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Article: Are all primary retinal detachments the same? Anatomic and functional differences between phakic and pseudophakic patients.

Gibelalde, Ane / Pinar-Sueiro, Sergio / Ibarrondo, Oliver / Martínez-Soroa, Itziar / Mendicute, Javier / Ruiz Miguel, Miguel

International journal of retina and vitreous

2023 Volume 9, Issue 1, Page(s) 17

Abstract: Background: Given differences in the pathogenic mechanisms underlying primary retinal detachment (RD) as a function of the status of the lens, the objective was to explore differences between pseudophakic and phakic patients with primary RD.: Methods!# ...

Abstract	Background: Given differences in the pathogenic mechanisms underlying primary retinal detachment (RD) as a function of the status of the lens, the objective was to explore differences between pseudophakic and phakic patients with primary RD. Methods: A retrospective study including 821 patients who underwent surgery for RD [491 cases of phakic and 330 of pseudophakic RD (pRD and psRD, respectively)] in our hospital between 2012 and 2020. Results: The mean age was 58.24 ± 12.76 years in the pRD group and 66.87 ± 11.18 years in the psRD group (p = 0.001). There were more men in both groups (70% and 64.23% of pseudophakic and phakic patients, respectively; p = 0.07). The most common location for the RD was superior in both groups (43.94% and 51.93% of pseudophakic and phakic patients, respectively), rates of inferior and total RD were somewhat higher in the psRD group (31.82% and 13.33% in pseudophakic vs 25.25% and 11.0% in phakic patients, p = 0.001). In pseudophakic and phakic patients respectively, macular involvement in 69.09% and 62.73% of cases (p = 0.067). Proliferative vitreoretinopathy was significantly more common in the psRD group (7.88% vs 3.6% in phakic patients, p = 0.01).The rate of final anatomic reattachment differed markedly between groups, with a higher rate in phakic (94.03%) than pseudophakic (87.27%) patients (p = 0.001). Conclusions: The specific pathogenic mechanism involved in psRD seems to be responsible for worse evolution characteristics which are associated with poorer final anatomic and functional outcomes in pseudophakic patients.
Language	English
Publishing date	2023-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2836254-8
ISSN	2056-9920
ISSN	2056-9920
DOI	10.1186/s40942-023-00455-y
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Article ; Online: Albuminuria as a biomarker of severity in diabetic retinopathy and in the response to intravitreal treatment in diabetic macular edema.

Gibelalde, Ane / Amenabar Alonso, Asier / Pinar-Sueiro, Sergio / Bilbao-Garay, Ismene / Juaristi Eizmendi, Leire / Sampedro, Amaia

International ophthalmology

2022 Volume 43, Issue 6, Page(s) 2049–2056

Abstract: Purpose: Diabetic macular edema (DME) presents a suboptimal response to antiangiogenic treatment in approximately 30% of patients. We analyzed the relationship between renal function and response to antiangiogenic therapy in patients with DME.: ... ...

Abstract	Purpose: Diabetic macular edema (DME) presents a suboptimal response to antiangiogenic treatment in approximately 30% of patients. We analyzed the relationship between renal function and response to antiangiogenic therapy in patients with DME. Methods: A total of 367 patients were collected and distributed into three main groups: uncomplicated diabetic retinopathy (DR) group (n = 97), proliferative diabetic retinopathy (PDR) group (n = 94) and DME group (n = 175). Likewise, patients with DME were divided into two groups: responders to antiangiogenic drugs (n = 96) and non-responders to antiangiogenic drugs (n = 79). Age, type of diabetes, arterial hypertension (AHT), creatinine, HbA1c, albuminuria and glomerular filtration rate were analyzed. In the statistical analysis, chi-square test and t student were used to compare each group. The relationship between albuminuria and response to treatment in the DME group was studied with a binary logistic regression model, estimating odds ratio and their confidence intervals. Results: There are differences between the three main groups in terms of the presence or not of albuminuria. The presence of albuminuria is greater in the group of patients with more severe DR (PDR and DME), compared to the uncomplicated DR group (p < 0.009). In the logistic regression analysis model, a positive relationship was found and the odds ratio for the albuminuria variable and is 2.78 (CI: 1.42-5.36). Conclusions: The presence of albuminuria is associated with a higher degree of DR and worse response to antiangiogenic therapy in patients with DME in our series. Multidisciplinary teams would be necessary to reduce albuminuria and thus optimize the treatment of patients with DME.
MeSH term(s)	Humans ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Macular Edema/etiology ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/drug therapy ; Albuminuria/drug therapy ; Albuminuria/complications ; Angiogenesis Inhibitors/therapeutic use ; Biomarkers ; Diabetes Mellitus, Type 2/complications
Chemical Substances	Angiogenesis Inhibitors ; Biomarkers
Language	English
Publishing date	2022-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-022-02604-y
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Article ; Online: Efficacy and safety of intense pulsed light of upper and lower eyelids in Meibomian gland dysfunction: A prospective multicentric study.

