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  1. Article ; Online: Fenretinide in Cancer and Neurological Disease

    Rosa Luisa Potenza / Pietro Lodeserto / Isabella Orienti

    International Journal of Molecular Sciences, Vol 23, Iss 7426, p

    A Two-Face Janus Molecule

    2022  Volume 7426

    Abstract: Recently, several chemotherapeutic drugs have been repositioned in neurological diseases, based on common biological backgrounds and the inverse comorbidity between cancer and neurodegenerative diseases. Fenretinide (all-trans-N-(4-hydroxyphenyl) ... ...

    Abstract Recently, several chemotherapeutic drugs have been repositioned in neurological diseases, based on common biological backgrounds and the inverse comorbidity between cancer and neurodegenerative diseases. Fenretinide (all-trans-N-(4-hydroxyphenyl) retinamide, 4-HPR) is a synthetic derivative of all-trans-retinoic acid initially proposed in anticancer therapy for its antitumor effects combined with limited toxicity. Subsequently, fenretinide has been proposed for other diseases, for which it was not intentionally designed for, due to its ability to influence different biological pathways, providing a broad spectrum of pharmacological effects. Here, we review the most relevant preclinical and clinical findings from fenretinide and discuss its therapeutic role towards cancer and neurological diseases, highlighting the hormetic behavior of this pleiotropic molecule.
    Keywords fenretinide ; anticancer drugs ; nanomicellar formulations ; repositioning ; neuroinflammation ; oxidative stress ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: NSD1 Mutations and Pediatric High-Grade Gliomas

    Antonio d’Amati / Arianna Nicolussi / Evelina Miele / Angela Mastronuzzi / Sabrina Rossi / Francesca Gianno / Francesca Romana Buttarelli / Simone Minasi / Pietro Lodeserto / Marina Paola Gardiman / Elisabetta Viscardi / Anna Coppa / Vittoria Donofrio / Isabella Giovannoni / Felice Giangaspero / Manila Antonelli

    Diagnostics, Vol 13, Iss 1, p

    A Comparative Genomic Study in Primary and Recurrent Tumors

    2022  Volume 78

    Abstract: Pediatric high-grade gliomas represent a heterogeneous group of tumors with a wide variety of molecular features. We performed whole exome sequencing and methylation profiling on matched primary and recurrent tumors from four pediatric patients with ... ...

    Abstract Pediatric high-grade gliomas represent a heterogeneous group of tumors with a wide variety of molecular features. We performed whole exome sequencing and methylation profiling on matched primary and recurrent tumors from four pediatric patients with hemispheric high-grade gliomas. Genetic analysis showed the presence of some variants shared between primary and recurrent tumors, along with other variants exclusive of primary or recurrent tumors. NSD1 variants, all novel and not previously reported, were present at high frequency in our series (100%) and were all shared between the samples, independently of primary or recurrence. For every variant, in silico prediction tools estimated a high probability of altering protein function. The novel NSD1 variant (c.5924T > A; p.Leu1975His) was present in one in four cases at recurrence, and in two in four cases at primary. The novel NSD1 variant (c.5993T > A; p.Met1998Lys) was present in one in four cases both at primary and recurrence, and in one in four cases only at primary. The presence of NSD1 mutations only at recurrence may suggest that they can be sub-clonal, while the presence in both primary and recurrence implies that they can also represent early and stable events. Furthermore, their presence only in primary, but not in recurrent tumors, suggest that NSD1 mutations may also be influenced by treatment.
    Keywords pediatric high-grade gliomas ; hemispheric pediatric high-grade gliomas ; high grade glioma H3-/IDH-wildtype ; glioma ; CNS tumors ; molecular biology ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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