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  1. Article ; Online: Brian E. Henderson: In Memoriam (1937-2015).

    Pike, Malcolm C

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2015  Volume 24, Issue 10, Page(s) 1437–1438

    MeSH term(s) California ; History, 20th Century ; History, 21st Century ; Humans ; Medical Oncology/history ; Preventive Medicine/history ; SEER Program/history
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Biography ; Historical Article ; Portraits
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-15-0856
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    Zs.A 3693: Show issues Location:
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  2. Book ; Conference proceedings: Hormones and breast cancer

    PIKE, MALCOLM C.

    (BANBURY REPORT ; 8)

    1981  

    Event/congress Conference on Hormones and Breast Cancer (1980, ColdSpringHarbor)
    Author's details ED. BY MALCOLM C. PIKE
    Series title BANBURY REPORT ; 8
    Banbury report
    Collection Banbury report
    Keywords BREAST NEOPLASMS / ETIOLOGY / CONGRESSES ; HORMONES / CONGRESSES ; Sexualhormon ; Physiologie ; Carcinogenese ; Hormon ; Brustkrebs ; Ätiologie
    Subject Krankheitsursache ; Krankheit ; Brustdrüsenkrebs ; Carcinoma mammae ; Mammacarcinom ; Mammakarzinom ; Hormone ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Humanphysiologie ; Mensch ; Körperfunktion ; Geschlechtshormon
    Size XI, 491 S.
    Publisher COLD SPRING HARBOR LABORATORY
    Publishing place COLD SPRING HARBOR
    Document type Book ; Conference proceedings
    Note 'THE BANBURY CONFERENCE ON HORMONES AND BREAST CANCER, HELD FROM 26 TO 29 OCT. 1980 ...'
    HBZ-ID HT002505707
    ISBN 0-87969-206-5 ; 978-0-87969-206-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1982 A 2107 order for loan Magazin

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  3. Article ; Online: Hormonal contraception and breast cancer.

    Westhoff, Carolyn L / Pike, Malcolm C

    Contraception

    2018  Volume 98, Issue 3, Page(s) 171–173

    Abstract: The recent Danish cohort study reported a 20% increased risk of breast cancer among current and recent hormonal contraception users. These results are largely consistent with previous studies. This study did not report on stage of disease at diagnosis, ... ...

    Abstract The recent Danish cohort study reported a 20% increased risk of breast cancer among current and recent hormonal contraception users. These results are largely consistent with previous studies. This study did not report on stage of disease at diagnosis, and it is not clear to what extent the apparent increased risk may be due to a small advance in the timing of diagnosis. This study did not report on the risk associated with the use of a 20-mcg ethinyl estradiol pill. They did find an increasing risk in current users of longer duration and an increased risk with use of the levonorgestrel intrauterine system-both of these potentially important findings have not been consistently found in previous studies and require further investigation. The breast cancer effects described now in multiple studies wane with time, and in the long term, hormonal contraception use has been found not to be associated with any increased total cancer risk.
    MeSH term(s) Breast Neoplasms ; Cohort Studies ; Contraception ; Ethinyl Estradiol ; Humans ; Levonorgestrel
    Chemical Substances Ethinyl Estradiol (423D2T571U) ; Levonorgestrel (5W7SIA7YZW)
    Language English
    Publishing date 2018-09-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2018.05.002
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  4. Article ; Online: Hormonal contraception and breast cancer.

    Westhoff, Carolyn L / Pike, Malcolm C

    American journal of obstetrics and gynecology

    2018  Volume 219, Issue 2, Page(s) 169.e1–169.e4

    Abstract: The recent Danish cohort study reported a 20% increased risk of breast cancer among current and recent hormonal contraception users. These results are largely consistent with previous studies. This study did not report on stage of disease at diagnosis ... ...

    Abstract The recent Danish cohort study reported a 20% increased risk of breast cancer among current and recent hormonal contraception users. These results are largely consistent with previous studies. This study did not report on stage of disease at diagnosis and it is not clear to what extent the apparent increased risk may be due to a small advance in the timing of diagnosis. This study did not report on the risk associated with the use of a 20-μg ethinyl estradiol pill. They did find an increasing risk in current users of longer duration and an increased risk with use of the levonorgestrel intrauterine system-both of these potentially important findings have not been consistently found in previous studies and require further investigation. The breast cancer effects described now in multiple studies wane with time, and in the long-term hormonal contraception use has been found not to be associated with any increased total cancer risk.
    MeSH term(s) Breast Neoplasms ; Cohort Studies ; Contraception ; Ethinyl Estradiol ; Humans ; Levonorgestrel
    Chemical Substances Ethinyl Estradiol (423D2T571U) ; Levonorgestrel (5W7SIA7YZW)
    Language English
    Publishing date 2018-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2018.03.032
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  5. Article ; Online: Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography.

