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  1. AU="Pietrzykowski, Łukasz"
  2. AU="Karimi, Poorya"
  3. AU="Mannava, Yamini"
  4. AU="Sangiovanni, Giuseppe"
  5. AU="Duff, John H."
  6. AU="Jin, Peng"
  7. AU="Bursill, Christina A"
  8. AU="Huchzermeyer, Cord"
  9. AU="Di Caprio, Simone"
  10. AU="Firl, Christina E M"
  11. AU="Davies, Jane" AU="Davies, Jane"
  12. AU="Srinivasan, Karpagam"
  13. AU="Pritam Banerjee"
  14. AU="Fried, Miriam"
  15. AU="Andita P. Newton"
  16. AU="Larsen, B. B."
  17. AU="McPheeters, D"

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  1. Artikel ; Online: Achieving Cardiovascular Risk Management Goals and Patient Quality of Life.

    Kosobucka-Ozdoba, Agata / Pietrzykowski, Łukasz / Michalski, Piotr / Ratajczak, Jakub / Grzelakowska, Klaudyna / Kasprzak, Michał / Kubica, Jacek / Kubica, Aldona

    Journal of cardiovascular development and disease

    2024  Band 11, Heft 2

    Abstract: 1) Background: Eliminating or reducing the severity of modifiable risk factors of cardiovascular disease (CVD) and undertaking health-promoting behaviors is the basis for prevention. (2) Methods: This study included 200 subjects without a history of CVD, ...

    Abstract (1) Background: Eliminating or reducing the severity of modifiable risk factors of cardiovascular disease (CVD) and undertaking health-promoting behaviors is the basis for prevention. (2) Methods: This study included 200 subjects without a history of CVD, aged 18 to 80 years, who had been diagnosed with hypertension, hypercholesterolemia, or diabetes 6 to 24 months before study enrolment. (3) Results: The median 10-year CV risk assessed by the SCORE2 and SCORE2-OP algorithms was 3.0 (IQR 1.5-7.0). An increase in mean cardiovascular risk in the range from low and moderate to very high was associated with a decrease in quality of life both in individual subscales and the overall score. The median number of controlled risk factors was 4.0 (IQR 3.0-5.0). As the mean number of controlled risk factors increased, the quality of life improved in both of HeartQoL questionnaire subscales (emotional
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd11020045
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  2. Artikel: Effects of Multidisciplinary Rehabilitation Program in Patients with Long COVID-19: Post-COVID-19 Rehabilitation (PCR SIRIO 8) Study.

    Ostrowska, Małgorzata / Rzepka-Cholasińska, Alicja / Pietrzykowski, Łukasz / Michalski, Piotr / Kosobucka-Ozdoba, Agata / Jasiewicz, Małgorzata / Kasprzak, Michał / Kryś, Jacek / Kubica, Aldona

    Journal of clinical medicine

    2023  Band 12, Heft 2

    Abstract: Up to 80% of COVID-19 survivors experience prolonged symptoms known as long COVID-19. The aim of this study was to evaluate the effects of a multidisciplinary rehabilitation program in patients with long COVID-19. The rehabilitation program was composed ... ...

    Abstract Up to 80% of COVID-19 survivors experience prolonged symptoms known as long COVID-19. The aim of this study was to evaluate the effects of a multidisciplinary rehabilitation program in patients with long COVID-19. The rehabilitation program was composed of physical training (aerobic, resistance, and breathing exercises), education, and group psychotherapy. After 6 weeks of rehabilitation in 97 patients with long COVID-19, body composition analysis revealed a significant decrease of abdominal fatty tissue (from 2.75 kg to 2.5 kg; p = 0.0086) with concomitant increase in skeletal muscle mass (from 23.2 kg to 24.2 kg; p = 0.0104). Almost 80% of participants reported dyspnea improvement assessed with the modified Medical Research Council scale. Patients’ physical capacity assessed with the 6 Minute Walking Test increased from 320 to 382.5 m (p < 0.0001), the number of repetitions in the 30 s Chair Stand Test improved from 13 to 16 (p < 0.0001), as well as physical fitness in the Short Physical Performance Battery Test from 14 to 16 (p < 0.0001). The impact of fatigue on everyday functioning was reduced in the Modified Fatigue Impact Scale from 37 to 27 (p < 0.0001). Cardiopulmonary exercise test did not show any change. The multidisciplinary rehabilitation program has improved body composition, dyspnea, fatigue and physical capacity in long COVID-19 patients.
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020420
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  3. Artikel: Gender-Related Effectiveness of Personalized Post-COVID-19 Rehabilitation.

