Article: MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing.
bioRxiv : the preprint server for biology
2023
Abstract: Native top-down proteomics (nTDP) integrates native mass spectrometry (nMS) with top-down proteomics (TDP) to provide comprehensive analysis of protein complexes together with proteoform identification and characterization. Despite significant advances ... ...
| Abstract | Native top-down proteomics (nTDP) integrates native mass spectrometry (nMS) with top-down proteomics (TDP) to provide comprehensive analysis of protein complexes together with proteoform identification and characterization. Despite significant advances in nMS and TDP software developments, a unified and user-friendly software package for analysis of nTDP data remains lacking. Herein, we have developed MASH Native to provide a unified solution for nTDP to process complex datasets with database searching capabilities in a user-friendly interface. MASH Native supports various data formats and incorporates multiple options for deconvolution, database searching, and spectral summing to provide a one-stop shop for characterizing both native protein complexes and proteoforms. The MASH Native app, video tutorials, written tutorials and additional documentation are freely available for download at https://labs.wisc.edu/gelab/MASH_Explorer/MASHNativeSoftware.php . All data files shown in user tutorials are included with the MASH Native software in the download .zip file. |
|---|---|
| Language | English |
| Publishing date | 2023-01-03 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.01.02.522513 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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