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  1. Article ; Online: Candidate Tracers for Imaging Colony-Stimulating Factor 1 Receptor in Neuroinflammation with Positron Emission Tomography: Issues and Progress.

    Altomonte, Stefano / Pike, Victor W

    ACS pharmacology & translational science

    2023  Volume 6, Issue 11, Page(s) 1632–1650

    Abstract: The tyrosine kinase, colony-stimulating factor 1 receptor (CSF1R), has attracted attention as a potential biomarker of neuroinflammation for imaging studies with positron emission tomography (PET), especially because of its location on microglia and its ... ...

    Abstract The tyrosine kinase, colony-stimulating factor 1 receptor (CSF1R), has attracted attention as a potential biomarker of neuroinflammation for imaging studies with positron emission tomography (PET), especially because of its location on microglia and its role in microglia proliferation. The development of an effective radiotracer for specifically imaging and quantifying brain CSF1R is highly challenging. Here we review the progress that has been made on PET tracer development and discuss issues that have arisen and which remain to be addressed and resolved.
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.3c00213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hypervalent aryliodine compounds as precursors for radiofluorination.

    Pike, Victor W

    Journal of labelled compounds & radiopharmaceuticals

    2018  Volume 61, Issue 3, Page(s) 196–227

    Abstract: Over the last 2 decades or so, hypervalent iodine compounds, such as diaryliodonium salts and aryliodonium ylides, have emerged as useful precursors for labeling homoarenes and heteroarenes with no-carrier-added cyclotron-produced [ ...

    Abstract Over the last 2 decades or so, hypervalent iodine compounds, such as diaryliodonium salts and aryliodonium ylides, have emerged as useful precursors for labeling homoarenes and heteroarenes with no-carrier-added cyclotron-produced [
    MeSH term(s) Fluorine Radioisotopes/chemistry ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/chemical synthesis
    Chemical Substances Fluorine Radioisotopes ; Radiopharmaceuticals
    Language English
    Publishing date 2018-02-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1332: Show issues Location:
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  3. Article ; Online: Gas Phase Transformations in Carbon-11 Chemistry.

    Lu, Shuiyu / Telu, Sanjay / Siméon, Fabrice G / Cai, Lisheng / Pike, Victor W

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: The short-lived positron-emitter carbon-11 ( ...

    Abstract The short-lived positron-emitter carbon-11 (
    MeSH term(s) Carbon Dioxide ; Biomedical Research ; Carbon Radioisotopes ; Hydrogen
    Chemical Substances Carbon-11 ; Carbon Dioxide (142M471B3J) ; Carbon Radioisotopes ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021167
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  4. Article ; Online: Copper(I)-free syntheses of [

    Jana, Susovan / Telu, Sanjay / Jakobsson, Jimmy E / Yang, Bo Yeun / Pike, Victor W

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 34, Page(s) 4589–4592

    Abstract: Herein, we report a copper(I)-free method for labeling the trifluoroacetyl group with positron-emitting carbon-11 ( ...

    Abstract Herein, we report a copper(I)-free method for labeling the trifluoroacetyl group with positron-emitting carbon-11 (
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00465e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Empirical Quantitative Structure-Activity Relationship Equation Assists the Discovery of High-Affinity Phosphodiesterase 4D Inhibitors as Leads to PET Radioligands.

    Jiang, Meijuan / Lu, Shuiyu / Telu, Sanjay / Pike, Victor W

    Journal of medicinal chemistry

    2023  Volume 66, Issue 2, Page(s) 1543–1561

    Abstract: A positron emission tomography (PET) radioligand for imaging phosphodiesterase 4D (PDE4D) would benefit drug discovery and the investigation of neuropsychiatric disorders. The most promising radioligand to date, namely, [ ...

    Abstract A positron emission tomography (PET) radioligand for imaging phosphodiesterase 4D (PDE4D) would benefit drug discovery and the investigation of neuropsychiatric disorders. The most promising radioligand to date, namely, [
    MeSH term(s) Humans ; Phosphodiesterase Inhibitors/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Quantitative Structure-Activity Relationship ; Positron-Emission Tomography/methods ; Brain/metabolism ; Structure-Activity Relationship ; Ligands ; Radiopharmaceuticals/chemistry
    Chemical Substances Phosphodiesterase Inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17) ; Ligands ; Radiopharmaceuticals
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.2c01745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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  6. Article ; Online: Tandem Mass Spectrometry as an Independent Method for Corroborating Fluorine-18 Radioactivity Measurements in Positron Emission Tomography.

    Shetty, H Umesha / Morse, Cheryl L / Pike, Victor W

    ACS measurement science Au

    2022  Volume 2, Issue 4, Page(s) 370–376

    Abstract: Positron emission tomography (PET) uses many tracers labeled with fluorine-18 ( ...

    Abstract Positron emission tomography (PET) uses many tracers labeled with fluorine-18 (
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 2694-250X
    ISSN (online) 2694-250X
    DOI 10.1021/acsmeasuresciau.2c00018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

    Pike, Victor W

    Current medicinal chemistry

    2016  Volume 23, Issue 18, Page(s) 1818–1869

    Abstract: The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of ... ...

    Abstract The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets.
    MeSH term(s) Brain/diagnostic imaging ; Brain/metabolism ; Humans ; Ligands ; Neuroimaging/methods ; Positron-Emission Tomography/methods ; Proteins/metabolism ; Radioisotopes/metabolism
    Chemical Substances Ligands ; Proteins ; Radioisotopes
    Language English
    Publishing date 2016-04-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867323666160418114826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: On the Risk of

    Zhao, Qunchao / Etersque, Jean M / Lu, Shuiyu / Telu, Sanjay / Pike, Victor W

    Organic letters

    2023  Volume 25, Issue 48, Page(s) 8650–8654

    Abstract: Aryliodonium precursors are widely applied for copper-free labeling of positron emission tomography (PET) tracers with fluorine-18. We ... ...

    Abstract Aryliodonium precursors are widely applied for copper-free labeling of positron emission tomography (PET) tracers with fluorine-18. We assessed
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03499
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  9. Article ; Online: [

    Taddei, Carlotta / Pike, Victor W

    EJNMMI radiopharmacy and chemistry

    2019  Volume 4, Issue 1, Page(s) 25

    Abstract: ...

    Abstract [
    Language English
    Publishing date 2019-09-18
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2365-421X
    ISSN (online) 2365-421X
    DOI 10.1186/s41181-019-0073-4
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  10. Article ; Online: Rapid and Efficient Synthesis of [

    Young, Nicholas J / Pike, Victor W / Taddei, Carlotta

    ACS omega

    2020  Volume 5, Issue 31, Page(s) 19557–19564

    Abstract: Prior studies have shown that trifluoromethylarenes can be labeled in high molar activities ( ...

    Abstract Prior studies have shown that trifluoromethylarenes can be labeled in high molar activities (
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c02027
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