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  1. AU="Pietro Costantini"
  2. AU="Viknaswaran, N L"
  3. AU="Luo, Huixin"
  4. AU="Li, Gordon"
  5. AU=Bauchner Howard
  6. AU=Markiewski Maciej M

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  1. Artikel ; Online: 18 months computed tomography follow-up after Covid-19 interstitial pneumonia

    Michela Barini / Ilaria Percivale / Pietro Danna / Vittorio Longo / Pietro Costantini / Andrea Paladini / Chiara Airoldi / Mattia Bellan / Luca Saba / Alessandro Carriero

    Journal of Public Health Research, Vol 11, Iss

    2022  Band 2

    Abstract: Background: Our aim is to evaluate the possible persistence of lung parenchyma alterations, in patients who have recovered from Covid-19. Design and methods: We enrolled a cohort of 115 patients affected by Covid-19, who performed a chest CT scan in the ... ...

    Abstract Background: Our aim is to evaluate the possible persistence of lung parenchyma alterations, in patients who have recovered from Covid-19. Design and methods: We enrolled a cohort of 115 patients affected by Covid-19, who performed a chest CT scan in the Emergency Department and a chest CT 18 months after hospital discharge. We performed a comparison between chest CT scan 18 months after discharge and spirometric data of patients enrolled. We obtained quantitative scores related to well-aerated parenchyma, interstitial lung disease and parenchymal consolidation. A radiologist recorded the characteristics indicated by the Fleischner Society and “fibrotic like” changes, expressed through a CT severity score ranging from 0 (no involvement) to 25 (maximum involvement). Results: 115 patients (78 men, 37 women; mean age 60.15 years old ±12.52). On quantitative analysis, after 18 months, the volume of normal ventilated parenchyma was significantly increased (16.34 points on average ±14.54, p<0.0001). Ground-glass opacities and consolidation values tend to decrease (-9.80 and -6.67 points, p<0.0001). On semiquantitative analysis, pneumonia extension, reactive lymph nodes and crazy paving reached statistical significance (p<0.0001). The severity score decreased by 2.77 points on average (SD 4.96; p<0.0001). There were not statistically significant changes on “fibrotic-like” changes correlated with level of treatment and there was not a statistically significant correlation between CT lung score and spirometric results obtained 18 months after discharge. Conclusions: Patients recovered from Covid-19 seem to have an improvement of ventilated parenchyma and “fibrotic-like” alterations. The level of treatment does not appear to influence fibrotic changes.
    Schlagwörter Covid-19 ; coronavirus ; CT ; lung ; pneumonia ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag PAGEPress Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Non-Invasive Diagnosis of Chronic Coronary Syndrome

    Léon Groenhoff / Giulia De Zan / Pietro Costantini / Agnese Siani / Eleonora Ostillio / Serena Carriero / Giuseppe Muscogiuri / Luca Bergamaschi / Giuseppe Patti / Carmine Pizzi / Sandro Sironi / Anna Giulia Pavon / Alessandro Carriero / Marco Guglielmo

    Journal of Clinical Medicine, Vol 12, Iss 3793, p

    A Focus on Stress Computed Tomography Perfusion and Stress Cardiac Magnetic Resonance

    2023  Band 3793

    Abstract: Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were ... ...

    Abstract Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. To date, clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. Standardized protocols for both S-CMR and CTP usually imply the administration of vasodilator agents to induce hyperemia and contrast agents to depict perfusion defects. However, both methods have their own limitations, meaning that optimizing their performance still requires a patient-tailored approach. This review focuses on the characteristics, drawbacks, and future perspectives of these two techniques.
    Schlagwörter coronary artery disease ; cardiac coronary syndrome ; stress imaging ; cardiac computed tomography perfusion ; stress magnetic cardiac resonance ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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