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  1. Article ; Online: Team emergency assessment measure (TEAM) of non-technical skills: The Brazilian Portuguese version of the TEAM tool.

    Giugni, Fernando Rabioglio / Dias, Roger Daglius / Rodrigues, Caio Godoy / Pinesi, Henrique Trombini / Scalabrini-Neto, Augusto

    Clinics (Sao Paulo, Brazil)

    2022  Volume 77, Page(s) 100043

    Abstract: Objectives: The aim of this study was to conduct the translation and cross-cultural adaptation of the original Team Emergency Assessment Measure (TEAM) tool into the Brazilian Portuguese language and investigate the internal consistency, inter-rater ... ...

    Abstract Objectives: The aim of this study was to conduct the translation and cross-cultural adaptation of the original Team Emergency Assessment Measure (TEAM) tool into the Brazilian Portuguese language and investigate the internal consistency, inter-rater reliability, and concurrent validity of this new version (bp-TEAM).
    Methods: Independent medical translators performed forward and backward translations of the TEAM tool between English and Portuguese, creating the bp-TEAM. The authors selected 23 videos from final-year medical students during in-situ emergency simulations. Three independent raters assessed all the videos using the bp-TEAM and provided a score for each of the 12 items of the tool. The authors assessed the internal consistency and the inter-rater reliability of the tool.
    Results: Raters assessed all 23 videos. Internal consistency was assessed among the 11 items of the bp-TEAM from one rater, yielding a Cronbach's alpha of 0.89. inter-item correlation analysis yielded a mean correlation coefficient rho of 0.46. Inter-rater reliability analysis among the three raters yielded an intraclass correlation coefficient of 0.86 (95% CI 0.83‒0.89), p < 0.001.
    Conclusion: The Brazilian Portuguese version of the TEAM tool presented acceptable psychometric properties, similar to the original English version.
    MeSH term(s) Brazil ; Cross-Cultural Comparison ; Humans ; Language ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires ; Translations
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2022.100043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Does the Mean Platelet Volume Decrease in the Presence of Coronary Artery Fistula?

    Pinesi, Henrique Trombini / Giraldez, Roberto Rocha C V

    Arquivos brasileiros de cardiologia

    2019  Volume 113, Issue 2, Page(s) 272–273

    MeSH term(s) Coronary Angiography ; Coronary Artery Disease ; Fistula ; Humans ; Mean Platelet Volume
    Language Portuguese
    Publishing date 2019-09-02
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.5935/abc.20190154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Case 4/2019 - 26-Year-Old Man with Congenital Chagas Disease and Heart Transplantation.

    Pinesi, Henrique Trombini / Strabelli, Tânia Mara Varejão / Aiello, Vera Demarchi

    Arquivos brasileiros de cardiologia

    2019  Volume 113, Issue 2, Page(s) 286–293

    MeSH term(s) Adult ; Biopsy ; Chagas Cardiomyopathy/congenital ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/pathology ; Chagas Cardiomyopathy/surgery ; Electrocardiography ; Heart Transplantation ; Humans ; Magnetic Resonance Imaging ; Male ; Radiography, Thoracic ; Recurrence ; Trypanosoma cruzi/isolation & purification
    Language Portuguese
    Publishing date 2019-09-02
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.5935/abc.20190162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Coronavirus disease-2019 and heart: assessment of troponin and cardiovascular comorbidities as prognostic markers in patients hospitalized with coronavirus disease-2019 in a tertiary center in Brazil.

    Pinesi, Henrique Trombini / Giugni, Fernando Rabioglio / Matuck, Bruna Romanelli Scarpa / Pitta, Fabio Grusnpun / Garzillo, Cibele Larrosa / Lima, Eduardo Gomes / Kalil Filho, Roberto / Serrano Junior, Carlos Vicente

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 7, Page(s) e20230350

    Abstract: Objective: Our study aimed to evaluate the correlation of cardiac troponin T levels with comorbidities and in-hospital outcomes in patients with coronavirus disease-2019 in Brazil.: Methods: Data from a cohort of 3,596 patients who were admitted with ...

