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Article ; Online: Sildenafil effect on prevention of thrombosis after microsurgical anastomosis: experimental rat model of thrombotic suture.

Pingarrón-Martín, Lorena / Arias-Gallo, Luis Javier

2013 Volume 18, Issue 1, Page(s) 53–58

Abstract: Introduction: Thrombosis of vascular anastomosis in the field of reconstructive microsurgery is a clinical problem of extraordinary importance for the devastating consequences for affected patients. Sildenafil has been shown to be relaxing vascular ... ...

Abstract	Introduction: Thrombosis of vascular anastomosis in the field of reconstructive microsurgery is a clinical problem of extraordinary importance for the devastating consequences for affected patients. Sildenafil has been shown to be relaxing vascular action on the peripheral vascular system in vivo and have an ability to reduce platelet aggregation. There is no study up to date on the effect of sildenafil on microvascular anastomosis, neither experimental studies nor clinical settings. Material and methods: A purposeful thrombotic back-wall stitch was performed in the groin flap pedicle to obtain an anastomosis with thrombotic potential where the drug effect was studied. Results: Data in the experimental group treated with papaverine or sildenafil indicate a considerable decrease in the percentage of necrotic flaps (20% necrotic flaps in papaverine group versus 30% necrotic flaps in sildenafil group) in comparison with control group (60% necrotic flaps). In papaverine group, in 100% cases, flap necrosis was established in the first 24 h, but in sildenafil group, 66% flap necrosis was established between the second and the seventh postoperative days. Conclusion: The study did not demonstrate significant differences between the groups, but it does suggest a benefit in applying papaverine and sildenafil in the anastomosis with already thrombogenetic disease, compared to the nonapplication of antithrombotic drugs. The establishment of thrombosis in the necrotic flaps in the group treated with sildenafil was later than in the group treated with papaverine, with a statistical trend but without becoming significant.
MeSH term(s)	Anastomosis, Surgical ; Animals ; Disease Models, Animal ; Free Tissue Flaps/blood supply ; Free Tissue Flaps/pathology ; Free Tissue Flaps/surgery ; Humans ; Male ; Microsurgery ; Necrosis ; Piperazines/pharmacology ; Postoperative Complications/prevention & control ; Purines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Sildenafil Citrate ; Sulfonamides/pharmacology ; Sutures ; Thrombosis/prevention & control ; Vasodilator Agents/pharmacology
Chemical Substances	Piperazines ; Purines ; Sulfonamides ; Vasodilator Agents ; Sildenafil Citrate (BW9B0ZE037)
Language	English
Publishing date	2013-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2406731-3
ISSN	1865-1569 ; 1865-1550
ISSN (online)	1865-1569
ISSN	1865-1550
DOI	10.1007/s10006-012-0387-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Malignant peripheral nerve sheath tumours in the head and neck region: retrospective analysis of clinicopathological features and treatment outcomes.

Ma, C / Ow, A / Shan, O H / Wu, Y / Zhang, C / Sun, J / Ji, T / Pingarron Martin, L / Wang, L

International journal of oral and maxillofacial surgery

2014 Volume 43, Issue 8, Page(s) 924–932

Abstract: Malignant peripheral nerve sheath tumours (MPNST) are rare soft tissue sarcomas. The aim of this study was to assess clinicopathological characteristics and prognostic factors in order to improve the treatment of such tumours in the head and neck region. ...

Abstract	Malignant peripheral nerve sheath tumours (MPNST) are rare soft tissue sarcomas. The aim of this study was to assess clinicopathological characteristics and prognostic factors in order to improve the treatment of such tumours in the head and neck region. We performed a retrospective analysis of head and neck MPNST patients in our hospital between 1996 and 2012. Clinical features and pathological findings of these cases (n=43) were summarized. In addition, prognostic variables were evaluated by univariate and multivariate analyses. The median age of the patients at presentation was 41 years. Surgery was the main treatment approach. Pertinent information regarding the presence of neurofibromatosis type 1 was found in 13 patients (30.2%). Two-thirds of these patients were admitted for a primary tumour (n=27, 62.8%), while one-third (n=16, 37.2%) were treated for recurrent neoplasms. The overall survival rate was 46.5%. Multivariable analysis identified tumour size, surgical margins, and postoperative radiotherapy to be independent prognostic factors. MPNST of the head and neck is extremely difficult to manage. Surgery with postoperative radiation may be the optimum choice of treatment for primary head and neck MPNST.
MeSH term(s)	Adult ; Aged ; Combined Modality Therapy ; Diagnostic Imaging ; Female ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Nerve Sheath Neoplasms/pathology ; Nerve Sheath Neoplasms/radiotherapy ; Nerve Sheath Neoplasms/surgery ; Prognosis ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2014-08
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2014.03.006
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Zs.A 931: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Experience with mandibular reconstruction using transport-disc-distraction osteogenesis.