Benitez-Del-Castillo, Jose Manuel / López-Pérez, María Dolores / Cano-Ortiz, Antonio / Peris-Martinez, Cristina / Pinar-Sueiro, Sergio / Gessa-Sorroche, Maria / García-Franco-Zuñiga, Carmen / Iradier, Maria T / Amesty, Maria A / Burgos-Blasco, Barbara

European journal of ophthalmology

2023 Volume 34, Issue 3, Page(s) 700–707

Abstract: Purpose: To demonstrate that intense pulsed light therapy (IPL) of the upper and lower eyelids with meibomian gland expression (MGX) is effective in improving dry eye disease due to meibomian gland dysfunction (MGD).: Methods: Patients with ocular ... ...

Abstract	Purpose: To demonstrate that intense pulsed light therapy (IPL) of the upper and lower eyelids with meibomian gland expression (MGX) is effective in improving dry eye disease due to meibomian gland dysfunction (MGD). Methods: Patients with ocular discomfort (Ocular Surface Disease Index -OSDI- above 13) and signs of MGD were recruited. All patients underwent OSDI, visual acuity (VA), intraocular pressure, Schirmer test, meibography, non-invasive tear breakup time (NITBUT), slit-lamp examination (corneal and conjunctival staining, hyperemia, gland expressibility, and meibum quality), tear osmolarity and lipid layer thickness. IPL was performed with Optima IPL (Lumenis Ltd.) following a standardized protocol on upper and lower eyelids of both eyes, with inferior eyelid MGX. Patients received four sessions separated by two weeks each. Four weeks after, examinations were repeated. Results: 160 patients (320 eyes) were included, of which 108 (67.5%) were women and mean age was 59.2 ± 15.08 (range 20-89). After four sessions, VA, OSDI, tear osmolarity, lipid layer thickness, NITBUT, hyperemia, corneal and conjunctival staining, gland expressibility, meibum quality, inferior eyelid Meiboscore and Schirmer test improved (all, p < 0.027). Changes in OSDI, initial and average NITBUT increased with dry eye disease severity (according to OSDI). Increased pre-treatment OSDI, hyperemia, corneal and conjunctival staining and Schirmer test were associated with an improvement in OSDI (all, p < 0.040). No adverse events were noted. Conclusions: The combination of IPL on upper and lower eyelids with MGX is safe and effective for the treatment of MGD. Patients with severe dry eye disease present greater improvements.
MeSH term(s)	Humans ; Female ; Meibomian Gland Dysfunction/therapy ; Meibomian Gland Dysfunction/physiopathology ; Meibomian Gland Dysfunction/diagnosis ; Middle Aged ; Male ; Prospective Studies ; Aged ; Adult ; Tears/physiology ; Tears/metabolism ; Meibomian Glands/metabolism ; Meibomian Glands/physiopathology ; Meibomian Glands/diagnostic imaging ; Aged, 80 and over ; Intense Pulsed Light Therapy/methods ; Young Adult ; Visual Acuity/physiology ; Treatment Outcome ; Dry Eye Syndromes/physiopathology ; Dry Eye Syndromes/therapy ; Dry Eye Syndromes/diagnosis ; Eyelids/physiopathology ; Osmolar Concentration ; Intraocular Pressure/physiology
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721231199121
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Article ; Online: Tratamiento de los fenómenos no dependientes de la presión intraocular en el síndrome de seudoexfoliación.

