Article ; Online: Inadvertent stem cell transfer demonstrating a way for tolerance induction.
2023 Volume 103, Issue 1, Page(s) 21–22
Abstract: In this issue, Sobrino et al. present a case of hematopoietic chimerism and subsequent tolerance after isolated kidney transplantation in a pediatric patient with syndromic combined immune deficiency. This report not only highlights the chimerism ... ...
Abstract | In this issue, Sobrino et al. present a case of hematopoietic chimerism and subsequent tolerance after isolated kidney transplantation in a pediatric patient with syndromic combined immune deficiency. This report not only highlights the chimerism approach for tolerance induction in transplantation, but it is also the first evidence of hematopoietic stem cells in human kidneys. This commentary discusses the potency and risks of the chimerism approach for tolerance induction after solid organ transplantation, especially in (pediatric) patients with immune deficiencies. |
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MeSH term(s) | Humans ; Child ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease ; Immune Tolerance ; Organ Transplantation ; Transplantation Chimera ; Transplantation Tolerance ; Chimerism |
Language | English |
Publishing date | 2023-01-02 |
Publishing country | United States |
Document type | Case Reports ; Journal Article ; Comment |
ZDB-ID | 120573-0 |
ISSN | 1523-1755 ; 0085-2538 |
ISSN (online) | 1523-1755 |
ISSN | 0085-2538 |
DOI | 10.1016/j.kint.2022.11.007 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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