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  1. Article ; Online: Potential drug-drug interactions in University Hospital Medical Intensive Care Unit patients in Turkey.

    Jafarova Demirkapu, M / Pinar Kara, S

    European review for medical and pharmacological sciences

    2021  Volume 25, Issue 22, Page(s) 7108–7114

    Abstract: Objective: Concomitant use of drugs not only enhances the therapeutic effect, but may also lead to undesirable interactions. Drug interactions are frequently seen in intensive care patients. In this study, we aimed to determine the frequency and ... ...

    Abstract Objective: Concomitant use of drugs not only enhances the therapeutic effect, but may also lead to undesirable interactions. Drug interactions are frequently seen in intensive care patients. In this study, we aimed to determine the frequency and clinical severity of drug interactions in Medical Intensive Care Unit (MICU) patients.
    Patients and methods: The ordered drugs and blood analysis results of 314 patients aged ≥18 years who stayed in the MICU for at least 24 h between January and December 2020 were evaluated. Using the Lexi-Interact online database, clinically significant types of drug interactions, frequently interacting drug/drug groups, and potential adverse reactions were identified.
    Results: The average number of drugs in 314 patients was 8.98±5.19. It was determined that polypharmacy was associated with comorbidity and the amount of drug used increased as the number of diagnoses increased. Potential drug-drug interactions were observed in 69.7% of the MICU patients, and it was determined that the amount of interactions increased as the amount of drug used increased. The most common X, D, and C type potential drug-drug interactions, were found between furosemide and salbutamol, enoxaparin and acetylsalicylic acid, ipratropium and potassium chloride, respectively.
    Conclusions: Use of frequently interacting drugs in the treatment of critically MICU patients may lead to potential drug-drug interactions and adverse reactions. Daily monitoring and updating of drug therapy can improve patient's quality of life by preventing or reducing potential drug-drug interactions.
    MeSH term(s) Aged ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Retrospective Studies ; Turkey/epidemiology
    Language English
    Publishing date 2021-12-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202111_27264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Carbonic anhydrase I and II autoantibody levels in primary hypertension: our preliminary results.

    Pinar Kara, S / Özkan, G / Kübra Emeksiz, G / Menteşe, A / Demir, S / Ulusoy, Ş

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 24, Page(s) 12821–12826

    Abstract: Objective: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II ... ...

    Abstract Objective: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT.
    Patients and methods: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty-four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups.
    Results: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis.
    Conclusions: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development.
    MeSH term(s) Autoantibodies/blood ; Autoantibodies/metabolism ; Carbonic Anhydrase I/blood ; Carbonic Anhydrase I/metabolism ; Carbonic Anhydrase II/blood ; Carbonic Anhydrase II/metabolism ; Female ; Humans ; Hypertension/blood ; Hypertension/diagnosis ; Male ; Middle Aged
    Chemical Substances Autoantibodies ; Carbonic Anhydrase I (EC 4.2.1.-) ; Carbonic Anhydrase II (EC 4.2.1.-)
    Language English
    Publishing date 2020-12-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202012_24183
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Reliable Quantification of the Potential for Equations Based on Spot Urine Samples to Estimate Population Salt Intake: Protocol for a Systematic Review and Meta-Analysis.

    Huang, Liping / Crino, Michelle / Wu, Jason Hy / Woodward, Mark / Land, Mary-Anne / McLean, Rachael / Webster, Jacqui / Enkhtungalag, Batsaikhan / Nowson, Caryl A / Elliott, Paul / Cogswell, Mary / Toft, Ulla / Mill, Jose G / Furlanetto, Tania W / Ilich, Jasminka Z / Hong, Yet Hoi / Cohall, Damian / Luzardo, Leonella / Noboa, Oscar /
    Holm, Ellen / Gerbes, Alexander L / Senousy, Bahaa / Pinar Kara, Sonat / Brewster, Lizzy M / Ueshima, Hirotsugu / Subramanian, Srinivas / Teo, Boon Wee / Allen, Norrina / Choudhury, Sohel Reza / Polonia, Jorge / Yasuda, Yoshinari / Campbell, Norm Rc / Neal, Bruce / Petersen, Kristina S

    JMIR research protocols

    2016  Volume 5, Issue 3, Page(s) e190

    Abstract: Background: Methods based on spot urine samples (a single sample at one time-point) have been identified as a possible alternative approach to 24-hour urine samples for determining mean population salt intake.: Objective: The aim of this study is to ... ...

    Abstract Background: Methods based on spot urine samples (a single sample at one time-point) have been identified as a possible alternative approach to 24-hour urine samples for determining mean population salt intake.
    Objective: The aim of this study is to identify a reliable method for estimating mean population salt intake from spot urine samples. This will be done by comparing the performance of existing equations against one other and against estimates derived from 24-hour urine samples. The effects of factors such as ethnicity, sex, age, body mass index, antihypertensive drug use, health status, and timing of spot urine collection will be explored. The capacity of spot urine samples to measure change in salt intake over time will also be determined. Finally, we aim to develop a novel equation (or equations) that performs better than existing equations to estimate mean population salt intake.
    Methods: A systematic review and meta-analysis of individual participant data will be conducted. A search has been conducted to identify human studies that report salt (or sodium) excretion based upon 24-hour urine samples and spot urine samples. There were no restrictions on language, study sample size, or characteristics of the study population. MEDLINE via OvidSP (1946-present), Premedline via OvidSP, EMBASE, Global Health via OvidSP (1910-present), and the Cochrane Library were searched, and two reviewers identified eligible studies. The authors of these studies will be invited to contribute data according to a standard format. Individual participant records will be compiled and a series of analyses will be completed to: (1) compare existing equations for estimating 24-hour salt intake from spot urine samples with 24-hour urine samples, and assess the degree of bias according to key demographic and clinical characteristics; (2) assess the reliability of using spot urine samples to measure population changes in salt intake overtime; and (3) develop a novel equation that performs better than existing equations to estimate mean population salt intake.
    Results: The search strategy identified 538 records; 100 records were obtained for review in full text and 73 have been confirmed as eligible. In addition, 68 abstracts were identified, some of which may contain data eligible for inclusion. Individual participant data will be requested from the authors of eligible studies.
    Conclusions: Many equations for estimating salt intake from spot urine samples have been developed and validated, although most have been studied in very specific settings. This meta-analysis of individual participant data will enable a much broader understanding of the capacity for spot urine samples to estimate population salt intake.
    Language English
    Publishing date 2016-09-21
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/resprot.6282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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