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Artikel: Cutaneous Lymphoma, Introduction.

Pincus, Laura B

Seminars in cutaneous medicine and surgery

2018 Band 37, Heft 1, Seite(n) 1

Sprache	Englisch
Erscheinungsdatum	2018-04-20
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1355511-x
ISSN	1558-0768 ; 1085-5629
ISSN (online)	1558-0768
ISSN	1085-5629
DOI	10.12788/j.sder.2019.017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Mycosis Fungoides.

Pincus, Laura B

Surgical pathology clinics

2014 Band 7, Heft 2, Seite(n) 143–167

Abstract: This article is a comprehensive review of mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma. The first portion of the article introduces epidemiologic features of MF. Next, the clinical presentation is described, followed by the ... ...

Abstract	This article is a comprehensive review of mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma. The first portion of the article introduces epidemiologic features of MF. Next, the clinical presentation is described, followed by the microscopic features. This article addresses how to establish a diagnosis of MF and includes a discussion of the utility of ancillary testing, such as immunohistochemistry and T-cell clonality testing. The differential diagnosis is also discussed, with attention to how to distinguish MF from histopathologic mimics. The final section of the article discusses prognosis and risk of disease progression in MF.
Sprache	Englisch
Erscheinungsdatum	2014-06
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2014.02.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma.

Hope, Charity B / Pincus, Laura B

Seminars in diagnostic pathology

2017 Band 34, Heft 1, Seite(n) 85–98

Abstract: In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent ... ...

Abstract	In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent two of the three most common types of primary cutaneous B-cell lymphoma recognized in the current WHO classification system.
Mesh-Begriff(e)	Humans ; Leg ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/pathology ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Vascular Neoplasms/diagnosis ; Vascular Neoplasms/genetics ; Vascular Neoplasms/pathology
Sprache	Englisch
Erscheinungsdatum	2017-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	605834-6
ISSN	1930-1111 ; 0740-2570
ISSN (online)	1930-1111
ISSN	0740-2570
DOI	10.1053/j.semdp.2016.11.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Primary Cutaneous B-cell Lymphomas.

Hope, Charity B / Pincus, Laura B

Clinics in laboratory medicine

2017 Band 37, Heft 3, Seite(n) 547–574

Abstract: B-cell lymphomas represent approximately 20% to 25% of primary cutaneous lymphomas. Within this group, most cases (>99%) are encompassed by 3 diagnostic entities: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and ... ...

Abstract	B-cell lymphomas represent approximately 20% to 25% of primary cutaneous lymphomas. Within this group, most cases (>99%) are encompassed by 3 diagnostic entities: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type. In this article, the authors present clinical, histopathologic, immunophenotypic, and molecular features of each of these entities and briefly discuss the rarer intravascular large B-cell lymphoma.
Sprache	Englisch
Erscheinungsdatum	2017-09
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2017.05.009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: An abdominal skin lesion: to lump or split? a case presentation.

Young, Albert T / Yedidi, Raagini S / Marano, Paul J / Pincus, Laura B / Lai, Andrew R

Dermatology online journal

2021 Band 27, Heft 6

Abstract: Syphilis has many atypical morphologies which can present a diagnostic challenge, especially in patients with HIV/AIDS who may have multiple concurrent conditions. We describe a 41-year-old man with recently diagnosed HIV who was admitted for acute right ...

Abstract	Syphilis has many atypical morphologies which can present a diagnostic challenge, especially in patients with HIV/AIDS who may have multiple concurrent conditions. We describe a 41-year-old man with recently diagnosed HIV who was admitted for acute right vision loss and a diffuse rash with involvement of the palms and soles. He received diagnoses of secondary syphilis and Kaposi sarcoma in the setting of AIDS. Examination revealed an unusual dark brown-to-purple umbilicated papule with a necrotic center on the abdomen, raising a diagnostic dilemma. Skin biopsy showed secondary syphilis, despite the concurrent diagnosis of Kaposi sarcoma. The patient was treated with antibiotic and antiretroviral therapy and symptoms resolved. This case aims to share the clinical reasoning behind diagnosing a patient with HIV/AIDS with multiple concurrent conditions and to raise awareness of the many atypical cutaneous manifestations of secondary syphilis.
Mesh-Begriff(e)	Abdomen ; Acquired Immunodeficiency Syndrome/complications ; Adult ; Humans ; Male ; Skin Diseases, Bacterial/complications ; Skin Diseases, Bacterial/diagnosis ; Syphilis/complications ; Syphilis/diagnosis
Sprache	Englisch
Erscheinungsdatum	2021-06-15
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2026239-5
ISSN	1087-2108 ; 1087-2108
ISSN (online)	1087-2108
ISSN	1087-2108
DOI	10.5070/D327654056
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association of a Dominant T-Cell Clone in Peripheral Blood With Time to Systemic Treatment in Patients With Stage IB Mycosis Fungoides.

