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  1. Article: Towards the Use of Natural Compounds for Crop Protection and Food Safety.

    Pilkington, Lisa I

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: The six research articles/communications and one review that comprise this Special Issue, which concerns studies towards natural compound use for crop protection and food safety purposes, highlight the most recent research and investigations into this ... ...

    Abstract The six research articles/communications and one review that comprise this Special Issue, which concerns studies towards natural compound use for crop protection and food safety purposes, highlight the most recent research and investigations into this exciting area [...].
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11050648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Towards the Use of Natural Compounds for Crop Protection and Food Safety

    Pilkington, Lisa I.

    Foods. 2022 Feb. 23, v. 11, no. 5

    2022  

    Abstract: The six research articles/communications and one review that comprise this Special Issue, which concerns studies towards natural compound use for crop protection and food safety purposes, highlight the most recent research and investigations into this ... ...

    Abstract The six research articles/communications and one review that comprise this Special Issue, which concerns studies towards natural compound use for crop protection and food safety purposes, highlight the most recent research and investigations into this exciting area [...]
    Keywords food crops ; food safety ; foods ; plant protection
    Language English
    Dates of publication 2022-0223
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11050648
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Total Synthesis of (-)-Amovillosumin A and Structure Correction of (-)-Amovillosumin C Using Chemical Synthesis.

    Kim, Irene Jeongin / Pilkington, Lisa I / Barker, David

    Journal of natural products

    2024  Volume 87, Issue 2, Page(s) 340–348

    Abstract: Norlignans are a rare class of natural products isolated from a diverse range of plant species, many of which have interesting biological activities including antibacterial, antioxidant, phytotoxic, platelet aggregation inhibitory effects, and more. ... ...

    Abstract Norlignans are a rare class of natural products isolated from a diverse range of plant species, many of which have interesting biological activities including antibacterial, antioxidant, phytotoxic, platelet aggregation inhibitory effects, and more. Isolated from
    MeSH term(s) Biological Products/analysis ; Cyclization ; Drugs, Chinese Herbal/chemistry ; Fruit/chemistry ; Lignans/chemistry ; Molecular Structure ; Zingiberaceae/chemistry
    Chemical Substances Biological Products ; Drugs, Chinese Herbal ; Lignans
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c01069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Total Syntheses and Absolute Stereochemical Correction of Negundin B, Vitexin 1, and Vitexin 6.

    Jia, Zong Hao / Pilkington, Lisa I / Barker, David

    The Journal of organic chemistry

    2024  Volume 89, Issue 5, Page(s) 3644–3651

    Abstract: A highly adaptable asymmetric synthetic route toward dihydronaphthalene lignans was developed, with its application to the syntheses of negundin B and vitexin 1/6 described herein. This developed pathway proceeded through an enantioselective aldol ... ...

    Abstract A highly adaptable asymmetric synthetic route toward dihydronaphthalene lignans was developed, with its application to the syntheses of negundin B and vitexin 1/6 described herein. This developed pathway proceeded through an enantioselective aldol reaction to establish the contiguous stereocenters present in the final structures with subsequent functional group transformations yielding (-)-negundin B and (-)-vitexin 1/6. The enantioselective synthesis of vitexin 1/6 allowed the correction of absolute configuration, which has been widely incorrectly reported.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Chemometric Analysis of Deep-Sea Natural Products.

    Pilkington, Lisa I

    Molecules (Basel, Switzerland)

    2019  Volume 24, Issue 21

    Abstract: Deep-sea natural products have been created by unique marine organisms that thrive in a challenging environment of extreme conditions for its inhabitants. In this study, 179 deep-sea natural products isolated from 2009 to 2013 were investigated by ... ...

    Abstract Deep-sea natural products have been created by unique marine organisms that thrive in a challenging environment of extreme conditions for its inhabitants. In this study, 179 deep-sea natural products isolated from 2009 to 2013 were investigated by analysing their physicochemical properties that are important indicators of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) profile of a compound. The study and analysis of these molecular descriptors and characteristics enabled the defining of these compounds in various chemical spaces, particularly as an indication of their
    MeSH term(s) 1-Octanol/chemistry ; Animals ; Aquatic Organisms/chemistry ; Bacteria/chemistry ; Biological Products/chemistry ; Biological Products/isolation & purification ; Fungi/chemistry ; Hydrogen Bonding ; Molecular Weight ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/isolation & purification ; Phylogeny ; Principal Component Analysis ; Water/chemistry
    Chemical Substances Biological Products ; Pharmaceutical Preparations ; Water (059QF0KO0R) ; 1-Octanol (NV1779205D)
    Language English
    Publishing date 2019-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24213942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Wastewater-based Epidemiology to Investigate Spatio-Temporal Trends in Alcohol Consumption in Aotearoa, New Zealand.