Pingarrón-Martín, Lorena / Otero, T González / Gallo, L J Arias

Craniomaxillofacial trauma & reconstruction

2014 Volume 8, Issue 2, Page(s) 117–122

Abstract: The goal of transport-disc-distraction osteogenesis (TDDO) is to restore bone continuity by using in-situ bone. It may be useful following trauma, gunshot injuries, or tumor ablation, especially when there may be contraindications at the donor site or ... ...

Abstract	The goal of transport-disc-distraction osteogenesis (TDDO) is to restore bone continuity by using in-situ bone. It may be useful following trauma, gunshot injuries, or tumor ablation, especially when there may be contraindications at the donor site or for prolonged surgery. To the best of the authors' knowledge, this is the first time TDDO has been used for mandibular reconstruction reporting additional procedures, which include osseointegrated dental implants rehabilitation and orthognathic surgery. A retrospective study is performed analyzing all mandibular reconstruction cases that may be suitable for distraction from January 2006 to December 2011. A thorough description of the documented cases includes details about sex, gender, complications, duration of hospitalization, etiology, size, and location of the defect. Eight cases of mandibular reconstruction were included. Six cases correspond to mandibular ameloblastoma. The remaining two cases were mandibular gunshot comminuted fractures. Range of the defects was from 45 to 60 mm. Length of the transport disc was 15 to 20 mm. Protocolized technique consisted of 5 days of latency period, 19 to 45 days of activation term (average 30 days), and 8 to 12 weeks for consolidation. Mean distraction length achieved was 40.45 mm. We can conclude that TDDO is an alternative to conventional and more invasive procedures, when we face severe segmental mandibular defects reconstruction. It shows the potential to restore a better anatomical bone regeneration, also providing soft tissues and reducing donor-site morbidity. Patients' education and awareness about the proper use of the transport-disc-distraction device is important to optimize functional outcomes.
Language	English
Publishing date	2014-11-18
Publishing country	United States
Document type	Journal Article
ISSN	1943-3875
ISSN	1943-3875
DOI	10.1055/s-0034-1393729
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Article: Remarkable Triple Pleomorphic Adenoma Affecting both Parotid and Submandibular Glands.

Pingarrón-Martín, Lorena / Arias-Gallo, L J / Demaría-Martínez, G / Chamorro Pons, M

Craniomaxillofacial trauma & reconstruction

2014 Volume 8, Issue 2, Page(s) 129–131

Abstract: The objective of this article is to present the first case reported in the literature of metachronous pleomorphic adenoma of bilateral parotid glands and submaxillary gland. The authors report the case of a 27-year-old female with metachronous mixed ... ...

Abstract	The objective of this article is to present the first case reported in the literature of metachronous pleomorphic adenoma of bilateral parotid glands and submaxillary gland. The authors report the case of a 27-year-old female with metachronous mixed tumors in her right parotid and submandibular glands. The patient has no history of previous radiotherapy. All three lesions were diagnosed by fine-needle aspiration. The histopathologic evaluation of all three major salivary gland masses demonstrated pleomorphic adenomas, with no occult malignancy observed on serial sections. The presentation of pleomorphic adenomas in the parotids and submandibular glands probably represents three unrelated primary sites of tumor, yet the possibility of metastasis from one gland to the other cannot be excluded.
Language	English
Publishing date	2014-05-29
Publishing country	United States
Document type	Case Reports
ISSN	1943-3875
ISSN	1943-3875
DOI	10.1055/s-0034-1378184
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Article ; Online: Fibroscopic findings in patients following maxillary osteotomies in orthognathic surgery.

Pingarrón Martín, L / Arias Gallo, L J / López-Arcas, J M / Chamorro Pons, M / Cebrián Carretero, J L / Burgueño García, M

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2011 Volume 39, Issue 8, Page(s) 588–592

Abstract: Objective: To evaluate the intranasal complications in patients submitted to maxillary Le Fort osteotomy within the orthognathic evaluation through flexible fibroscope, method which is safety, reliable and minimally invasive.: Materials and methods: ... ...