Raychaudhuri, Suravi / Charli-Joseph, Yann / Huang, Chiung-Yu / Mintz, Michelle A / Pincus, Laura B / Ai, Weiyun Z

JAMA dermatology

2022 Band 158, Heft 8, Seite(n) 954–956

Mesh-Begriff(e)	Administration, Cutaneous ; Clone Cells ; Humans ; Mycosis Fungoides/drug therapy ; Skin Neoplasms/drug therapy ; T-Lymphocytes
Sprache	Englisch
Erscheinungsdatum	2022-06-22
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2022.2100
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Cicatricial pemphigoid Brunsting-Perry variant masquerading as neutrophil-mediated cicatricial alopecia.

Rahbar, Ziba / Cohen, Jarish N / McCalmont, Timothy H / LeBoit, Philip E / Connolly, M Kari / Berger, Timothy / Pincus, Laura B

Journal of cutaneous pathology

2022 Band 49, Heft 4, Seite(n) 408–411

Abstract: A 72-year-old male presented with scarring alopecia on the scalp vertex, multiple crusted plaques on the hairline, and a history of vesicular eruption on the face. The scalp showed crusted plaques with loss of follicular ostia. No follicular pustules or ... ...

Abstract	A 72-year-old male presented with scarring alopecia on the scalp vertex, multiple crusted plaques on the hairline, and a history of vesicular eruption on the face. The scalp showed crusted plaques with loss of follicular ostia. No follicular pustules or compound follicles were present. An initial transverse scalp biopsy showed perifollicular neutrophils, lymphocytes, and plasma cells along with dermal fibrosis. Focal epidermal/dermal and follicular/adventitial dermal clefts were apparent but were thought to be secondary to fibrosis, and the biopsy result was interpreted to represent a neutrophil-mediated cicatricial alopecia. Concurrently, direct immunofluorescence (DIF) analysis showed linear junctional deposition of IgG and C3. A repeat scalp biopsy revealed more prominent epidermal/dermal clefts, fibrosis, mixed infiltrate with neutrophils, lymphocytes, histiocytes, and plasma cells, as well as prominent follicular/adventitial dermal clefts with perifollicular neutrophils. Given the combination of clefts, perijunctional neutrophils, and positive DIF findings, it became clear that this eruption represented the Brunsting-Perry variant of cicatricial pemphigoid. Here, we illustrated that a neutrophil-rich form of cicatricial pemphigoid can masquerade as a neutrophil-mediated scarring alopecia. In evaluating a specimen suspected to be a neutrophil-mediated scarring alopecia, one should be alert to the presence of subepidermal and perifollicular clefting, and consider cicatricial pemphigoid.
Mesh-Begriff(e)	Aged ; Alopecia/pathology ; Humans ; Male ; Neutrophils/pathology ; Pemphigoid, Benign Mucous Membrane/pathology
Sprache	Englisch
Erscheinungsdatum	2022-01-05
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.14177
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ki-67 and p16 Immunostaining Differentiates Pagetoid Bowen Disease From "Microclonal" Seborrheic Keratosis.

Bahrani, Eman / Sitthinamsuwan, Panitta / McCalmont, Timothy H / Pincus, Laura B

American journal of clinical pathology

2019 Band 151, Heft 6, Seite(n) 551–560

Abstract: Objectives: We observed keratoses with "clonal" nests present as numerous tiny collections, in which cells in "pagetoid" array are found, a configuration we termed microclonal seborrheic keratosis (MSK). To better distinguish MSK from pagetoid Bowen ... ...