    Abstract Objective: Our study aimed to evaluate the correlation of cardiac troponin T levels with comorbidities and in-hospital outcomes in patients with coronavirus disease-2019 in Brazil.
    Methods: Data from a cohort of 3,596 patients who were admitted with suspected coronavirus disease-2019 in a Brazilian tertiary center, between March and August 2020, were reviewed. A total of 2,441 (68%) patients had cardiac troponin T determined in the first 72 h of admission and were stratified into two groups: elevated cardiac troponin T (cardiac troponin T >0.014 ng/mL) and normal cardiac troponin T. Associations between troponin, comorbidities, biomarkers, and outcomes were assessed. Regression models were built to assess the association of several variables with in-hospital mortality.
    Results: A total of 2,441 patients were embraced, of which 924 (38%) had normal cardiac troponin T and 1,517 (62%) had elevated cardiac troponin T. Patients with elevated cardiac troponin T were older and had more comorbidities, such as cardiovascular disease, hypertension, diabetes, arrhythmia, renal dysfunction, liver disease, stroke, cancer, and dementia. Patients with abnormal cardiac troponin T also had more altered laboratory parameters on admission (i.e., leukocytes, C-reactive protein, D-dimer, and B-type natriuretic peptide), as well as more need for intensive care unit, vasoactive drugs, mechanical ventilation, dialysis, and blood transfusion. All-cause mortality was markedly higher among patients with increased cardiac troponin T (42 vs. 16%, P<0.001). Multiple regression analysis demonstrated that in-hospital mortality was not independently associated with troponin elevation.
    Conclusion: This study showed that cardiac troponin T elevation at admission was common and associated with several comorbidities, biomarkers, and clinical outcomes in patients hospitalized with coronavirus disease-2019, but it was not an independent marker of in-hospital mortality.
    MeSH term(s) Humans ; COVID-19 ; Troponin ; Brazil/epidemiology ; Troponin T ; Prognosis ; Biomarkers ; Coronavirus
    Chemical Substances Troponin ; Troponin T ; Biomarkers
    Language English
    Publishing date 2023-07-17
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20230350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Two-Year Follow-Up of Chronic Ischemic Heart Disease Patients in a Specialized Center in Brazil.

    Moreira, Eduardo Martelli / Pinesi, Henrique Trombini / Martins, Eduardo Bello / Pitta, Fábio Grunspun / Bolta, Paula Mathias Paulino / Segre, Carlos Alexandre Wainrober / Favarato, Desiderio / Rached, Fabiana Hanna / Hueb, Whady Armindo / Lima, Eduardo Gomes / Kalil Filho, Roberto / Garzillo, Cibele Larrosa / Serrano, Carlos Vicente

    Arquivos brasileiros de cardiologia

    2023  Volume 120, Issue 10, Page(s) e20220440

    Abstract: The incidence of cardiovascular events in patients with chronic ischemic heart disease (CIHD) may vary significantly among countries. Although populous, Brazil is often underrepresented in international records. This study aimed to describe the quality ... ...

    Title translation Acompanhamento de Dois Anos de Pacientes com Cardiopatia Isquêmica Crônica em um Centro Especializado no Brasil.
    Abstract The incidence of cardiovascular events in patients with chronic ischemic heart disease (CIHD) may vary significantly among countries. Although populous, Brazil is often underrepresented in international records. This study aimed to describe the quality of care and the two-year incidence of cardiovascular events and associated prognostic factors in CIHD patients in a tertiary public health care center in Brazil. Patients with CIHD who reported for clinical evaluation at Instituto do Coração (São Paulo, Brazil) were registered and followed for two years. The primary endpoint was a composite of myocardial infarction (MI), stroke, or death. A significance level of 0.05 was adopted. From January 2016 to December 2018, 625 participants were included in the study. Baseline characteristics show that 33.1% were women, median age 66.1 [59.6 - 71.9], 48.6% had diabetes, 83.1% had hypertension, 62.6% had previous MI, and 70.4% went through some revascularization procedure. At a median follow-up (FU) of 881 days, we noted 37 (7.05%) primary endpoints. After adjustments, age, previous stroke, and LDL-cholesterol were independently associated with the primary endpoint. Comparing baseline versus FU, participants experienced relief of angina based on the Canadian Cardiovascular Society (CCS) scale according to the following percentages: 65.7% vs. 81.7% were asymptomatic and 4.2% vs. 2.9% CCS 3 or 4 (p < 0.001). They also experienced better quality of medication prescription: 65.8% vs. 73.6% (p < 0.001). However, there was no improvement in LDL-cholesterol or blood pressure control. This study shows that CIHD patients had a two-year incidence of the primary composite endpoint of 7.05%, and the reduction of LDL-cholesterol was the only modifiable risk factor associated with prognosis.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Follow-Up Studies ; Brazil/epidemiology ; Canada ; Myocardial Ischemia/epidemiology ; Myocardial Infarction ; Cholesterol, LDL ; Stroke/epidemiology
    Chemical Substances Cholesterol, LDL
    Language Portuguese
    Publishing date 2023-11-01
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20220440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cardiology referral during the COVID-19 pandemic.