Pinar-Sueiro, Sergio / Martínez-Alday, Nerea

Archivos de la Sociedad Espanola de Oftalmologia

2011 Volume 86, Issue 9, Page(s) 275–276

Title translation	Treatment of intraocular-pressure-independent phenomena in pseudoexfoliation syndrome.
MeSH term(s)	Amino Acid Oxidoreductases/deficiency ; Amino Acid Oxidoreductases/genetics ; Elastic Tissue/metabolism ; Exfoliation Syndrome/drug therapy ; Exfoliation Syndrome/etiology ; Exfoliation Syndrome/genetics ; Exfoliation Syndrome/metabolism ; Folic Acid Deficiency/complications ; Folic Acid Deficiency/diagnosis ; Folic Acid Deficiency/drug therapy ; Humans ; Hyperhomocysteinemia/complications ; Hyperhomocysteinemia/diagnosis ; Hyperhomocysteinemia/drug therapy ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/etiology ; Oxidative Stress ; Polymorphism, Single Nucleotide ; Risk Factors ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/diagnosis ; Vitamin B 12 Deficiency/drug therapy ; Vitamin B 6 Deficiency/complications ; Vitamin B 6 Deficiency/diagnosis ; Vitamin B 6 Deficiency/drug therapy
Chemical Substances	Amino Acid Oxidoreductases (EC 1.4.-) ; LOXL1 protein, human (EC 1.4.3.-)
Language	Spanish
Publishing date	2011-09
Publishing country	Spain
Document type	Journal Article
ZDB-ID	194943-3
ISSN	1989-7286 ; 0365-6691
ISSN (online)	1989-7286
ISSN	0365-6691
DOI	10.1016/j.oftal.2011.06.014
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Article ; Online: Prevention of retinal ganglion cell swelling by systemic brimonidine in a rat experimental glaucoma model.

Pinar-Sueiro, Sergio / Urcola, Haritz / Rivas, Miren Agurtzane / Vecino, Elena

Clinical & experimental ophthalmology

2011 Volume 39, Issue 8, Page(s) 799–807

Abstract: Background: The objective of this study was to evaluate the neuroprotective effect of brimonidine on retinal ganglion cells in rats with elevated intraocular pressure and to characterize the subpopulation of cells that can be rescued, as well as assess ... ...

Abstract	Background: The objective of this study was to evaluate the neuroprotective effect of brimonidine on retinal ganglion cells in rats with elevated intraocular pressure and to characterize the subpopulation of cells that can be rescued, as well as assess the effect of this drug on retinal ganglion cell soma size. Methods: Episcleral vein cauterization was used to increase intraocular pressure for 5 weeks on left eyes, considering right eyes as intrinsic controls in all cases. All the animals were then given weekly intraperitoneal injections, the experimental group receiving brimonidine, and the control group were administered only phosphate-buffered saline. Surviving retinal ganglion cells were quantified and their area and distribution measured by retrograde labelling with fluorogold. Results: Brimonidine administered systemically has a neuroprotective effect on retinal ganglion cells, which is unrelated to its capacity to lower intraocular pressure. It prevents the increase of cell size that is associated with stages prior to cell death. This phenomenon is particularly evident in the zones of the retina most susceptible to the damage caused by glaucoma (middle and periphery). Conclusion: This effect of preventing retinal ganglion cell swelling can be considered as a new marker to study neuroprotection from antiglaucomatous drugs in the early stages of neurodegeneration in glaucoma.
MeSH term(s)	Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Animals ; Brimonidine Tartrate ; Cell Count ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Glaucoma, Open-Angle/complications ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/pathology ; Injections, Intraperitoneal ; Intraocular Pressure/drug effects ; Papilledema/etiology ; Papilledema/pathology ; Papilledema/prevention & control ; Quinoxalines/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/pathology ; Treatment Outcome
Chemical Substances	Adrenergic alpha-2 Receptor Agonists ; Quinoxalines ; Brimonidine Tartrate (4S9CL2DY2H)
Language	English
Publishing date	2011-11
Publishing country	Australia
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2014008-3
ISSN	1442-9071 ; 1442-6404
ISSN (online)	1442-9071
ISSN	1442-6404
DOI	10.1111/j.1442-9071.2011.02573.x
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Article ; Online: Neuroprotective effects of topical CB1 agonist WIN 55212-2 on retinal ganglion cells after acute rise in intraocular pressure induced ischemia in rat.

Pinar-Sueiro, Sergio / Zorrilla Hurtado, José Ángel / Veiga-Crespo, Patricia / Sharma, Sansar C / Vecino, Elena

Experimental eye research

2013 Volume 110, Page(s) 55–58

Abstract: Neuroprotection in retinal experimental work consists primarily of preventing retinal ganglion cell (RGC) loss after exposure to a hostile event. We have studied the neuroprotective effect on RGCs in an ischemia-reperfusion model by activation of the ... ...