    Wilson, Miriama K / Phung, Kaitlyn / Chappell, Andrew / Pilkington, Lisa I

    Chemistry, an Asian journal

    2024  Volume 19, Issue 6, Page(s) e202301120

    Abstract: Alcohol is an influential drug that has extensive societal impact. In Aotearoa New Zealand, there are a number of worrying trends related to alcohol consumption including rates of alcohol-related harm and violence and heavy episodic drinking. To ... ...

    Abstract Alcohol is an influential drug that has extensive societal impact. In Aotearoa New Zealand, there are a number of worrying trends related to alcohol consumption including rates of alcohol-related harm and violence and heavy episodic drinking. To understand and address these issues, alcohol consumption rates and related trends need to be understood. A wastewater-based epidemiology study was carried out over the course of six months (April-September 2021), sampling one week per month from ten catchment areas covering ~40 % of the national population. The average alcohol consumption was found to be 12.2 mL/person/day. Temporal and geographical trends in alcohol consumption were found; there was higher alcohol consumption on the weekends compared to weekdays, alcohol consumption was inversely related to settlement size, there was increased alcohol consumption due to public holidays and alcohol consumption was not seen to increase during COVID restrictions, however there was a notable change in the weekly trend during lockdowns. This application of alcohol WBE to Aotearoa New Zealand represents a comprehensive national study to understand alcohol consumption and its influences. The knowledge obtained will allow appropriate services and public policies to be reviewed to best serve communities.
    MeSH term(s) Humans ; Wastewater-Based Epidemiological Monitoring ; New Zealand/epidemiology ; Wastewater ; Alcohol Drinking/epidemiology ; Ethanol
    Chemical Substances Wastewater ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202301120
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  7. Article ; Online: Insights into the relative contribution of four precursors to 3-sulfanylhexan-1-ol and 3-sulfanylhexylacetate biogenesis during fermentation.

    Muhl, Jennifer R / Pilkington, Lisa I / Fedrizzi, Bruno / Deed, Rebecca C

    Food chemistry

    2024  Volume 449, Page(s) 139193

    Abstract: The desirable wine aroma compounds 3-sulfanylhexan-1-ol (3SH) and 3-sulfanylhexyl acetate (3SHA) are released during fermentation from non-volatile precursors present in the grapes. This work explores the relative contribution of four precursors (E-2- ... ...

    Abstract The desirable wine aroma compounds 3-sulfanylhexan-1-ol (3SH) and 3-sulfanylhexyl acetate (3SHA) are released during fermentation from non-volatile precursors present in the grapes. This work explores the relative contribution of four precursors (E-2-hexenal, 3-S-glutathionylhexan-1-ol, 3-S-glutathionylhexanal, and 3-S-cysteinylhexan-1-ol) to 3SH and 3SHA. Through the use of isotopically labelled analogues of these precursors in defined fermentation media, new insights into the role of each precursor have been identified. E-2-Hexenal was shown to contribute negligible amounts of thiols, while 3-S-glutathionylhexan-1-ol was the main precursor of both 3SH and 3SHA. The glutathionylated precursors were both converted to 3SHA more efficiently than 3-S-cysteinylhexan-1-ol. Interestingly, 3-S-glutathionylhexanal generated 3SHA without detectable concentrations of 3SH, suggesting possible differences in the way this precursor is metabolised compared to 3-S-glutathionylhexan-1-ol and 3-S-cysteinylhexan-1-ol. We also provide the first evidence for chemical conversion of 3-S-glutathionylhexan-1-ol to 3-S-(γ-glutamylcysteinyl)-hexan-1-ol in an oenological system.
    MeSH term(s) Fermentation ; Wine/analysis ; Vitis/chemistry ; Vitis/metabolism ; Acetates/metabolism ; Acetates/chemistry ; Aldehydes/metabolism ; Aldehydes/chemistry ; Odorants/analysis ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/chemistry
    Chemical Substances Acetates ; Aldehydes
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.139193
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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  8. Article ; Online: Total Synthesis of Linear Coumarniolignoids (+) and (-)-Sapiumin C, (-)-Moluccanin, and (-)-Hemidesminine.