    Santorio, Nathalia Conci / Cardozo, Francisco Akira Malta / Miada, Rodrigo Freddi / Pitta, Fabio Grunspun / Tavares, Caio de Assis Moura / Habrum, Fabio Cetinic / Pinesi, Henrique Trombini / Magalhães, Iuri Resedá / Menezes, Maria Clara Saad / Caramelli, Bruno / Calderaro, Daniela

    Clinics (Sao Paulo, Brazil)

    2021  Volume 76, Page(s) e3538

    Abstract: Objectives: This study presents the cardiology referral model adopted at the University of São Paulo-Hospital das Clínicas complex during the initial period of the coronavirus disease (COVID-19) pandemic, main reasons for requesting a cardiologic ... ...

    Abstract Objectives: This study presents the cardiology referral model adopted at the University of São Paulo-Hospital das Clínicas complex during the initial period of the coronavirus disease (COVID-19) pandemic, main reasons for requesting a cardiologic evaluation, and clinical profile of and prognostic predictors in patients with COVID-19.
    Methods: In this observational study, data of all cardiology referral requests between March 30, 2020 and July 6, 2020 were collected prospectively. A descriptive analysis of the reasons for cardiologic evaluation requests and the most common cardiologic diagnoses was performed. A multivariable model was used to identify independent predictors of in-hospital mortality among patients with COVID-19.
    Results: Cardiologic evaluation was requested for 206 patients admitted to the ICHC-COVID. A diagnosis of COVID-19 was confirmed for 180 patients. Cardiologic complications occurred in 77.7% of the patients. Among these, decompensated heart failure was the most common complication (38.8%), followed by myocardial injury (35%), and arrhythmias, especially high ventricular response atrial fibrillation (17.7%). Advanced age, greater need of ventilatory support on admission, and pre-existing heart failure were independently associated with in-hospital mortality.
    Conclusions: A hybrid model combining in-person referral with remote discussion and teaching is a viable alternative to overcome COVID-19 limitations. Cardiologic evaluation remains important during the pandemic, as patients with COVID-19 frequently develop cardiovascular complications or decompensation of the underlying heart disease.
    MeSH term(s) COVID-19 ; Cardiology ; Humans ; Pandemics ; Referral and Consultation ; SARS-CoV-2
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2021/e3538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Understanding yellow fever-associated myocardial injury: an autopsy study.

    Giugni, Fernando Rabioglio / Aiello, Vera Demarchi / Faria, Caroline Silverio / Pour, Shahab Zaki / Cunha, Marielton Dos Passos / Giugni, Melina Valdo / Pinesi, Henrique Trombini / Ledesma, Felipe Lourenço / Morais, Carolina Esteves / Ho, Yeh-Li / Sztajnbok, Jaques / de Morais Fernezlian, Sandra / Ferraz da Silva, Luiz Fernando / Mauad, Thais / Ferreira Alves, Venâncio Avancini / Hilário do Nascimento Saldiva, Paulo / Antonangelo, Leila / Dolhnikoff, Marisa / Duarte-Neto, Amaro Nunes

    EBioMedicine

    2023  Volume 96, Page(s) 104810

    Abstract: Background: Yellow fever (YF) is a viral hemorrhagic fever, endemic in parts of South America and Africa. There is scarce evidence about the pathogenesis of the myocardial injury. The objective of this study is to evaluate the cardiac pathology in fatal ...