    Rzepka-Cholasińska, Alicja / Ratajczak, Jakub / Michalski, Piotr / Kasprzak, Michał / Kosobucka-Ozdoba, Agata / Pietrzykowski, Łukasz / Grzelakowska, Klaudyna / Kubica, Jacek / Kryś, Jacek / Kubica, Aldona

    Journal of clinical medicine

    2024  Band 13, Heft 4

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13040938
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  4. Artikel ; Online: The influence of patient expectations on adherence to treatment regimen after myocardial infarction.

    Pietrzykowski, Łukasz / Kasprzak, Michał / Michalski, Piotr / Kosobucka, Agata / Fabiszak, Tomasz / Kubica, Aldona

    Patient education and counseling

    2021  Band 105, Heft 2, Seite(n) 426–431

    Abstract: Objective: In-hospital patient education is one of the elements affecting patient adherence to treatment regimen after myocardial infarction (MI). Its effectiveness is determined by educator and patient-dependent factors. Previous studies did not ... ...

    Abstract Objective: In-hospital patient education is one of the elements affecting patient adherence to treatment regimen after myocardial infarction (MI). Its effectiveness is determined by educator and patient-dependent factors. Previous studies did not identify patient expectations as an independent determinant of successful education. The aim of this study was to assess whether patient knowledge and expectations affect adherence to treatment regimen in a 1-year follow-up.
    Methods: This was a single-center, cohort study with a 1-year follow-up. Patient knowledge and expectations were evaluated using the Readiness for Hospital Discharge after Myocardial Infarction Scale (RHD-MIS scale). Medication adherence (including angiotensin converting enzyme inhibitors (ACEI), P2Y12 receptor inhibitors and statins) was verified based on prescription refill data extracted from The National Health Fund database.
    Results: The study included 225 patients aged 30-91 years (mean age 62.9 ± 11.9 years). In the 4th quarter of follow-up, patients with the highest expectations had lower adherence regarding ACEI (p = 0.01), P2Y12 receptor inhibitors (p = 0.03) and the combination of all three analysed medications (p = 0.003).
    Conclusions: The initial results suggest presence of a relationship between patient expectations and long-term adherence to treatment.
    Practice implications: Post-MI patient education directed at fulfilling or modification of patient expectations could possibly improve execution of treatment regimen.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Cohort Studies ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Medication Adherence ; Middle Aged ; Motivation ; Myocardial Infarction/drug therapy
    Chemische Substanzen Angiotensin-Converting Enzyme Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2021-05-23
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 605590-4
    ISSN 1873-5134 ; 0738-3991
    ISSN (online) 1873-5134
    ISSN 0738-3991
    DOI 10.1016/j.pec.2021.05.030
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The occurrence of cardiovascular risk factors and functioning in chronic illness in the Polish population of EUROASPIRE V.

    Kubica, Aldona / Pietrzykowski, Łukasz / Michalski, Piotr / Kasprzak, Michał / Ratajczak, Jakub / Siódmiak, Joanna / Fabiszak, Tomasz / Buczkowski, Krzysztof / Krintus, Magdalena / Jankowski, Piotr

    Cardiology journal

    2022  

    Abstract: Background: The aim of this study was to assess the impact of cardiovascular risk on the functioning of patients without a history of atherosclerotic cardiovascular disease.: Methods: Two hundred patients diagnosed with arterial hypertension, ... ...