    Watt, Gordon P / Keshavamurthy, Krishna N / Nguyen, Tuong L / Lobbes, Marc B I / Jochelson, Maxine S / Sung, Janice S / Moskowitz, Chaya S / Patel, Prusha / Liang, Xiaolin / Woods, Meghan / Hopper, John L / Pike, Malcolm C / Bernstein, Jonine L

    JNCI cancer spectrum

    2024  Volume 8, Issue 3

    Abstract: Women with high mammographic density have an increased risk of breast cancer. They may be offered contrast-enhanced mammography to improve breast cancer screening performance. Using a cohort of women receiving contrast-enhanced mammography, we evaluated ... ...

    Abstract Women with high mammographic density have an increased risk of breast cancer. They may be offered contrast-enhanced mammography to improve breast cancer screening performance. Using a cohort of women receiving contrast-enhanced mammography, we evaluated whether conventional and modified mammographic density measures were associated with breast cancer. Sixty-six patients with newly diagnosed unilateral breast cancer were frequency matched on the basis of age to 133 cancer-free control individuals. On low-energy craniocaudal contrast-enhanced mammograms (equivalent to standard mammograms), we measured quantitative mammographic density using CUMULUS software at the conventional intensity threshold ("Cumulus") and higher-than-conventional thresholds ("Altocumulus," "Cirrocumulus"). The measures were standardized to enable estimation of odds ratio per adjusted standard deviation (OPERA). In multivariable logistic regression of case-control status, only the highest-intensity measure (Cirrocumulus) was statistically significantly associated with breast cancer (OPERA = 1.40, 95% confidence interval = 1.04 to 1.89). Conventional Cumulus did not contribute to model fit. For women receiving contrast-enhanced mammography, Cirrocumulus mammographic density may better predict breast cancer than conventional quantitative mammographic density.
    MeSH term(s) Humans ; Female ; Mammography ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Middle Aged ; Contrast Media/administration & dosage ; Case-Control Studies ; Aged ; Breast Density ; Logistic Models ; Adult ; Odds Ratio ; Breast/diagnostic imaging ; Breast/pathology
    Chemical Substances Contrast Media
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkae026
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  6. Article: MRI background parenchymal enhancement, breast density and breast cancer risk factors: A cross-sectional study in pre- and post-menopausal women.

    Brooks, Jennifer D / Christensen, Rebecca A G / Sung, Janice S / Pike, Malcolm C / Orlow, Irene / Bernstein, Jonine L / Morris, Elizabeth A

    NPJ breast cancer

    2022  Volume 8, Issue 1, Page(s) 97

    Abstract: Breast tissue enhances on contrast MRI and is called background parenchymal enhancement (BPE). Having high BPE has been associated with an increased risk of breast cancer. We examined the relationship between BPE and the amount of fibroglandular tissue ... ...

    Abstract Breast tissue enhances on contrast MRI and is called background parenchymal enhancement (BPE). Having high BPE has been associated with an increased risk of breast cancer. We examined the relationship between BPE and the amount of fibroglandular tissue on MRI (MRI-FGT) and breast cancer risk factors. This was a cross-sectional study of 415 women without breast cancer undergoing contrast-enhanced breast MRI at Memorial Sloan Kettering Cancer Center. All women completed a questionnaire assessing exposures at the time of MRI. Prevalence ratios (PR) and 95% confidence intervals (CI) describing the relationship between breast cancer risk factors and BPE and MRI-FGT were generated using modified Poisson regression. In multivariable-adjusted models a positive association between body mass index (BMI) and BPE was observed, with a 5-unit increase in BMI associated with a 14% and 44% increase in prevalence of high BPE in pre- and post-menopausal women, respectively. Conversely, a strong inverse relationship between BMI and MRI-FGT was observed in both pre- (PR = 0.66, 95% CI 0.57, 0.76) and post-menopausal (PR = 0.66, 95% CI 0.56, 0.78) women. Use of preventive medication (e.g., tamoxifen) was associated with having low BPE, while no association was observed for MRI-FGT. BPE is an imaging marker available from standard contrast-enhanced MRI, that is influenced by endogenous and exogenous hormonal exposures in both pre- and post-menopausal women.
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2374-4677
    ISSN 2374-4677
    DOI 10.1038/s41523-022-00458-2
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  7. Article ; Online: The progesterone-receptor modulator, ulipristal acetate, drastically lowers breast cell proliferation.

    Westhoff, Carolyn L / Guo, Hua / Wang, Zhong / Hibshoosh, Hanina / Polaneczky, Margaret / Pike, Malcolm C / Ha, Richard

    Breast cancer research and treatment

    2022  Volume 192, Issue 2, Page(s) 321–329

    Abstract: Purpose: The proliferation of breast epithelial cells increases during the luteal phase of the menstrual cycle, when they are exposed to progesterone, suggesting that ulipristal acetate, a selective progestin-receptor modulator (SPRM), may reduce breast ...

