Article ; Online: PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity.
2024 Volume 43, Issue 3, Page(s) 113831
Abstract: Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit ... ...
Abstract | Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit CD8 |
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MeSH term(s) | Humans ; CD8-Positive T-Lymphocytes/metabolism ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; Histocompatibility Antigens Class I/genetics ; Immunity, Cellular ; Interferon-gamma/metabolism ; Melanoma/pathology ; Repressor Proteins/genetics ; Repressor Proteins/metabolism |
Chemical Substances | Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; Histocompatibility Antigens Class I ; Interferon-gamma (82115-62-6) ; PRMT1 protein, human (EC 2.1.1.319) ; Repressor Proteins |
Language | English |
Publishing date | 2024-02-23 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2649101-1 |
ISSN | 2211-1247 ; 2211-1247 |
ISSN (online) | 2211-1247 |
ISSN | 2211-1247 |
DOI | 10.1016/j.celrep.2024.113831 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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