Abstract	Objectives: We observed keratoses with "clonal" nests present as numerous tiny collections, in which cells in "pagetoid" array are found, a configuration we termed microclonal seborrheic keratosis (MSK). To better distinguish MSK from pagetoid Bowen disease (PBD), we investigated use of immunohistochemical staining. Methods: Biopsy specimens of 26 MSKs, 17 PBDs, and 11 borderline cases were reviewed for histopathology and stained with p53, Ki-67, and p16. Results: High expression of Ki-67 and p16 was observed in 12 (80%) of 15 PBDs and in one (4%) of 23 MSKs. Low expression of p16 and high expression of Ki-67 were observed in 16 (70%) of 23 MSKs and in two (13%) of 15 PBDs. Expression of p16 was elevated in 12 (80%) of 15 PBDs and in three (13%) of 23 MSKs (P < .0001). Conclusions: We describe a "microclonal" variant of seborrheic keratosis with morphology sometimes challenging to distinguish from PBD. High expression of p16 and Ki-67 or p16 alone favors the diagnosis of PBD over MSK.
Mesh-Begriff(e)	Bowen's Disease/chemistry ; Bowen's Disease/diagnosis ; Cyclin-Dependent Kinase Inhibitor p16/analysis ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Keratosis, Seborrheic/diagnosis ; Keratosis, Seborrheic/metabolism ; Ki-67 Antigen/analysis ; Skin Neoplasms/diagnosis
Chemische Substanzen	CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; Ki-67 Antigen
Sprache	Englisch
Erscheinungsdatum	2019-03-09
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqz001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association of Facial Pustular Neutrophilic Eruption With Messenger RNA-1273 SARS-CoV-2 Vaccine.

Merrill, Eric Dean / Kashem, Sakeen W / Amerson, Erin H / Pincus, Laura B / Lang, Ursula E / Shinkai, Kanade / Chang, Aileen Y

JAMA dermatology

2021 Band 157, Heft 9, Seite(n) 1128–1130

Mesh-Begriff(e)	Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/adverse effects ; Dermatologic Agents/administration & dosage ; Diagnosis, Differential ; Drug Eruptions/diagnosis ; Drug Eruptions/drug therapy ; Drug Eruptions/immunology ; Drug Eruptions/pathology ; Drug Therapy, Combination ; Facial Dermatoses/diagnosis ; Facial Dermatoses/drug therapy ; Facial Dermatoses/immunology ; Facial Dermatoses/pathology ; Humans ; Male ; Middle Aged ; Neutrophils/immunology ; Rosacea/diagnosis ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Skin/immunology ; Skin/pathology ; Treatment Outcome
Chemische Substanzen	Anti-Bacterial Agents ; COVID-19 Vaccines ; Dermatologic Agents ; mRNA-1273 vaccine (EPK39PL4R4)
Sprache	Englisch
Erscheinungsdatum	2021-07-28
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2021.2474
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Remission of subcutaneous panniculitis-like T-cell lymphoma in a pregnant woman after treatment with oral corticosteroids as monotherapy.

West, Emily S / Shinkai, Kanade / Ai, Weiyun Z / Pincus, Laura B

JAAD case reports

2017 Band 3, Heft 2, Seite(n) 87–89

Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous T-cell lymphoma characterized by neoplastic α/β T cells infiltrating subcutaneous tissues in a lobular pattern. Few data support the optimal treatment regimen for patients, ...

Abstract	Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous T-cell lymphoma characterized by neoplastic α/β T cells infiltrating subcutaneous tissues in a lobular pattern. Few data support the optimal treatment regimen for patients, given the rarity of this condition, and even fewer data describe treatment when diagnosed during pregnancy. We describe a case of SPTCL in a pregnant patient who achieved clinical remission after treatment with corticosteroid monotherapy. Our case suggests that corticosteroids should be considered as first-line treatment in pregnant patients with SPTCL.
Sprache	Englisch
Erscheinungsdatum	2017-03-20
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2016.12.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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