    Kim, Irene Jeongin / Pilkington, Lisa I / Barker, David

    The Journal of organic chemistry

    2023  Volume 88, Issue 9, Page(s) 5900–5912

    Abstract: Coumarinolignoids (CLs) are a class of natural products isolated from a diverse range of plant species. Due to their unique structural scaffold, they exhibit a wide range of interesting biological activities including hepatoprotective, antitumor, anti- ... ...

    Abstract Coumarinolignoids (CLs) are a class of natural products isolated from a diverse range of plant species. Due to their unique structural scaffold, they exhibit a wide range of interesting biological activities including hepatoprotective, antitumor, anti-inflammatory, and antioxidant activities among others. In this research, key intermediate
    MeSH term(s) Lignans/chemistry ; Antioxidants/pharmacology
    Chemical Substances Lignans ; Antioxidants
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Lignans: A Chemometric Analysis.

    Pilkington, Lisa I

    Molecules (Basel, Switzerland)

    2018  Volume 23, Issue 7

    Abstract: The physicochemical properties of classical lignans, neolignans, flavonolignans and carbohydrate-lignan conjugates (CLCs) were analysed to assess their ADMET profiles and establish if these compounds ... ...

    Abstract The physicochemical properties of classical lignans, neolignans, flavonolignans and carbohydrate-lignan conjugates (CLCs) were analysed to assess their ADMET profiles and establish if these compounds are
    MeSH term(s) Flavonolignans/chemistry ; Hydrogen Bonding ; Lignans/chemistry ; Molecular Structure ; Molecular Weight ; Principal Component Analysis
    Chemical Substances Flavonolignans ; Lignans
    Language English
    Publishing date 2018-07-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23071666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article ; Online: An account of strategies and innovations for teaching chemistry during the COVID-19 pandemic.

    Pilkington, Lisa I / Hanif, Muhammad

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2021  Volume 49, Issue 3, Page(s) 320–322

    Abstract: The COVID-19 pandemic led to an abrupt suspension of face-to-face teaching activities in higher education institutions across the globe. The instructors and faculty at most institutions have had to adapt, invent, and implement adjustments quickly to ... ...

    Abstract The COVID-19 pandemic led to an abrupt suspension of face-to-face teaching activities in higher education institutions across the globe. The instructors and faculty at most institutions have had to adapt, invent, and implement adjustments quickly to adopt an online learning environment. This has been an extraordinarily challenging time for both students and instructors, particularly as many were not aware of the affordances and weaknesses of the online learning environment before it was uptaken. Particularly for chemistry and related disciplines, this change in delivery mode is even more disruptive in courses that have laboratory components due to loss of access to laboratories. As a teaching community, it was our responsibility to respond quickly and effectively to students' learning needs during this unprecedented global crisis. In our course, we provided succinct pre-recorded lecture-videos by topic rather than live-streaming of lectures. The recordings were made available to students a minimum of 24 h before the scheduled lecture time. Students were then provided opportunities to attend live tutorial sessions (held on Zoom and live Q&A feature on Piazza) if they had any questions that they wanted to ask the lecturer directly. We believe that the asynchronous sessions were more equitable than synchronous ones. This meant that students with difficult and challenging home/learning environments (i.e., disruptions at home, work/family schedules, poor internet, limited access to devices, etc.) were minimally disadvantaged. The approach worked well in general for teaching chemistry to pharmacy students and we believe that it can be adopted for other subjects.
    MeSH term(s) COVID-19/epidemiology ; Chemistry/education ; Chemistry, Pharmaceutical/education ; Curriculum ; Education, Distance ; Education, Pharmacy/methods ; Humans ; New Zealand/epidemiology ; Pandemics ; SARS-CoV-2 ; Universities
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2039717-3
    ISSN 1539-3429 ; 1470-8175
    ISSN (online) 1539-3429
    ISSN 1470-8175
    DOI 10.1002/bmb.21511
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