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  1. AU="Ping, Xiaofang"
  2. AU="Suzuki, Kana"
  3. AU="Hackett, Fiona"
  4. AU="Berhe, T."
  5. AU="Rajesh, K S"
  6. AU=Nichols Kenneth J
  7. AU="Annarita, Santoro"
  8. AU="Fluerant, Marshall"
  9. AU="Di Marino, Luca"
  10. AU="Lu, Zonghong"
  11. AU="Saz-Leal, Paula"
  12. AU="Caillier, Stacy J"
  13. AU="Curran, Kathryn G"
  14. AU=Wu Jun
  15. AU="Singhal, Jyotsana"
  16. AU="Fossa, Paola"
  17. AU="Hu, Chung-Chi"
  18. AU="Azad, Rashid"
  19. AU="Bumcrot, David"
  20. AU="Jun, Yu Kyung"
  21. AU="Ganapathy, Kalaiselvan"
  22. AU=Laue Thomas
  23. AU="Yanlan Wang"

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  1. Artikel ; Online: Evaluation of linear dermatoses by reflectance confocal microscopy in children.

    Wang, Ying / Chen, Lixin / Shi, Jing / Ping, Xiaofang / Li, Qinfeng

    European journal of dermatology : EJD

    2024  Band 34, Heft 1, Seite(n) 55–58

    Abstract: Lichen striatus (LS), linear psoriasis (LPs), linear cutaneous lupus erythematosus (LCLE) and linear lichen planus (LLP) often have similar clinical manifestations, which makes clinical diagnosis with the naked eye difficult; therefore, they are easily ... ...

    Abstract Lichen striatus (LS), linear psoriasis (LPs), linear cutaneous lupus erythematosus (LCLE) and linear lichen planus (LLP) often have similar clinical manifestations, which makes clinical diagnosis with the naked eye difficult; therefore, they are easily misdiagnosed. The purpose of this study was to determine whether reflectance confocal microscopy (RCM) is helpful in differentiating between these four linear dermatoses in children. This retrospective study included 14 patients with LS, nine with LPs, eight with LCLE and 12 with LLP. All patients were analysed using RCM, and biopsies were collected from lesions previously imaged by RCM. For LS, the dermal papillary rings were partially absent, but when present, manifested with small, homogeneously round, bright cells and occasionally highly refractive plump cellular structures, aggregated in clusters. LPs exhibited dark cyst-like structures with small, bright, round cells aggregated at the epidermal level; at the dermal-epidermal junction, homogeneously distributed, enlarged, faint dermal papillary rings and numerous enlarged low-refractive canalicular structures were observed in the superficial dermis. LCLE and LLP exhibited similar manifestations, including epidermal disarray, almost total absence of dermal papillary rings, and various sized refractive structures densely distributed in the dermis. The key distinguishing features of LCLE were the different sized structures mainly clustered around hair follicles, while LLP demonstrated dense structures with a scattered distribution. RCM may be used to distinguish between the key features of LS, LPs, LCLE and LLP in children.
    Mesh-Begriff(e) Child ; Humans ; Retrospective Studies ; Lipopolysaccharides ; Epidermis/pathology ; Lichen Planus/pathology ; Keratosis/pathology ; Psoriasis/pathology ; Pruritus/pathology ; Microscopy, Confocal/methods
    Chemische Substanzen Lipopolysaccharides
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2024.4634
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Performance of Janus kinase inhibitors in psoriatic arthritis with axial involvement in indirect comparison with ankylosing spondylitis: a retrospective analysis from pooled data.

    Wang, Lin / Ping, Xiaofang / Chen, Wei / Xing, Weibin

    Clinical rheumatology

    2020  Band 40, Heft 5, Seite(n) 1725–1737

    Abstract: Background and objective: As the well-acknowledged autoimmune disease, Janus kinase (JAK) is thought to play important roles in the progression of tissue injury in spondyloarthropathy. From a current perspective, JAK inhibitors could be applied to both ... ...

    Abstract Background and objective: As the well-acknowledged autoimmune disease, Janus kinase (JAK) is thought to play important roles in the progression of tissue injury in spondyloarthropathy. From a current perspective, JAK inhibitors could be applied to both psoriatic arthritis (PsA) and ankylosing spondylitis (AS). Nonetheless, it is reasonable to doubt whether PsA and AS differentially respond to JAK inhibitors.
    Methods: Different databases were searched for full-text publication based on inclusion and exclusion criteria. For data-pooling, a fixed-effect model was applied if heterogeneity was not detected. All results of the analysis were illustrated as forest plots. Publication bias was assessed using Begg's adjusted rank correlation test. The standard mean difference (SMD) was calculated in continuous variables. The pooled odds ratio was calculated in categorical variables.
    Results: Nine clinical studies were finally included with a 3-month follow-up. The efficacy and safety of JAK inhibitors were comprehensively investigated. JAK inhibitors were proved to be effectively improving disease condition within 3 months (12 weeks) in both PsA and AS. Besides, psoriasis-related dermal lesions could also be improved by JAK inhibitors. Dose-dependent effects suggested that higher dose tofacitinib could bring not only a higher level of treatment response but also more safety concerns.
    Conclusion: JAK inhibitors were proved to be effective in improving arthritis symptoms and enhancing the quality of life in both PsA and AS patients. Compared with AS, JAK inhibitors seemed to perform better in PsA treatment. However, the frequency of adverse events PsA and AS in comparison with the placebo group showed no difference. Higher dose of tofacitinib could attain better treatment response without increasing adverse events in short-term follow-up.
    Key points: • JAK inhibitors were proved to be effective in improving arthritis symptoms and enhancing the quality of life in both PsA and AS patients. • Compared with AS, JAK inhibitors seemed to perform better in PsA treatment. • The frequency of adverse events PsA and AS in comparison with the placebo group showed no difference. • Higher dose of tofacitinib could attain better treatment response without increasing adverse events in short-term follow-up.
    Mesh-Begriff(e) Arthritis, Psoriatic/drug therapy ; Humans ; Janus Kinase Inhibitors/therapeutic use ; Quality of Life ; Retrospective Studies ; Spondylitis, Ankylosing/drug therapy
    Chemische Substanzen Janus Kinase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2020-10-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-05442-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1740: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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