Abstract	Objective: To evaluate the intranasal complications in patients submitted to maxillary Le Fort osteotomy within the orthognathic evaluation through flexible fibroscope, method which is safety, reliable and minimally invasive. Materials and methods: A prospective, systematic non-randomized study is presented with a series of 47 patients who underwent a Le Fort I maxillary osteotomy due to dentofacial deformity between January 2008 and December 2008. The patients who were included underwent an evaluation of nasal respiratory function using a questionnaire designed for this objective, after which a fibroscopic examination was carried out. Results: With regards to the results of the NOSE questionnaire, 4/47 patients had Grade 2 nasal obstruction before the surgery. After the intervention, three improved to a 0-1 grade. 3/47 patients reported snoring during sleep without OSAS that was not modified as a result of the surgery. 2/47 patients presented with sequelae regarding the deviation of the septum, and 1/47 had a luxation of the anterior nasal spine that had not been recorded before the orthognathic surgery. The presence of synechiae was observed in 3/47 cases. A septal perforated mucosa was found in the IV area of the nasal septum. Hypertrophy of the lower turbinate was observed in 4/47 cases. Conclusion: The fibroscope procedure is minimally invasive and it does not require local anesthesia or sedation, and it allows the surgeon to carry out an immediate and exhaustive evaluation, on an outpatient basis, of possible septal and nasal sequelae in patients undergoing orthognathic surgery.
MeSH term(s)	Adult ; Endoscopy/methods ; Female ; Follow-Up Studies ; Humans ; Hypertrophy ; Male ; Maxilla/surgery ; Middle Aged ; Nasal Mucosa/injuries ; Nasal Obstruction/therapy ; Nasal Septum/injuries ; Nose/pathology ; Optical Fibers ; Orthognathic Surgical Procedures/methods ; Osteotomy, Le Fort/methods ; Postoperative Complications/diagnosis ; Prospective Studies ; Pulmonary Ventilation/physiology ; Respiration ; Rhinitis ; Tissue Adhesions/diagnosis ; Turbinates/pathology ; Young Adult
Language	English
Publishing date	2011-12
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2010.11.013
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Zs.A 882: Show issues

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Article: Le fort I osteotomy with bone grafts in preprosthetic surgery: technical note.

Pingarron-Martin, Lorena / Arias-Gallo, Javier / Ong, Hui Shan / Chamorro Pons, Manuel

Craniomaxillofacial trauma & reconstruction

2013 Volume 6, Issue 2, Page(s) 143–146

Abstract: Background Being edentulous causes progressive bony resorption in maxillae, which can lead to altered maxillomandibular relationships. Discussion should consider Le Fort I osteotomy with inlay grafts for a better success rate. Thus, this article ... ...

Abstract	Background Being edentulous causes progressive bony resorption in maxillae, which can lead to altered maxillomandibular relationships. Discussion should consider Le Fort I osteotomy with inlay grafts for a better success rate. Thus, this article introduces a technical note in improving the success rate. Case Report The presented technical note permits transformation of the surgery in a conventional Le Fort I with a simple fixation not only of the grafts but also of the osteotomy. The surgical steps are explained as well as the follow-up results. Discussion Adding additional wire anchorage around bone grafts greatly improved our success rate and reduced our operative time. Bone grafting concurrently with Le Fort I osteotomy immediately improved the facial skeletal profile. Several in vitro studies have shown that galvanic corrosion does not play a significant role when combining stainless steel and titanium. Our novel technique is relatively simple and can be easily picked up by young surgeons.
Language	English
Publishing date	2013-03-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1943-3875
ISSN	1943-3875
DOI	10.1055/s-0033-1333876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Experience with Mandibular Reconstruction Using Transport-Disc-Distraction Osteogenesis

Pingarrón-Martín, Lorena / Otero, T. González / Gallo, L.J. Arias

Craniomaxillofacial Trauma & Reconstruction

2014 Volume 08, Issue 02, Page(s) 117–122

Abstract	The goal of transport-disc-distraction osteogenesis (TDDO) is to restore bone continuity by using in-situ bone. It may be useful following trauma, gunshot injuries, or tumor ablation, especially when there may be contraindications at the donor site or for prolonged surgery. To the best of the authors' knowledge, this is the first time TDDO has been used for mandibular reconstruction reporting additional procedures, which include osseointegrated dental implants rehabilitation and orthognathic surgery. A retrospective study is performed analyzing all mandibular reconstruction cases that may be suitable for distraction from January 2006 to December 2011. A thorough description of the documented cases includes details about sex, gender, complications, duration of hospitalization, etiology, size, and location of the defect. Eight cases of mandibular reconstruction were included. Six cases correspond to mandibular ameloblastoma. The remaining two cases were mandibular gunshot comminuted fractures. Range of the defects was from 45 to 60 mm. Length of the transport disc was 15 to 20 mm. Protocolized technique consisted of 5 days of latency period, 19 to 45 days of activation term (average 30 days), and 8 to 12 weeks for consolidation. Mean distraction length achieved was 40.45 mm. We can conclude that TDDO is an alternative to conventional and more invasive procedures, when we face severe segmental mandibular defects reconstruction. It shows the potential to restore a better anatomical bone regeneration, also providing soft tissues and reducing donor-site morbidity. Patients' education and awareness about the proper use of the transport-disc-distraction device is important to optimize functional outcomes.
Keywords	transport-disc-distraction osteogenesis ; TDDO ; mandibular reconstruction ; gunshot injury ; ameloblastoma
Language	English
Publishing date	2014-11-18
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	1943-3883 ; 1943-3875
ISSN (online)	1943-3883
ISSN	1943-3875
DOI	10.1055/s-0034-1393729
Database	Thieme publisher's database

