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  1. Article ; Online: Alcohol protects the CNS by activating HSF1 and inducing the heat shock proteins.

    Pignataro, Leonardo

    Neuroscience letters

    2019  Volume 713, Page(s) 134507

    Abstract: Although alcohol abuse and dependence have profound negative health consequences, emerging evidence suggests that exposure to low/moderate concentrations of ethanol protects multiple organs and systems. In the CNS, moderate drinking decreases the risk of ...

    Abstract Although alcohol abuse and dependence have profound negative health consequences, emerging evidence suggests that exposure to low/moderate concentrations of ethanol protects multiple organs and systems. In the CNS, moderate drinking decreases the risk of dementia and Alzheimer's disease. This neuroprotection correlates with an increased expression of the heat shock proteins (HSPs). Multiple epidemiological studies revealed an inverse association between ethanol intoxication and traumatic brain injury mortality. In this case, ethanol-induced HSPs limit the inflammatory immune response diminishing cell death and improving the neurobehavioural outcome. Ethanol also protects the brain against ischemic injuries via the HSPs. In our laboratory, we demonstrated that ethanol increased the expression of several HSP genes in neurons and astrocytes by activating the transcription factor, heat shock factor 1 (HSF1). HSF1 induces HSPs that target misfolded proteins for refolding or degradation, increasing the survival chances of the cells. These data indicate that ethanol neuroprotection is mediated by the activation HSF1 and the induction of HSPs.
    MeSH term(s) Animals ; Cells, Cultured ; Ethanol/pharmacology ; Heat Shock Transcription Factors/metabolism ; Heat-Shock Proteins/biosynthesis ; Humans ; Neuroprotection/drug effects
    Chemical Substances Heat Shock Transcription Factors ; Heat-Shock Proteins ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2019-09-18
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2019.134507
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  2. Article ; Online: The piercing-stretching suture technique for the treatment of simple oral floor ranula.

    Gaffuri, M / Torretta, S / Pignataro, L / Capaccio, P

    The Journal of laryngology and otology

    2021  Volume 136, Issue 1, Page(s) 68–72

    Abstract: Background: Oral floor ranulas are pseudocysts located in the floor of the mouth that result from the extravasation of mucus from a sublingual gland. Historically, there has been little consensus on the ideal first-line treatment. Currently, definitive ... ...

    Abstract Background: Oral floor ranulas are pseudocysts located in the floor of the mouth that result from the extravasation of mucus from a sublingual gland. Historically, there has been little consensus on the ideal first-line treatment. Currently, definitive treatment involves sublingual gland excision, which can injure the lingual nerve and submandibular duct. Minimally invasive surgical techniques have been proposed, but so far have been associated with a high rate of recurrence.
    Methods: The so-called piercing-stretching suture technique was performed in 14 naïve adult and paediatric patients (6 females, with a mean age of 20.3 years (range, 7-55 years)). Clinical and ultrasonographic evaluations were performed in all patients; post-operative sialendoscopy was conducted in two paediatric patients.
    Results: The surgical procedure was successful in all patients, and complete recovery of the ranula was seen in all but one of the patients who underwent suture replacement. No major or minor complications were encountered.
    Conclusion: This minimally invasive procedure may be considered a reliable and first-line treatment for management of simple oral floor ranulas.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Ranula/surgery ; Suture Techniques ; Young Adult
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215121003327
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  3. Article: Editorial: Plasticity of inhibitory cells in health and disease.

    Gravielle, María Clara / Pignataro, Leonardo / Varodayan, Florence P

    Frontiers in synaptic neuroscience

    2023  Volume 14, Page(s) 1127609

    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592086-8
    ISSN 1663-3563
    ISSN 1663-3563
    DOI 10.3389/fnsyn.2022.1127609
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  4. Article ; Online: Image-guided and sialendoscopy-assisted transoral approach for parotid duct stenosis and megaduct.