    Abstract Background: Yellow fever (YF) is a viral hemorrhagic fever, endemic in parts of South America and Africa. There is scarce evidence about the pathogenesis of the myocardial injury. The objective of this study is to evaluate the cardiac pathology in fatal cases of YF.
    Methods: This retrospective autopsy study included cases from the São Paulo (Brazil) epidemic of 2017-2019. We reviewed medical records and performed cardiac tissue histopathological evaluation, electron microscopy, immunohistochemical assays, RT-qPCR for YF virus (YFV)-RNA, and proteomics analysis on inflammatory and endothelial biomarkers.
    Findings: Seventy-three confirmed YF cases with a median age of 48 (34-60) years were included. We observed myocardial fibrosis in 68 (93.2%) patients; cardiomyocyte hypertrophy in 68 (93.2%); endothelial alterations in 67 (91.8%); fiber necrosis in 50 (68.5%); viral myocarditis in 9 (12.3%); and secondary myocarditis in 5 (6.8%). Four out of five patients with 17DD vaccine-associated viscerotropic disease presented with myocarditis. The cardiac conduction system showed edema, hemorrhages and endothelial fibrinoid necrosis. Immunohistochemistry detected CD68-positive inflammatory interstitial cells and YFV antigens in endothelial and inflammatory cells. YFV-RNA was detected positive in 95.7% of the cardiac samples. The proteomics analysis demonstrated that YF patients had higher levels of multiple inflammatory and endothelial biomarkers in comparison to cardiovascular controls, and higher levels of interferon gamma-induced protein 10 (IP-10) in comparison to sepsis (p = 0.01) and cardiovascular controls (p < 0.001) in Dunn test.
    Interpretation: Myocardial injury is frequent in severe YF, due to multifactorial mechanisms, including direct YFV-mediated damage, endothelial cell injury, and inflammatory response, with a possible prominent role for IP-10.
    Funding: This study was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo, Bill and Melinda Gates Foundation, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
    MeSH term(s) Humans ; Middle Aged ; Yellow Fever/epidemiology ; Myocarditis/etiology ; Chemokine CXCL10 ; Retrospective Studies ; Brazil/epidemiology ; Heart Injuries ; RNA ; Autopsy ; Biomarkers ; Necrosis
    Chemical Substances Chemokine CXCL10 ; RNA (63231-63-0) ; Biomarkers
    Language English
    Publishing date 2023-09-25
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Amyloidosis: an unusual cause of portal hypertension.

    Takayasu, Vilma / Laborda, Lorena Silva / Bernardelli, Raquel / Pinesi, Henrique Trombini / Silva, Marilia Polo Minguete E / Chiavelli, Viviane / Simões, Angélica Braz / Felipe-Silva, Aloisio

    Autopsy & case reports

    2016  Volume 6, Issue 2, Page(s) 9–18

    Abstract: Amyloidosis comprises a group of diseases that occurs in five to nine cases per million patients per year worldwide irrespective of its classification. Although the hepatic involvement in primary amyloidosis is frequent, the clinical manifestations of ... ...

    Abstract Amyloidosis comprises a group of diseases that occurs in five to nine cases per million patients per year worldwide irrespective of its classification. Although the hepatic involvement in primary amyloidosis is frequent, the clinical manifestations of liver amyloidosis are mild or even absent. The authors report the case of an aged man who complained of diffuse abdominal pain and marked weight loss and presented clinical signs of hepatopathy. Clinical workup revealed portal hypertension with ascites, hemorrhoids, and esophageal varices. The laboratory tests showed the cholestatic pattern of liver enzymes, hyperbilirubinemia, renal insufficiency and massive proteinuria accompanied by the presence of serum pike of monoclonal lambda light chain protein. The outcome was unfavorable, and the patient died. The autopsy findings revealed the diagnosis of amyloidosis predominantly involving the liver and kidneys. The bone marrow examination demonstrated the deposition of amyloid material associated with clonal plasma cells infiltration. The authors call attention to portal hypertension as a rare manifestation of primary amyloidosis. Meanwhile, this diagnosis should be taken into account whenever the hepatopathy is accompanied by laboratory abnormalities consistent with hepatic space-occupying lesions concomitantly with other organs involvement. In the case reported herein, kidney involvement was also present with renal failure, massive proteinuria with monoclonal serum gammopathy, what reinforced the diagnostic possibility of primary amyloidosis.
    Language English
    Publishing date 2016-06-30
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2016.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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