberti / Eva Polverino / Bridget Harris / Tove Berg / Annette Posthumus / Thomas Ruddy / Pieter Goeminne / Ernie Lloyd / Timothy Alan / Josje Altenburg / Barbara Crossley / Francesco Blasi / James Chalmers

    ERJ Open Research, Vol 7, Iss

    2021  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Recommendations for travelling with bronchiectasis

    Michal Shteinberg / Barbara Crossley / Tal Lavie / Sima Nadler / Jeanette Boyd / Felix C. Ringshausen / Tim Aksamit / James D. Chalmers / Pieter Goeminne

    ERJ Open Research, Vol 5, Iss

    a joint ELF/EMBARC/ERN-Lung collaboration

    2019  Volume 4

    Abstract: Introduction People with bronchiectasis frequently request specialist advice to prepare for travelling, but there are few publications providing advice on safe travel with bronchiectasis. There is a need for recommendations on adapting everyday treatment ...

    Abstract Introduction People with bronchiectasis frequently request specialist advice to prepare for travelling, but there are few publications providing advice on safe travel with bronchiectasis. There is a need for recommendations on adapting everyday treatment to the requirements during travelling. Methods A panel of 13 patient volunteers formulated questions regarding different aspects of travelling, including safety of travel, maintaining regular treatment during travel, and dealing with deterioration while away. Patient input was used to derive a questionnaire and circulated among a panel of bronchiectasis experts. Where 80% or more experts agreed on a response, a recommendation was made. Results A total of 26 bronchiectasis experts answered the questionnaire. Recommendations were made on safety of travel, choice of destinations and activities, choice of travel insurance, carrying medications and devices, maintaining regular treatments in transport, documentation to be provided and oxygen requirements. Some statements did not reach an 80% agreement; in many cases these statements may be valid for some, but not all bronchiectasis patients. Conclusions The general agreement was that it is considered safe for most people with bronchiectasis to travel. Careful planning and preparation with robust communication between patients and their healthcare provider prior to travel for different scenarios is fundamental to a successful journey.
    Keywords Medicine ; R
    Subject code 380
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Azithromycin for treatment of hospitalised COVID-19 patients

    Iwein Gyselinck / Laurens Liesenborghs / Ann Belmans / Matthias M. Engelen / Albrecht Betrains / Quentin Van Thillo / Pham Anh Hong Nguyen / Pieter Goeminne / Ann-Catherine Soenen / Nikolaas De Maeyer / Charles Pilette / Emmanuelle Papleux / Eef Vanderhelst / Aurélie Derweduwen / Patrick Alexander / Bernard Bouckaert / Jean-Benoît Martinot / Lynn Decoster / Kurt Vandeurzen /
    Rob Schildermans / Peter Verhamme / Wim Janssens / Robin Vos

    ERJ Open Research, Vol 8, Iss

    a randomised, multicentre, open-label clinical trial (DAWn-AZITHRO)

    2022  Volume 1

    Abstract: Background and objectives Azithromycin was rapidly adopted as a repurposed drug to treat coronavirus disease 2019 (COVID-19) early in the pandemic. We aimed to evaluate its efficacy in patients hospitalised for COVID-19. Methods In a series of randomised, ...

    Abstract Background and objectives Azithromycin was rapidly adopted as a repurposed drug to treat coronavirus disease 2019 (COVID-19) early in the pandemic. We aimed to evaluate its efficacy in patients hospitalised for COVID-19. Methods In a series of randomised, open-label, phase 2 proof-of-concept, multicentre clinical trials (Direct Antivirals Working against the novel coronavirus (DAWn)), several treatments were compared with standard of care. In 15 Belgian hospitals, patients hospitalised with moderate to severe COVID-19 were allocated 2:1 to receive standard of care plus azithromycin or standard of care alone. The primary outcome was time to live discharge or sustained clinical improvement, defined as a two-point improvement on the World Health Organization (WHO) ordinal scale sustained for at least 3 days. Results Patients were included between April 22 and December 17, 2020. When 15-day follow-up data were available for 160 patients (56% of preset cohort), an interim analysis was performed at request of the independent Data Safety and Monitoring Board. Subsequently, DAWn-AZITHRO was stopped for futility. In total, 121 patients were allocated to the treatment arm and 64 patients to the standard-of-care arm. We found no effect of azithromycin on the primary outcome with a hazard ratio of 1.044 (95% CI 0.772–1.413; p=0.7798). None of the predefined subgroups showed significant interaction as covariates in the Fine–Gray regression analysis. No benefit of azithromycin was found on any of the short- and longer-term secondary outcomes. Conclusion Time to clinical improvement is not influenced by azithromycin in patients hospitalised with moderate to severe COVID-19.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The EMBARC European Bronchiectasis Registry

    James D. Chalmers / Stefano Aliberti / Eva Polverino / Montserrat Vendrell / Megan Crichton / Michael Loebinger / Katerina Dimakou / Ian Clifton / Menno van der Eerden / Gernot Rohde / Marlene Murris-Espin / Sarah Masefield / Eleanor Gerada / Michal Shteinberg / Felix Ringshausen / Charles Haworth / Wim Boersma / Jessica Rademacher / Adam T. Hill /
    Timothy Aksamit / Anne O'Donnell / Lucy Morgan / Branislava Milenkovic / Leandro Tramma / Joao Neves / Rosario Menendez / Perluigi Paggiaro / Victor Botnaru / Sabina Skrgat / Robert Wilson / Pieter Goeminne / Anthony De Soyza / Tobias Welte / Antoni Torres / J. Stuart Elborn / Francesco Blasi

    ERJ Open Research, Vol 2, Iss

    protocol for an international observational study

    2016  Volume 1

    Abstract: Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no approved therapies and few large-scale, representative epidemiological studies. The EMBARC (European Multicentre Bronchiectasis Audit and Research Collaboration) ... ...

    Abstract Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no approved therapies and few large-scale, representative epidemiological studies. The EMBARC (European Multicentre Bronchiectasis Audit and Research Collaboration) registry is a prospective, pan-European observational study of patients with bronchiectasis. The inclusion criterion is a primary clinical diagnosis of bronchiectasis consisting of: 1) a clinical history consistent with bronchiectasis; and 2) computed tomography demonstrating bronchiectasis. Core exclusion criteria are: 1) bronchiectasis due to known cystic fibrosis; 2) age <18 years; and 3) patients who are unable or unwilling to provide informed consent. The study aims to enrol 1000 patients by April 2016 across at least 20 European countries, and 10 000 patients by March 2020. Patients will undergo a comprehensive baseline assessment and will be followed up annually for up to 5 years with the goal of providing high-quality longitudinal data on outcomes, treatment patterns and quality of life. Data from the registry will be available in the form of annual reports. and will be disseminated in conference presentations and peer-reviewed publications. The European Bronchiectasis Registry aims to make a major contribution to understanding the natural history of the disease, as well as guiding evidence-based decision making and facilitating large randomised controlled trials.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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