    Gaffuri, Michele / Battilocchi, Ludovica / Pignataro, Lorenzo / Capaccio, Pasquale

    The Journal of laryngology and otology

    2023  , Page(s) 1–3

    Abstract: Objective: The aim of this communication was to introduce a novel combined image (magnetic resonance and computed tomography-guided and sialendoscopy-assisted transoral approach for the treatment of a parotid duct stenosis with megaduct.: Methods: A ... ...

    Abstract Objective: The aim of this communication was to introduce a novel combined image (magnetic resonance and computed tomography-guided and sialendoscopy-assisted transoral approach for the treatment of a parotid duct stenosis with megaduct.
    Methods: A 46-year-old woman was referred to our department for recurrent infections of the right parotid gland following unsuccessful multiple transoral surgical approaches for a Stensen's duct stricture with megaduct. An image (magnetic resonance and computed tomography)-guided and sialendoscopy-assisted transoral sialodochoplasty was planned and performed.
    Results: No complications occurred. The patient was discharged 2 days after surgery. No more swelling or infections occurred. The patient is currently symptom-free after a follow up of 11 months.
    Conclusion: Although imaging navigation means more technical effort and costs, this novel approach can be considered a viable surgical opportunity for distal and mid-third parotid duct stenosis with concomitant megaduct, particularly in cases of persistent inflammation or iatrogenic scars due to previous surgery.
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215123001731
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  5. Article ; Online: Recurrent obstructive salivary disease after sialendoscopy. A narrative literature review.

    Capaccio, Pasquale / Gaffuri, Michele / Canzi, Pietro / Pignataro, Lorenzo

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2023  Volume 43, Issue Suppl 1, Page(s) S95–S102

    Language English
    Publishing date 2023-09-12
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-suppl.1-43-2023-12
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  6. Article ; Online: Commentary on "Characterization of otologic symptoms appearing after COVID-19 vaccination".

    Aldè, Mirko / Zanetti, Diego / Pignataro, Lorenzo / Cantarella, Giovanna

    American journal of otolaryngology

    2023  Volume 44, Issue 4, Page(s) 103924

    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.103924
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  7. Article ; Online: Mother with child (1921): a Graves' disease painted by Otto Dix.

    Accorona, R / Guastella, C / Pignataro, L

    Journal of endocrinological investigation

    2020  Volume 44, Issue 6, Page(s) 1341–1342

    MeSH term(s) Germany ; Graves Disease ; Humans ; Medicine in the Arts ; Paintings
    Language English
    Publishing date 2020-09-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-020-01420-4
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    Zs.A 1480: Show issues Location:
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  8. Article ; Online: A goitrous model for Bartolomeo Vivarini (1432-1499).

    Accorona, R / Torretta, S / Pignataro, L

    Journal of endocrinological investigation

    2020  Volume 43, Issue 8, Page(s) 1179–1180

    Abstract: Introduction: Bartolomeo Vivarini (Venezia 1432c.-Venezia 1499c.) was an Italian painter during the Renaissance. The artist was widely influenced by Andrea Mantegna, whose opera was characterized by personages with anatomical details meticulously ... ...

    Abstract Introduction: Bartolomeo Vivarini (Venezia 1432c.-Venezia 1499c.) was an Italian painter during the Renaissance. The artist was widely influenced by Andrea Mantegna, whose opera was characterized by personages with anatomical details meticulously described.
    Materials and methods: Some of the most valued paintings of Bartolomeo Vivarini were analyzed. Purpose of the present article is to describe these artworks focusing on female personages represented with thyroid swelling.
    Results: A recurring female model in Vivarini's artworks is portrayed with a goitrous neck. This might display a real prevalence of thyroid diseases among young women in the Renaissance age (e.g. postpartum thyroiditis).
    Conclusions: Representation of goiter in the artworks of Vivarini and Mantegna reflects the increased anatomic accuracy and knowledge developed in art since Renaissance and Baroque.
    MeSH term(s) Female ; Goiter/history ; History, 15th Century ; Humans ; Italy ; Male ; Medicine in the Arts ; Models, Biological ; Paintings/history
    Language English
    Publishing date 2020-03-10
    Publishing country Italy
    Document type Historical Article ; Journal Article
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-020-01217-5
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  9. Article ; Online: A High-Definition 3-Dimensional Exoscope With the ARTip Cruise System as an Effective New Tool for Phonosurgery: A Preliminary Report.