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Article: Bronchial impaction of an implant screwdriver after accidental aspiration report of a case and revision of the literature

Pingarrón Martin, L. / Morán Soto, M. J. / Sánchez Burgos, R. / Burgueño Garcia, M.

Oral and maxillofacial surgery

2010 Volume 14, Issue 1, Page(s) 43

Language	English
Document type	Article
ZDB-ID	2406731-3
ISSN	1865-1550
Database	Current Contents Medicine

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Zs.A 4767: Show issues

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Article: Remarkable Triple Pleomorphic Adenoma Affecting both Parotid and Submandibular Glands

Pingarrón-Martín, Lorena / Arias-Gallo, L. J. / Demaría-Martínez, G. / Chamorro Pons, M.

Craniomaxillofacial Trauma & Reconstruction

2014 Volume 08, Issue 02, Page(s) 129–131

Abstract	The objective of this article is to present the first case reported in the literature of metachronous pleomorphic adenoma of bilateral parotid glands and submaxillary gland. The authors report the case of a 27-year-old female with metachronous mixed tumors in her right parotid and submandibular glands. The patient has no history of previous radiotherapy. All three lesions were diagnosed by fine-needle aspiration. The histopathologic evaluation of all three major salivary gland masses demonstrated pleomorphic adenomas, with no occult malignancy observed on serial sections. The presentation of pleomorphic adenomas in the parotids and submandibular glands probably represents three unrelated primary sites of tumor, yet the possibility of metastasis from one gland to the other cannot be excluded.
Keywords	pleomorphic adenoma ; metachronous ; salivary gland ; bilateral parotid tumor
Language	English
Publishing date	2014-05-29
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	1943-3883 ; 1943-3875
ISSN (online)	1943-3883
ISSN	1943-3875
DOI	10.1055/s-0034-1378184
Database	Thieme publisher's database

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Article ; Online: Bronchial impaction of an implant screwdriver after accidental aspiration: report of a case and revision of the literature.

Pingarrón Martín, Lorena / Morán Soto, María José / Sánchez Burgos, Rocío / Burgueño García, Miguel

Oral and maxillofacial surgery

2009 Volume 14, Issue 1, Page(s) 43–47

Abstract: Background: Adverse outcomes resulting from aspiration or ingestion of instruments and materials can occur in any dental procedure. Clinical manifestation depends on the location, the obstructive potential of the foreign body, and the temporal factor ... ...

Abstract	Background: Adverse outcomes resulting from aspiration or ingestion of instruments and materials can occur in any dental procedure. Clinical manifestation depends on the location, the obstructive potential of the foreign body, and the temporal factor since the accidental incident. Accidental inhalation of dental appliances can be an even more serious event than ingestion and must always be treated as an emergency situation. Case report: A 62-year-old woman was admitted to our hospital with the suspicion of ingestion of a screwdriver implants. In spite of the clinically asymptomatic presentation, chest radiography in posteroanterior and lateral projections showed a radiopaque dental instrument impacted on the right main inferior bronchus. Rigid bronchoscope was successful to remove the dental instrument under general anesthesia, and the patient was discharged 24 h later. Conclusion: Aspiration and ingestion of dental foreign objects are infrequent, but they can occur at large multidisciplinary dental procedures. These episodes have the potential to result in acute medical and life-threatening emergencies since the beginning of the event or at a late stage in proceeding in the underdiagnosed patient. Prevention of such incidents is, therefore, the best approach via the mandatory use of precautions during all dental procedures, and in case of suspicion with no retrievable material, patient must always be submitted to a radiographic study.
MeSH term(s)	Accidents ; Bronchi ; Bronchoscopy ; Dental Implantation, Endosseous/instrumentation ; Dental Instruments ; Emergencies ; Female ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/therapy ; Humans ; Middle Aged ; Radiography ; Respiratory Aspiration
Language	English
Publishing date	2009-10-16
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	2406731-3
ISSN	1865-1569 ; 1865-1550
ISSN (online)	1865-1569
ISSN	1865-1550
DOI	10.1007/s10006-009-0178-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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