Abstract	Neuroprotection in retinal experimental work consists primarily of preventing retinal ganglion cell (RGC) loss after exposure to a hostile event. We have studied the neuroprotective effect on RGCs in an ischemia-reperfusion model by activation of the cannabinoid receptor CB1 using topical application of WIN 55212-2. Intraocular pressure (IOP) was increased by continuous infusion of phosphate buffer saline (PBS) into the anterior chamber of the eye. Mean intraocular pressure was increased up to 88.5 ± 0.29 mm Hg (control normal IOP 15.1 ± 0.25 mm Hg), for 35 min. Animals were distributed in 3 groups. Left eyes underwent acute rise in intraocular pressure. First group was treated with topical Tocrisolve™ 100 in both eyes. Second group was treated with 1% solution of CB1 agonist WIN 55212-2 in both eyes. Third group was treated with WIN 55212-2 1% and CB1 antagonist AM 251 1% solutions in both eyes. Subsequently, RGCs were immunolabeled with Brn3a and automated quantification of retinal mosaics of RGCs were performed. The ischemic damage led to a mean loss in RGC density of 12.33%. After topic administration of WIN 55212-2, mean loss of RGCs was of 2.45%. Co-treatment with CB1 antagonist AM 251 abolished almost completely the neuroprotective effect of WIN 55212-2. Topic 1% WIN 55212-2 showed a neuroprotective effect on RGC degeneration after ischemia-reperfusion without pre-activation of CB1 receptors.
MeSH term(s)	Administration, Topical ; Animals ; Benzoxazines/therapeutic use ; Cell Count ; Disease Models, Animal ; Female ; Intraocular Pressure ; Morpholines/therapeutic use ; Naphthalenes/therapeutic use ; Neuroprotective Agents/therapeutic use ; Ocular Hypertension/etiology ; Piperidines/therapeutic use ; Pyrazoles/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Reperfusion Injury/etiology ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Retinal Diseases/etiology ; Retinal Diseases/pathology ; Retinal Diseases/prevention & control ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/pathology ; Tonometry, Ocular
Chemical Substances	Benzoxazines ; Morpholines ; Naphthalenes ; Neuroprotective Agents ; Piperidines ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; AM 251 (3I4FA44MAI) ; (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone (5H31GI9502)
Language	English
Publishing date	2013-02-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2013.02.009
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Article ; Online: Study on the effectiveness of antibiotic prophylaxis in external dacryocystorhinostomy: a review of 697 cases.

Pinar-Sueiro, Sergio / Fernández-Hermida, Roberto-Víctor / Gibelalde, Ane / Martínez-Indart, Lorea

Ophthalmic plastic and reconstructive surgery

2010 Volume 26, Issue 6, Page(s) 467–472

Abstract: Purpose: To evaluate the prophylactic use of antibiotics in external dacryocystorhinostomy for the prevention of postoperative complications.: Methods: This study included 697 patients diagnosed with distal nasolacrimal duct obstruction and who were ... ...

Abstract	Purpose: To evaluate the prophylactic use of antibiotics in external dacryocystorhinostomy for the prevention of postoperative complications. Methods: This study included 697 patients diagnosed with distal nasolacrimal duct obstruction and who were operated on by the same surgeon. Direct culture of the lacrimal sac content was carried out. Data were collected regarding clinical signs and symptoms, use of intraoperative antibiotics, results of culture samples obtained during surgery, and antibiogram analysis. Also, the postoperative period was analyzed with regard to the presence of postoperative complications. Results: Out of 697 patients, 536 were women. The mean age at surgery was 67.0 ± 13.3 years. Prior to surgery, 19.5%, 18.5%, 11%, and 17.8% of patients showed recurrent conjunctivitis, mucocele, mucopyocele, and episodes of acute dacryocystitis, respectively. Seventy-three patients did not receive prophylactic treatment during surgery. A total of 8.3% of lacrimal sacs were culture positive, the most commonly isolated organism being Staphylococcus aureus. The use of antibiotics during surgery was not associated with a lower rate of postoperative complications. A statistically significant association was found between some clinical pictures, such as mucocele, mucopyocele, and dacryocystitis, and a higher rate of positive cultures. Conclusions: This study questions the generalized use of prophylactic antibiotics for external dacryocystorhinostomy, while providing evidence to indicate their use for patients who have had prior episodes of mucocele, mucopyocele, or acute dacryocystitis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/therapeutic use ; Antibiotic Prophylaxis ; Bacteria/drug effects ; Bacteria/isolation & purification ; Child ; Child, Preschool ; Dacryocystorhinostomy ; Female ; Humans ; Lacrimal Duct Obstruction/microbiology ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Nasolacrimal Duct/microbiology ; Nasolacrimal Duct/surgery ; Retrospective Studies ; Surgical Wound Infection/prevention & control ; Treatment Outcome ; Young Adult
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2010-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0b013e3181d644cf
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Article ; Online: Optic neuropathy in methylmalonic acidemia: the role of neuroprotection.