    Abstract Background: The aim of this study was to assess the impact of cardiovascular risk on the functioning of patients without a history of atherosclerotic cardiovascular disease.
    Methods: Two hundred patients diagnosed with arterial hypertension, hypercholesterolemia, or diabetes were enrolled in the study. The median age was 52.0 years (interquartile range [IQR] 43.0-60.0). The following risk factors were assessed: blood pressure, body mass index, waist circumference, physical activity, smoking, LDL-cholesterol, triglycerides, and fasting plasma glucose concentration. Total cardiovascular risk was determined as the number of uncontrolled risk factors, and with the Systemic Coronary Risk Evaluation Score (SCORE). The Functioning in the Chronic Illness Scale (FCIS) was applied to assess the physical and mental functioning of patients.
    Results: The median number of measures of cardiovascular risk factors was 4.0 (IQR 3.0-5.0). The median of SCORE for the whole study population was 2.0 (IQR 1.0-3.0). Patients with lower total cardiovascular risk as defined by SCORE and number of uncontrolled risk factors had better functioning as reflected by higher FCIS (R = -0.315, p < 0.0001; R = -0.336, p < 0.0001, respectively). Multivariate logistic regression analysis identified abnormal blood pressure, abnormal waist circumference, tobacco smoking, and lack of regular physical activity to be negative predictors of functioning. Lack of regular physical activity was the only predictor of low FCIS total score (odds ratio 9.26, 95% confidence interval 1.19-71.77, p = 0.03).
    Conclusions: The functioning of patients worsens as the total cardiovascular risk increases. Each of the risk factors affects the functioning of subjects without coronary artery disease with different strength, with physical activity being the strongest determinant of patient functioning.
    Sprache Englisch
    Erscheinungsdatum 2022-11-17
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2488680-4
    ISSN 1898-018X ; 1897-5593
    ISSN (online) 1898-018X
    ISSN 1897-5593
    DOI 10.5603/CJ.a2022.0102
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  6. Buch ; Online: Effects of Multidisciplinary Rehabilitation Program in Patients with Long COVID-19

    Ostrowska, Małgorzata / Rzepka-Cholasińska, Alicja / Pietrzykowski, Łukasz / Michalski, Piotr / Kosobucka-Ozdoba, Agata / Jasiewicz, Małgorzata / Kasprzak, Michał / Kryś, Jacek / Kubica, Aldona

    J Clin Med

    Post-COVID-19 Rehabilitation (PCR SIRIO 8) Study

    2023  

    Abstract: Up to 80% of COVID-19 survivors experience prolonged symptoms known as long COVID-19. The aim of this study was to evaluate the effects of a multidisciplinary rehabilitation program in patients with long COVID-19. The rehabilitation program was composed ... ...

    Abstract Up to 80% of COVID-19 survivors experience prolonged symptoms known as long COVID-19. The aim of this study was to evaluate the effects of a multidisciplinary rehabilitation program in patients with long COVID-19. The rehabilitation program was composed of physical training (aerobic, resistance, and breathing exercises), education, and group psychotherapy. After 6 weeks of rehabilitation in 97 patients with long COVID-19, body composition analysis revealed a significant decrease of abdominal fatty tissue (from 2.75 kg to 2.5 kg; p = 0.0086) with concomitant increase in skeletal muscle mass (from 23.2 kg to 24.2 kg; p = 0.0104). Almost 80% of participants reported dyspnea improvement assessed with the modified Medical Research Council scale. Patients’ physical capacity assessed with the 6 Minute Walking Test increased from 320 to 382.5 m (p < 0.0001), the number of repetitions in the 30 s Chair Stand Test improved from 13 to 16 (p < 0.0001), as well as physical fitness in the Short Physical Performance Battery Test from 14 to 16 (p < 0.0001). The impact of fatigue on everyday functioning was reduced in the Modified Fatigue Impact Scale from 37 to 27 (p < 0.0001). Cardiopulmonary exercise test did not show any change. The multidisciplinary rehabilitation program has improved body composition, dyspnea, fatigue and physical capacity in long COVID-19 patients.
    Schlagwörter Article
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Verlag MDPI
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Therapy Discontinuation after Myocardial Infarction.

    Pietrzykowski, Łukasz / Kasprzak, Michał / Michalski, Piotr / Kosobucka, Agata / Fabiszak, Tomasz / Kubica, Aldona

    Journal of clinical medicine

    2020  Band 9, Heft 12

    Abstract: The discontinuation of recommended therapy after myocardial infarction predisposes patients to serious thrombotic complications. The aim of this study was a comprehensive analysis of permanent as well as short- and long-term discontinuation of ... ...

    Abstract The discontinuation of recommended therapy after myocardial infarction predisposes patients to serious thrombotic complications. The aim of this study was a comprehensive analysis of permanent as well as short- and long-term discontinuation of pharmacotherapy, taking into consideration the basic groups of medications and nonadherence determinants in a one-year follow-up in post-myocardial infarction (MI) patients.
    Material and methods: The study was a single center cohort clinical trial with a one-year follow-up including 225 patients (73.3% men, 26.7% women) aged 62.9 ± 11.9 years. In eight cases (3.6%), the follow-up duration was less than one year due to premature death. The following factors were analyzed: lack of post-discharge therapy initiation; short-term therapy discontinuation (<30 days); long-term therapy discontinuation (≥30 days); and permanent cessation of therapy. The analysis of therapy discontinuation was performed based on prescription filling data.
    Results: Occupational activity (Odds Ratio (OR) 5.15; 95% Confidence interval (CI) 1.42-18.65;
    Conclusions: The vast majority of post-MI patients discontinue, either temporarily or permanently, one of the essential medications within one year following myocardial infarction. The most likely medication class to be discontinued are statins. Older age and prior cardiac revascularization are independent determinants of therapy discontinuation.
    Sprache Englisch
    Erscheinungsdatum 2020-12-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9124109
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  8. Artikel ; Online: The impact of readiness to discharge from hospital on adherence to treatment in patients after myocardial infarction.

