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  1. Article: Metal chelators as part of a strategy for the treatment of neurodegenerative diseases

    Leal, M. Fernanda C. / Catarino, Rita I. L. / Pimenta, Adriana M. / Souto, M. Renata S.

    Trace elements and electrolytes

    2023  Volume 40, Issue 3, Page(s) 126

    Language German
    Document type Article
    ZDB-ID 1181166-3
    ISSN 0946-2104
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1976: Show issues Location:
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  2. Article: Lead migration from toys by anodic stripping voltammetry using a bismuth film electrode.

    Leal, M Fernanda C / Catarino, Rita I L / Pimenta, Adriana M / Souto, M Renata S / Afonso, Christelle S / Fernandes, Ana F Q

    Archives of environmental & occupational health

    2016  Volume 71, Issue 5, Page(s) 300–306

    Abstract: Metals may be released from toys via saliva during mouthing, via sweat during dermal contact, or via gastric and intestinal fluids after partial or whole ingestion. In this study, we determined the lead migration from toys bought on the Portuguese market ...

    Abstract Metals may be released from toys via saliva during mouthing, via sweat during dermal contact, or via gastric and intestinal fluids after partial or whole ingestion. In this study, we determined the lead migration from toys bought on the Portuguese market for children below 3 years of age. The lead migration was performed according to the European Committee for Standardization EN 71-3, which proposes a 2-hour migration test that simulates human gastric conditions. The voltammetric determination of migrated lead was performed by anodic stripping voltammetry (ASV) at a bismuth film electrode (BiFE). For all the analyzed toys, the values of migrated lead did not exceed the limits imposed by the European Committee for Standardization EN 71-3 (90 mg kg
    MeSH term(s) Bismuth/chemistry ; Child, Preschool ; Electrochemical Techniques ; Electrodes ; Environmental Pollutants/analysis ; Humans ; Infant ; Infant, Newborn ; Lead/analysis ; Play and Playthings ; Portugal
    Chemical Substances Environmental Pollutants ; Lead (2P299V784P) ; Bismuth (U015TT5I8H)
    Language English
    Publishing date 2016-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2245323-4
    ISSN 1933-8244 ; 0003-9896
    ISSN 1933-8244 ; 0003-9896
    DOI 10.1080/19338244.2015.1096757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ofloxacin determination in urine, serum and pharmaceuticals using an automatic flow potentiometric system.

    Pimenta, Adriana M / Souto, M Renata S / Catarino, Rita I L / Leal, M Fernanda C / Lima, José L F Costa

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2013  Volume 29, Issue 9, Page(s) 893–898

    Abstract: An automatic system was developed to determine ofloxacin in biological fluids and pharmaceutical formulations. Drug detection was carried out by a potentiometric membrane sensor based on [bis(trifluoromethyl)phenyl]borate as molecular-recognition ... ...

    Abstract An automatic system was developed to determine ofloxacin in biological fluids and pharmaceutical formulations. Drug detection was carried out by a potentiometric membrane sensor based on [bis(trifluoromethyl)phenyl]borate as molecular-recognition material. The tubular shaped detector system was solidly attached to the manifold, creating a high-throughput stable setup (50 samples per hour) appropriate for routine antibiotic assessment. Under the optimized flow conditions, the sensor displayed a mean detection limit of 1 × 10(-5) M, a linear response over the concentrations of 2 × 10(-5) to 5 × 10(-3) M (slope of 57.4 mV decade(-1)) and a wide working pH range (2.1 - 6.6). The procedure was successfully applied to ofloxacin analysis in pharmaceuticals (relative deviation lower than 6%) and biological fluids at levels usually found after drug administration of clinical doses (recoveries between 91 and 106%). No significant interference from common excipients found in commercial formulations and inorganic ions usually present in biological fluids was noticed.
    MeSH term(s) Automation/instrumentation ; Humans ; Molecular Structure ; Ofloxacin/analysis ; Ofloxacin/blood ; Ofloxacin/urine ; Pharmaceutical Preparations/chemistry ; Potentiometry/instrumentation
    Chemical Substances Pharmaceutical Preparations ; Ofloxacin (A4P49JAZ9H)
    Language English
    Publishing date 2013-10-22
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 0910-6340
    ISSN (online) 1348-2246
    ISSN 0910-6340
    DOI 10.2116/analsci.29.893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A sequential injection analysis system for potassium clavulanate determination using two potentiometric detectors.