Pinar-Sueiro, Sergio / Martínez-Fernández, Ricardo / Lage-Medina, Sergio / Aldamiz-Echevarria, Luis / Vecino, Elena

Journal of inherited metabolic disease

2010 Volume 33 Suppl 3, Page(s) S199–203

Abstract: We report the case of a patient with an optic neuropathy induced by neurotoxicity in the setting of methylmalonic acidemia. The patient responded with a significant and long-term improvement in visual acuity, perimetry, and chromatic function after a ... ...

Abstract	We report the case of a patient with an optic neuropathy induced by neurotoxicity in the setting of methylmalonic acidemia. The patient responded with a significant and long-term improvement in visual acuity, perimetry, and chromatic function after a neuroprotective treatment with vitamin E and coenzyme Q10 was started. Coenzyme Q10 levels had been proven to be normal before starting treatment. This case report is particularly important because it describes a possible treatment for optic neuropathy in methylmalonic patients. Although the response might be, in part, specific to the individual, it suggests the existence of a cause-effect relationship between the treatment undergone by our patient and the improvement in her visual acuity. To date, no other treatments with beneficial effects have been reported for the few optic neuropathies caused by methylmalonic acidemia. Further studies should determine the applicability of coenzyme Q10 and vitamin E for the treatment of optic neuropathies in methylmalonic acidemia.
MeSH term(s)	Adolescent ; Amino Acid Metabolism, Inborn Errors/complications ; Amino Acid Metabolism, Inborn Errors/diagnosis ; Amino Acid Metabolism, Inborn Errors/diet therapy ; Amino Acid Metabolism, Inborn Errors/genetics ; Antioxidants/therapeutic use ; Cells, Cultured ; DNA Mutational Analysis ; Diet, Protein-Restricted ; Dietary Supplements ; Drug Therapy, Combination ; Female ; Humans ; Neuroprotective Agents/therapeutic use ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/drug therapy ; Optic Nerve Diseases/etiology ; Optic Nerve Diseases/physiopathology ; Recovery of Function ; Time Factors ; Treatment Outcome ; Ubiquinone/analogs & derivatives ; Ubiquinone/therapeutic use ; Visual Acuity ; Vitamin E/therapeutic use
Chemical Substances	Antioxidants ; Neuroprotective Agents ; Ubiquinone (1339-63-5) ; Vitamin E (1406-18-4) ; coenzyme Q10 (EJ27X76M46)
Language	English
Publishing date	2010-05-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	438341-2
ISSN	1573-2665 ; 0141-8955
ISSN (online)	1573-2665
ISSN	0141-8955
DOI	10.1007/s10545-010-9084-8
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Article: Dacryocystitis: Systematic Approach to Diagnosis and Therapy.

Pinar-Sueiro, Sergio / Sota, Mercedes / Lerchundi, Telmo-Xabier / Gibelalde, Ane / Berasategui, Bárbara / Vilar, Begoña / Hernandez, Jose Luis

Current infectious disease reports

2012

Abstract: The objective of this paper is to review the main findings of the largest studies on the etiopathogenesis and microbiology of the development of dacryocystitis and to formulate clinical and surgical guidelines based on said studies and on our experience ... ...

Abstract	The objective of this paper is to review the main findings of the largest studies on the etiopathogenesis and microbiology of the development of dacryocystitis and to formulate clinical and surgical guidelines based on said studies and on our experience at Cruces Hospital, the Basque Country, Spain. The most common sign of this entity is the distal nasolacrimal duct obstruction, and this should be treated to prevent clinical relapse. The time when surgery should be indicated mainly depends on the clinical signs and symptoms, age and general status of a patient. Given the germs isolated in cases of dacryocystitis, antibiotic therapy against Gram positive (S. aureus, S. pneumoniae, S. epidermidis) and Gram negative bacteria (H. influenzae, P. aeruginosa) should be administered, orally in adults and intravenously in pediatric patients, prior to surgery. Gentamicin and amoxicillin-clavulanic acid have been found to be effective against the bacteria commonly implicated in the etiopathogenesis of this entity.
Language	English
Publishing date	2012-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
DOI	10.1007/s11908-012-0238-8
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