    Kosobucka, Agata / Michalski, Piotr / Pietrzykowski, Łukasz / Kasprzak, Michał / Fabiszak, Tomasz / Felsmann, Mirosława / Kubica, Aldona

    Cardiology journal

    2020  Band 29, Heft 4, Seite(n) 582–590

    Abstract: Background: The healthcare professionals involved in in-hospital treatment of myocardial infarction (MI) are also responsible to patients for their education before leaving the hospital. This education aims to modify patient behaviour in order to reduce ...

    Abstract Background: The healthcare professionals involved in in-hospital treatment of myocardial infarction (MI) are also responsible to patients for their education before leaving the hospital. This education aims to modify patient behaviour in order to reduce relevant risk factors and improve self-control and adherence to medications. The aim of the study was to analyse the relationship between readiness for discharge from hospital and adherence to treatment at follow-up in MI patients.
    Methods: An observational, single-center, MI cohort study with 6-month follow-up was conducted between May 2015 and July 2016. The Readiness for Hospital Discharge after Myocardial Infarction Scale (RHD-MIS) and the Adherence in Chronic Diseases Scale (ACDS) were applied.
    Results: Two hundred and thirteen patients aged 30-91 years (62.91 ± 11.26) were enrolled in the study. The RHD-MIS general score ranged from 29 to 69 points (51.16 ± 9.87). A high level of readiness was found in 66 patients (31%), intermediate in 92 (43.2%), and low in 55 (25.8%) of patients. Adherence level assessed with the ACDS 6-months after discharge from hospital ranged from 7 to 28 points (23.34 ± 4.06). An increase in objective assessment of patient knowledge according to RHD-MIS subscale resulted in significantly higher level of adherence at the follow-up visit (p = 0.0154); R Spearman = 0.16671, p = 0.015; p for trend = 0.005. During the 6-month follow-up 3 (1.41%) patients died and 17 (7.98%) were hospitalized for a subsequent acute coronary syndrome.
    Conclusions: This study provided preliminary evidence of a long-term association between the results of assessment of readiness for discharge from hospital and adherence to treatment in patients after MI.
    Mesh-Begriff(e) Cohort Studies ; Hospitals ; Humans ; Medication Adherence ; Myocardial Infarction/drug therapy ; Myocardial Infarction/therapy ; Patient Discharge
    Sprache Englisch
    Erscheinungsdatum 2020-02-10
    Erscheinungsland Poland
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 2488680-4
    ISSN 1898-018X ; 1897-5593
    ISSN (online) 1898-018X
    ISSN 1897-5593
    DOI 10.5603/CJ.a2020.0005
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  9. Artikel: Determinants of Lipid Parameters in Patients without Diagnosed Cardiovascular Disease-Results of the Polish Arm of the EUROASPIRE V Survey.

    Ratajczak, Jakub / Kubica, Aldona / Michalski, Piotr / Pietrzykowski, Łukasz / Białczyk, Aleksandra / Kosobucka-Ozdoba, Agata / Bergmann, Katarzyna / Buczkowski, Krzysztof / Krintus, Magdalena / Jankowski, Piotr / Kubica, Jacek

    Journal of clinical medicine

    2023  Band 12, Heft 7

    Abstract: To assess the determinants of lipid parameters in primary care patients without diagnosed cardiovascular disease (CVD), a cross-sectional study was conducted during 2018-2019 with a total of 200 patients. The following lipid parameters were measured: ... ...

