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  1. Article ; Online: Intracellular

    Malet, Karim / Faure, Emmanuel / Adam, Damien / Donner, Jannik / Liu, Lin / Pilon, Sarah-Jeanne / Fraser, Richard / Jorth, Peter / Newman, Dianne K / Brochiero, Emmanuelle / Rousseau, Simon / Nguyen, Dao

    American journal of respiratory and critical care medicine

    2024  

    Abstract: Rationale: Pseudomonas aeruginosa: Objectives: To detect and characterize intracellular : Methods: We sampled the lung explant tissues from CF patients undergoing lung transplantation and non-CF lung donor control. We analyzed lung tissue sections ...

    Abstract Rationale: Pseudomonas aeruginosa
    Objectives: To detect and characterize intracellular
    Methods: We sampled the lung explant tissues from CF patients undergoing lung transplantation and non-CF lung donor control. We analyzed lung tissue sections for the presence of intracellular
    Measurements and main results: P.a.
    Conclusion: This is the first study describing the presence of intracellular
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1451OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case report on lipofuscin deposition in a graft biopsy two years after kidney transplantation: an insignificant bystander or a pathogenic benefactor?

    Leung, Vivian W Y / Pilon, Sarah-Jeanne / Fiset, Pierre O / Sandal, Shaifali

    BMC nephrology

    2019  Volume 20, Issue 1, Page(s) 376

    Abstract: Background: Lipofuscin deposition is a characteristic manifestation of aging. There is very limited literature in humans and in animals describing these deposits in native kidneys. Overall, it is thought to be non-pathogenic and successful transplants ... ...

    Abstract Background: Lipofuscin deposition is a characteristic manifestation of aging. There is very limited literature in humans and in animals describing these deposits in native kidneys. Overall, it is thought to be non-pathogenic and successful transplants from a donor with lipofuscin deposits have been reported. We present the case of a patient who underwent a kidney transplant and a for-cause biopsy post-transplantation incidentally revealed lipofuscin deposition.
    Case presentation: A 48-year old gentleman with a past medical history of diabetes, hypertension, coronary artery disease, and ischemic and then hemorrhagic cardiovascular accident underwent a successful kidney transplant. His donor was an expanded criteria donor with no major past medical history. Post-transplant course was complicated by delayed graft function requiring one dialysis treatment for hyperkalemia. After that he had an uneventful course and achieved a baseline creatinine of 1.2 mg/dL, with no proteinuria. On a routine 19-month follow-up he was noted to have proteinuria and an antibody against the major-histocompatibility-complex class I-related chain A. A graft biopsy revealed acute antibody-mediated rejection and impressive lipofuscin deposition. He was subsequently treated with an antibody-mediated rejection protocol that included high dose steroids, Rituximab, plasmapheresis, and intravenous immunoglobulin, but responded poorly to this regimen. A 6-month follow up biopsy continued to show lipofuscin deposition, with similar microvascular injury scores and 12-months later his creatinine remained stable but his proteinuria worsened. Patient was struggling with recurrent infectious episodes requiring hospitalizations and thus no further diagnostic or therapeutic treatments were pursued.
    Conclusions: Lipofuscin deposition has been reported in solid organ transplants but the significance and cause are not well understood. Several physiologic and some pathologic causes to these deposits have been reported including age, diabetes, medications and a genetic syndrome. We propose that immunologic causes such as rejection in the presence of other risk factors could potentiate the oxidative stress leading to excessive lipofuscin deposition in kidney transplants. In the case of our patient, we conclude that these deposits were likely recipient-derived, and postulate that the cumulative burden of inflammation from rejection, and underlying medical conditions led to increased lipofuscin deposition. We speculate them to be an innocent bystander.
    MeSH term(s) Allografts/metabolism ; Allografts/pathology ; Biopsy ; Graft Rejection/metabolism ; Graft Rejection/pathology ; Humans ; Incidental Findings ; Kidney/metabolism ; Kidney/pathology ; Kidney Transplantation ; Lipofuscin/metabolism ; Male ; Microvessels/pathology ; Middle Aged
    Chemical Substances Lipofuscin
    Language English
    Publishing date 2019-10-17
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-019-1569-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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