    Abstract Purpose: The proliferation of breast epithelial cells increases during the luteal phase of the menstrual cycle, when they are exposed to progesterone, suggesting that ulipristal acetate, a selective progestin-receptor modulator (SPRM), may reduce breast cell proliferation with potential use in breast cancer chemoprevention.
    Methods: Women aged 18-39 were randomized 1:1 to ulipristal 10-mg daily or to a combination oral contraceptive (COC) for 84 days. Participants underwent a breast biopsy and breast MRI at baseline and at end of study treatment. Proliferation of breast TDLU cells was evaluated by Ki67 immunohistochemical stain. We evaluated the breast MRIs for background parenchymal enhancement (BPE). All slides and images were masked for outcome evaluation.
    Results: Twenty-eight treatment-compliant participants completed the study; 25 of whom had evaluable Ki67 results at baseline and on-treatment. From baseline to end of treatment, Ki67 % positivity (Ki67%+) decreased a median of 84% in the ulipristal group (N = 13; 2-sided p (2p) = 0.040) versus a median increase of 8% in the COC group (N = 12; 2p = 0.85). Median BPE scores decreased from 3 to 1 in the ulipristal group (p = 0.008) and did not decrease in the COC group.
    Conclusion: Ulipristal was associated with a major decrease in Ki67%+ and BPE. Ulipristal would warrant further investigation for breast cancer chemoprevention were it not for concerns about its liver toxicity. Novel SPRMs without liver toxicity could provide a new approach to breast cancer chemoprevention.
    Trial registration: NCT02922127, 4 October 2016.
    MeSH term(s) Adolescent ; Adult ; Breast Neoplasms/drug therapy ; Cell Proliferation ; Female ; Humans ; Leiomyoma ; Norpregnadienes ; Progesterone ; Receptors, Progesterone ; Young Adult
    Chemical Substances Norpregnadienes ; Receptors, Progesterone ; Progesterone (4G7DS2Q64Y) ; ulipristal acetate (YF7V70N02B)
    Language English
    Publishing date 2022-01-11
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-021-06503-1
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    Zs.A 1655: Show issues Location:
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  8. Article ; Online: Reservations About Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations-Reply.

    Shu, Catherine A / Pike, Malcolm C / Kauff, Noah D

    JAMA oncology

    2016  Volume 3, Issue 3, Page(s) 417–418

    MeSH term(s) Female ; Humans ; Hysterectomy ; Mutation ; Ovariectomy ; Salpingectomy ; Salpingo-oophorectomy
    Language English
    Publishing date 2016-11-09
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2016.3900
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  9. Article ; Online: Comment on "the predictive capacity of personal genome sequencing".

    Begg, Colin B / Pike, Malcolm C

    Science translational medicine

    2012  Volume 4, Issue 135, Page(s) 135le3; author reply 135lr3

    MeSH term(s) Female ; Genome, Human ; Humans ; Male ; Precision Medicine/methods
    Language English
    Publishing date 2012-05-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.3004162
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    Zs.A 6941: Show issues Location:
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  10. Article: The role of mammographic density in evaluating changes in breast cancer risk.

    Pike, Malcolm C

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2005  Volume 21 Suppl 1, Page(s) 1–5

    Abstract: The Women's Health Initiative (WHI) study showed that postmenopausal continuous combined estrogen-progestogen therapy (EPT) significantly increases the risk of breast cancer, thus confirming the results from large epidemiological studies. These results ... ...

    Abstract The Women's Health Initiative (WHI) study showed that postmenopausal continuous combined estrogen-progestogen therapy (EPT) significantly increases the risk of breast cancer, thus confirming the results from large epidemiological studies. These results were predicted approximately 15 years previously based on the epidemiology of breast cancer and the relationship of ovarian hormone levels to breast cell proliferation. However, the prediction had little effect on prescribing habits due to its theoretical nature. Many questions remain regarding menopausal therapy and breast cancer risk, especially the effects of other schedules and regimens. Epidemiological case-control studies and randomized clinical trials with breast cancer as the outcome cannot answer these questions in an appropriate timeframe. Some intermediate marker of breast cancer risk must therefore be used as a basis of rational prescribing. There is considerable evidence in support of using changes in mammographic densities as such a marker. For example, measurement of changes in mammographic density in the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial showed that EPT was likely to be associated with a notably greater risk than estrogen therapy alone, that sequential EPT regimens are likely to increase the risk as much as continuous regimens (if the total progestin dose is similar), and that replacing medroxyprogesterone acetate with progesterone is unlikely to significantly alter the additional risk.
    MeSH term(s) Biomarkers ; Breast/drug effects ; Breast/pathology ; Contraceptive Agents, Female/pharmacology ; Estrogen Replacement Therapy/adverse effects ; Female ; Humans ; Mammography ; Risk Factors
    Chemical Substances Biomarkers ; Contraceptive Agents, Female
    Language English
    Publishing date 2005-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590400030038
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    Zs.MO 608: Show issues

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