    Cantarella, Giovanna / Pignataro, Lorenzo

    Journal of voice : official journal of the Voice Foundation

    2021  Volume 38, Issue 1, Page(s) 210–213

    Abstract: The aim of phonosurgery is to improve voice quality and efficiency by performing precise, minimally invasive, conservative treatment. Magnified visualization of the vocal folds is mandatory to achieve optimal results; operative microscopy has been ... ...

    Abstract The aim of phonosurgery is to improve voice quality and efficiency by performing precise, minimally invasive, conservative treatment. Magnified visualization of the vocal folds is mandatory to achieve optimal results; operative microscopy has been utilized so far to perform phonosurgery. In recent decades, the use of an exoscope (extracorporeal telescope) has been proposed in several fields of surgery that necessitate magnification. Further technological advancements have enabled 3-dimensional (3D) technology to be added to existing exoscopes. Recently, a motorized holding arm (the ARTip Cruise System) was developed to allow smooth precise positioning of the 3D Vitom exoscope (Karl Storz, Tuttlingen, Germany) by the surgeon without need for assistance. To evaluate the feasibility of phonosurgery by means of this innovative system, we utilized it for six consecutive procedures for benign laryngeal pathologies, including two vocal fold polyps, two cysts, one Reinke's edema and one unilateral vocal fold paralysis treated by fat augmentation. All procedures were performed without any technical difficulty and with excellent results at follow-up, as demonstrated by GRBAS, VHI-10 and maximal phonation time evaluations. Main advantages of this technique were the enhanced depth of field and high definition of anatomical details. Communication with the operating room team was facilitated by the shared view of the same images on screen; furthermore, the surgeon could perform the procedures visualizing the surgical site without need to position the eyes on the microscope eyepieces and so being able to wear full face protection, which was of paramount importance in the era of the COVID-19 pandemic. In conclusion, the 4K 3D exoscope system with the ARTip Cruise System represents a promising innovation in the field of voice surgery to allow highly precise procedures optimizing safety and co-operation with the operating room team.
    MeSH term(s) Humans ; Neurosurgical Procedures/methods ; Pandemics ; Microscopy ; Laryngeal Diseases/diagnostic imaging ; Laryngeal Diseases/surgery ; Laryngeal Edema ; Microsurgery/adverse effects ; Microsurgery/methods
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2021.07.008
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  10. Article ; Online: Laryngeal Leishmaniasis: A Neglected, Emerging Disease in Northern Italy.

    Lazzeroni, Matteo / Reato, Serena / Antinori, Spinello / Milazzo, Laura / Pignataro, Lorenzo / Cantarella, Giovanna

    Journal of voice : official journal of the Voice Foundation

    2024  

    Abstract: Leishmaniasis represents an emerging public health issue in Mediterranean countries. The incidence of this condition has progressively risen in Northern Italy due to the growing number of immunocompromised people and probably due to climate changes. We ... ...

    Abstract Leishmaniasis represents an emerging public health issue in Mediterranean countries. The incidence of this condition has progressively risen in Northern Italy due to the growing number of immunocompromised people and probably due to climate changes. We hereby describe a case of relapsing laryngeal leishmaniasis in a female immunocompetent patient, presenting as aspecific chronic laryngitis. She was affected by severe asthma treated by inhaled steroid therapy, likely responsible for the parasite's diffusion through a locus minori resistentiae. The aspecific clinical presentation led to a delayed diagnosis and the lack of guidelines for the treatment caused multiple relapses. Biopsies of laryngeal lesions in the follow-up were performed by operative flexible videolaryngoscopy, thus avoiding general anesthesia and reducing associated healthcare costs. The aim of this report is to underline the diagnostic and therapeutic challenges that patients with this condition face and to present what is, to the best of our knowledge, the first application of prophylactic aerosolized pentamidine for relapsing laryngeal leishmaniasis.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2024.04.006
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