Article ; Online: Sildenafil effect on prevention of thrombosis after microsurgical anastomosis: experimental rat model of thrombotic suture.
Oral and maxillofacial surgery
2013 Volume 18, Issue 1, Page(s) 53–58
Abstract: Introduction: Thrombosis of vascular anastomosis in the field of reconstructive microsurgery is a clinical problem of extraordinary importance for the devastating consequences for affected patients. Sildenafil has been shown to be relaxing vascular ... ...
Abstract | Introduction: Thrombosis of vascular anastomosis in the field of reconstructive microsurgery is a clinical problem of extraordinary importance for the devastating consequences for affected patients. Sildenafil has been shown to be relaxing vascular action on the peripheral vascular system in vivo and have an ability to reduce platelet aggregation. There is no study up to date on the effect of sildenafil on microvascular anastomosis, neither experimental studies nor clinical settings. Material and methods: A purposeful thrombotic back-wall stitch was performed in the groin flap pedicle to obtain an anastomosis with thrombotic potential where the drug effect was studied. Results: Data in the experimental group treated with papaverine or sildenafil indicate a considerable decrease in the percentage of necrotic flaps (20% necrotic flaps in papaverine group versus 30% necrotic flaps in sildenafil group) in comparison with control group (60% necrotic flaps). In papaverine group, in 100% cases, flap necrosis was established in the first 24 h, but in sildenafil group, 66% flap necrosis was established between the second and the seventh postoperative days. Conclusion: The study did not demonstrate significant differences between the groups, but it does suggest a benefit in applying papaverine and sildenafil in the anastomosis with already thrombogenetic disease, compared to the nonapplication of antithrombotic drugs. The establishment of thrombosis in the necrotic flaps in the group treated with sildenafil was later than in the group treated with papaverine, with a statistical trend but without becoming significant. |
---|---|
MeSH term(s) | Anastomosis, Surgical ; Animals ; Disease Models, Animal ; Free Tissue Flaps/blood supply ; Free Tissue Flaps/pathology ; Free Tissue Flaps/surgery ; Humans ; Male ; Microsurgery ; Necrosis ; Piperazines/pharmacology ; Postoperative Complications/prevention & control ; Purines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Sildenafil Citrate ; Sulfonamides/pharmacology ; Sutures ; Thrombosis/prevention & control ; Vasodilator Agents/pharmacology |
Chemical Substances | Piperazines ; Purines ; Sulfonamides ; Vasodilator Agents ; Sildenafil Citrate (BW9B0ZE037) |
Language | English |
Publishing date | 2013-01-10 |
Publishing country | Germany |
Document type | Journal Article |
ZDB-ID | 2406731-3 |
ISSN | 1865-1569 ; 1865-1550 |
ISSN (online) | 1865-1569 |
ISSN | 1865-1550 |
DOI | 10.1007/s10006-012-0387-9 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 4767: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.