    Pimenta, Adriana M / Araújo, Alberto N / Montenegro, Maria Conceição B S M

    Journal of pharmaceutical and biomedical analysis

    2002  Volume 30, Issue 4, Page(s) 931–937

    Abstract: Two almost independent potentiometric methods were implemented in a multi-task flow system based on the concept of sequential injection analysis for the analytical control of potassium clavulanate in pharmaceutical formulations. In addition to in-line ... ...

    Abstract Two almost independent potentiometric methods were implemented in a multi-task flow system based on the concept of sequential injection analysis for the analytical control of potassium clavulanate in pharmaceutical formulations. In addition to in-line preparation of the solutions submitted to the analysis, the system simultaneously detected the clavulanate anion and the potassium cation using two potentiometric detectors selective to each of the species referred. For the two determinations, the system developed presented an analytical range of 2 mM-0.1 M. Relative standard deviations of 0.5 and 0.6%, respectively, for clavulanate and potassium, were calculated from the signals obtained for 10 consecutive injections of a solution of 5x10(-3) M potassium clavulanate. The frequency of sampling was 53 samples h(-1). The quality of results supplied was evaluated by comparison with the reference procedure revealing relative errors less than 2% for the two determinations. The simultaneous attainment of two measurements permitted the standardisation of results in real time, the detection of faults in the procedure and monitoring the chemical stability of clavulanate.
    MeSH term(s) Chemistry, Pharmaceutical ; Clavulanic Acid/analysis ; Flow Injection Analysis/instrumentation ; Flow Injection Analysis/methods ; Potentiometry/instrumentation ; Potentiometry/methods
    Chemical Substances Clavulanic Acid (23521W1S24)
    Language English
    Publishing date 2002-11-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/s0731-7085(02)00474-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Chloride-selective membrane electrodes and optodes based on an indium(III) porphyrin for the determination of chloride in a sequential injection analysis system.

    Pimenta, Adriana M / Araújo, Alberto N / Montenegro, Maria Conceição B S M / Pasquini, Celio / Rohwedder, Jarbas J R / Raimundo, Ivo M

    Journal of pharmaceutical and biomedical analysis

    2004  Volume 36, Issue 1, Page(s) 49–55

    Abstract: Two quasi-independent methods for potentiometric and optical determination of chloride were simultaneously implemented in a flow system, providing real-time assessment of the quality of results. A potentiometric and an optical polymeric membrane doped ... ...

    Abstract Two quasi-independent methods for potentiometric and optical determination of chloride were simultaneously implemented in a flow system, providing real-time assessment of the quality of results. A potentiometric and an optical polymeric membrane doped with the same indium(III) octaethyl-porphyrin were used as sensor ionophore. The working mechanism and the analytical characteristics of these porphyrin-based sensors with respect to dynamic range, selectivity, repeatability and lifetime are discussed. These sensors, utilised as detectors in a flow system, were applied for the analysis of chloride in pharmaceutical solutions. The quality of the results obtained was evaluated by comparison with those provided by the reference method and no significant statistical differences at the 95% confidence level were observed. The simultaneous attainment of two measurements permitted the standardisation of results in real time and the detection of failures in the procedure.
    MeSH term(s) Calibration ; Chlorides/analysis ; Flow Injection Analysis/methods ; Ion-Selective Electrodes ; Ionophores ; Membranes, Artificial ; Metalloporphyrins/chemistry ; Pharmaceutical Preparations/chemistry ; Polyvinyl Chloride ; Potentiometry/methods ; Reference Standards ; Reproducibility of Results ; Sensitivity and Specificity ; Spectrophotometry, Ultraviolet/methods
    Chemical Substances Chlorides ; Ionophores ; Membranes, Artificial ; Metalloporphyrins ; Pharmaceutical Preparations ; indium(III) octaethylporphyrin ; Polyvinyl Chloride (9002-86-2)
    Language English
    Publishing date 2004-09-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2004.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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