    Abstract To assess the determinants of lipid parameters in primary care patients without diagnosed cardiovascular disease (CVD), a cross-sectional study was conducted during 2018-2019 with a total of 200 patients. The following lipid parameters were measured: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), small, dense LDL (sdLDL-C), and lipoprotein (a) (Lp(a)). Predictors of elevated and adequately controlled lipid parameters were assessed with logistic regression analysis. Older age was related to higher risk of TC ≥ 6.2 mmol/L [OR 1.03 (95% CI 1.0-1.05)], sdLDL-C ≥ 1.0 mmol/L [OR 1.05 (95% CI 1.0-1.1)], and decreased risk of Lp(a) ≥ 50 mg/dL [OR 0.97 (95% CI 0.94-0.99)]. Patients with diabetes mellitus (DM) had increased probability of TG ≥ 2.25 mmol/L [OR 3.77 (95% CI 1.34-10.6)] and Lp(a) ≥ 50 mg/dL [OR 2.97 (1.34-6.10)] as well as adequate control of TG and Lp(a). Higher material status was related to lower risk of TC ≥ 6.2 mmol/L [OR 0.19 (95% CI 0.04-0.82)] and LDL-C ≥ 3.6 mmol/L [OR 0.33 (95% CI 0.12-0.92)]. High BMI was related to increased [OR 1.14 (95% CI 1.02-1.29)], and female gender [OR 0.33 (95% CI 0.12-0.96)] and hypertension [OR 0.29 (95% CI 0.1-0.87)] to decreased risk of TG ≥ 2.25 mmol/L [OR 1.14 (95% CI 1.02-1.29)]. Taking lipid-lowering drugs (LLD) was associated with LDL-C < 2.6 mmol/L [OR 2.1 (95% CI 1.05-4.19)] and Lp(a) < 30 mg/dL [OR 0.48 (95% CI 0.25-0.93)]. Physical activity was related to LDL-C < 2.6 mmol/L [OR 2.02 (95% CI 1.02-3.98)]. Higher abdominal circumference was associated with decreased risk of TG < 1.7 mmol/L [OR 0.96 (95% CI 0.93-0.99)]. Elevated lipid parameters were related to age, gender, material status, BMI, history of DM, and hypertension. Adequate control was associated with age, education, physical activity, LLD, history of DM, and abdominal circumference.
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12072738
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  10. Artikel: Determinants of the Level of Anti-SARS-CoV-2 IgG ANTibodiEs after Vaccination (DANTE-SIRIO 7) Study in a Large Cohort of Healthcare Workers.

    Krintus, Magdalena / Piasecki, Maciej / Lackowski, Piotr / Buszko, Katarzyna / Kubica, Aldona / Kosobucka-Ozdoba, Agata / Michalski, Piotr / Pietrzykowski, Lukasz / Stolarek, Wioleta / Wojcik, Agata / Tomczak, Maria / Wojtal, Emilia / Krys, Jacek / Wlodarczyk, Zbigniew / Kubica, Jacek

    Vaccines

    2022  Band 10, Heft 12

    Abstract: The aim of this study was to determine anti-SARS-CoV-2 IgG concentrations and their major determinants in healthcare workers (HCWs) after full vaccination with the BNT162b2 vaccine. We recruited 847 individuals vaccinated with two doses of the BNT162b2 ... ...

    Abstract The aim of this study was to determine anti-SARS-CoV-2 IgG concentrations and their major determinants in healthcare workers (HCWs) after full vaccination with the BNT162b2 vaccine. We recruited 847 individuals vaccinated with two doses of the BNT162b2 vaccine, who completed the questionnaire, and whose antibody concentrations were tested after 3 and 6 months after full vaccination. Anti-SARS-CoV-2 IgG levels were measured on the routinely employed Siemens Atellica system. The cutoff for positivity was ≥21.8 BAU/mL. Three and 6 months after vaccination, the majority of participants were seropositive. Median concentrations of anti-SARS-CoV-2 IgG significantly decreased from 1145 BAU/mL (IQR: 543-2095) to 225 BAU/mL (IQR: 100-510). Major positive determinants of antibody levels were fever after both doses of vaccine, prior-COVID-19 exposure, and muscle pain after the first dose. Lack of symptoms after the second dose and time since vaccination were significant negative determinants of anti-SARS-CoV-2 IgG concentrations. No other factors, including age and gender, or underlying comorbidities had a significant effect on antibody levels in HCWs. The anti-SARS-CoV-2 response after two doses of BNT162b2 vaccine was independently associated with prior-COVID-19 exposure, time since vaccination, and the occurrence of symptoms after either dose of vaccine. Easily reportable adverse reactions may facilitate the identification of immune response in HCWs.
    Sprache Englisch
    Erscheinungsdatum 2022-12-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10122125
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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